Article
Oncology
Chih-Ting Chang, Cherng-Jye Jeng, Cheng-Yu Long, Linus T. Chuang, Jenta Shen
Summary: This retrospective study analyzed the data of patients treated with ultrasound-guided high-intensity focused ultrasound for uterine fibroids. The study found that this treatment method was effective in reducing the volume of the uterus and fibroids and improving clinical symptoms and quality of life for the patients.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Article
Oncology
Gudny Jonsdottir, Marie Beermann, Annika Lundgren Cronsioe, Klara Hasselrot, Helena Kopp Kallner
Summary: This study aimed to evaluate the effectiveness, feasibility, and acceptability of microwave ablation (MWA) compared to uterine artery embolization (UAE) for treating uterine fibroids. The results showed no significant difference in volume reduction between MWA and UAE, but the MWA group had shorter hospitalization days and sick leave. Therefore, MWA shows promise as a treatment for uterine fibroids.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2022)
Review
Obstetrics & Gynecology
Pasquapina Ciarmela, Giovanni Delli Carpini, Stefania Greco, Alessandro Zannotti, Nina Montik, Luca Giannella, Lucia Giuliani, Camilla Grelloni, Francesca Panfoli, Michela Paolucci, Gloria Pierucci, Federica Ragno, Pamela Pellegrino, Felice Petraglia, Andrea Ciavattini
Summary: Understanding the vascular network and angiogenesis in uterine fibroids is crucial for predicting treatment effectiveness, differentiating from other conditions, and developing new therapeutic approaches. This review explores the current knowledge on fibroid vascularization and its implications in clinical manifestations, highlighting the role of ultrasound in evaluating vascularization.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Joshua Cornman-Homonoff, Zhen Ni Zhou, Tamatha B. Fenster, Marc H. Schiffman
Summary: Uterine artery embolization for symptomatic uterine fibroids may lead to transcervical fibroid expulsion, causing patient distress and potential reintervention. However, the success of hysteroscopic resection decreases with fibroid size, while the risk of complications increases. Preoperative imaging can predict the need for hysteroscopic resection, allowing for an alternative management strategy to be employed.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lutfi Ali S. Kurban, Hesham Metwally, Mudar Abdullah, Abdurzag Kerban, Abderrahim Oulhaj, Jamal Aldeen Alkoteesh
Summary: This article evaluates MRI features of uterine leiomyomas predicting volumetric response after uterine artery embolization (UAE). Submucosal location, hyperintensity on T2-weighted MRI, small baseline leiomyoma volume (< 58 cm(3)), and hyperintensity on subtraction imaging are independent predictors of leiomyoma volumetric response. A five-variable ROC model showed high diagnostic accuracy for predicting at least 40% leiomyoma volumetric response.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nathan E. Frenk, Jai W. Jung, Moaz M. Choudhary, JiMin Ko, Donna Buckley, James B. Spies
Summary: This study aimed to evaluate the rates of fibroid expulsion after uterine artery embolization (UAE) and identify risk factors. The results showed that approximately 16% of patients experienced fibroid expulsion after UAE, with most cases being asymptomatic or minimally symptomatic. The International Federation of Gynecology and Obstetrics (FIGO) classification was significantly associated with symptomatic fibroid expulsion and the need for additional care.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Shannon K. Laughlin-Tommaso, Krzysztof R. Gorny, Gina K. Hesley, Lisa E. Vaughan, David A. Woodrum, Maureen A. Lemens, Elizabeth A. Stewart
Summary: The study compared the effectiveness of magnetic resonance-guided focused ultrasound surgery (MRgFUS) and uterine artery embolization (UAE) in treating uterine fibroids. The results showed similar fibroid volume reduction in both treatment arms after 24 and 36 months, with higher nonperfused volume in the UAE group at 24 months.
JOURNAL OF WOMENS HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Madina Yerezhepbayeva, Milan Terzic, Gulzhanat Aimagambetova, Byron Crape
Summary: This systematic review analyzed the effectiveness and complications of Uterine Artery Embolization (UAE) and Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) for uterine leiomyoma. The results showed that UAE had a significantly higher percentage of fibroid volume shrinkage than MRgHIFU at 6, 12, and 24 months follow-up, but had more complications.
Review
Physiology
Elizabeth A. Stewart, Romana A. Nowak
Summary: Uterine fibroids are a common condition in women that can cause serious health issues. The mechanisms behind their growth and development are currently not well understood and require further research.
Article
Medicine, General & Internal
Jakub Kociuba, Tomasz Lozinski, Kamil Latra, Lidia Korczynska, Artur Skowyra, Elzbieta Zarychta, Michal Ciebiera
Summary: This study analyzed the reasons and risk factors for treatment discontinuation in patients with symptomatic uterine fibroids undergoing magnetic resonance-guided high-intensity focused ultrasound (MR-HIFU). The main reason for discontinuation was malposition of the intestines. Thermoablation of subserosal uterine fibroids was identified as a significant risk factor for treatment discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rishi Philip Mathew, Swati Francis, Vinayak Jayaram, Shameema Anvarsadath
Summary: Uterine leiomyomas, or fibroids, are common neoplasms in women, with a significant percentage of patients being asymptomatic. Typical leiomyomas are easily diagnosed on imaging, but larger, extrauterine, or degenerate tumors can pose challenges for diagnosis. Understanding the imaging appearance of atypical leiomyomas and their differential diagnosis is crucial for effective patient management.
ABDOMINAL RADIOLOGY
(2021)
Article
Acoustics
Yun Zhou, Xiang Ji, Jianmei Niu, Taotao Sun, Zhaoxia Qian, Yuhong Li, Jiangjing Yuan, Qiong Fan, Qianwen Huang, Jingfeng Bai, Yudong Wang
Summary: This study demonstrates the feasibility of ultrasound-guided high-intensity focused ultrasound for devascularization of uterine fibroids, with significant reduction in fibroid volume and improvement in symptoms and quality of life. No serious adverse events were observed, suggesting the need for further studies on safety and efficacy.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maliha Sadick, Leonie Hofmann, Christel Weiss, Benjamin Tuschy, Stefan O. Schoenberg, Frank G. Zoellner
Summary: This study evaluates the efficacy of uterine fibroid embolisation (UFE) in reducing the size and perfusion of fibroids, as well as improving the quality of life for patients. The results show a significant decrease in fibroid-related symptoms and a reduction in both uterine and myoma volume after 12 months, while healthy uterine tissue remains unaffected.
BMC MEDICAL IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
L. Liao, Y. H. Xu, J. Bai, P. Zhan, J. Zhou, M. X. Li, Y. Zhang
Summary: This study investigated the predictive value of MRI parameters in evaluating the efficacy of ultrasonic ablation for fibroids. The results showed that the signal intensity of MRI T2-weighted imaging and blood supply type could serve as predictors of ablation efficacy. Fibroids with hyperintensity on MRI T2WI and a rich blood supply had poor efficacy in ultrasonic ablation.
CLINICAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chin-Jung Wang, Gigin Lin, Yi-Ting Huang, Cindy Hsuan Weng, Kai-Yun Wu, Yu-Ying Su, Yu-Shan Lin, Kit-Sum Mak
Summary: The study showed the safety and feasibility of ArcBlate MRgHIFU in treating uterine fibroids and adenomyosis, with no adverse effects during the procedure and significant reduction in tumor volumes at 3 months post-treatment. Patients also experienced improved quality of life as evidenced by SF-36 scale scores improvement.
ABDOMINAL RADIOLOGY
(2021)
Article
Genetics & Heredity
Ye Zhu, James P. Moriarty, Kristi M. Swanson, Paul Y. Takahashi, Suzette J. Bielinski, Richard Weinshilboum, Liewei Wang, Bijan J. Borah
Summary: This study found that preemptive PGx panel testing is cost-effective compared to usual care in managing cardiovascular diseases, while reactive testing is not. Sensitivity analyses suggested that longer follow-up and the age group 45-64 years were factors influencing the cost-effectiveness results.
GENETICS IN MEDICINE
(2021)
Article
Clinical Neurology
Praveen Mummaneni, John F. Burke, Andrew K. Chan, Julie Ann Sosa, Errol P. Lobo, Valli P. Mummaneni, Sheila Antrum, Sigurd H. Berven, Michael S. Conte, Sarah B. Doernberg, Andrew N. Goldberg, Christopher P. Hess, Steven W. Hetts, S. Andrew Josephson, Maureen P. Kohi, C. Benjamin, Vaikom S. Mahadevan, Annette M. Molinaro, Andrew H. Murr, Sirisha Narayana, John P. Roberts, Marshall L. Stoller, Philip Theodosopoulos, Thomas P. Vail, Sandra Wienholz, Michael A. Gropper, Adrienne Green, Mitchel S. Berger
Summary: During the COVID-19 pandemic, quaternary-care facilities are providing care for patients in need of urgent and emergent invasive procedures. A multidisciplinary panel at the University of California, San Francisco developed consensus-based perioperative protocols to streamline care for these patients despite capacity and resource constraints. The protocols aim to optimize perioperative care during the pandemic, including quantifying outbreak levels, triaging patients, providing checklists for procedures, and creating a novel scoring system for personal protective equipment allocation.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Andrew Y. Lee, Alexander Lam, Robert B. Hicks, Masis Isikbay, Michael B. Heller, Mark D. Sugi, Spencer Behr, Maureen P. Kohi
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Oncology
Sanaz Keyhan, Emily Burke, Rose Schrott, Zhiqing Huang, Carole Grenier, Thomas Price, Doug Raburn, David L. Corcoran, Adelheid Soubry, Catherine Hoyo, Susan K. Murphy
Summary: Male obesity is associated with altered sperm DNA methylation profiles that appear to affect reprogramming fidelity in a subset of sperm, suggestive of an influence on the spermatogonia. Further work is required to determine the potential heritability of these DNA methylation alterations. If heritable, these changes have the potential to impede normal development.
CLINICAL EPIGENETICS
(2021)
Article
Medicine, General & Internal
Diana G. Redwood, Tuan A. Dinh, John B. Kisiel, Bijan J. Borah, James P. Moriarty, Ellen M. Provost, Frank D. Sacco, James J. Tiesinga, David A. Ahlquist
Summary: The study aimed to evaluate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska Native adults. Results showed that MT-sDNA demonstrated significant cost-effectiveness in different adherence scenarios, with clear advantages in terms of QALYs savings.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Endocrinology & Metabolism
Adelheid Soubry, Susan K. Murphy, Greet Vansant, Yang He, Thomas M. Price, Cathrine Hoyo
Summary: Animal experiments show that high fat diets can harm male reproductive health and increase the risk of chronic diseases in the next generation. The link between dietary habits, sperm epigenetic outcomes, and possible implications for offspring's health are explored in this study.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Rose Schrott, Susan K. Murphy, Jennifer L. Modliszewski, Dillon E. King, Bendu Hill, Nilda Itchon-Ramos, Douglas Raburn, Thomas Price, Edward D. Levin, Ryan Vandrey, David L. Corcoran, Scott H. Kollins, John T. Mitchell
Summary: The study found that cannabis use alters sperm DNA methylation, but these changes are reduced after cessation, especially in genes related to early development.
ENVIRONMENTAL EPIGENETICS
(2021)
Review
Obstetrics & Gynecology
Nicole C. Zanolli, Katherine C. Bishop, Jeffrey A. Kuller, Thomas M. Price, Benjamin S. Harris
Summary: This review provides an in-depth summary of the effects on fertility and reproductive outcomes following myomectomy and uterine artery embolization (UAE) for the treatment of symptomatic fibroids. The results show that myomectomy has superior reproductive outcomes compared to UAE, making it the preferred option for women who desire future pregnancy.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Editorial Material
Obstetrics & Gynecology
Jessica H. Selter, Thomas M. Price, Benjamin S. Harris
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Darby Herkert, Vivienne Meljen, Lisa Muasher, Thomas M. Price, Jeffrey A. Kuller, Sarah Dotters-Katz
Summary: The measurement of human chorionic gonadotropin (hCG) levels is crucial in obstetrics and gynecology but may lead to incorrect conclusions about pregnancy status and reveal alternative pathologies such as malignancy. Understanding the nuances of hCG physiology and testing methods is essential for appropriate patient management.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Review
Obstetrics & Gynecology
Kathryn L. Shaia, Benjamin S. Harris, Jessica H. Selter, Thomas M. Price
Summary: The classic transcriptional regulation by nuclear progesterone receptors A and B has been well-studied, but the mitochondrial progesterone receptor (PR-M) responsible for non-nuclear activities has received less attention. PR-M, derived from the progesterone receptor gene, binds to the mitochondrial outer membrane and increases cellular respiration to meet the metabolic demands of pregnancy, spermatozoa activation, and myometrial growth. Its presence may play a role in extended gestation and brain development in primates.
REPRODUCTIVE SCIENCES
(2023)
Article
Anesthesiology
Jamie R. Privratsky, Matthew Fuller, Karthik Raghunathan, Tetsu Ohnuma, Raquel R. Bartz, Rebecca Schroeder, Thomas M. Price, Michael R. Martinez, Martin Sigurdsson, Michael R. Mathis, Bhiken Naik, Vijay Krishnamoorthy
Summary: This study aimed to determine the association of age and sex with postoperative AKI. The results showed that younger females have a lower risk of postoperative AKI, which gradually increases with age. These findings suggest that age-related changes in women should be further investigated as modifiers of postoperative AKI risk.
Article
Multidisciplinary Sciences
Viengneesee P. Thao, Emily E. J. Sharpe, Ruchita C. Dholakia, Hannah H. N. Ahn, James P. Moriarty, Bijan J. Borah, Margaret C. Gill, Regan N. Theiler
Summary: True penicillin allergy is rare and commonly incorrectly reported. Testing shows that less than 5% of patients who report a penicillin allergy will have an active hypersensitivity when appropriately tested. Penicillin allergy testing is safe and cost-effective, and inaccurate penicillin allergy status may lead to inappropriate antibiotic use.
Article
Obstetrics & Gynecology
Benjamin J. Peipert, Benjamin S. Harris, Jessica H. Selter, Khaila Ramey-Collier, Randa Blenden, Shakthi Unnithan, Alaattin Erkanli, Thomas M. Price
Summary: The study found that infertility patients commonly utilize various methods of ovulation prediction. However, there is significant discordance in the perceived utility of direct-to-consumer fertility tests between patients and reproductive endocrinologists. Patient education and guidelines are needed to better inform individuals considering direct-to-consumer fertility tests.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Gastroenterology & Hepatology
Juan E. Corral, Joshua Y. Kwon, Freddy Caldera, Surakit Pungpapong, Aaron C. Spaulding, Bijan J. Borah, James P. Moriarty, Francis A. Farraye
Summary: The study compared the cost-effectiveness of two recombinant HBV vaccines in inflammatory bowel disease patients, showing that HEPLISAV-B is more cost-effective than Engerix-B for patients receiving immunosuppressive therapy. Benefits increase with population aging and lower vaccine costs, and adjuvanted vaccines are favored when vaccination is needed.
CROHNS & COLITIS 360
(2021)