Synthesis of functionalized magnetic nanoparticles as a nanocarrier for targeted drug delivery

In this research, iron oxide magnetic nanoparticles (NPs) were synthesized by chemical co-precipitation method. The surface of particles was grafted with beta-cyclodextrin/N,N-dimethylacrylamide (beta-CD/DMAA) copolymer. Potency of NPs as carrier of antibiotic ofloxacin (OFL) was evaluated. They were characterized by scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetric analysis. The effect of the adsorption parameters such as pH, contact time, and temperature for sorption of drug onto NPs was evaluated and optimized. The drug release profile showed that approximately 60% of the adsorbed drug was released in the first 10 min at pH of 1.2 (simulated gastric fluid) and 55% was released within 30 hr in pH of 7.4 (simulated intestinal fluid). Findings of study suggested the suitability of beta-CD/DMAA grafted magnetic NPs for OFL delivery.