Review
Biochemistry & Molecular Biology
Duaa Ahmed Elhag, Manoj Kumar, Marwa Saadaoui, Anthony K. Akobeng, Fatma Al-Mudahka, Mamoun Elawad, Souhaila Al Khodor
Summary: Inflammatory bowel disease is a chronic immune-mediated inflammation of the gastrointestinal tract with a relapsing and remitting clinical course. Continuous disease monitoring and personalized therapy algorithms are crucial for effective treatment. New therapeutic approaches are being evaluated in controlled clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Vincent Joustra, Andrew Y. F. Li Yim, Ishtu Hageman, Evgeni Levin, Alex Adams, Jack Satsangi, Wouter J. de Jonge, Peter Henneman, Geert D'Haens
Summary: This study investigated the long-term stability of DNA methylation in peripheral blood leukocytes of patients with inflammatory bowel disease. Approximately 60% of the loci showed poor intra-individual stability, while 9% showed good stability and 5% showed excellent stability. Some previously identified differentially methylated loci demonstrated high stability over time, including loci associated with HLA genes. These findings have implications for selecting stable epigenetic biomarkers associated with IBD and understanding disease pathogenesis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Matthias Pierce, Richard Emsley
Summary: The regression approach performs better than Kraemer's approach in various data-generating scenarios. The modification of Kraemer's approach shows improved treatment recommendations, unless there is a strong unobserved prognostic biomarker. In the FINE trial, the regression method demonstrates slight improvement under its personalized treatment recommendation algorithm.
Review
Biochemistry & Molecular Biology
Montse Baldan-Martin, Maria Chaparro, Javier P. Gisbert
Summary: Inflammatory bowel diseases (IBDs) are chronic and inflammatory conditions affecting the gastrointestinal tract. Despite endoscopy being the gold standard test for assessing IBD, it is invasive and uncomfortable for patients. Therefore, non-invasive biomarkers for IBD diagnosis are urgently needed. This review summarizes proteomics and metabolomics studies in animals and humans, identifying urinary biomarkers for IBD diagnosis. Large-scale multi-omics studies with collaboration between clinicians, researchers, and industry are necessary for the development of sensitive and specific diagnostic biomarkers for personalized medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Vibeke Andersen, Tue B. Bennike, Corinna Bang, John D. Rioux, Isabelle Hebert-Milette, Toshiro Sato, Axel K. Hansen, Ole H. Nielsen
Summary: Inflammatory bowel diseases (IBD) are challenging to manage due to the diversity between patients and the lack of reliable biomarkers. Diet, gut microbiota, genetics, and patient factors are all crucial for disease occurrence and progression. Recent research has identified potential biomarkers for IBD management, but further evaluation is needed. This review provides an update on cutting-edge research in IBD to improve disease management and patient quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Qiuyun Xu, Weichen Sun, Jie Zhang, Youmin Mei, Jingyin Bao, Shengping Hou, Xiaorong Zhou, Liming Mao
Summary: Inflammatory bowel disease (IBD) seriously affects human health and causes a significant social and economic burden. The dysfunction of the intestinal immune system plays a key role in the development of IBD. Inflammasomes, such as NLRP3 and NLRP6, have been proven to be important in the pathogenesis of IBD. Regulating inflammasome activation has been considered a promising strategy for IBD treatment. Recent studies have shown that herbal compounds derived from traditional medicine can effectively prevent colon inflammation by targeting inflammasomes. Improving the efficacy, specificity, and safety of herbal compounds and discovering new compounds using emerging technologies will enhance our understanding of the roles and mechanisms of herbal compounds in inflammasome regulation and IBD treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Amanda E. Starr, Shelley A. Deeke, Zhibin Ning, Joseph de Nanassy, Ruth Singleton, Eric Benchimol, David R. Mack, Alain Stintzi, Daniel Figeys
Summary: Proteomic and bioinformatic analyses were conducted on colon biopsies from treatment-naive pediatric patients with IBD to characterize disease pathogenesis, revealing distinct proteomic patterns in inflamed and noninflamed tissues. Comparing pre- and post-treatment proteomes from CD patients identified proteins associated with therapy response, such as creatine kinase B and basigin.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Medicine, General & Internal
Oliver D. Mowforth, Jamie Brannigan, Marc El Khoury, Celine Iswarya Partha Sarathi, Harry Bestwick, Faheem Bhatti, Richard Mair
Summary: Personalised glioblastoma therapies have not shown consistent evidence of survival benefit, and there is a high risk of bias in the available evidence.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Giuseppe Privitera, Daniela Pugliese, Gian Ludovico Rapaccini, Antonio Gasbarrini, Alessandro Armuzzi, Luisa Guidi
Summary: Inflammatory bowel diseases are chronic conditions that affect the gastrointestinal tract, with a significant clinical heterogeneity. Despite an expanding pipeline of therapies, there is currently no ideal marker to predict patient response, but multiparametric models show promise in this regard.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Szymon Hryhorowicz, Marta Kaczmarek-Rys, Aleksandra Zielinska, Rodney J. Scott, Ryszard Slomski, Andrzej Plawski
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease and ulcerative colitis. The endocannabinoid system (ECS) plays a crucial role in modulating intestinal inflammation, suggesting potential therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Nikolas Plevris, Charlie W. Lees
Summary: Inflammatory bowel disease is a progressive and debilitating condition, emphasizing the importance of early and effective treatment for improving patient outcomes. Proactive monitoring is crucial to ensuring treatment strategies are working, highlighting the need for an optimal treat-to-target monitoring strategy during key phases of the disease. The advent of new technology may enhance monitoring capabilities and shape future monitoring strategies for inflammatory bowel diseases.
Article
Cell Biology
Yongyu Chen, Jing Lei, Song He
Summary: Evidence suggests a connection between m(6)A modification and immune infiltration in IBD. The study identified decreased expression of IGF2BP1 and IGF2BP2 in CD tissues, and decreased expression of IGF2BP2 in UC tissues. It also found associations between different m(6)A clusters and specific immune cell types in the intestinal mucosa.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nutrition & Dietetics
Berit Lieske, Nataliya Makarova, Bettina Jagemann, Carolin Walther, Merle Ebinghaus, Birgit-Christiane Zyriax, Ghazal Aarabi
Summary: Research has shown a significant increase in inflammatory biomarkers in the oral biofilm of pregnant women, which are associated with oral health and other systemic diseases, highlighting the importance of monitoring oral inflammatory responses during pregnancy for maternal and infant health.
Review
Medicine, General & Internal
Irene Mignini, Rossella Maresca, Maria Elena Ainora, Luigi Larosa, Franco Scaldaferri, Antonio Gasbarrini, Maria Assunta Zocco
Summary: Therapeutic options for IBD have expanded, but choosing the best treatment for each patient is still a challenge. Early prediction of response to biological drugs is important for optimizing therapeutic strategies. Recent research has focused on imaging techniques to identify predictive markers of response to biologic therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Sara Salvador-Martin, Alejandra Melgarejo-Ortuno, Luis A. Lopez-Fernandez
Summary: The use of biological drugs in pediatric inflammatory bowel disease has shown significant improvements, and predicting response to these drugs is particularly valuable in children. Clinical, biochemical, and genetic parameters can potentially predict response to biological drugs in children with IBD.
Article
Gastroenterology & Hepatology
Jurij Hanzel, Jeroen M. Jansen, Rinze W. F. ter Steege, Krisztina B. Gecse, Geert R. D'Haens
Summary: The study investigated the effectiveness and safety of multiple successive switches and switching between biosimilars of IFX in IBD patients. The results showed no significant differences in the remission rate and treatment persistence at 12 months between the three groups, regardless of clinical assessment or biochemical measures. Infusion reactions occurred only in patients with antidrug antibodies in the second group.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Floris De Voogd, Harshad Joshi, Elsa Van Wassenaer, Steven Bots, Geert D'Haens, Krisztina Gecse
Summary: Assessing disease activity in inflammatory bowel disease patients during pregnancy is crucial for maternal and fetal outcomes. This study evaluated the feasibility and accuracy of intestinal ultrasound in objectively assessing disease activity during pregnancy, showing correlation with clinical activity and FCP results, and providing a noninvasive strategy for monitoring patients during pregnancy.
INFLAMMATORY BOWEL DISEASES
(2022)
Letter
Gastroenterology & Hepatology
Steven Bots, Kim Nylund, Krisztina Gecse
JOURNAL OF CROHNS & COLITIS
(2022)
Editorial Material
Gastroenterology & Hepatology
Jurij Hanzel, Laura H. Bukkems, Krisztina B. Gecse, Geert R. D'Haens, Ron A. A. Mathot
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Gaurav Syal, Miles P. Sparrow, Fernando Velayos, Adam S. Cheifetz, Shane Devlin, Peter M. Irving, Gilaad G. Kaplan, Laura E. Raffals, Thomas Ullman, Krisztina B. Gecse, Phillip R. Fleshner, Amy L. Lightner, Corey A. Siegel, Gil Y. Melmed
Summary: According to expert evaluations, chronic antibiotic therapy is only appropriate for asymptomatic antibiotic-dependent patients without CD-like complications. Ileal-release budesonide is considered appropriate for patients with significant prepouch ileitis but no CD-like complications. Probiotic therapy is considered inappropriate or uncertain. Biologic therapy is considered appropriate in most scenarios, except in cases where significant prepouch ileitis or CD-like complications are absent. Permanent ileostomy is considered appropriate for most medically refractory patients, except in asymptomatic patients without CD-like complications.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Adriaan Volkers, Peter Bossuyt, Jitteke de Jong, Lieven Pouillon, Krisztina Gecse, Marjolijn Duijvestein, Cyriel Ponsioen, Geert D'Haens, Mark Lowenberg
Summary: The study showed that Pan-CE is a useful technique for assessing mucosal disease activity changes in Crohn's disease patients, aiding in the observation of treatment effects.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Corine A. Lansdorp, Christianne J. Buskens, Krisztina B. Gecse, Mark Lowenberg, Jaap Stoker, Willem A. Bemelman, Geert R. A. M. D'Haens, Rob A. Hulst
Summary: This study assessed the long-term efficacy, safety and feasibility of hyperbaric oxygen therapy in Crohn's disease patients with perianal fistulas. The results showed significant improvement in clinical and radiologic outcomes, as well as fistula drainage assessment, at week 16, and these improvements were maintained at the 1-year follow-up.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Infectious Diseases
Tania Martins Garcia, Manon van Roest, Jacqueline L. M. Vermeulen, Sander Meisner, Jan Koster, Manon E. Wildenberg, Ruurd M. van Elburg, Vanesa Muncan, Ingrid B. Renes
Summary: This study investigated whether the effects of early life antibiotic use on the gut persist into adulthood and whether there are long-term consequences for gut functioning. The results showed that the majority of the antibiotic-induced gut effects did not persist into adulthood, but early life antibiotic use did impact later life gut functioning.
Article
Gastroenterology & Hepatology
Gorm Roager Madsen, Rune Wilkens, Trine Boysen, Johan Burisch, Robert Bryant, Dan Carter, Krisztina Gecse, Christian Maaser, Giovanni Maconi, Kerri Novak, Carolina Palmela, Leizl Joy Nayahangan, Martin Gronnebaek Tolsgaard
Summary: International experts reached consensus on the knowledge and skills that should be expected from newly certified Intestinal Ultrasound (IUS) practitioners. These consensus statements can be used for designing training programs and evaluating the competencies of trainees.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Gastroenterology & Hepatology
Charlotte Wong, Joep van Oostrom, Peter Bossuyt, Valerie Pittet, Jurij Hanzel, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Krisztina Gecse, Naila Arebi
Summary: There is heterogeneity in reported outcomes and outcome measurement instruments (OMI) from observational studies. This systematic review describes and classifies clinical and patient-reported outcomes in inflammatory bowel disease (IBD), providing information for future real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Elsa A. van Wassenaer, Rick R. van Rijn, Floris A. E. de Voogd, Floor L. Noels, Eline E. Deurloo, Joost van Schuppen, Jonathan I. M. L. Verbeke, Krisztina B. Gecse, Geert R. D'Haens, Marc A. Benninga, Bart G. P. Koot
Summary: Training healthcare physicians to perform intestinal ultrasound (IUS) in children with IBD can achieve comparable diagnostic accuracy as experienced radiologists. The interobserver agreement is moderate. This study supports the usage of IUS in the clinical management of children with IBD.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Elise M. Meima-van Praag, Kyra L. van Rijn, Karin A. T. G. M. Wasmann, Harmanna J. Snijder, Jaap Stoker, Geert R. D'Haens, Krisztina B. Gecse, Michael F. Gerhards, Jeroen M. Jansen, Marcel G. W. Dijkgraaf, Jarmila D. W. van der Bilt, Marco W. Mundt, Antonino Spinelli, Silvio Danese, Willem A. Bemelman, Christianne J. Buskens
Summary: This study compared the radiological healing between patients who received short-term anti-TNF treatment and surgical closure and those who received anti-TNF treatment alone. The results showed that the surgical closure group had a higher rate of radiological healing compared to the anti-TNF group.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Jeroen Geldof, Nusrat Iqbal, Jean-Frederic Leblanc, Sulak Anandabaskaran, Rachel Sawyer, Christianne Buskens, Willem Bemelman, Krisztina Gecse, Lilli Lundby, Amy L. Lightner, Silvio Danese, Antonino Spinelli, Michele Carvello, Omar Faiz, Janindra Warusavitarne, Phillip Lung, Danny De Looze, Andre D'Hoore, Severine Vermeire, Ailsa Hart, Phil Tozer
Summary: This article proposes a new classification system for perianal fistulising Crohn's disease, developed through an expert consensus process. The classification system identifies four groups of patients based on disease severity and outcome, and provides treatment strategy suggestions and descriptions of clinical trial suitability.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Arjan J. Kwakernaak, Rob W. van der Pluijm, Neelke C. van der Weerd, Lianne Koens, Wytske M. Westra, Krisztina B. Gecse, Ankie Kleinjan
Summary: This case highlights the importance of EBV-driven PTLD in renal transplant patients and emphasizes the need for focus on the diagnosis and treatment of this complication.
CLINICAL CASE REPORTS
(2022)
Article
Immunology
Manon de Krijger, Ishtu L. Hageman, Andrew Y. F. Li Yim, Jan Verhoeff, Juan J. Garcia Vallejo, Patricia H. P. van Hamersveld, Evgeni Levin, Theodorus B. M. Hakvoort, Manon E. Wildenberg, Peter Henneman, Cyriel Y. Ponsioen, Wouter J. de Jonge
Summary: Distinguishing patients with PSC-UC from those with UC alone is possible through peripheral blood DNA methylation, indicating a potential for biomarker development.
FRONTIERS IN IMMUNOLOGY
(2022)