Article
Polymer Science
Emma Barrett-Catton, Murial L. Ross, Prashanth Asuri
Summary: The incorporation of nanoparticles into hydrogels has been explored to enhance and add to the physical and biochemical properties of hydrogels, improving their potential for various applications.
Article
Chemistry, Applied
Shanyi Wu, Rongjun Xiao, Yong Wu, Laijun Xu
Summary: This review discusses the emerging advances and applications of Gellan gum (GG)-based hydrogels in tissue engineering, highlighting their potential in bone, cartilage, nerve, and retina tissue engineering. The review also explores the use of GG-based hydrogels as bioink components for 3D bioprinting.
CARBOHYDRATE POLYMERS
(2024)
Review
Biochemistry & Molecular Biology
Chaymaa Hachimi Alaoui, Gildas Rethore, Pierre Weiss, Ahmed Fatimi
Summary: Different techniques have been developed to extract lignin biopolymer from lignocellulosic biomass. Lignin has gained considerable interest in the biomedical field due to its attractive properties and has been used in the preparation of value-added products such as hydrogels. Lignin-based hydrogels have shown great potential for various biomedical applications, and their copolymerization with other polymers and biopolymers further expands their possibilities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Annika C. Dell, Grayson Wagner, Jason Own, John P. Geibel
Summary: 3D bioprinting plays a crucial role in tissue engineering in medicine by providing precise and highly customizable methods for creating biological tissues. The selection of appropriate cell ink formulations is vital for process optimization and customization to suit target tissues. Hydrogel-based cell ink formulations show promise for future development in bioprinting technology.
Review
Chemistry, Multidisciplinary
Anam Saddique, In Woo Cheong
Summary: Cellulose, the most abundant biopolymer on earth, has become a promising material for biomedical applications due to its excellent physical and biological traits. Cellulose-based hydrogels, particularly those prepared using 3D bioprinting, offer customizability for complex morphology in drug delivery, tissue engineering, and scaffold applications. Despite an increasing amount of research, various issues exist that prevent the advanced applications of cellulose-based hydrogels.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Applied
Christine Gering, Anum Rasheed, Janne T. Koivisto, Jenny Parraga, Sampo Tuukkanen, Minna Kellomaki
Summary: This study examines modification strategies suitable for gellan gum to overcome processing limitations, emphasizing the thorough assessment of precursor solutions and final hydrogels. Different modification methods significantly affect the viscosity, toughness, and molecular weight of GG, expanding its processing capabilities without compromising its hydrogel formation ability.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Chemical
Jian Yao Ng, Peiyan Yu, Dhanya Mahalakshmi Murali, Yuan-Siang Liu, Rajeev Gokhale, Pui Lai Rachel Ee
Summary: A novel ADC-laden collagen-gellan gum hydrogel compatible with 3D bioprinting technology was developed. The hydrogel showed improved printability and scaffold quality, maintaining cell culture for 21 days. This study may contribute to the clinical application of synthetic skin grafts.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Review
Materials Science, Biomaterials
Tarun Agarwal, Sung Yun Hann, Irene Chiesa, Haitao Cui, Nehar Celikkin, Simone Micalizzi, Andrea Barbetta, Marco Costantini, Timothy Esworthy, Lijie Grace Zhang, Carmelo De Maria, Tapas Kumar Maiti
Summary: The article discusses the combination of 3D printing technology and smart materials in additive manufacturing to create biomimetic structures that can dynamically reshape in response to external stimuli. This approach shows promise in various biomedical areas.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Review
Pharmacology & Pharmacy
Dongsik Park, Su Jin Lee, Dong Kyu Choi, Jee-Woong Park
Summary: Tissue engineering integrates multiple disciplines to repair or regenerate damaged tissues and organs. Fibrous scaffolds loaded with therapeutic agents have shown great potential in this field. This comprehensive review examines methods for fabricating bioactive molecule-loaded fibrous scaffolds, their biomedical applications, and aims to contribute to the development of new technologies or improvements to existing ones.
Review
Chemistry, Multidisciplinary
Zhiqiang Luo, Lingyu Sun, Feika Bian, Yu Wang, Yunru Yu, Zhuxiao Gu, Yuanjin Zhao
Summary: Erythrocytes, with their unique morphology and cellular composition, have inspired the development of various artificial biomaterials that have broad prospects in biomedical applications. This comprehensive review covers the fabrication and applications of erythrocyte-inspired functional materials, highlighting the synthesis strategies of particles with erythrocyte-inspired morphologies and discussing their practical biomedical applications. The future possibilities of advanced erythrocyte-inspired biomaterials are also explored, with the aim of inspiring researchers to develop novel biomaterials and accelerate their progress towards clinical biomedical applications.
Review
Biochemistry & Molecular Biology
Chien-Chi Lin, Ellen Frahm, Favour O. Afolabi
Summary: The thiol-norbornene photo-click reaction offers fast crosslinking efficiency and modularity in crosslinking synthetic and naturally derived macromolecules. Gelatin-norbornene (GelNB), derived from collagen, is commonly used for crosslinking cell-laden hydrogels and has various applications in cell and tissue engineering, including disease modeling, tissue regeneration, and bioprinting.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Polymer Science
Masrina Mohd Nadzir, Retno Wahyu Nurhayati, Farhana Nazira Idris, Minh Hong Nguyen
Summary: Bacterial exopolysaccharides (EPSs) are important compounds secreted by bacteria, with a wide range of biomedical applications. The diverse properties of different types of EPSs allow for various controlled applications in the field of biomedicine.
Review
Biochemistry & Molecular Biology
Yunwei Niu, Jiahe Wu, Yanxiang Kang, Pingli Sun, Zuobing Xiao, Di Zhao
Summary: Magnetic chitosan hydrogels are a type of organic-inorganic composite material that combines the characteristics of magnetic materials and natural polysaccharides. These hydrogels, which are made by adding magnetic nanoparticles to chitosan, have improved mechanical strength and exhibit magnetic thermal effects, targeting capabilities, magnetically-sensitive release characteristics, and easy separation and recovery. They have been used in various applications including drug delivery, magnetic resonance imaging, mag-netothermal therapy, and adsorption of heavy metals and dyes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Engineering, Biomedical
Bin Kong, Rui Liu, Jiahui Guo, Ling Lu, Qing Zhou, Yuanjin Zhao
Summary: Nano/micro fibers have attracted much attention in fiber science due to their special functions and properties, and they have a wide range of applications in fields such as environmental engineering, electronics, and biomedicine.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Francesca Cadamuro, Francesco Nicotra, Laura Russo
Summary: Manufacturing technologies such as 3D printing and bio-printing are valuable tools for developing new advanced constructs resembling the structural and functional properties of human organs and tissues. This review focuses on the morphological and biochemical properties of extracellular matrices (ECM) and describes how 3D printing and bioprinting can be used to generate ECM mimics with desired properties.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Yifei Jin, Kaidong Song, Nevada Gellermann, Yong Huang
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Nanoscience & Nanotechnology
Ashley M. Compaan, Kaidong Song, Wenxuan Chai, Yong Huang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Engineering, Manufacturing
Yang Li, Qijiang Mao, Xiaokeng Li, Jun Yin, Yifang Wang, Jianzhong Fu, Yong Huang
ADDITIVE MANUFACTURING
(2019)
Article
Nanoscience & Nanotechnology
Kaidong Song, Ashley M. Compaan, Wenxuan Chai, Yong Huang
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Engineering, Manufacturing
Roland Chen, Robert C. Chang, Bruce Tai, Yong Huang, Burak Ozdoganlar, Wei Li, Albert Shih
JOURNAL OF MANUFACTURING SCIENCE AND ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Engineering, Manufacturing
Kaidong Song, Deming Zhang, Jun Yin, Yong Huang
Summary: The study computationally analyzed the printing performance of jammed gelatin microgel-based composite ink during extrusion, focusing on filament cross-sectional morphology and ink yield-stress fluid property influence on structural printability. Results showed that under small gap distances, the filament cross-section shape becomes flat rectangular, and the maximum achievable length of the ink under different conditions was successfully estimated.
ADDITIVE MANUFACTURING
(2021)
Article
Engineering, Chemical
Xixia Liu, Xingchen Lu, Zonghuan Wang, Xiaohui Yang, Guangli Dai, Jun Yin, Yong Huang
Summary: PLGA HFMs fabricated with different DMSO contents in bore fluid showed significant changes in morphology and performance, with higher DMSO content resulting in smaller dimensions but increased porosity. In vitro cell culture experiments indicated that HFMs prepared with 60% DMSO bore fluid exhibited enhanced cell adhesion and neurite outgrowth alignment along the HFM longitudinal axis. This study provides insights into the mechanism of HFM porous morphology formation and its potential applications in tissue engineering.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Engineering, Biomedical
Kaidong Song, Bing Ren, Yingnan Zhai, Wenxuan Chai, Yong Huang
Summary: Three-dimensional bioprinting is a powerful engineering method for developing cellular structures with unique mechanical and biological properties. This study establishes a direct mapping between the printability of a gelatin microgel-gelatin solution composite bioink and the concentration and cross-linking time of the transglutaminase (TG) enzyme. The results show that by optimizing the TG concentration and cross-linking time, the bioink exhibits good injectability, feature formability, and cell viability.
Article
Physics, Applied
Bing Ren, Kaidong Song, Anil Reddy Sanikommu, Yejun Chai, Matthew A. Longmire, Wenxuan Chai, Walter Lee Murfee, Yong Huang
Summary: This study investigates the printability of sacrificial inks and the creation of perfusable channels in a cross-linkable yield-stress hydrogel matrix during embedded printing. The results show that sacrificial inks with shear-thinning properties can be used to print channels with varying diameters by adjusting the extrusion pressure. Bi-directional diffusion may affect the sacrificial ink removal process and final channel diameter.
APPLIED PHYSICS REVIEWS
(2022)
Review
Biotechnology & Applied Microbiology
Arinola O. Lampejo, Nien-Wen Hu, Daniela Lucas, Banks M. Lomel, Christian M. Nguyen, Carmen C. Dominguez, Bing Ren, Yong Huang, Walter L. Murfee
Summary: The development of biomimetic models bridges the gap between in vitro and in vivo assays, providing tools for studying microvascular dynamics. A key challenge is to recreate the functional complexity of a real network environment. Engineering design requirements and top-down tissue culture methods help achieve the matching of physiological function.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biophysics
Bing Ren, Zhihua Jiang, Walter Lee Murfee, Adam J. Katz, Dietmar Siemann, Yong Huang
Summary: This review discusses the latest progress in organ-like vascularized constructs, including design considerations, construction technologies, and applications. Vascularization is essential for thick and functional tissue constructs, and has broad prospects in in vitro research and in vivo transplantation.
BIOPHYSICS REVIEWS
(2023)
Review
Engineering, Biomedical
Bing Ren, Tryanni R. Chiaravalloti, Nadine L. Belony, Diana I. Romero, Wenxuan Chai, Christopher Leon, Lizi Wu, Nazarius S. Lamango, Ite A. Offringa, Yong Huang
Summary: Advanced in vitro models, such as self-assembled and engineered organoids, have become promising platforms for studying COVID-19. These models surpass conventional cultures and animal models in terms of cellular complexity, relevance to humans, and cost-effectiveness.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Biochemical Research Methods
Ruitong Xiong, Wenxuan Chai, Yong Huang
Article
Engineering, Biomedical
Yifei Jin, Danyang Zhao, Yong Huang
BIO-DESIGN AND MANUFACTURING
(2018)