Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Biochemistry & Molecular Biology
Silvia Concetta Colucci, Cinzia Buccoliero, Lorenzo Sanesi, Mariella Errede, Graziana Colaianni, Tiziana Annese, Mohd Parvez Khan, Roberta Zerlotin, Manuela Dicarlo, Ernestina Schipani, Kenneth M. Kozloff, Maria Grano
Summary: The study found that irisin promotes bone formation and accelerates the fracture healing process, suggesting its potential use as a novel pharmacologic modulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Yasmine Hachemi, Anna E. Rapp, Sooyeon Lee, Ann-Kristin Dorn, Benjamin T. Krueger, Kathrin Kaiser, Anita Ignatius, Jan Tuckermann
Summary: Effective GR dimerization plays a role in trauma-induced compromised fracture healing, as revealed by a study on mice with decreased GR dimerization ability. GR(dim) mice were found to be protected from the impairment of fracture healing caused by additional thorax trauma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Deepak Kumar Khajuria, Irene Reider, Fadia Kamal, Christopher C. Norbury, Reyad A. Elbarbary
Summary: This study investigates the changes in immune cells during the process of fracture healing and finds distinct immune cell populations enriched and activated in different phases of healing. Obesity-associated hyperglycemia and insulin resistance lead to impaired immune response during fracture healing. These findings contribute to the future development of immunomodulatory therapeutics for impaired fracture healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Takayuki Nabeshima, Manabu Tsukamoto, Ke-Yong Wang, Yosuke Mano, Daisuke Arakawa, Kenji Kosugi, Takafumi Tajima, Yoshiaki Yamanaka, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Kagaku Azuma, Akinori Sakai
Summary: The effect of COPD pathogenesis on bone fracture healing is unclear. This study found that delayed bone healing and impaired nuclear translocation of Nrf2 are involved in the delayed cortical bone healing in COPD mice. Sulforaphane, an Nrf2 activator, improved the delayed cortical bone healing in the mice model. These findings suggest that Nrf2 may be a potential target for bone fracture treatment in COPD patients.
Article
Physiology
Melanie Haffner-Luntzer, Verena Fischer, Anita Ignatius
Summary: The study found that male mice demonstrated faster fracture healing with more prominent cartilaginous callus formation in diaphyseal fractures. This may be attributed to the higher body weight of male mice, resulting in increased mechanical loading at the fracture site. Additionally, male mice exhibited higher activation of osteogenic Wnt/beta-catenin signaling during the fracture healing process.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Immunology
Bartlomiej J. Witczak, Soren E. Pischke, Anna Reisaeter, Karsten Midtvedt, Judith K. Ludviksen, Kristian Heldal, Trond Jenssen, Anders Hartmann, Anders Asberg, Tom E. Mollnes
Summary: Early complement activation, assessed by plasma TCC levels, is associated with impaired long-term patient and graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takeshi Moriishi, Takuro Ito, Ryo Fukuyama, Xin Qin, Hisato Komori, Hitomi Kaneko, Yuki Matsuo, Noriaki Yoshida, Toshihisa Komori
Summary: The relationship between lacunocanalicular network structure and mechanoresponse has not been well researched. In wild-type femoral cortical bone, there were variations in the lacunocanalicular structures between compression and tension sides, regions, and genders. Overexpression of Sp7 in osteoblasts resulted in thin and porous cortical bone with reduced canaliculi and an impaired lacunocanalicular network. Unloading in Sp7 transgenic mice led to decreased trabecular and cortical bone due to reduced bone formation. Sost-positive osteocytes increased on the compression side in wild-type femurs but not on the tension side. However, these differential responses were lost in Sp7 transgenic femurs. Serum Sost increased in Sp7 transgenic mice but not in wild-type mice. Unloading reduced the expression of Col1a1 and Bglap/Bglap2 in Sp7 transgenic mice but not wild-type mice. Therefore, the impaired lacunocanalicular network in Sp7 transgenic mice induced Sost expression in response to unloading but lost the differential regulation in the compression and tension sides, resulting in a failure to restore bone formation, highlighting the importance of the relationship between lacunocanalicular network structure and regulation of bone formation in mechanoresponse.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Dominik Saul, David G. Monroe, Jennifer L. Rowsey, Robyn Laura Kosinsky, Stephanie J. Vos, Madison L. Doolittle, Joshua N. Farr, Sundeep Khosla
Summary: Senescent cells and senescence-related secretory phenotype markers increase during fracture healing. Intermittent treatment with senolytics reduces senescence markers in the fracture callus and accelerates the time course of fracture healing.
Article
Endocrinology & Metabolism
Jose Valdes-Fernandez, Tania Lopez-Martinez, Purificacion Ripalda-Cemborain, Isabel A. Calvo, Borja Saez, Juan Antonio Romero-Torrecilla, Javier Aldazabal, Emma Muinos-Lopez, Veronica Montiel, Josune Orbe, Jose Antonio Rodriguez, Jose Antonio Paramo, Felipe Prosper, Froilan Granero-Molto
Summary: The study highlights the vital role of MMP-10 in cartilage resorption during secondary fracture healing, with its expression by hematopoietic cells being crucial for optimal bone regeneration. Global silencing of Mmp10 results in impaired fracture healing, characterized by delayed cartilage resorption and decreased gelatinase activity, specifically in macrophages lacking proMMP-9 processing capacity.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Yan Peng, Huaizhi Liu, Hao Peng, Jiuyang Zhang
Summary: Self-healing materials have long struggled to achieve both high mechanical strength and self-healing ability. This work successfully achieves self-repair in mechanically robust materials, inspired by biological self-healing. The mechanical performance and self-healing behavior of these materials can be precisely controlled through temperature and composition. An artificial bone-tissue system is created with bionic structure, effective self-healing, and high modulus.
Article
Endocrinology & Metabolism
Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, Irena Nowak, Diana E. Sepulveda, Gregory S. Lewis, Christopher C. Norbury, Wesley M. Raup-Konsavage, Kent E. Vrana, Fadia Kamal, Reyad A. Elbarbary
Summary: Bone fractures are common musculoskeletal injuries that require effective pain management. This study found that both cannabidiol (CBD) and cannabigerol (CBG) have potent analgesic effects and promote bone healing in a mouse model for tibial fracture. Therefore, CBD and CBG have the potential to be alternative therapeutic agents for managing postfracture pain.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Carlos Marin, Jolien Tuts, Frank P. Luyten, Katleen Vandamme, Greet Kerckhofs
Summary: The study assessed alterations in bone fracture healing in DIO mice and found that osteogenesis and chondrogenesis were altered in these mice compared to lean controls. In vitro experiments showed that high glucose conditions affected osteogenic and chondrogenic differentiation, potentially impacting callus formation and maturation during fracture healing.
Article
Geriatrics & Gerontology
Maximilian M. Menger, Maximilian Stief, Claudia Scheuer, Mika F. Rollmann, Steven C. Herath, Benedikt J. Braun, Sabrina Ehnert, Andreas K. Nussler, Michael D. Menger, Matthias W. Laschke, Tina Histing
Summary: Nonsteroidal anti-inflammatory drugs (NSAIDs), such as diclofenac, are commonly used analgesic medication for traumatic injuries. However, there is increasing evidence that NSAIDs can impair fracture healing. This study found that diclofenac delays fracture healing in aged mice by affecting osteogenic growth factor expression and bone formation as well as osteoclast activity and callus remodeling.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Nutrition & Dietetics
Aleksey Bychkov, Vyacheslav Koptev, Varvara Zaharova, Polina Reshetnikova, Elena Trofimova, Elena Bychkova, Ekaterina Podgorbunskikh, Oleg Lomovsky
Summary: This study presents findings on the biological action of a supplement containing vitamin D and soluble silicon, which are involved in bone formation and mineralization. The supplement showed the ability to stimulate bone tissue regeneration, accelerate bone cell differentiation, and promote the restoration of bone structure. Additionally, it enhanced calcium absorption and reduced skeletal damage.
