Article
Surgery
Marilena Gregorini, Elena Ticozzelli, Massimo Abelli, Maria A. Grignano, Eleonora F. Pattonieri, Alessandro Giacomoni, Luciano De Carlis, Antonio Dell'Acqua, Rossana Caldara, Carlo Socci, Andrea Bottazzi, Carmelo Libetta, Vincenzo Sepe, Stefano Malabarba, Federica Manzoni, Catherine Klersy, Giuseppe Piccolo, Teresa Rampino
Summary: This study reports on 11 years of Italian experience comparing the outcomes of kidney transplants from DCD and EPD. Despite similar graft and patient survival rates, EPD showed better clinical outcomes and the use of ECMO in the procurement phase improved graft outcomes.
TRANSPLANT INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Shivank Madan, Omar Saeed, Stephen J. Forest, Daniel J. Goldstein, Ulrich P. Jorde, Snehal R. Patel
Summary: This study provides a preliminary analysis of adult donation after circulatory death heart transplantations (DCD-HTs) in the United States, showing favorable early outcomes and suggesting the potential for a substantial increase in adult heart transplant volumes with the use of DCD donors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Immunology
Marit Kalisvaart, Kristopher P. Croome, Roberto Hernandez-Alejandro, Jacques Pirenne, Miriam Cortes-Cerisuelo, Eduardo Minambres, Peter L. Abt
Summary: Donation after circulatory death (DCD) grafts are commonly used in liver transplantation, but carry increased risks due to ischemic events. The International Liver Transplantation Society held a Consensus Conference in 2020 to discuss definitions and thresholds for DWIT, vital parameters, and acceptable durations of functional DWIT.
Article
Cardiac & Cardiovascular Systems
Jawad Salman, Beeke-Alina Bernhard, Fabio Ius, Reza Poyanmehr, Wiebke Sommer, Khalil Aburahma, Hani Alhadidi, Thierry Siemeni, Christian Kuehn, Murat Avsar, Axel Haverich, Gregor Warnecke, Igor Tudorache
Summary: This study aimed to identify risk factors for the need of intra-operative ECMO use in lung transplant patients with pulmonary fibrosis. Factors such as preoperative proof of pulmonary hypertension, mean pulmonary arterial pressure, and pulmonary vascular resistance were identified as risk factors, while increased recipient body surface area and higher cardiac output were protective factors. The post-operative course was found to be more complicated in the ECMO+ group, although long-term survival did not differ significantly among groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Immunology
Angela Kotsopoulos, Piet Vos, Marloes Witjes, Meint Volbeda, Hildegard Franke, Jelle Epker, Hans Sonneveld, Koen Simons, Ewald Bronkhorst, Ruud Mullers, Nichon Jansen, Hans van der Hoeven, Wilson F. Abdo
Summary: This study aimed to develop prediction models for circulatory death within 1 or 2 hours after withdrawal of life-sustaining treatment in controlled donation after circulatory death (cDCD) donors. The models were developed using LASSO regression and machine learning-artificial intelligence analysis, and their predictive ability was externally validated. The results showed that the models had a reasonable ability to predict circulatory death.
Article
Immunology
Raphael P. H. Meier, Miguel Nunez, Shareef M. Syed, Sandy Feng, Mehdi Tavakol, Chris E. Freise, John P. Roberts, Nancy L. Ascher, Ryutaro Hirose, Garrett R. Roll
Summary: Donation after circulatory death (DCD) liver transplantation is feasible and can achieve comparable survival to donation after brain death (DBD) liver transplantation in selected recipient/donor pairs. However, without selection criteria, the outcomes of DCDLTs remain worse than those of DBD-LTs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Hiroyoshi Iwata, Hiromichi Obara, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa, Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Mizuho Ohara, Hideki Yokoo, Naoto Matsuno
Summary: This study investigated the benefits of using subnormothermic extracorporeal membrane oxygenation (ECMO) and hypothermic machine perfusion (HMP) in a porcine model of liver transplantation from donors after cardiac death (DCD). The results suggested that the combination of ECMO and HMP could improve the functional outcome of DCD liver grafts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rene Ferrera, Marie Vedere, Megane Lo-Grasso, Lionel Augeul, Christophe Chouabe, Gabriel Bidaux, Delphine Baetz
Summary: This study aimed to evaluate the protective effects of postconditioning on DCD hearts. The results showed that CsA and POST could reduce necrosis and improve heart function. However, the efficacy of POST was lost if delayed beyond 3 minutes of reperfusion, while CsA treatment remained effective even if applied after a delay. Delayed CsA application correlated with better functional recovery and higher mitochondrial respiratory index, suggesting the crucial role of MPTP in delayed protection of DCD hearts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Critical Care Medicine
Christiaan L. Meuwese, Daniel Brodie, Dirk W. Donker
Summary: This article provides an overview of pivotal factors that potentially prevent successful weaning from V-A ECMO support. It emphasizes the importance of a systematic approach to optimize clinical management and improve patient outcomes.
Article
Surgery
Jose Luis Campo-Canaveral de la Cruz, Eduardo Minambres, Elisabeth Coll, Maria Padilla, Gloria Sanchez Antolin, Gloria de la Rosa, Joel Rosado, Francisco Javier Gonzalez Garcia, Silvana Crowley Carrasco, Gabriel Sales Badia, Eva Maria Fieria Costa, Jose Alberto Garcia Salcedo, Victor Mora, Carlos de la Torre, Rafael Badenes, Lander Atutxa Bizkarguenaga, Beatriz Dominguez-Gil
Summary: This study aimed to investigate the outcomes of lung and liver transplantation using NRP in cDCD donors and compare them with transplants using DBD grafts. The results showed that simultaneous transplantation of lungs and livers from cDCD donors using NRP offers similar outcomes to transplants using DBD grafts.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Review
Immunology
Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson
Summary: Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can be as good as or even comparable to those after transplantation with organs from donation after brain death donors. The key to success lies in establishing common practices and accepted protocols to safely utilize DCD organs and maximize the use of the DCD donor pool.
TRANSPLANTATION REVIEWS
(2023)
Article
Engineering, Biomedical
Antonio F. Corno, Gail M. Faulkner, Chris Harvey
Summary: Mobile ECMO team consists of ECMO-trained healthcare professionals and utilizes road, air, or combination transfers. Over the past decade, 571 patients have undergone mobile ECMO transfers, with the majority being completed by road. The average duration of mobile ECMO transfer is 5.5 hours, and it proves to be safe and reliable for transferring the sickest patients.
Review
Cardiac & Cardiovascular Systems
Ibrahim Migdady, Robert Scott Stephens, Carrie Price, Romergryko G. Geocadin, Glenn Whitman, Sung-Min Cho
Summary: The use of apnea test in ECMO patients is associated with a high failure rate and hemodynamic complications; ancillary tests are recommended to determine brain death in ECMO patients, highlighting the variability in practice regarding the apnea test.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Urology & Nephrology
Argiris Asderakis, Tarique K. Sabah, William J. Watkins, Usman Khalid, Laszlo Szabo, Michael R. Stephens, Sian Griffin, Rafael Chavez
Summary: This study evaluated the effects of different induction immunosuppression agents on the outcome of kidney transplants from donors after circulatory death (DCD). The results suggest that thymoglobulin induction may provide better patient survival compared to alemtuzumab, while having similar advantage in terms of acute rejection.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Surgery
Laura DiChiacchio, Matthew L. Goodwin, Hiroshi Kagawa, Eric Griffiths, Ian C. Nickel, Josef Stehlik, Craig H. Selzman
Summary: Heart transplantation is the preferred treatment for end-stage heart failure, but there is a lack of available donor hearts. Donating hearts following circulatory death is a potential solution to increase the donor pool.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Transplantation
George H. B. Greenhall, Matthew Robb, Rachel J. Johnson, Maria Ibrahim, Rachel Hilton, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This study examined the relationship between deceased donor albuminuria and kidney utilization, survival, and function. The findings suggest that kidneys from donors with albuminuria are less likely to be accepted for transplantation, but there is no evidence of an association between albuminuria and graft survival or function.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Immunology
Patrick B. Trotter, John Dark, Andrew J. Fisher, Matthew Robb, Christopher Watson, James Neuberger
Summary: The transplant outcomes for recipients of organs from donors who died from ligature asphyxiation are similar to those from donors who died from other causes. However, the impact on recipients of other solid organ transplants remains uncertain.
Article
Immunology
Gabriel C. Oniscu, Jennifer Mehew, Andrew J. Butler, Andrew Sutherland, Rohit Gaurav, Rachel Hogg, Ian Currie, Mark Jones, Christopher J. E. Watson
Summary: The use of normothermic regional perfusion (NRP) during controlled donation after circulatory death (cDCD) is associated with increased organ recovery and improved transplant outcomes.
Article
Surgery
Claire Albert, Matthew Harris, Jenna DiRito, Audrey Shi, Christopher Edwards, Lauren Harkins, Taras Lysyy, Sanjay Kulkarni, David C. Mulligan, Sarah A. Hosgood, Christopher J. E. Watson, Peter J. Friend, Michael L. Nicholson, Danielle Haakinson, Kourosh Saeb-Parsy, Gregory T. Tietjen
Summary: Transplantation is a life-saving treatment, but the shortage of donor organs and concerns about post-transplant outcomes result in many patients dying while waiting for organs or organs being declined for transplant. This article discusses the need for a new mindset in how we honor organ donation and suggests using transplant-declined organs for translational research to accelerate breakthrough discoveries. The article also addresses the practical challenges of such research and offers potential solutions based on the authors' experiences in their own laboratories.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Education, Scientific Disciplines
Emma E. Howie, Harini Dharanikota, Eilidh Gunn, Olivia Ambler, Roger Dias, Stephen J. Wigmore, Richard J. E. Skipworth, Steven Yule
Summary: This article highlights the importance of considering Cognitive Load (CL) and Cognitive Load Theory (CLT) in surgical training to enhance current strategies and surgical performance. Feedback and assessment methods in surgical training are subjective and at risk of bias, but Surgical Sabermetrics aims to provide objective, real-time feedback through the analysis of surgical and audio-visual data. Real-time measurement of CL can enhance feedback and improve surgical performance. The principles of Cognitive Load and Surgical Sabermetrics can contribute to making surgical training better and providing higher quality care for patients.
JOURNAL OF SURGICAL EDUCATION
(2023)
Article
Multidisciplinary Sciences
Teresa Brevini, Mailis Maes, Gwilym J. Webb, Binu John, Claudia D. Fuchs, Gustav Buescher, Lu Wang, Chelsea Griffiths, Marnie L. Brown, William E. Scott, Pehuen Pereyra-Gerber, William T. H. Gelson, Stephanie Brown, Scott Dillon, Daniele Muraro, Jo Sharp, Megan Neary, Helen Box, Lee Tatham, James Stewart, Paul Curley, Henry Pertinez, Sally Forrest, Petra Mlcochova, Sagar S. Varankar, Mahnaz Darvish-Damavandi, Victoria L. Mulcahy, Rhoda E. Kuc, Thomas L. Williams, James A. Heslop, Davide Rossetti, Olivia C. Tysoe, Vasileios Galanakis, Marta Vila-Gonzalez, Thomas W. M. Crozier, Johannes Bargehr, Sanjay Sinha, Sara S. Upponi, Corrina Fear, Lisa Swift, Kourosh Saeb-Parsy, Susan E. Davies, Axel Wester, Hannes Hagstrom, Espen Melum, Darran Clements, Peter Humphreys, Jo Herriott, Edyta Kijak, Helen Cox, Chloe Bramwell, Anthony Valentijn, Christopher J. R. Illingworth, Bassam Dahman, Dustin R. Bastaich, Raphaella D. Ferreira, Thomas Marjot, Eleanor Barnes, Andrew M. Moon, Alfred S. Barritt, Ravindra K. Gupta, Stephen Baker, Anthony P. Davenport, Gareth Corbett, Vassilis G. Gorgoulis, Simon J. A. Buczacki, Joo-Hyeon Lee, Nicholas J. Matheson, Michael Trauner, Andrew J. Fisher, Paul Gibbs, Andrew J. Butler, Christopher J. E. Watson, George F. Mells, Gordon Dougan, Andrew Owen, Ansgar W. Lohse, Ludovic Vallier, Fotios Sampaziotis
Summary: Modulating the expression of angiotensin-converting enzyme 2 (ACE2) through farnesoid X receptor (FXR) can reduce susceptibility to SARS-CoV-2 infection, as shown in various tissues and organoids in vitro, in vivo, and ex vivo. The use of z-guggulsterone and ursodeoxycholic acid (UDCA) can downregulate ACE2 and decrease viral infection, including in the nasal epithelium. Clinical data also indicate positive outcomes with UDCA treatment in SARS-CoV-2 infection. These findings suggest that targeting the FXR-ACE2 pathway could be a potential strategy for preventing COVID-19.
Article
Immunology
Christopher J. E. Watson, Stephen MacDonald, Christopher Bridgeman, Rebecca Brais, Sara S. Upponi, Theodora Foukaneli, Lisa Swift, Corrina Fear, Linda Selves, Vasilis Kosmoliaptsis, Michael Allison, Rachel Hogg, Kourosh Saeb Parsy, Will Thomas, Rohit Gaurav, Andrew J. Butler
Summary: This study aimed to determine the underlying cause of biliary complications leading to liver retransplantation and evaluate the role of fibrinolysis. The results showed the presence of fibrin during cold storage and its association with poor posttransplant outcomes. Fibrinolytic therapy may be a promising intervention.
Article
Cardiac & Cardiovascular Systems
Simon Messer, Sally Rushton, Lewis Simmonds, Debbie Macklam, Mubbasher Husain, Anand Jothidasan, Stephen Large, Steven Tsui, Pradeep Kaul, Jennifer Baxter, Mohamed Osman, Vipin Mehta, Derval Russell, Uli Stock, John Dunning, Diana Garcia Saez, Rajamiyer Venkateswaran, Philip Curry, Lynne Ayton, Majid Mukadam, Jorge Mascaro, Jacob Simmonds, Guy Macgowan, Stephen Clark, Jerome Jungschleger, Zdenka Reinhardt, Richard Quigley, Jane Speed, Jayan Parameshwar, David Jenkins, Sarah Watson, Fiona Marley, Ayesha Ali, Dale Gardiner, Antonio Rubino, Julie Whitney, Sarah Beale, Catherine Slater, Ian Currie, Liz Armstrong, Jeanette Foley, Marian Ryan, Sharon Gibson, Karen Quinn, Anna-Maria Macleod, Susan Spence, Christopher J. E. Watson, Pedro Catarino, Anthony Clarkson, John Forsythe, Derek Manas, Marius Berman
Summary: The UK conducted a national pilot program for heart transplantation using DCD hearts, retrieved using the direct procurement and perfusion technique. The outcomes showed comparable posttransplant survival rates between DCD and DBD hearts.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
George H. B. Greenhall, Brian A. Rous, Matthew L. Robb, Chloe Brown, Gillian Hardman, Rachel M. Hilton, James M. Neuberger, John H. Dark, Rachel J. Johnson, John L. R. Forsythe, Laurie A. Tomlinson, Chris J. Callaghan, Christopher J. E. Watson
Summary: This cohort study suggests that the risk of cancer transmission in transplants from deceased donors with primary brain tumors is lower than previously thought, and long-term transplant outcomes are favorable, providing a possibility for safely expanding organ usage.
Article
Oncology
Leo R. Brown, Michael I. Ramage, Ross D. Dolan, Judith Sayers, Nikki Bruce, Lachlan Dick, Sharukh Sami, Donald C. McMillan, Barry J. A. Laird, Stephen J. Wigmore, Richard J. E. Skipworth
Summary: This study aimed to assess CT body composition in patients who had anastomotic leak post-oesophagectomy. The results showed that skeletal muscle index decreased and subcutaneous fat area increased following neoadjuvant treatment and anastomotic leak. Although tissue radiodensity and subcutaneous fat area normalized on late follow-up scans, skeletal muscle index remained below pre-treatment levels.
Review
Medicine, General & Internal
David Martin, Piero Alberti, Stephen J. Wigmore, Nicolas Demartines, Gaetan-Romain Joliat
Summary: Pancreatic cancer is a deadly disease with unknown origins and limited treatment options. Surgical resection, the primary curative treatment, is associated with high morbidity and mortality rates and frequent recurrence. Patient-centered care and understanding patient perspectives are crucial for improving outcomes in pancreatic cancer surgery. Standardized patient-reported outcome and experience measures are needed to assess patient perspectives accurately.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Stephen O'Neill, Ellie Asgari, Chris Callaghan, Dale Gardiner, Hermien Hartog, Satheesh Iype, Alex Manara, David Nasralla, Gabi C. Oniscu, Chris Watson
Summary: Recipient outcomes after transplantation with organs from donation after circulatory death (DCD) donors can be as good as or even comparable to those after transplantation with organs from donation after brain death donors. The key to success lies in establishing common practices and accepted protocols to safely utilize DCD organs and maximize the use of the DCD donor pool.
TRANSPLANTATION REVIEWS
(2023)
Article
Surgery
James A. Richards, Rohit Gaurav, Sara S. Upponi, Lisa Swift, Corrina Fear, Gwilym J. Webb, Michael E. D. Allison, Christopher J. E. Watson, Andrew J. Butler
Summary: The liver is crucial for life, and without a transplant from a donor, patients with liver failure will die. Unfortunately, limited availability of liver organs results in some patients dying while waiting. This article presents a novel technique that enables resuscitation and testing of potential donor livers, increasing the chances for safe transplantation.
BRITISH JOURNAL OF SURGERY
(2023)
