Review
Oncology
Tomomi Kogiso, Katsutoshi Tokushige
Summary: The incidence of NAFLD-related HCC is increasing, emphasizing the need for effective screening. Revised guidelines in Japan propose new management and surveillance strategies for NAFLD/NASH. Advanced fibrosis and lifestyle-related diseases are associated with HCC development.
Review
Gastroenterology & Hepatology
Yuri Cho, Bo Hyun Kim, Joong-Won Park
Summary: The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) is increasing globally, including Asia. Compared to virus-related HCC, most patients with NAFLD-related HCC are diagnosed at a late stage and older age due to lack of HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLD-related HCC, and surveillance strategies for patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Review
Cell Biology
Amila Iriskic Atic, Maja Thiele, Alexander Munk, Louise Torp Dalgaard
Summary: MicroRNAs (miRNAs) secreted by the liver have the potential to be important biomarkers for nonalcoholic liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Several miRNAs, including miR-122, miR-21, miR-34a, miR-192, miR-193, and the miR-17-92 miRNA-cluster, are consistently associated with NAFLD/NASH. These miRNAs show potential as diagnostic markers for NAFLD/NASH, although more research is needed to understand their specificity and regulation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Review
Gastroenterology & Hepatology
Simona Cernea, Danusia Onisor
Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is a common type of cancer worldwide. In addition to viral infections and certain liver diseases, other risk factors such as old age, obesity, insulin resistance, and type 2 diabetes also contribute to the occurrence of HCC. Screening for HCC in nonalcoholic fatty liver disease (NAFLD) patients is still lacking, and identifying individuals who progress to HCC without cirrhosis is a challenge. Lifestyle changes and pharmacological interventions may play a protective role in preventing NAFLD/NASH-associated HCC, but more research is needed to understand the relationship.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Medicine, General & Internal
Mohamed Salaheldin, Heba Aly, Louis Lau, Shimaa Afify, Mohamed El-Kassas
Summary: Over the years, the complications of viral hepatitis and alcohol-related liver diseases have been a major concern in hepatology. However, recent advancements in the field have revealed a paradigm shift towards nonalcoholic fatty liver disease (NAFLD) as the leading cause of liver cirrhosis and cancer. This review focuses on updating knowledge about the pathogenesis of NAFLD-induced hepatocellular carcinoma (HCC), surveillance challenges, and potential disease markers, such as molecular biomarkers, which may revolutionize risk stratification, early detection, and treatment selection for NAFLD-related HCC.
Review
Oncology
Ilias D. Vachliotis, Ioannis Valsamidis, Stergios A. Polyzos
Summary: The prevalence of nonalcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is increasing rapidly. The mechanisms of progression from NAFLD to HCC are not fully understood, but tumor necrosis factor-alpha (TNF-alpha) and adiponectin may play a role. TNF-alpha initially aims to protect against hepatocarcinogenesis, but during the progression of NAFLD, TNF-alpha is increased, thus possibly inducing hepatocarcinogenesis. On the other hand, adiponectin, which is expected to have anti-tumorigenic effects, is decreased during the progression of the disease, but paradoxically increased at the end stage when cirrhosis and HCC are present. Both TNF-alpha and adiponectin may serve as diagnostic biomarkers and therapeutic targets in the treatment of NAFLD-associated HCC, possibly in combination with immune checkpoint inhibitors.
Review
Gastroenterology & Hepatology
Lorenzo A. Orci, Marco Sanduzzi-Zamparelli, Berta Caballol, Victor Sapena, Nicola Colucci, Ferran Torres, Jordi Bruix, Maria Reig, Christian Toso
Summary: Nonalcoholic fatty liver disease (NAFLD) may be a risk factor for hepatocellular carcinoma (HCC), and this study used meta-analysis to analyze the incidence rates of HCC in NAFLD patients. The results showed that NAFLD patients with cirrhosis have a similar risk of developing HCC compared to cirrhosis patients with other causes. However, the incidence of HCC in nonalcoholic steatohepatitis or simple steatosis patients is lower.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Yi-Chuan Yu, Pedram Paragomi, Renwei Wang, Feiran Liang, Hung N. N. Luu, Jaideep Behari, Jian-Min Yuan
Summary: This study examined the association between serum magnesium levels and the risk of HCC among patients with NAFLD. The results showed that higher levels of serum magnesium were significantly associated with a decreased risk of HCC among patients with NAFLD.
Review
Endocrinology & Metabolism
Rong Liu, Ming-Ping Qian, Ying-Yu Cui
Summary: Protein kinases (PKs) are a large protein family that can be divided into different groups based on their substrate or structure and function. They play important roles as signaling messengers in various life activities, including cell metabolism, proliferation, division, differentiation, senescence, death, and disease. Accumulating evidence suggests that PKs are involved in the pathogenesis of nonalcoholic fatty liver disease-derived hepatocellular carcinoma (NAFLD-HCC) through aberrant metabolism, hypoxia, autophagy, gut microbiota dysbiosis, and/or immune cell rearrangement. This review aims to summarize the latest research advances and highlight the feasibility and effectiveness of therapeutic strategies that regulate PKs.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Oncology
Federico Costante, Carlo Airola, Francesco Santopaolo, Antonio Gasbarrini, Maurizio Pompili, Francesca Romana Ponziani
Summary: About one-fourth of adults globally suffer from nonalcoholic fatty liver disease (NAFLD), which is becoming a leading cause of chronic liver disease worldwide. NAFLD is a leading cause of hepatocellular carcinoma (HCC), and the tumor microenvironment (TME) in HCC patients is characterized by complex interactions and immune suppression. Treatment with immune checkpoint inhibitors (ICIs) may not be as effective in patients with NAFLD-related HCC, while the addition of an angiogenesis inhibitor shows better results. Future strategies should consider novel biomarkers and modulation of gut microbiota to improve personalized medicine and response to ICIs in NAFLD-related HCC.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Biyao Zou, Michelle C. Odden, Mindie H. Nguyen
Summary: Recent evidence suggests potential clinical benefits of statin in cancer chemoprevention and treatment. This study aimed to investigate the association between statin initiation and the risk of HCC among patients with NAFLD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Guizhi Zhang, Yinghui Hou
Summary: This study aimed to identify potential aberrantly methylated and differentially expressed genes in nonalcoholic fatty liver disease (NAFLD) of HCC patients with cirrhosis. By analyzing data from the Cancer Genome Atlas (TCGA) database, the researchers identified several candidate genes that were significantly correlated with the overall survival time of NAFLD patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Article
Cell Biology
Monika Gjorgjieva, Anne-Sophie Ay, Marta Correia de Sousa, Etienne Delangre, Dobrochna Dolicka, Cyril Sobolewski, Christine Maeder, Margot Fournier, Christine Sempoux, Michelangelo Foti
Summary: This study demonstrates that miR-22 acts as a tumor suppressor in liver cancer by regulating energy metabolism and mitochondrial functions to restrict pro-carcinogenic metabolic deregulations.
Article
Oncology
Jae Seung Lee, Dong Hyun Sinn, Soo Young Park, Hye Jung Shin, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Joo Hyun Oh, Jung Il Lee, Seung Up Kim
Summary: A new liver stiffness-based risk prediction model for the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease showed acceptable performance in both internal and external validation, demonstrating its usefulness in predicting the risk of HCC development in NAFLD patients.
Review
Medicine, Research & Experimental
Zijun Xie, Chenming Zhong, Jinze Shen, Yunhua Jia, Shiwei Duan
Summary: LINC00963 is a long intergenic noncoding RNA located on human chromosome 9q34.11. It plays an oncogenic role by regulating various cellular processes and is associated with clinicopathological features and prognosis in multiple cancers. LINC00963 is involved in several signaling pathways and is associated with drug resistance and chemotherapy efficacy prediction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Immunology
Qiudan Zhang, Jinze Shen, Yuchen Wu, Wenjing Ruan, Feng Zhu, Shiwei Duan
Summary: LINC00520, a highly conserved long non-coding RNA, is abnormally expressed in cancer and is associated with tumor cell proliferation and migration. Its expression is regulated by transcription factors and is involved in multiple signaling pathways. This research suggests that LINC00520 could serve as a potential biomarker for cancer diagnosis, prognosis, and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Limnology
Sujay S. Kaushal, Paul M. Mayer, Gene E. Likens, Jenna E. Reimer, Carly M. Maas, Megan A. Rippy, Stanley B. Grant, Ian Hart, Ryan M. Utz, Ruth R. Shatkay, Barret M. Wessel, Christine E. Maietta, Michael L. Pace, Shuiwang Duan, Walter L. Boger, Alexis M. Yaculak, Joseph G. Galella, Kelsey L. Wood, Carol J. Morel, William Nguyen, Shane Elizabeth C. Querubin, Rebecca A. Sukert, Anna Lowien, Alyssa Wellman Houde, Anais Roussel, Andrew J. Houston, Ari Cacopardo, Cristy Ho, Haley Talbot-Wendlandt, Jacob M. Widmer, Jairus Slagle, James A. Bader, Jeng Hann Chong, Jenna Wollney, Jordan Kim, Lauren Shepherd, Matthew T. Wilfong, Megan Houlihan, Nathan Sedghi, Rebecca Butcher, Sona Chaudhary, William D. Becker
Summary: The severity and recovery chances of freshwater salinization syndrome (FSS) are influenced by various factors, including human activities, geology, flowpaths, climate, and time. These factors drive the spread of FSS across ecosystems in different stages, leading to failures in systems-level functions.
LIMNOLOGY AND OCEANOGRAPHY LETTERS
(2023)
Article
Multidisciplinary Sciences
Peijie Zheng, Chenshu Pan, Chuntao Zhou, Bin Liu, Linlin Wang, Shiwei Duan, Yuemin Ding
Summary: This review systematically analyzes the role and mechanism of Nischarin/IRAS in the CNS, providing necessary references and potential treatment targets for neurological diseases, thereby expanding the direction of Nischarin/IRAS research and facilitating clinical translation.
JOURNAL OF ADVANCED RESEARCH
(2023)
Editorial Material
Oncology
Peijie Zheng, Chuntao Zhou, Yuemin Ding, Shiwei Duan
Summary: Altered metabolism in cancer can be targeted for treatment by exploiting regulated cell death (RCD) mechanisms. A recent study discovered a new metabolic-related RCD called disulfidptosis, which can be triggered by glucose transporter (GLUT) inhibitors, leading to inhibition of cancer growth. This review summarizes the underlying mechanisms of disulfidptosis and discusses potential future research directions, as well as the challenges in translating disulfidptosis research into clinical applications.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, Research & Experimental
Jinze Shen, Qurui Wang, Yunan Mao, Wei Gao, Shiwei Duan
Summary: Tumor suppressor p53 activates downstream genes in response to stress and regulates various biological responses. Activation and inactivation of p53 are finely regulated through post-translational modifications. Abnormal activation of p53 is closely related to cancer, and targeted therapy of the p53 signaling pathway is expected to be widely used in the future.
Review
Genetics & Heredity
Jinze Shen, Jiahua Si, Qurui Wang, Yunan Mao, Wei Gao, Shiwei Duan
Summary: miR-492, a single-stranded small non-coding RNA, plays a crucial role in cell behavior regulation and is involved in the regulation of multiple signaling pathways. Higher expression is associated with shorter overall survival in various cancer patients.
Review
Endocrinology & Metabolism
Peijie Zheng, Zihao Lin, Yuemin Ding, Shiwei Duan
Summary: This commentary discusses the dynamic changes of tumor metabolic reprogramming and its clinical implications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Kaijie Qiu, Qing Xia, Hao Chen, Qiong Ye, Haixiang Mao, Mei Tian, Yichao Gan, Qinyuan Huang, Haibiao Wang, Shiwei Duan
Summary: This study demonstrates that Actinidia chinensis Planch Root extracts (acRoots) effectively inhibits the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells. It induces apoptosis and autophagy by blocking the AKT/mTOR signaling pathway. These findings suggest that acRoots has potential as a promising antitumor agent for HCC.
Review
Medicine, Research & Experimental
Peijie Zheng, Chuntao Zhou, Yuemin Ding, Bin Liu, Liuyi Lu, Feng Zhu, Shiwei Duan
Summary: Since its development in 1977, Sanger sequencing has played a crucial role in molecular biology research by decoding biological genetic codes. Nanopore sequencing, a leading third-generation sequencing technology known for its long reads, portability, and affordability, is widely used in various scientific domains, including epidemic prevention and control, disease diagnosis, and animal and plant breeding. Despite initial concerns regarding its high error rates, constant advancements in sequencing platforms and algorithm analysis have effectively addressed the issue of accuracy. During the COVID-19 pandemic, nanopore sequencing has been instrumental in detecting the SARS-CoV-2 virus genome and containing the outbreak. However, limited understanding of this technology hinders its widespread adoption and application. Nanopore sequencing has the potential to become the primary choice for COVID-19 prevention and control, as well as future epidemics, while also creating value in fields such as oncology and botany. This article aims to introduce the contributions of nanopore sequencing during the COVID-19 pandemic, promote public understanding, and facilitate its utilization in emerging outbreaks worldwide. The applications of nanopore sequencing in microbial detection, cancer genomes, and plant genomes are discussed, along with strategies to enhance its accuracy.
Article
Oncology
Yunan Mao, Jinze Shen, Li Fang, Feng Zhu, Shiwei Duan
Summary: miRNAs are important regulators of gene expression, and miR-1294 has been found to be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. It affects cancer cell proliferation, migration, invasion, and apoptosis, and its target genes are involved in important signaling pathways. Low expression of miR-1294 is associated with drug resistance and poorer prognosis in several types of cancer, emphasizing its clinical significance as a tumor suppressor.
Article
Materials Science, Biomaterials
Xinming Su, Xiaoyu Jin, Zehua Wang, Shiwei Duan
Summary: This article discusses the adaptive immune systems of Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) in prokaryotes, focusing on the three main stages: adaptation, expression, and interference. Recent research highlights a new model in a type I-E CRISPR system which lacks Cas4, involving DnaQ-like exonuclease (DEDDh) and Cas1-Cas2 complexes in protospacer processing within CRISPR arrays. This study offers valuable insights for both fundamental and applied CRISPR studies.
Review
Cell Biology
Qibin Yan, Xinming Su, Yunzhu Chen, Zehua Wang, Wenbo Han, Qing Xia, Yunan Mao, Jiahua Si, Hanbing Li, Shiwei Duan
Summary: LINC00941, also known as lncRNA-MUF, is an intergenic non-coding RNA that plays a vital role in multiple signaling pathways by regulating the expression of microRNA and its downstream proteins. Its consistently high expression in various tumor types is closely associated with clinicopathological features and cancer prognoses. Additionally, LINC00941 and its associated genes are linked to various targeted drugs available in the market.
Article
Gastroenterology & Hepatology
Xiaoxiao Mi, Yu Song, Chaohua Deng, Jian Yan, Zhihui Li, Yingniang Li, Jun Zheng, Wenjun Yang, Ling Gong, Junping Shi
Summary: This study investigates the function and heterogeneity of neutrophils in Wilson's disease using zebrafish, mice, and cellular models. The researchers discover that pharmacologic modulation of N2-neutrophil activity could be explored as an alternative therapeutic approach to improve liver function in Wilson's disease.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
