Article
Substance Abuse
Jerome C. Foo, Marcus W. Meinhardt, Ivan Skorodumov, Rainer Spanagel
Summary: By studying alcohol-addicted rats, this research has found associations between compulsive-like drinking behavior and individual drinking patterns and solution preference. These findings provide a theoretical basis for the prevention and treatment of drinking problems.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Neurosciences
Sean C. Monroe, Anna K. Radke
Summary: The study aimed to develop an aversion-resistant, oral fentanyl self-administration paradigm using mice as animal models. The results showed that male mice were affected by quinine, while female mice were not. Mice were able to detect quinine in fentanyl but continued to respond and consume fentanyl with quinine in both paradigms.
PSYCHOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jerome C. Foo, Ivan Skorodumov, Rainer Spanagel, Marcus W. Meinhardt
Summary: Biological factors, such as sex and age, have a significant impact on the development of alcohol addiction. Preclinical research using rodent models allows for detailed monitoring of behaviors over the lifespan. In this study, female rats consumed more alcohol than male rats, especially weaker alcohol solutions. Differences in access size and frequency drove increased consumption in females. The findings highlight the importance of considering sex-specific factors in understanding addiction development and developing effective treatment strategies.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Substance Abuse
Antonia M. Savarese, Angela R. Ozburn, Amanda M. Barkley-Levenson, Pamela Metten, John C. Crabbe
Summary: The High Drinking in the Dark mouse lines (HDID-1 and HDID-2) were selectively bred for high blood ethanol concentrations. Through a series of experiments, it was found that the lack of choice and the length of ethanol access are important factors contributing to high ethanol intake in HDID mice.
Article
Neurosciences
Elizabeth A. Sneddon, Brianna M. Masters, Haifei Shi, Anna K. Radke
Summary: Female rodents consume more ethanol and show greater aversion-resistant drinking compared to males. The role of ovarian hormones in aversion-resistant drinking has not been assessed yet.
PSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Bryan E. Jensen, Kayla G. Townsley, Kolter B. Grigsby, Pamela Metten, Meher Chand, Miracle Uzoekwe, Alex Tran, Evan Firsick, Katherine LeBlanc, John C. Crabbe, Angela R. Ozburn
Summary: Alcohol use disorder (AUD) is a significant psychiatric disorder with wide-reaching effects. Selectively bred mouse lines, such as the High Drinking in the Dark (HDID)-1 and -2 mice, are used to explore the genetic mechanisms underlying AUD. Results from behavioral studies show that different mouse lines exhibit varying levels of ethanol consumption and sensitivity to intoxicating effects, highlighting the complexity of alcohol-related behaviors across different genetic backgrounds and sexes.
Article
Psychiatry
Hongxuan Wang, Lihuan Lan, Xiaochang Lan, Peiyun Chen, Gaoxin Liu, Xiaoming Rong, Lei Liu, Chuan-Yi Kang, Jianzhong Yang, Yan-Zhong Guan, Xiao-Feng Zhu, Jian Hu, Mei Yang, Dong Zheng, Ying Peng
Summary: The Chinese version of the Obsessive Compulsive Drinking Scale (OCDS) has been translated and validated, showing high internal consistency and good test-retest reliability, making it suitable for use in clinical studies and research among the Chinese population.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Substance Abuse
Meera Rath, Jasmin Tawfic, Aziza Abrorkhujaeva, Sam Sowell, Sara Wu, Shainnel O. Eans, Joanna Peris, Jay P. McLaughlin, Stanley M. Stevens, Bin Liu
Summary: The study successfully modeled acute movement impairments and anxiety-like behaviors in mice after binge ethanol consumption using a modified drinking-in-the-dark model. The individual mice's ethanol intake positively correlated with blood ethanol concentration levels.
Article
Neurosciences
Sahir Hussain, Heidi M. D. Lesscher, Darren J. Day, Bart A. Ellenbroek
Summary: This study examined the effects of serotonin dysfunction on ethanol consumption in adolescents and the intergenerational effects of drinking. The findings suggest that there may be gender differences in the way genetic factors act, and epigenetic mechanisms may be involved in the intergenerational effects of alcohol. Additionally, paternal alcohol consumption was found to reduce the ethanol induced motor side effects in offspring, independent of gender and genotype.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
S. Gallegos, L. San Martin, A. Araya, D. M. Lovinger, G. E. Homanics, L. G. Aguayo
Summary: The alpha 2 subunit of the inhibitory glycine receptor is important for enhancing GlyRs in the adult brain, potentially leading to reduced sedation and increased ethanol consumption.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Substance Abuse
Jared R. Bagley, Elissa J. Chesler, Vivek M. Philip, James D. Jentsch
Summary: Genetic factors play a role in voluntary ethanol consumption and pharmacokinetics, with different mouse populations showing varying levels of genetic diversity. The PWK/PhJ strain exhibits the highest ethanol consumption, and it was found that sex moderates genetic effects on voluntary ethanol drinking.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
James C. Nelson, Eva Greengrove, Kala N. Nwachukwu, Isabella R. Grifasi, S. Alex Marshall
Summary: Alcoholism leads to maladaptations in the central nervous system, including the neuroimmune system. Research on binge-like alcohol consumption shows changes in microglial reactivity, particularly in the hippocampus, indicating a potential role in the development of alcohol use disorders. Ethanol-induced upregulation of microglial genes suggests a persistent altered neuroimmune state even after periods of abstinence.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Oncology
Qian Zhang, Hongjing Jiang, Miao Liu, Xinchen Li, Murong Zhou, Yansi Lyu, Jingkai Huang, Si Chen, Li Wang
Summary: Quinine showed therapeutic effects in AD-like mice by improving skin damage, reducing IgE expression in blood, inhibiting IKK alpha and NF-kappa B expression, decreasing cytokine secretion, lowering KLK7 expression, reducing scratching frequency, increasing FLG expression, and repairing the skin barrier.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Brice Williams, Joseph Del Rosario, Tomaso Muzzu, Kayla Peelman, Stefano Coletta, Edyta K. Bichler, Anderson Speed, Lisa Meyer-Baese, Aman B. Saleem, Bilal Haider
Summary: The visual system responds to changes in luminance with action potentials, where OFF responses dominate in the central visual field and are more balanced in the periphery, possibly influenced by species, experimental techniques, and stimulus properties.
Article
Psychology, Multidisciplinary
Macpherson Uchenna Nnam, James E. Effiong, David O. Iloma, Imbur M. Terfa, Benjamin Okorie Ajah
Summary: In recent times, the increase in lack of morality, grandiose identity, emotional insecurity, impulsivity, and manipulative behaviors have been identified as random traits that contribute to students' tendency to cheat and manipulate others. This study explored the relationship between hazardous drinking, selected demographic factors, and social aversive personality traits among a group of 264 purposively sampled undergraduate students. The results demonstrated a strong correlation between hazardous alcohol use and dependence syndrome. Multiple linear regression analysis confirmed the hypothesis that demographic variables and dark triad traits jointly predict hazardous drinking.
CURRENT PSYCHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patrick T. Piantadosi, Lindsay R. Halladay, Anna K. Radke, Andrew Holmes
Summary: The risk of aversive consequences from reward-seeking behavior can significantly impact future actions, with individuals adapting differently to negative and positive punishment risks. Those with substance use disorders or behavioral addictions may struggle to reduce addictive behaviors despite aversive consequences. Dopamine signaling and interconnected ventral striatal, cortical, and amygdala regions play critical roles in punishment learning and risky reward seeking behavior.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Anna K. Radke, Elizabeth A. Sneddon, Raizel M. Frasier, Frederic W. Hopf
Summary: Alcohol use disorder remains a significant social, health, and economic issue, with levels of problem drinking in women on the rise recently. Exploring the underlying mechanisms that drive drinking behaviors differently in males and females is crucial for developing more targeted therapeutic treatments. Research has shown similarities and differences in alcohol drinking patterns between the sexes, highlighting the importance of studying female and male mechanisms to gain a comprehensive understanding of addiction and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Elizabeth A. Sneddon, Kristen M. Schuh, John W. Frankel, Anna K. Radke
Summary: The study found that inhibiting the NAc core can reduce compulsive ethanol intake in mice, but exciting the NAc core has no effect. Inhibiting neurons expressing D-1 or D-2 receptors does not alter compulsive ethanol intake.
Article
Substance Abuse
Kristen M. Schuh, Elizabeth A. Sneddon, Austin M. Nader, Marissa A. Muench, Anna K. Radke
Summary: This study investigated the role of the medial and lateral subregions of the orbitofrontal cortex (OFC) in alcohol consumption using a mouse model. The results showed that inhibiting neurons in the lateral subregion increased ethanol consumption, while inhibiting neurons in the medial subregion did not affect ethanol intake.
Article
Biochemistry & Molecular Biology
Elizabeth A. Sneddon, Lindsay N. Rasizer, Natalie G. Cavalco, Asa H. Jaymes, Noah J. Ostlie, Brianna L. Minshall, Brianna M. Masters, Michael R. Hughes, Haley Hrncir, Arthur P. Arnold, Anna K. Radke
Summary: Alcohol use and high-risk drinking behaviors among women are increasing rapidly. In rodent models, females tend to consume more ethanol than males. This study investigated the influence of gonadal hormones and sex chromosome complement on ethanol drinking behaviors using the four core genotypes (FCG) mouse model. The results suggest that aspects of ethanol drinking behavior may be independently regulated by sex hormones and chromosomes, providing insights into the neurobiological mechanisms underlying ethanol dependence in male and female mice.
Article
Substance Abuse
Elizabeth A. Sneddon, Kristen M. Schuh, Kaila A. Fennell, Nicholas J. Grahame, Anna K. Radke
Summary: This study found that cHAP mice, which display compulsive-like drinking, have a high level of resistance to aversive stimuli such as quinine and footshock. The history of alcohol exposure did not affect this resistance. There were no sex differences in the response to quinine or footshock, but females showed lower sensitivity to footshock than males.
Article
Substance Abuse
Elizabeth A. A. Sneddon, Kaila A. A. Fennell, Sachi Bhati, Joshua E. E. Setters, Kristen M. M. Schuh, Jenelle N. N. DeMedio, Brandon J. J. Arnold, Sean C. C. Monroe, Jennifer J. J. Quinn, Anna K. K. Radke
Summary: One characteristic of alcohol use disorder is compulsive drinking or drinking despite negative consequences. Female rodents typically are more resistant to punishment than males when quinine is used to model aversion-resistant drinking. In this study, the researchers aimed to determine whether this vulnerability to aversion-resistant drinking behavior is similarly observed with footshock punishment.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Neurosciences
Sean C. Monroe, Anna K. Radke
Summary: Withdrawal from opioids involves negative emotions and physical symptoms that contribute to drug-seeking behavior and relapse. This paper focuses on the neural systems that mediate the affective and somatic signs of opioid withdrawal. Evidence from preclinical studies suggests that these systems are altered following opioid exposure and contribute to the aversive and anxious behaviors during withdrawal. Understanding the neural mechanisms of opioid withdrawal is important for relapse prevention and developing effective treatments.
PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Elizabeth A. A. Sneddon, Brianna M. M. Masters, Kiara D. D. Ream, Kaila A. A. Fennell, Jenelle N. N. DeMedio, Miranda M. M. Cash, Brynn P. P. Hollingsworth, Sai Pandrangi, Chloe M. M. Thach, Haifei Shi, Anna K. K. Radke
Summary: Research suggests that sex chromosomes play a role in regulating ethanol consumption, preference, and aversion resistance in mice, and sex chromosome complement may be an important contributor to alcohol drinking behaviors.
FRONTIERS IN PSYCHIATRY
(2023)
Meeting Abstract
Substance Abuse
E. A. Sneddon, L. Rasizer, N. Cavalco, A. Jaymes, N. Ostlie, B. Masters, A. P. Arnold, A. K. Radke
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Neurosciences
Elizabeth A. Sneddon, Collin A. Riddle, Kristen M. Schuh, Jennifer J. Quinn, Anna K. Radke
Summary: This study found that traumatic events in infancy have lasting effects on fear learning and extinction learning in adult mice, but have limited impact on other behaviors.