Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Satoshi Katayama, Victor M. Schuettfort, Benjamin Pradere, Keiichiro Mori, Hadi Mostafaei, Fahad Quhal, Reza Sari Motlagh, Ekaterina Laukhtina, Nico C. Grossmann, Abdulmajeed Aydh, Pawel Rajwa, Frederik Koenig, Pierre Karakiewicz, Martin Haydter, Marco Moschini, Mohammad Abufaraj, Yair Lotan, Richard K. Lee, Quoc-Dien Trinh, Eva Comperat, Jeremy Teoh, Yasutomo Nasu, Shahrokh F. Shariat
Summary: The study assessed the clinical utility of plasma HGF level as a prognostic biomarker in patients with MIBC. The findings indicated that higher HGF levels were associated with worse disease outcomes and could be used to predict prognosis in MIBC patients. However, the absolute magnitude of the effect remained limited.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Urology & Nephrology
Satoshi Katayama, Keiichiro Mori, Benjamin Pradere, Ekaterina Laukhtina, Victor M. Schuettfort, Fahad Quhal, Reza Sari Motlagh, Hadi Mostafaei, Nico C. Grossmann, Pawel Rajwa, Marco Moschini, Romain Mathieu, Mohammad Abufaraj, David D'Andrea, Eva Comperat, Martin Haydter, Shin Egawa, Yasutomo Nasu, Shahrokh F. Shariat
Summary: The study assessed the prognostic value of systemic immune-inflammation index (SII) in non-muscle-invasive bladder cancer (NMIBC) patients, finding that high SII was significantly associated with worse progression-free survival and cancer-specific survival. Adding SII to the standard predictive model improved its discrimination ability.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Enfang Shan, Yi-nan Cao, Yang Zhang, Wen Chen, Xurui Ren, Shanjie Zhu, Xueru Xi, Shuai Mu, Mian Ma, Tongle Zhi, Xianwen Li
Summary: This study investigates the role of CACNG3 in the progression and survival outcome of gliomas and identifies it as a potential new molecular target for diagnosis and treatment. CACNG3 expression is negatively associated with glioma grades and is significantly reduced in certain molecular subtypes. Functional analysis suggests that CACNG3 may affect glioma development through interference with synaptic transmission. In addition, the commonly used glioma treatment, temozolomide, increases CACNG3 expression. Overall, CACNG3 plays a vital role in glioma occurrence and development and could serve as a biomarker for targeted therapy.
Article
Oncology
Yi-Fan Wang, Yu-Ning Hu, Ze-Fan Shen, Chang-Feng Zhao, Kun Liu, Heng Wang, Qi Zhang
Summary: EFNA3, a member of the Eph/ephrin tyrosine kinase family, is upregulated in bladder cancer and may serve as a potential biomarker for bladder tumor occurrence and patient prognosis.
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Xiaoyan Li, Jie He, Guodong Wang, Jian Sun
Summary: miRNA-155 shows promising diagnostic potential for active TB, with higher accuracy and efficacy in pediatric cases.
Article
Oncology
Xuemin Liu, Qingyu Chang, Haiqiang Wang, Hairong Qian, Yikun Jiang
Summary: The study demonstrated that miR-155 may serve as a promising diagnostic biomarker for breast cancer due to its high diagnostic accuracy and important role in the pathogenesis of the disease. Well-designed cohort studies and biological experiments are needed to confirm its diagnostic value before routine clinical application.
Article
Medicine, Research & Experimental
Jialiang Zheng, Fenglin Miao, Zhao Wang, Yuan Ma, Zhenhang Lin, Yaqin Chen, Xu Kong, Yue Wang, Aobo Zhuang, Ting Wu, Wengang Li
Summary: This study conducted a comprehensive analysis of the role of MDM2 in human cancer and found that MDM2 is a reliable prognostic biomarker closely related to cancer immunity, providing a potential immunotherapeutic target for breast cancer, bladder cancer, and ovarian cancer.
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Biochemical Research Methods
Ying Lu, Jing Shao, Xu Shu, Yaofei Jiang, Jianfang Rong, Yongkang Lai, Ji Liu
Summary: This study investigated the role of FADS1 in bladder cancer prognosis using TCGA data. High FADS1 expression in bladder cancer is associated with advanced clinico-pathological features and may serve as a potential biomarker for poor prognosis.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Oncology
Ferran Moratalla-Navarro, Anna Diez-Villanueva, Ainhoa Garcia-Serrano, Adria Closa, David Cordero, Xavier Sole, Elisabet Guino, Rebeca Sanz-Pamplona, Xavier Sanjuan, Cristina Santos, Sebastiano Biondo, Ramon Salazar, Victor Moreno
Summary: In this study, a microRNA signature was identified to recognize patients at high recurrence risk in stage II colorectal cancer. The validity of these findings has been confirmed in an independent group of stage II microsatellite stable colon adenocarcinoma patients. Most of the microRNAs present in the signature have prognostic relevance in various other cancer types. Some of these microRNAs are involved in pivotal pathways of cancer progression.
Article
Oncology
Kalle E. Mattila, Siru Makela, Soili Kytola, Emma Andersson, Pia Vihinen, Susan Ramadan, Tanja Skytta, Leena Tiainen, Meri-Sisko Vuoristo, Kristiina Tyynela-Korhonen, Jussi Koivunen, Laura Kohtamaki, Kristiina Aittomaki, Micaela Hernberg
Summary: This study demonstrates that higher pretreatment plasma ctDNA levels and sustained detectable plasma ctDNA levels during treatment are associated with poor prognosis in metastatic melanoma patients.
