Article
Environmental Sciences
Run Liu, Dankang Li, Junqing Xie, Lulin Wang, Yonghua Hu, Yaohua Tian
Summary: Evidence on the association between exposure to air pollution and liver enzymes was lacking in low pollution areas. This cross-sectional study aimed to investigate this association and explored the influence of alcohol intake. The results showed that long-term low-level exposure to PM2.5, PM10, NOx, and NO2 was significantly associated with elevated levels of liver enzymes. Moreover, alcohol consumption exacerbated the effect of air pollution on liver enzymes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Substance Abuse
Steven J. J. Nieto, Craig K. K. Enders, Katie Witkiewitz, Stephanie S. S. O'Malley, Lara A. A. Ray
Summary: This study aimed to test the effectiveness of combined varenicline and naltrexone treatment in reducing continuous drinking and drinking risk. The results of the study showed that the combination treatment had a positive effect on individuals who smoke daily and drink heavily, helping to reduce drinking risk levels.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Substance Abuse
Emily E. Hartwell, Richard Feinn, Katie Witkiewitz, Timothy Pond, Henry R. Kranzler
Summary: Although continuous measures of drinking and alcohol-related problems yielded larger effect sizes than the WHO RDLs, the latter nonetheless provide a categorical alternative for use in both clinical care and pharmacotherapy trials.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Katie Witkiewitz, Henry R. Kranzler, Kevin A. Hallgren, Deborah S. Hasin, Arnie P. Aldridge, Gary A. Zarkin, Karl F. Mann, Stephanie S. O'Malley, Raymond F. Anton
Summary: This study examined the stability of WHO risk drinking level reductions and their association with long-term functioning for up to 3 years following treatment in patients with alcohol use disorder. Results showed that patients who achieved WHO RDL reductions at the end of treatment maintained those reductions for up to 3 years, and experienced significantly better mental health, quality of life, and fewer drinking consequences compared to those who did not reduce their drinking.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Louis Onghena, Yves Van Nieuwenhove, Laurissa Demeulenaere, Lindsey Devisscher, Xavier Verhelst, Helena Degroote, Sarah Raevens, Hans Van Vlierberghe, Sander Lefere, Anja Geerts
Summary: This study found that patients who had undergone bariatric surgery were more susceptible to alcohol-related liver disease. They were predominantly younger women with lower alcohol consumption compared to those without prior surgery. Bariatric surgery and older age at diagnosis were both associated with poorer survival outcomes.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Lindsay A. Sobotka, Khalid Mumtaz, Alice Hinton, Lanla F. Conteh
Summary: Liver transplant recipients are more likely to experience pregnancy-related complications such as miscarriage, intrauterine growth restriction, and hypertension, leading to higher costs and longer hospital stays. However, they have zero inpatient mortalities compared with the general population, indicating no increased risk of mortality during pregnancy.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Peter Lemmer, Paul Manka, Jan Best, Alisan Kahraman, Julia Kaelsch, Ramiro Vilchez-Vargas, Alexander Link, Hsin Chiang, Guido Gerken, Ali Canbay, Lars P. Bechmann, Svenja Sydor
Summary: Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are leading causes of chronic liver diseases worldwide. While clinically distinguished by alcohol consumption, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Studies have shown that even moderate alcohol consumption has impacts on liver injury, lipid metabolism, and the composition of gut microbiota.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jin-Seok Lee, Sung-Bae Lee, Dong-Woon Kim, Nara Shin, Seon-Ju Jeong, Chae-Ha Yang, Chang-Gue Son
Summary: Social isolation contributes to depressive disorders and alcohol abuse, with depression increasing vulnerability to alcohol consumption. This study using a mouse model found that microglial activation plays a key role in the vicious cycle between depression and alcohol consumption, while dopaminergic reward might also be involved in this pathogenicity.
Article
Endocrinology & Metabolism
Jiaqi Li, Ahmed Arafa, Rena Kashima, Masayuki Teramoto, Yoko M. Nakao, Kyoko Honda-Kohmo, Yukie Sakai, Emi Watanabe, Tomoharu Dohi, Yoshihiro Kokubo
Summary: The study found that higher levels of liver enzymes were associated with an increased risk of diabetes, while current light drinkers had a lower risk of diabetes, even if their liver enzyme levels were high.
ACTA DIABETOLOGICA
(2022)
Article
Public, Environmental & Occupational Health
Jirada Prasartpornsirichoke, Rasmon Kalayasiri, Polathep Vichitkunakorn, Woraphat Ratta-apha, Wanlop Atsariyasing, Natwarat Anekwit, Warot Lamyai, Chanchai Thongpanich, Surinporn Likhitsathian, Teerayuth Rungnirundorn, Wanida Rattanasumawong, Nawapat Chuatai, Sakol Srisuklorm, Athip Tanaree, Roengrudee Patanavanich
Summary: Parental supply of alcohol is associated with alcohol-related harms and severity of alcohol use disorder in Thai middle school students. Supply of alcohol from peers and siblings plays an important role in both outcomes. An increasing number of sources of alcohol supply increases the risk of alcohol-related harm and severity of alcohol use disorder.
Article
Public, Environmental & Occupational Health
M. Arantxa Colchero, Tonatiuh Barrientos-Gutierrez, Carlos M. Guerrero-Lopez, Sergio Bautista-Arredondo
Summary: Studies in Mexico found that binge drinking is associated with the density of alcohol-selling outlets and alcohol prices, with living in areas with more outlets associated with higher binge drinking risk, and living in states with lower prices associated with more frequent binge drinking. Implementing spatial restrictions to alcohol-selling outlets could help reduce binge drinking along with strong fiscal policies.
PREVENTIVE MEDICINE
(2022)
Article
Psychology, Clinical
Andrew W. Hertel, Scott A. Baldwin, Kirsten P. Peterson, Kristen P. Lindgren
Summary: Endorsing and frequently thinking about having a drinking identity are positively associated with alcohol consumption and risk for hazardous drinking. Greater identification with drinking predicts subsequent increases in alcohol consumption and risk for hazardous drinking, although drinking behavior variables do not predict changes in identification with drinking.
ADDICTIVE BEHAVIORS
(2021)
Article
Substance Abuse
Cheng-Che Chen, Kai-Wen Cheng, Hsin-Yi Chang, Shu-Sen Chang
Summary: After Taiwan's accession to the World Trade Organization and abolishing its alcohol monopoly, the preferences for alcoholic beverages shifted significantly. There was a decrease in rice spirits and Asian wine drinkers, and an increase in fruit wine and Asian spirits drinkers.
Article
Substance Abuse
Anna Mejldal, Kjeld Andersen, Silke Behrendt, Randi Bilberg, Michael Bogenschutz, Barbara Braun-Michl, Gerhard Buehringer, Anette Sogaard Nielsen
Summary: The study showed that reductions in WHO risk levels were maintained over time in older adults seeking treatment for AUD, and were associated with decreased consequences of drinking and AUD symptoms, as well as minor but statistically significant improvements in quality of life.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Review
Physiology
Soo K. Shin, Erin E. Kaiser, Franklin D. West
Summary: Pigs, as an animal model for simulating human alcohol use disorder, exhibit similar voluntary alcohol consumption and intoxication behaviors observed in humans, along with anatomical similarities in the brain and liver, making them a promising tool for studying the complex nature of AUD and its development in humans.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Substance Abuse
Cassandra L. L. Boness, Victoria R. R. Votaw, Meredith W. W. Francis, Ashley L. L. Watts, Sarah H. H. Sperry, Christopher S. S. Kleva, Linda Nellis, Yoanna McDowell, Antoine B. B. Douaihy, Kenneth J. J. Sher, Katie Witkiewitz
Summary: This paper discusses the evolution of conceptualizations and diagnostic criteria for alcohol use disorder (AUD) in the United States, influenced by sociopolitical factors. It provides four examples of how DSM-defined alcoholism, abuse/dependence, and AUD have been influenced by sociopolitical factors. The importance of recognizing and understanding these sociopolitical factors in the application of AUD diagnoses is emphasized. Furthermore, a roadmap is offered to improve the diagnosis of AUD, focusing on falsifiability, acknowledging researchers' assumptions about human behavior, and collaboration across subfields. Such efforts have the potential to minimize sociopolitical influences in the development of diagnostic criteria and maximize the treatment utility of diagnoses.
ADDICTION RESEARCH & THEORY
(2023)
Review
Substance Abuse
Molly Magill, Stephan Maisto, Brian Borsari, Joseph E. Glass, Kevin Hallgren, Jon Houck, Brian Kiluk, Alexis Kuerbis
Summary: This manuscript aims to contribute to the next phase of mechanisms of behavior change (MOBC) science on alcohol or other drug use, encouraging the transition from basic science orientation to translational science orientation. The authors examine MOBC science and implementation science and discuss how they can intersect to capitalize on their goals and methodologies. They provide research recommendations to facilitate the translation of MOBC science and emphasize the importance of direct patient care and continued development of basic MOBC research.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Kevin A. Hallgren, Helen E. Jack, Malia Oliver, Douglas Berger, Jennifer F. Bobb, Daniel R. Kivlahan, Katharine A. Bradley
Summary: This study assessed the association between changes in AUDIT-C scores and changes in depression symptoms. The results showed that patients with increased AUDIT-C scores had an increased prevalence of positive depression screens, while those with decreased AUDIT-C scores had a decreased prevalence of positive depression screens. Patients with stable AUDIT-C scores had little change in the prevalence of positive depression screens.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Psychology, Clinical
Kevin A. Hallgren, Gantt P. Galloway, Katie Witkiewitz, Paul Linde, Bob Nix, John E. Mendelson
Summary: This study investigated the 90-day treatment retention and changes in blood alcohol concentration (BAC) in a large cohort receiving AUD telehealth. The results showed that most patients had good retention rates during the 90-day treatment period, and there was a significant reduction in estimated daily peak BAC. This suggests that telehealth is a viable approach for promoting drinking reductions in AUD treatment.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Article
Psychology, Multidisciplinary
Katie Witkiewitz, Kevin E. Vowles
Summary: Chronic pain and substance use disorders (SUDs) are prevalent and persisting issues, with a significant proportion of the adult population being affected by them. Accessing evidence-based treatments for both conditions is challenging, but ongoing research is shedding light on the mechanisms and co-occurrence of chronic pain and substance use. Integrated behavioral treatments based on acceptance and mindfulness are being developed and tested, and there are increasing efforts in research funding, training, dissemination, and implementation of evidence-based treatments.
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
(2023)
Review
Substance Abuse
Rory A. Pfund, Shelby A. King, David P. Forman, James M. Zech, Meredith K. Ginley, Samuel C. Peter, Nicholas W. McAfee, Katie Witkiewitz, James P. Whelan
Summary: The objective of this study was to examine the effect of cognitive behavioral techniques on gambling-related harms, psychological symptoms, and quality of life. The results showed that cognitive behavioral techniques significantly reduced anxiety and depression symptoms, and improved the quality of life. However, further research is needed to explore the relationships between gambling harms, psychological symptoms, and quality of life.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2023)
Review
Psychology, Clinical
Cassandra L. L. Boness, Victoria R. R. Votaw, Frank J. J. Schwebel, David I. K. Moniz-Lewis, R. Kathryn McHugh, Katie Witkiewitz
Summary: Cognitive behavioral therapy (CBT) is an effective treatment for substance use disorders (SUDs), particularly during the early follow-up period.
CLINICAL PSYCHOLOGY-SCIENCE AND PRACTICE
(2023)
Review
Substance Abuse
Juliana I. Byanyima, Xinyi Li, Sianneh A. Vesslee, Henry R. Kranzler, Zhenhao Shi, Corinde E. Wiers
Summary: Opioid use disorder (OUD) is a chronic condition with serious adverse consequences, including high incarceration rates and overdose-related fatalities. Medications used for OUD treatment have been shown to cause metabolic impairments, but the effects vary depending on the individual's metabolic condition. Further research is needed to determine the best approach for reducing the risk of metabolic disorders in OUD treatment.
CURRENT ADDICTION REPORTS
(2023)
Article
Substance Abuse
Theresa E. Matson, Emily C. Williams, Gwen T. Lapham, Malia Oliver, Kevin A. Hallgren, Katharine A. Bradley
Summary: Despite documented symptoms, diagnosis and treatment of cannabis use disorder are still rare in medical settings.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Health Care Sciences & Services
Bulat Idrisov, Kevin A. Hallgren, Alyssa Michaels, Sean Soth, James Darnton, Paul Grekin, Steve Woolworth, Andrew J. Saxon, Judith Tsui
Summary: This study assessed the workload, usability, and engagement of a video-based DOT mobile app for patients with opioid use disorder receiving methadone treatment. The results showed that the app had low workload and high usability for both patients and counselors, but there were opportunities to improve the usability and engagement for the counselor-facing portal.
JMIR HUMAN FACTORS
(2023)
Article
Psychology, Clinical
Zachary L. Mannes, Ofir Livne, Justin Knox, Deborah S. Hasin, Henry R. Kranzler
Summary: This study aims to examine the prevalence and clinical correlates of opioid withdrawal syndrome (OWS) among adults in the U.S. who engage in non-medical use of prescription opioids (NMOU). Results revealed that OWS is prevalent among individuals with NMOU and is associated with psychiatric disorders and opioid use disorder (OUD).
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Article
Substance Abuse
Katie Witkiewitz, Megan Kirouac, James W. Baurley, Christopher S. McMahan
Summary: This study analyzed data from the Project MATCH and COMBINE studies to explore baseline predictors of drinking patterns. The findings suggest that prior drinking patterns are the most consistent predictors of future drinking patterns. Social network drinking, AUD severity, mental health symptoms, and constructs based on the addiction cycle were associated with patterns of drinking prior to treatment. Addiction cycle constructs, AUD severity, purpose in life, social network, legal history, craving, and motivation were associated with drinking during and following treatment.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
H. M. Hebden, V. R. Votaw, L. Herchenroeder, K. Witkiewitz, E. W. Yeung
Summary: A valid measure for identifying reward and relief drinking subgroups in college students with binge drinking has been established. This could be useful for precision prevention efforts targeting individuals in the high-reward/low-relief and high-reward/high-relief subgroups.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Substance Abuse
Carrie M. Mintz, Justin Knox, Sarah M. Hartz, Deborah S. Hasin, Silvia S. Martins, Henry R. Kranzler, Emily Greene, Elvin H. Geng, Richard A. Grucza, Laura J. Bierut
Summary: This study analyzed demographic disparities in the implementation of SBIRT for unhealthy alcohol use. The results showed that gender, age, race, and insurance status were factors that influenced the likelihood of screening and intervention. Addressing these disparities and reducing attrition from treatment could improve outcomes for individuals with unhealthy alcohol use.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)