Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity

Drug–protein hydrogen bonds govern the inhibition of the ATP hydrolysis of the multidrug transporter P-glycoprotein

(2016) Eduardo E. Chufan et al.   BIOCHEMICAL PHARMACOLOGY

Research progress on berberine with a special focus on its oral bioavailability

(2016) Chang-Shun Liu et al.   FITOTERAPIA

Structural and dynamic perspectives on the promiscuous transport activity of P-glycoprotein

(2016) Nandhitha Subramanian et al.   NEUROCHEMISTRY INTERNATIONAL

Multiple Drug Transport Pathways through Human P-Glycoprotein

(2015) James W. McCormick et al.   BIOCHEMISTRY

Current knowledge and pharmacological profile of berberine: An update

(2015) Anil Kumar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Do Drugs Have Access to the P-Glycoprotein Drug-Binding Pocket through Gates?

(2015) Ricardo J. Ferreira et al.   Journal of Chemical Theory and Computation

Poor permeability and absorption affect the activity of four alkaloids from Coptis

(2015) HAN-MING CUI et al.   Molecular Medicine Reports

Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis

(2014) M. Iranshahy et al.   RSC Advances

P-glycoprotein ABCB1: a major player in drug handling by mammals

(2013) Piet Borst et al.   JOURNAL OF CLINICAL INVESTIGATION

Excretion of Berberine and Its Metabolites in Oral Administration in Rats

(2013) Jing‐Yi Ma et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exploring Transition Pathway and Free-Energy Profile of Large-Scale Protein Conformational Change by Combining Normal Mode Analysis and Umbrella Sampling Molecular Dynamics

(2013) Jinan Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Catalytic Transitions in the Human MDR1 P-Glycoprotein Drug Binding Sites

(2012) John G. Wise   BIOCHEMISTRY

Pharmacokinetic properties, potential herb–drug interactions and acute toxicity of oralRhizoma coptidisalkaloids

(2012) Bing-Liang Ma et al.   Expert Opinion on Drug Metabolism & Toxicology

Insights on P-Glycoprotein’s Efflux Mechanism Obtained by Molecular Dynamics Simulations

(2012) Ricardo J. Ferreira et al.   Journal of Chemical Theory and Computation

The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet

(2012) Xin-xia Chang et al.   Lipids in Health and Disease

Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux

(2012) Yong-Qiang Shan et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

(2012) Lihong Wang et al.   PLoS One

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines

(2011) Donna A Volpe   Future Medicinal Chemistry

P-glycoprotein Retains Drug-stimulated ATPase Activity upon Covalent Linkage of the Two Nucleotide Binding Domains at Their C-terminal Ends

(2011) Brandy Verhalen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein

(2011) Xinfeng Zhang et al.   XENOBIOTICA

Predicting Binding to P-Glycoprotein by Flexible Receptor Docking

(2011) Elena Dolghih et al.   PLoS Computational Biology

Berberine Moderates Glucose and Lipid Metabolism through Multipathway Mechanism

(2010) Qian Zhang et al.   Evidence-based Complementary and Alternative Medicine

Therapeutic potential of nucleic acid-binding isoquinoline alkaloids: Binding aspects and implications for drug design

(2010) Kakali Bhadra et al.   MEDICINAL RESEARCH REVIEWS

ABC proteins in antigen translocation and viral inhibition

(2010) David Parcej et al.   Nature Chemical Biology

Combined Pharmacophore Modeling, Docking, and 3D QSAR Studies of ABCB1 and ABCC1 Transporter Inhibitors

(2009) Ilza K. Pajeva et al.   ChemMedChem

Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation

(2009) Tripta Bansal et al.   DRUG DISCOVERY TODAY

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Isolation and Identification of Urinary Metabolites of Berberine in Rats and Humans

(2008) F. Qiu et al.   DRUG METABOLISM AND DISPOSITION

Berberine Analogues as a Novel Class of the Low-Density-Lipoprotein Receptor Up-Regulators: Synthesis, Structure−Activity Relationships, and Cholesterol-Lowering Efficacy

(2008) Ying-Hong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application and limitation of inhibitors in drug–transporter interactions studies

(2007) Qing Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS