Article
Agriculture, Dairy & Animal Science
Kayo Furumoto, Kumi Ogita, Tomomi Kamisaka, Asami Kawasumi, Koushi Takata, Noritaka Maeta, Takamasa Itoi, Masakatsu Nohara, Kaori Saeki, Teppei Kanda
Summary: The study showed that a multimodal analgesic protocol using buprenorphine and meloxicam was effective in managing postoperative pain in mice, but was not sufficient to prevent food intake and weight decrease. It is suggested to focus not only on relieving surgery-related pain, but also on other types of distress to minimize negative side effects that may interfere with postoperative recovery.
Article
Biochemistry & Molecular Biology
Katarzyna Ciapala, Ewelina Rojewska, Katarzyna Pawlik, Agata Ciechanowska, Joanna Mika
Summary: The study aimed to determine the effects of nonselective modulators of MAP kinases and PI3K on peripheral neuropathy and their impact on opioid-induced analgesia. The results showed that fisetin, peimine, and astaxanthin effectively reduced tactile and thermal hypersensitivity in mice with neuropathic pain, while artemisinin did not exhibit analgesic potency. Bardoxolone methyl and 740 Y-P showed analgesic effects and enhanced opioid effectiveness. Combined administration of astaxanthin and bardoxolone methyl with opioids further increased analgesia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Juliet M. Ross, Stephanie A. Kleine, Christopher K. Smith, Rebekah K. DeBolt, Jennifer Weisent, Emma Hendrix, Reza Seddighi
Summary: This study evaluates and compares the postoperative analgesic effects of grapiprant and carprofen in dogs undergoing ovariohysterectomy. The results indicate that grapiprant is noninferior to carprofen in terms of pain relief. This study supports the use of grapiprant as an alternative analgesic to carprofen in this surgical procedure.
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2023)
Article
Chemistry, Medicinal
Beiwei Liang, Chunlai Li, Zhan Zhou, Yubo Xie
Summary: This study aimed to investigate the effect of hydromorphone on the growth of human gastric cancer cells. The results showed that within a certain concentration range, hydromorphone can suppress the growth of human gastric cancer cells, and the inhibitory effect is enhanced with longer incubation time and higher concentrations. Hydromorphone inhibits the growth of human gastric cancer cells through cell cycle arrest and induction of apoptosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Psychiatry
Jessica Delorme, Lucie Pennel, Georges Brousse, Jean-Pierre Daulouede, Jean-Michel Delile, Philippe Lack, Antoine Gerard, Maurice Dematteis, Jean-Luc Kabore, Nicolas Authier, Chouki Chenaf
Summary: Chronic pain is highly prevalent in patients receiving opioid agonist treatments, with a prevalence of 33.2% in this French study. Chronic pain patients tended to be older, unemployed, had higher rates of psychiatric comorbidities, and reported moderate to severe pain intensity. Management of chronic pain in these patients remains a challenge, with many resorting to additional self-medication with analgesics or illicit drugs.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Veterinary Sciences
Kara L. Moreno, Elizabeth M. Scallan, Beatriz P. Monteiro, Paulo Steagall, Bradley T. Simon
Summary: Evaluation of thermal antinociceptive effects in conscious cats using high-concentration buprenorphine alone or in combination with hydromorphone showed that the combination did not provide additional analgesic effects.
VETERINARY ANAESTHESIA AND ANALGESIA
(2021)
Article
Medicine, General & Internal
Jessica S. Merlin, Dmitry Khodyakov, Robert Arnold, Hailey W. Bulls, Emily Dao, Jennifer Kapo, Caroline King, Diane Meier, Judith Paice, Christine Ritchie, Jane M. Liebschutz
Summary: This study provides consensus-based guidance for clinicians in managing cancer pain in patients with opioid use disorder, highlighting critical research and policy gaps that need to be addressed for implementation.
Article
Medicine, General & Internal
Joshua A. Barocas, Samantha K. Nall, Sarah Axelrath, Courtney Pladsen, Alaina Boyer, Alex H. Kral, Ashley A. Meehan, Alexandra Savinkina, David Peery, Michael Bien, Christine Agnew-Brune, Jesse Goldshear, Joey Chiang, Benjamin P. Linas, Gregg Gonsalves, Ricky N. Bluthenthal, Emily Mosites, NHBS Study Grp
Summary: At least 500,000 people in the US are homeless every night, and over 30% of them also have substance use disorders. Involuntary displacement is a common response to unsheltered homelessness. It is important to understand the health implications of displacement, especially regarding substance use disorder outcomes.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Psychiatry
Amit Singh, Ravindra Rao, Biswadip Chatterjee, Ashwani Kumar Mishra, Gaurishanker Kaloiya, Atul Ambekar
Summary: This study aimed to assess the cognitive functions in participants maintained on buprenorphine for opioid dependence at peak and trough buprenorphine levels. The results indicated significant differences between peak and trough groups in the Wisconsin Card Sorting Test, suggesting that the time since buprenorphine dose has a significant impact on specific cognitive tasks in patients maintained on buprenorphine for opioid dependence.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Immunology
Katarzyna Pawlik, Agata Ciechanowska, Katarzyna Ciapala, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
Summary: Neuropathic pain presents a significant clinical challenge with mechanisms not fully understood. The modulation of CCR3 in pain relief and enhancing drug efficacy is a potential target for future investigations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Anesthesiology
Jessica Delorme, Celian Bertin, Noemie Delage, Alain Eschalier, Denis Ardid, Nicolas Authier, Chouki Chenaf
Summary: This study used the capture-recapture method to estimate the prevalence of chronic pain in opioid-maintained patients, finding that the prevalence of chronic pain in this group was 3- to 4-fold higher than in the general population.
Article
Psychology, Clinical
LaTrice Montgomery, Theresa Winhusen, Jennifer Scodes, Martina Pavlicova, Dylanne Twitty, Aimee N. C. Campbell, An Li Wang, Edward V. Nunes, John Rotrosen
Summary: Treatment with XR-NTX in OUD patients resulted in a greater reduction in cigarette use compared to treatment with BUP-NX, suggesting that XR-NTX combined with other smoking cessation interventions may be a better choice for OUD smokers looking to reduce their tobacco use.
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2021)
Article
Medicine, General & Internal
Johanne Naper Tronnes, Angela Lupattelli, Marte Handal, Svetlana Skurtveit, Eivind Ystrom, Hedvig Nordeng
Summary: This study examined the association between prenatal analgesic opioid exposure and ADHD in children, finding a slightly increased risk of ADHD diagnosis for exposure lasting 5 weeks or more compared to exposure lasting 4 weeks or less. Further research is needed to confirm these findings and explore potential confounding factors.
Article
Medicine, General & Internal
Ying Zhang, Shixuan Xie, Guanglei Zhang, Xun Gong
Summary: This study evaluated the analgesic effect of butorphanol tartrate combined with hydromorphone in patients undergoing cesarean section. The results showed that the butorphanol group had significantly lower pain scores at 3 and 4 hours after stopping intravenous analgesia compared to the control group. However, there were no significant differences between the two groups in other aspects such as vital signs, adverse reactions, and neonatal jaundice.
Article
Oncology
Katie Fitzgerald Jones, Dmitry Khodyakov, Robert Arnold, Hailey Bulls, Emily Dao, Jennifer Kapo, Diane Meier, Judith Paice, Jane Liebschutz, Christine Ritchie, Jessica Merlin
Summary: This qualitative study aims to establish consensus among palliative care and addiction specialists on the appropriateness of various opioid management strategies in individuals with advanced cancer-related pain and opioid misuse or OUD. The findings provide urgently needed guidance for clinicians and highlight critical research and policy gaps.
Article
Substance Abuse
Andrew S. Huhn, Eric C. Strain, Jasmyne Jardot, Gavin Turner, Cecilia L. Bergeria, Sandeep Nayak, Kelly E. Dunn
Summary: This study explored patient-reported experiences in substance use disorder treatment during the early stages of the COVID-19 crisis. It found that disruptions in treatment and increased stress were reported by participants, with those using drugs/alcohol experiencing more difficulties and psychological issues. Therefore, it is important to improve continuity and quality of care for substance use disorder treatment during the COVID-19 crisis, with a focus on addressing childcare difficulties and providing remote methods to improve mental health.
JOURNAL OF ADDICTION MEDICINE
(2022)
Article
Neurosciences
Jill A. Rabinowitz, Adrian Campos, Jue-Sheng Ong, Luis M. Garcia-Marin, Sarael Alcauter, Brittany L. Mitchell, Katrina L. Grasby, Gabriel Cuellar-Partida, Nathan A. Gillespie, Andrew S. Huhn, Nicholas G. Martin, Paul M. Thompson, Sarah E. Medland, Brion S. Maher, Miguel E. Renteria
Summary: The study uncovered a shared genetic etiology between cortical brain morphology and substance use behaviors, suggesting that genetic variants associated with substance use may be causally related to brain structure differences. This may help to better understand the association between brain structure and substance use.
Article
Psychology, Biological
Andrew S. Huhn, Patrick H. Finan
Summary: The importance of addressing sleep disturbances in individuals with opioid use disorder is highlighted in this narrative review. Sleep issues are commonly reported among this population and are associated with negative treatment outcomes. More research and clinical trials are needed to explore the potential benefits of targeting sleep to improve OUD treatment.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Biological
Kelly E. Dunn, Patrick H. Finan, Andrew S. Huhn, Charlene Gamaldo, Cecilia L. Bergeria, Eric C. Strain
Summary: Many individuals withdrawing off of opioids experience severe sleep impairment and insomnia. The study shows that a wireless EEG sleep monitor is a feasible and useful tool for objective monitoring of sleep in this population, providing more accurate information than standard sleep diaries.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Substance Abuse
Jennifer D. Ellis, Jami L. Mayo, Patrick H. Finan, Charlene E. Gamaldo, Andrew S. Huhn
Summary: The study shows that drug-related dreams are common among individuals with opioid use disorder, and are associated with sleep disturbances, anxiety symptoms, and history of substance use issues.
AMERICAN JOURNAL ON ADDICTIONS
(2022)
Article
Substance Abuse
Cameron M. Yi, Andrew S. Huhn, J. Gregory Hobelmann, John Finnerty, Bernadette Solounias, Kelly E. Dunn
Summary: This study embedded patient-reported outcome measures into a residential treatment program to assess the effectiveness of different treatment strategies. The results showed that alcohol and/or opioid use at admission were associated with worse physical and mental health, sleep quality, and quality of life. Previous treatment history and/or withdrawal management were also linked to poorer health outcomes and increased cravings. Overall, physical and mental health improved over time, but individuals with opioid use disorder had worse physical health and more severe negative emotions at discharge.
JOURNAL OF ADDICTION MEDICINE
(2022)
Article
Clinical Neurology
Jennifer D. Ellis, Jill A. Rabinowitz, Jonathan Wells, Fangyu Liu, Patrick H. Finan, Michael D. Stein, Denis G. Antoine, Gregory J. Hobelmann, Andrew S. Huhn
Summary: The study found that in early treatment for opioid use disorder, some individuals experience persistent and significant anxiety and depressive symptoms, while others experience symptom remission. Females and individuals with heavy past-month benzodiazepine use are more likely to have persistent moderate-to-severe anxiety and depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Jennifer D. Ellis, Jami L. Mayo, Charlene E. Gamaldo, Patrick H. Finan, Andrew S. Huhn
Summary: This study aimed to investigate the characteristics associated with sleep quality and sleep disturbances in individuals with opioid use disorder (OUD). The study found that sleep quality declined over time and persistent sleep disturbance was correlated with female sex, a greater number of treatment episodes, and positive screens for chronic pain and insomnia. Regular screening for sleep disturbances and chronic pain in OUD patients is recommended, and interventions addressing OUD, sleep disturbance, and chronic pain concurrently are needed.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Editorial Material
Substance Abuse
Andrew S. Huhn, Jennifer D. Ellis
Article
Psychology, Biological
Cecilia L. Bergeria, Hongjun Tan, Denis Antoine, Elise M. Weerts, Andrew S. Huhn, J. Gregory Hobelmann, Kelly E. Dunn
Summary: Successful management of opioid withdrawal can improve treatment outcomes and reduce related morbidity and mortality. Buspirone, as an adjunct to opioid withdrawal, can alleviate withdrawal symptoms and positively impact sleep quality.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
Neil B. Varshneya, Kelly E. Dunn, Caitlyn J. Grubb, Sandra Okobi, Andrew S. Huhn, Cecilia L. Bergeria
Summary: This study examined the relationship between initial subjective effects of alcohol or cannabis use and the severity of alcohol or cannabis use disorders. The results showed that the initial subjective effects were associated with the severity of use disorders, consistent with reports of feeling energized or relieved.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Cell Biology
Andrew S. Huhn, Patrick H. Finan, Charlene E. Gamaldo, Alexis S. Hammond, Annie Umbricht, Cecilia L. Bergeria, Eric C. Strain, Kelly E. Dunn
Summary: This study examined the use of a dual-orexin receptor antagonist in opioid withdrawal and found that it may have potential benefits for improving sleep and withdrawal outcomes.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Andrew S. Huhn, Jennifer D. Ellis
Article
Substance Abuse
Caitlyn J. Durgin, Andrew S. Huhn, Cecilia L. Bergeria, Patrick H. Finan, Claudia M. Campbell, Denis G. Antoine, Kelly E. Dunn
Summary: In a primarily opioid-naive population, sensitivity to opioids varied depending on the measure used. Some participants did not subjectively respond to the opioid dose tested, while those who did respond showed more evidence of drug-dependent effects.
DRUG AND ALCOHOL DEPENDENCE REPORTS
(2023)
Article
Psychology, Clinical
Jill A. Rabinowitz, Beth A. Reboussin, Johannes Thrul, Deborah A. G. Drabick, Geoffrey Kahn, Kerry M. Green, Nicholas S. Ialongo, Andrew S. Huhn, Brion S. Maher
Summary: The study found that childhood aggressive behavior and attention problems are associated with later opioid misuse. Females with higher attention problems are more likely to misuse opioids, particularly prescription opioids, while males with lower peer social preference/likability are more likely to misuse opioids.
JOURNAL OF CLINICAL CHILD AND ADOLESCENT PSYCHOLOGY
(2022)