Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 15, Pages 4901-4905Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201813149
Keywords
cytotoxicity; hepatocellular carcinoma; peptides; platinum nanoparticles; selectivity
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Funding
- European Union [705970]
- Swiss National Science Foundation [CRSII2 160805]
- Swiss National Science Foundation (SNF) [CRSII2_160805] Funding Source: Swiss National Science Foundation (SNF)
- Marie Curie Actions (MSCA) [705970] Funding Source: Marie Curie Actions (MSCA)
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Peptide-stabilized platinum nanoparticles (PtNPs) were developed that have significantly greater toxicity against hepatic cancer cells (HepG2) than against other cancer cells and non-cancerous liver cells. The peptide H-Lys-Pro-Gly-dLys-NH2 was identified by a combinatorial screening and further optimized to enable the formation of water-soluble, monodisperse PtNPs with average diameters of 2.5 nm that are stable for years. In comparison to cisplatin, the peptide-coated PtNPs are not only more toxic against hepatic cancer cells but have a significantly higher tumor cell selectivity. Cell viability and uptake studies revealed that high cellular uptake and an oxidative environment are key for the selective cytotoxicity of the peptide-coated PtNPs.
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