Article
Chemistry, Medicinal
Ziyaur Rahman, Eman M. Mohamed, Sathish Dharani, Tahir Khuroo, Mimy Young, Charles Feng, Todd Cecil, Mansoor A. Khan
Summary: This study developed a quality control test method to identify and differentiate moist snuff and snus products. Dissolution testing revealed significant variations in the amount of nicotine dissolved among different products, and the developed method produced distinct profiles for all tested products.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Marzieh Araghi, Maria Rosaria Galanti, Michael Lundberg, Zhiwei Liu, Weimin Ye, Anton Lager, Gunnar Engstrom, Lars Alfredsson, Anders Knutsson, Margareta Norberg, Patrik Wennberg, Ylva Trolle Lagerros, Rino Bellocco, Nancy L. Pedersen, Per-Olof Ostergren, Cecilia Magnusson
Summary: Through analyzing individual data from the Swedish Collaboration on Health Effects of Snus Use, it was found that Swedish snus use does not appear to be implicated in the development of oral cancer in men, even lower intensity use was associated with reduced risk.
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Jenny Becam, Edouard Martin, Gildas Pouradier, Natalia Doudka, Caroline Solas, Romain Guilhaumou, Nicolas Fabresse
Summary: We present a case of accidental nicotine intoxication in a 22-year-old man working in an e-liquid manufacturing company. The patient spilled 300 mL of pure nicotine solution on his leg without protection, experiencing symptoms such as dizziness, nausea, and burning sensations. He recovered without treatment after five hours. This case highlights the importance of protective clothing when handling nicotine-containing liquid products.
Article
Chemistry, Analytical
Matthias M. Knopp, Nikolai K. Kiil-Nielsen, Anna E. Masser, Mikael Staaf
Summary: This study aimed to develop a biorelevant dissolution method to evaluate the release of nicotine from oral tobacco-derived nicotine and snus pouches. Using mu DISS Profiler(TM) and a custom-made sinker, nicotine release was determined in artificial saliva. The method was able to differentiate between different products and predict in vivo behavior.
Article
Public, Environmental & Occupational Health
Nicholas J. Felicione, Liane M. Schneller, Maciej L. Goniewicz, Andrew J. Hyland, K. Michael Cummings, Maansi Bansal-Travers, Geoffrey T. Fong, Richard J. O'Connor
Summary: This study investigated the awareness and use of oral nicotine products and found that the prevalence of their use is low. Users of oral nicotine products have similar demographics to those who smoke/vape and use smokeless tobacco. Future research is needed to understand the usage patterns and purposes of oral nicotine products.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Review
Oncology
Hakon Valen, Rune Becher, Gunn Elisabeth Vist, Jorn Andreas Holme, Ibrahimu Mdala, Ida-Kristin Orjasaeter Elvsaas, Jan Alexander, Vigdis Underland, Bendik Christian Brinchmann, Tom Kristian Grimsrud
Summary: This systematic review analyzed 14 cohort studies and 1 case-control study, finding increased cancer risk and mortality after cancer diagnosis for exclusive users of Swedish snus. Cancer risk evaluation was only possible for men due to lack of data for women. The report revealed an association between snus use and increased risk of esophageal, pancreatic, stomach, and rectal cancer, as well as mortality after cancer diagnosis. Confidence in the risk estimates varied from moderate, to low, to very low.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Shuai Yuan, Olga E. Titova, Scott M. Damrauer, Agneta Akesson, Susanna C. Larsson
Summary: Swedish snus dipping is not associated with an increased risk of peripheral artery disease, while smoking is.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Elisabet Soderstrom, Torbjorn K. Nilsson, Jorn Schneede, Per-Magne Ueland, Oivind Midttun, Bjorn Gylling, Ingegerd Johansson, Johan Hultdin
Summary: This study investigated the impact of smoking and snus use on plasma homocysteine levels, finding that cotinine, creatinine, methylmalonic acid, and MTHFR T allele were positively associated with tHcy in smokers but not in snus users, suggesting that substances other than nicotine in tobacco smoke may contribute to differential effects on homocysteine status.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Chemistry, Multidisciplinary
David Azzopardi, Chuan Liu, James Murphy
Summary: Compared with snus, NPs have lower levels of harmful compounds and expose users to lower levels of toxic compounds. NPs and NRTs have the lowest toxicant profiles and estimations of relative toxicant exposure across the product categories.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Georg E. Matt, Ashley L. Merianos, Lara Stone, Chase Wullenweber, Penelope J. E. Quintana, Eunha Hoh, Nathan G. Dodder, Nicolas Lopez Galvez, E. Melinda Mahabee-Gittens
Summary: This study found that hand nicotine levels provide additional insights into children's exposure to tobacco smoke pollutants than reported child TSE and urinary biomarkers. Changes in hand nicotine levels show that consistent home smoking bans in homes of children of smokers can lower THS exposure. Hand nicotine levels may be influenced by the environmental settings in which they are collected.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Substance Abuse
Olivia A. Wackowski, Richard J. O'Connor, Destiny Diaz, Mariam Rashid, M. Jane Lewis, Kathryn Greene
Summary: Studies have shown that consumers are interested in receiving specific statistical data on harm reduction for electronic cigarettes and smokeless tobacco products. However, there is skepticism among participants regarding the source and accuracy of these quantitative messages, suggesting that they may be misleading and attractive to young people. Participants also found that messages emphasizing high levels of reduced risk compared to smoking could be attention-grabbing and persuasive, particularly if coming from credible sources.
Review
Dentistry, Oral Surgery & Medicine
R. Holliday, B. W. Chaffee, N. S. Jakubovics, R. Kist, P. M. Preshaw
Summary: Novel nicotine products, particularly e-cigarettes, have gained popularity as a potentially less harmful alternative to tobacco smoking, with evidence suggesting their role in smoking cessation. However, concerns about health consequences, particularly in non-smokers and long-term users, have been raised. Studies show distinct microbiome in e-cigarette users, possibly more pathogenic. Limited clinical evidence of oral health effects underscores the need for further research to understand potential harms and benefits of e-cigarette use.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Green & Sustainable Science & Technology
Marc W. Beutel, Thomas C. Harmon, Thomas E. Novotny, Jeremiah Mock, Michelle E. Gilmore, Stephen C. Hart, Samuel Traina, Srimanti Duttagupta, Andrew Brooks, Christopher L. Jerde, Eunha Hoh, Laurie C. van de Werfhorst, Van Butsic, Ariani C. Wartenberg, Patricia A. Holden
Summary: The impact of cigarette and e-cigarette contamination on the environment is significant, affecting various biota from bacteria to mammals. Chemical substances released from cigarette butts and e-cigarette components can be toxic to a wide range of organisms, highlighting the potential for large-scale environmental impacts of tobacco product waste. However, there are still critical gaps in understanding the full extent of these impacts on environmental health and ecosystem functioning.
Article
Environmental Sciences
E. Melinda Mahabee-Gittens, Ashley L. Merianos, Lara Stone, Chase A. Wullenweber, Penelope J. E. Quintana, Eunha Hoh, Nathan G. Dodder, Nicolas Lopez-Galvez, Georg E. Matt
Summary: This study compared the levels of hand nicotine and urinary tobacco smoke exposure (TSE) biomarkers, and investigated the association between hand nicotine and children's exposure to active smoking. The results showed that hand nicotine and cotinine had the strongest overall associations, and only cotinine showed significantly higher levels among Black children. Hand nicotine levels were associated with modifiable tobacco-related behaviors and could serve as a marker of sources of THS pollution in a child's environment that are not captured by measurement of urinary cotinine alone.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Dentistry, Oral Surgery & Medicine
Simen E. Kopperud, Vibeke Ansteinsson, Ibrahimu Mdala, Rune Becher, Hakon Valen
Summary: This study aimed to investigate the relationship between use of snus, oral mucosal lesions (snus induced lesions) and gingival retractions among adolescents in Norway. The study found that 79.2% of daily snus users had snus induced lesions, and the severity of the lesion increased with the amount of snus used. The study also found that the odds of gingival retractions were significantly higher with each year of snus use.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Substance Abuse
Felicia Nordenstam, Bo Lundell, Gary Cohen, Mesfin K. Tessma, Pauline Raaschou, Ronny Wickstrom
NICOTINE & TOBACCO RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Felicia Nordenstam, Mikael Norman, Ronny Wickstrom
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Review
Pediatrics
Felicia Nordenstam
Summary: This structured review aimed to discuss the knowledge of nicotine use during pregnancy and its long-term effects on children's cardiovascular function. The 34 original papers included in the review covered 172,696 subjects from foetuses to 19 years of age, showing an association between prenatal nicotine exposure and long-term developmental changes in the cardiovascular system and regulation. It is recommended that women abstain from nicotine products when planning a pregnancy due to the lack of safe periods, doses, or products.
Editorial Material
Medicine, General & Internal
Gizem Seyda Erbas, Felicia Nordenstam, Renate Oberhoffer-Fritz, Christina Sitzberger, Annette Wacker-Gussmann
JOURNAL OF CLINICAL MEDICINE
(2023)
