Article
Oncology
Meerim Park, Jiwon Lim, Jun Ah Lee, Hyeon Jin Park, Byung Kiu Park, Myong Cheol Lim, Sang-Yoon Park, Young-Joo Won
Summary: Malignant ovarian germ cell tumors (MOGCTs) in Korean women demonstrated a slight increase in prevalence, with a more pronounced growth among patients aged <19 years. Patients with dysgerminoma showed significantly higher survival rates compared to those with non-dysgerminoma. Following MOGCT diagnosis, the risk of developing subsequent malignancies doubled compared with the general population.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Oncology
Hitomi Sakaguchi-Mukaida, Shinya Matsuzaki, Yutaka Ueda, Satoko Matsuzaki, Mamoru Kakuda, Misooja Lee, Satoki Deguchi, Mina Sakata, Michihide Maeda, Reisa Kakubari, Tsuyoshi Hisa, Seiji Mabuchi, Shoji Kamiura
Summary: This systematic review examines the effectiveness of neoadjuvant chemotherapy (NACT) for women with malignant ovarian germ cell tumors (MOGCT). The results indicate that NACT is used in approximately 40% of advanced MOGCT cases with a response rate of 95.8%. The uterine preservation rate is around 70% and the cumulative resumed menstruation rate is 100%. Comparisons with primary debulking surgery show similar overall survival, disease-free survival, recurrence rate, and adverse event rate from chemotherapy.
Article
Oncology
Zixuan Song, Yizi Wang, Yangzi Zhou, Dandan Zhang
Summary: This study constructed a nomogram using multiple clinical indicators to predict the prognosis of malignant ovarian germ cell tumors (MOGCTs), which was more accurate than FIGO staging alone. The nomogram may assist clinicians in identifying high-risk patients and implementing personalized treatment regimens.
Article
Biochemistry & Molecular Biology
Dennis M. Timmerman, Thomas F. Eleveld, Ad J. M. Gillis, Carlijn C. Friedrichs, Sanne Hillenius, Tessa L. Remmers, Sruthi Sriram, Leendert H. J. Looijenga
Summary: Germ cell tumors (GCTs) have varying responses to platinum-based chemotherapy depending on their anatomical origin, with mediastinal GCTs showing resistance compared to testicular GCTs. TP53 mutations may play a role in causing cisplatin resistance in mediastinal GCTs, suggesting a potential target for treatment. The study provides insights into the underlying mechanisms of TP53 mutant and mediastinal GCTs for alternative treatment approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ling Han, Yali Chen, Yana Liu, Ai Zheng, Hengxi Chen
Summary: Lymphadenectomy (LND) was associated with improved disease-free survival (DFS) in patients with malignant ovarian germ cell tumors (MOGCTs), but did not significantly affect overall survival (OS). The LND+ group had longer operation time, higher blood loss, and higher complication rate compared to the LND- group.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
B. J. Dicken, D. F. Billmire, B. Rich, F. K. Hazard, M. Nuno, M. Krailo, N. Fallahazad, F. Pashankar, F. Shaikh, A. L. Frazier
Summary: In pediatric and adolescent patients with malignant ovarian germ cell tumors, the use of intra-operative frozen section to guide extent of surgical staging showed a concordance with final diagnosis in most cases, highlighting its importance in operative decision-making.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Ran Chu, Penglin Liu, Jingying Chen, Xiaodong Cheng, Kezhen Li, Yanci Che, Jianliu Wang, Li Li, Xi Zhang, Shu Yao, Li Song, Ying Zhao, Changzhen Huang, Ying Xue, Xiyu Pan, Junting Li, Zhongshao Chen, Jie Jiang, Beihua Kong, Kun Song
Summary: This study evaluated the impact of BEP and PC chemotherapy regimens on fertility and prognostic outcomes in MOGCT patients who underwent FSS. The results showed that there were no significant differences in fertility outcome, disease-free survival, and overall survival between the BEP and PC groups. It can be concluded that the PC regimen is as safe as the BEP regimen for preserving fertility and clinical prognosis in MOGCT patients.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Scarlett Acklin, Fen Xia
Summary: Platinum-based chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating complication in cancer treatment, with dorsal root ganglia sensory neurons playing a key role in symptom development. Nucleotide excision repair is crucial for repairing platinum adducts and may serve as potential targets for future therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Aina Calls, Abel Torres-Espin, Xavier Navarro, Victor J. Yuste, Esther Udina, Jordi Bruna
Summary: The study used single-cell RNA sequencing to investigate the transcriptomic profile of sensory neurons in a CIPN mouse model, revealing that cisplatin treatment upregulates biological pathways related to DNA damage response in DRG neurons. Following cisplatin-induced DNA damage, DRG neurons exhibited senescence hallmarks without activation of apoptosis pathways.
Article
Acoustics
F. Moro, L. M. Castellano, D. Franchi, E. Epstein, D. Fischerova, W. Froyman, D. Timmerman, G. F. Zannoni, G. Scambia, L. Valentin, A. C. Testa, F. Mascilini
Summary: This study retrospectively described the clinical and ultrasound characteristics of rare malignant ovarian germ cell tumors, providing insight into the unique features of embryonal carcinoma, non-gestational choriocarcinoma, and malignant mixed germ cell tumor. The findings can aid in improving awareness and diagnostic accuracy of these rare malignant tumors.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sofia C. Nunes, Joana Sousa, Fernanda Silva, Margarida Silveira, Antonio Guimaraes, Jacinta Serpa, Ana Felix, Luis G. Goncalves
Summary: Ovarian cancer is a major cause of death from gynecological cancer and is the third most common gynecological malignancy worldwide. The cure rate for ovarian carcinoma has not improved due to late diagnosis and resistance to therapy. This study suggests that 1H-NMR metabolomics analysis can distinguish between patients with ovarian cancer and those with benign ovarian tumors, and may be able to predict the malignant potential of tumors. The findings support the use of 1H-NMR metabolomics analysis as a screening method for ovarian cancer and for predicting the malignancy of borderline tumors.
Article
Obstetrics & Gynecology
Ali Ayhan, Mehmet Tunc, Huseyin Akilli, Nihan Haberal, Ali Haberal
Summary: This study evaluated the oncologic and obstetric outcomes of patients diagnosed with malignant ovarian germ cell tumors (MOGCTs). The results showed that fertility preservation should be the first treatment option in young patients due to the unilateral involvement of the disease and its chemosensitive nature.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Reproductive Biology
Juan Chen, Yan Li, Jianlei Wu, Yakun Liu, Shan Kang
Summary: This study focused on identifying potential germline and somatic mutations in malignant ovarian germ cell tumors (MOGCTs) by whole-exome sequencing. The most significant mutated gene identified was POU5F1, with mutations in both copy number alteration deletion and duplication regions. Genes corresponding to these alterations were found to be enriched in signaling pathways related to regulating pluripotency of stem cells and immune response.
BIOLOGY OF REPRODUCTION
(2021)
Review
Medicine, General & Internal
Nicolae Gica, Gheorghe Peltecu, Raluca Chirculescu, Corina Gica, Mihai Ciprian Stoicea, Andreea Nicoleta Serbanica, Anca Maria Panaitescu
Summary: Ovarian germ cell tumors are a rare pathology that often affects young women. The treatment is individualized, with fertility-sparing surgery being the standard for young patients in early stages of the disease.
Article
Oncology
Ting-Huan Huang, Giun-Yi Hung, Te-Fu Weng, Fu-Mien Wang, Chih-Ying Lee, Dong-Tsamn Lin, Bow-Wen Chen, Kai-Hsin Lin, Kang-Hsi Wu, Hsi-Che Liu, Jiann-Shiuh Chen, Shiann-Tarng Jou, Jen-Yin Hou, Yung-Li Yang, Shih-Hsiang Chen, Hsiu-Hao Chang, Shyh-Shin Chiou, Pei-Chin Lin, Rong-Long Chen, Chih-Cheng Hsiao, Hsiu-Ju Yen, Chao-Ping Yang, Te-Kau Chang, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Yu-Mei Liao, Min-Yu Su, Ting-Chi Yeh
Summary: This study retrospectively analyzed the prognostic factors and treatment outcomes of primary malignant mediastinal germ cell tumors (GCTs) in Taiwanese children. The results showed that surgical treatment was associated with better outcomes, while advanced disease stage and choriocarcinoma histology subtype were associated with poorer outcomes. Additionally, there was no difference in treatment outcomes between cisplatin-based and carboplatin-based chemotherapy.
Article
Oncology
Bente Vilming, Jorgen Fallas Dahl, Anne Gry Bentzen, Vibeke Anett Ingebrigtsen, Elisabeth Berge Nilsen, Ingvild Vistad, Anne Dorum, Olesya Solheim, Line Bjorge, Manuela Zucknick, Guro Aune, Kristina Lindemann
Summary: The objective of this study was to provide real-world efficacy and safety data on niraparib maintenance treatment for patients with non-gBRCA1/2 mutated platinum-sensitive recurrent ovarian cancer. The results showed that niraparib treatment demonstrated comparable effectiveness to published phase III studies and acceptable safety in a real-world setting. Individualized dosing could reduce adverse events, and CA125 levels at the start of niraparib treatment may help estimate individual prognosis.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Marius C. Normann, Martin Turzer, Lien My Diep, Jan Oldenburg, Beata Gajdzik, Olesya Solheim, Erik Rud
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)