Article
Pharmacology & Pharmacy
Muhammad Sohail Arshad, Munazza Kiran, Jahanzeb Mudassir, Muhammad Farhan, Amjad Hussain, Nasir Abbas
Summary: This study aimed to design, optimize and characterize gastro retentive floating levofloxacin tablets for sustained drug delivery. The floating tablets were prepared using polymers and showed excellent floating behavior and controlled drug release kinetics. The optimized formulation exhibited prolonged floating time and appropriate drug release rate, making it suitable for the treatment of peptic ulcer.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Barkat Ali Khan, Arshad Ali, Khaled M. Hosny, Abdulrahman A. Halwani, Alshaimaa M. Almehmady, Muhammad Iqbal, Waleed S. Alharbi, Walaa A. Abualsunun, Rana B. Bakhaidar, Samar S. A. Murshid, Muhammad Khalid Khan
Summary: The aim of this study was to develop a polymeric dosage form of ebastine using Carbopol 940 and a mixture of span and tween, for the treatment of urticaria. The formulated emulgel exhibited good physical stability and suitable drug release characteristics, and showed significant in vivo anti-allergic activity in an animal model.
Article
Chemistry, Medicinal
Mahmoud A. Elgewelly, Soha M. Elmasry, Nesrine S. El Sayed, Haidy Abbas
Summary: This study aimed to develop a new efficient and safe treatment for psoriasis using resveratrol-loaded spanlastics. The results showed that the optimized formulations had nano-sized particles with high drug entrapment efficiency and sustained release. The incorporation of these formulations into carbopol 934 gels resulted in acceptable pH, non-irritant properties, and reasonable viscosity. In vivo studies on mice demonstrated that the gel formulation exhibited significant improvement in erythema and scaling, and had minimal impact on inflammatory cytokine expression. This suggests that the selected carbopol gel with resveratrol-loaded spanlastics can enhance the topical anti-psoriatic effect of resveratrol.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Xuemei Wen, Zhaoyou Deng, Yangfeng Xu, Guoqing Yan, Xin Deng, Liqin Wu, Qiuling Liang, Fang Fang, Xin Feng, Meiling Yu, Jiakang He
Summary: This study aimed to develop orally disintegrating/sustained-release praziquantel tablets using the hot-melt extrusion technique and direct compression, and evaluate their release and pharmacokinetics. The results showed that PZQ ODSRTs exhibited enteric-coating properties and had a higher relative bioavailability compared to marketed tablets.
Article
Medicine, Research & Experimental
Adrian Rump, Carolin Tetyczka, Eva Littringer, Marie-Luise Kromrey, Robin Buelow, Eva Roblegg, Werner Weitschies, Michael Grimm
Summary: Gastroretentive dosage forms, which can release drugs inside the stomach for a prolonged period, offer advantages such as improved pharmacokinetics/bioavailability and reduced intake frequency, leading to better patient adherence. However, there are currently no gastroretentive products with proven efficacy in humans. One effective approach is the use of mucoadhesive properties to prevent gastric emptying. The adhesion time of minitablets containing Carbopol 71G NF was significantly longer compared to non-adhesive minitablets, resulting in delayed gastric emptying. However, further improvement is needed to achieve clinical benefits, and variations in gastric residence time were observed.
MOLECULAR PHARMACEUTICS
(2023)
Article
Polymer Science
Miroslava Spaglova, Martina Papadakos, Maria Cuchorova, Desana Matusova
Summary: This study aimed to evaluate the effect of reference microemulsion and lecithin-containing microemulsion on the release of tretinoin and its retention in the skin. The results showed that microemulsion-Carbopol gel formulations exhibited better performance in tretinoin release and skin retention.
Article
Pharmacology & Pharmacy
Bazigha K. Abdul Rasool, Rana Sammour
Summary: This study aimed to formulate FMT gastro-retentive floating tablets (FMT-GRFTs) to improve drug bioavailability and therapeutic activity, as well as patient adherence to treatment. The optimized formulation of FMT floating tablets showed nearly eight hours of gastric residence in vivo, and significantly increased drug bioavailability compared to the reference product.
CURRENT DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Changzhi Shi, Kewei Guo, Li Zhang, Yi Guo, Yu Feng, Sandra Cvijic, Dongmei Cun, Mingshi Yang, Jyrki Heinaemaeki, Ain Raal
Summary: This study investigated lung exposure to various inhalable ciprofloxacin (CIP) formulations with different drug release rates in a rat model. The results showed that drug release rate plays an important role in lung exposure to inhaled antibiotics, implying that lung exposure can be improved by using sustained-release formulations.
Article
Polymer Science
Qin Zhang, Xinying Yang, Yifang Wu, Chang Liu, Hongmei Xia, Xiaoman Cheng, Yongfeng Cheng, Ying Xia, Yu Wang
Summary: The aim of this study was to prepare and evaluate kaempferol-loaded carbopol polymer hydrogel, investigate its antioxidant activity, and compare drug release under different pH conditions.
Article
Pharmacology & Pharmacy
Muhammad Ahsan Hafiz, Mohsin Ahmad Ghauri, Nasir Abbas, Talib Hussain, Nadeem Irfan Bukhari
Summary: The aim of this study was to develop a novel hydrogel carrier containing carboplatin-loaded nanosponges for the treatment of cervical cancer. The hydrogel exhibited smooth and uniform appearance, sustained release of carboplatin, and enhanced cytotoxicity compared to pure carboplatin solution. It also showed good bioadhesion and limited permeation through the vaginal mucosal membrane. This innovative approach could potentially improve the localized delivery of carboplatin for cervical cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Medicinal
Mingjin Xun, Hui Guo, Qingyan Cui, Guimin Zhang, Zhong Feng, Lei Gui, Liying Zhai
Summary: This paragraph is about establishing documented evidence that ensures a specific wet granulation process for manufacturing 40 mg rosuvastatin calcium tablets can consistently produce a product that meets its predetermined specifications and quality attributes.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2022)
Article
Polymer Science
Mohamed Rahamathulla, Srinivasan Saisivam, Abdullah Alshetaili, Umme Hani, Hosahalli Veerabhadrappa Gangadharappa, Sultan Alshehri, Mohammed M. Ghoneim, Faiyaz Shakeel
Summary: The study aimed to develop a direct compressed effervescent floating matrix tablet of Losartan potassium to improve its poor bioavailability. The optimized formulation showed good floating capabilities, controlled release for over 24 hours, and enhanced relative bioavailability compared to an oral solution in Albino rabbits, suggesting a potential method for effectively treating hypertension.
Article
Pharmacology & Pharmacy
Mohamed Rahamathulla, Md Naushad Alam, Umme Hani, Qais Ibrahim, Yahya Alhamhoom
Summary: The study aimed to improve the bioavailability of Neratinib in the gastrointestinal tract by developing a novel gastro-retentive system. The findings suggest that the optimized formulation has potential application as a drug delivery system for the treatment of breast cancer.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Fadilah Sfouq Aleanizy, Ehab Taha, Mounir M. Salem-Bekhit, Alaa M. J. Felimban, Saleh A. Al-Suwayeh, Fakhria A. Al-Joufi, Magdy M. Muharram, Fulwah Y. Alqahtani, Faiyaz Shakeel, Abdullah M. E. Youssof, Mohsen Bayomi, Amal E. F. Abouelela
Summary: Surfactant-stabilized mucoadhesive nanogels (NGs) were prepared and evaluated for vaginal delivery of fluconazole (FLZ). The NGs exhibited non-Newtonian flow behavior and the viscosity of the NGs correlated with the FLZ release profile. The pH study confirmed the physiological suitability of the formulations for vaginal application. In vitro and in vivo antimicrobial tests demonstrated the enhanced antimicrobial effect of FLZ incorporated into the mucoadhesive NGs.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Chemistry, Medicinal
Rouheena Shakir, Sana Hanif, Ahmad Salawi, Rabia Arshad, Rai Muhammad Sarfraz, Muhammad Irfan, Syed Atif Raza, Kashif Barkat, Fahad Y. Sabei, Yosif Almoshari, Meshal Alshamrani, Muhammad Ali Syed
Summary: The aim of this study was to develop a buccal delivery system with mucoadhesive properties for sustained release of metformin and sitagliptin in the treatment of diabetes mellitus. The use of Carbopol 940, agarose, and polyvinylpyrrolidone K30 as mucoadhesive agents in tablet formulations resulted in favorable mucoadhesive properties. Formulation R4 showed complete drug release within 6 hours, with a mucoadhesive strength of 26.99 g and a mucoadhesive time of 8.1 h in ex vivo studies. The CP and PVP blend demonstrated stability for up to 6 months. Overall, the CP and PVP blend was found to be appropriate for achieving the desired release and mucoadhesive properties in buccal tablets.
Correction
Pharmacology & Pharmacy
Mohamed Rahamathulla, Umme Hani, Ali Alqahtani, H. V. Gangadharappa, M. Yasmin Begum, Mohammed Jafar, Riyaz Ali M. Osmani, Kumarappan Chidambaram, Afrasim Moin, S. J. Shankar
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Review
Pharmacology & Pharmacy
Rohini Bhattacharya, Asha P. Johnson, T. Shailesh, Mohamed Rahamathulla, H. Gangadharappa
Summary: Diabetes mellitus type-1 is caused by the destruction of pancreatic islets, resulting in insulin deficiency. Oral insulin delivery systems provide a patient-centered and painless alternative to subcutaneous injections. Various carriers and strategies can help overcome the barriers in the gastrointestinal tract, enhancing the stability and bioavailability of insulin.
CURRENT DRUG DELIVERY
(2022)
Review
Pharmacology & Pharmacy
Yahya Alhamhoom, Greeshma Kakinani, Mohamed Rahamathulla, Riyaz Ali M. Osmani, Umme Hani, Kamal Yoonus Thajudeen, G. Kiran Raj, Devegowda V. Gowda
Summary: Cancer immunotherapy, including the use of immune checkpoint inhibitors and chimeric antigen receptor-modified T cells, has made significant advancements in recent years. Nanocarriers like liposomes can enhance immune responses and improve the efficacy of anti-tumor therapeutics. Liposomes offer advantages such as the ability to load both hydrophilic and hydrophobic drugs, protect immunotherapeutic agents, and accurately deliver them to targeted neoplasms with minimal damage to healthy cells.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Polymer Science
Mohammad Akhlaquer Rahman, Abuzer Ali, Mohamed Rahamathulla, Shahana Salam, Umme Hani, Shadma Wahab, Musarrat Husain Warsi, Mohammad Yusuf, Amena Ali, Vineet Mittal, Ranjit Kumar Harwansh
Summary: The goal of this research was to develop and test the efficacy of curcumin-loaded solid lipid nanoparticles (Cur-SLNs) as a new effective drug for lung cancer treatment. Optimization of the formulation was performed by evaluating particle size, polydispersity index (PI), zeta potential (ZP), entrapment efficiency (EE), and drug loading (DL) of different batches of SLNs. The optimized formulation showed desirable properties and stability and exhibited higher cytotoxicity and cellular uptake compared to plain curcumin. This study suggests that curcumin-loaded SLNs can be a promising drug delivery system for lung cancer treatment.
Article
Pharmacology & Pharmacy
Meghana Goravinahalli Shivananjegowda, Umme Hani, Riyaz Ali M. Osmani, Ali H. Alamri, Mohammed Ghazwani, Yahya Alhamhoom, Mohamed Rahamathulla, Sathishbabu Paranthaman, Devegowda Vishakante Gowda, Ayesha Siddiqua
Summary: This study evaluated the effects of Memantine Hydrochloride (MeHCl) and Tramiprosate (TMPS) loaded solid lipid nanoparticles (SLNs) on the clearance of A beta in rat hippocampus. The SLNs showed enhanced neuroprotection against SHSY5Y cells and improved pharmacokinetic profiles. Behavioral tests and histological studies confirmed the therapeutic potential of the SLNs in Alzheimer's disease (AD) management.
Article
Pharmacology & Pharmacy
Vishwa J. Kalaria, S. Saisivam, Anas Alshishani, Jameel S. Aljariri S. Alhesan, Sumit Chakraborty, Mohamed Rahamathulla
Summary: Traditional eye drops have poor bioavailability due to eye barriers. This study aimed to develop nanoparticles of Gemifloxacin Mesylate and incorporate them into an in situ gel to improve drug delivery. The optimized formulation showed a particle size of 71 nm and 81.11% entrapment efficiency. The nanoparticles exhibited biphasic release and when incorporated into the gel, sustained drug release with efficient antimicrobial activity was observed.
Article
Biochemistry & Molecular Biology
Tatineni Spandana, Veera Venkata Nishanth Goli, Mohamed Rahamathulla, Sirajunisa Talath, Riyaz Ali M. Osmani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Shalam Mohamed Hussain, Bannimath Gurupadayya
Summary: The stereoselective deposition and activity of pioglitazone in female albino Wistar rats were studied. A bioanalytical technique was used to assess the separation of pioglitazone enantiomers in rat plasma. The study found significant differences in the enantioselectivity of pioglitazone.
Article
Polymer Science
M. P. Gowrav, K. G. Siree, T. M. Amulya, M. B. Bharathi, Mohammed Ghazwani, Ali Alamri, Abdulatef Y. Alalkami, T. M. Pramod Kumar, Mohammed Muqtader Ahmed, Mohamed Rahamathulla
Summary: A new approach to treating sinusitis involves the use of nasal stents loaded with corticosteroids to prevent complications in wound healing and keep the sinus from closing. These stents are 3D printed using polylactic acid (PLA) and the drug is loaded onto the polymer using a solvent casting method.
Article
Polymer Science
Prasanth Viswanadhan Vasantha, Sheri Peedikayil Sherafudeen, Mohamed Rahamathulla, Sam Thomarayil Mathew, Sandhya Murali, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Ala Yahya Sirhan, Bhageerathy Anantha Narayana Iyer
Summary: The purpose of this study is to develop and evaluate mucoadhesive in situ nasal gel formulations of loratadine and chlorpheniramine maleate to improve drug bioavailability. Different permeation enhancers were studied for their influence on the nasal absorption of loratadine and chlorpheniramine from in situ nasal gels containing different polymeric combinations. Sodium taurocholate, Pluronic F127, and oleic acid showed significant enhancement in the nasal flux of loratadine, while oleic acid had the most pronounced effect on chlorpheniramine maleate permeation.
Article
Polymer Science
Bhakti Dhimmar, Rahul Pokale, Mohamed Rahamathulla, Umme Hani, Mohammad Y. Alshahrani, Sultan Alshehri, Faiyaz Shakeel, Prawez Alam, Riyaz Ali M. Osmani, Amit B. Patil
Summary: Luliconazole is used to design an alkaline pH-based antifungal spray solution for effective antifungal treatment. The solution is formulated using Eudragit RS 100, propylene glycol, water, sodium bicarbonate, and ethanol. The optimized formulation showed satisfactory drug release and compatibility with human skin, making it a promising option for topical antifungal treatments.
Article
Polymer Science
Benedict Jose Chellathurai, Ramyadevi Anburose, Mohammad H. H. Alyami, Mohan Sellappan, Mohammad F. F. Bayan, Balakumar Chandrasekaran, Kumarappan Chidambaram, Mohamed Rahamathulla
Summary: The present study aimed to develop and evaluate a polyherbal gel for treating acne by formulating a mixture of Aloe barbadensis pulp and Vigna radiata extract using Carbopol 940, triethanolamine, and propylene glycol as gelling, viscosity modifying, and pH modifying agents respectively. The developed gel exhibited significant antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans, with promising inhibition zones. The gel formulation also showed beneficial effects on acne, with the additional benefit of Aloe barbadensis on the skin.
Article
Pharmacology & Pharmacy
Sharadha Madhusudhan, Naresh Vishal Gupta, Mohamed Rahamathulla, Saravana Babu Chidambaram, Riyaz Ali M. Osmani, Mohammed Ghazwani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohammed Y. Sarhan, Ahmed Hediyal Tousif
Summary: This study aimed to evaluate the efficacy of sorafenib-tosylate-loaded cubosome nanocarriers (ST-CUBs) compared to a sorafenib tosylate suspension (ST-Suspension) in treating diabetic retinopathy (DR). The results showed that ST-CUBs improved the concentration of sorafenib-tosylate in the retina and exhibited a better inhibitory effect on VEGF and inflammatory cytokines compared to ST-Suspension.
Article
Chemistry, Medicinal
Yahya Alhamhoom, Syed Sagheer Ahmed, M. Rupesh Kumar, MD. Salahuddin, D. R. Bharathi, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohamed Rahamathulla
Summary: Polyherbal formulation (PHF) enhances therapeutic efficacy and minimizes side effects, while allopolyherbal formulation (APHF) combines polyherbal extracts with allopathic medication, effectively reducing the latter's required dose and mitigating associated adverse effects. This study demonstrates the safety and efficacy of PHF and APHF in the treatment of diabetes mellitus.
Article
Chemistry, Multidisciplinary
Amr Selim Abu Lila, Rohini Bhattacharya, Afrasim Moin, Turki Al Hagbani, Marwa Helmy Abdallah, Syed Mohd Danish Rizvi, El-Sayed Khafagy, Talib Hussain, Hosahalli Veerabhadrappa Gangadharappa
Summary: The aim of this study was to develop Bio-Chi decorated MWCNTs for breast cancer therapy with the tyrosine kinase inhibitor, neratinib. Carboxylic acid functionalized MWCNTs were decorated non-covalently with biotin-chitosan coating for dual targeting. The formulation was loaded with neratinib and showed pH-dependent release. Cytotoxicity assay revealed superior cytotoxicity with Bio-Chi coated MWCNTs, suggesting their promise as a drug delivery vehicle for breast cancer cells.
Article
Chemistry, Medicinal
Yahya Alhamhoom, Abhay Sharma, Shivakumar Hagalavadi Nanjappa, Avichal Kumar, Anas Alshishani, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Mohamed Rahamathulla
Summary: This study aimed to develop solid dispersion-based sublingual films of Nisoldipine to improve drug dissolution. The incorporation of Nisoldipine solid dispersion into rapidly bioadhesive sublingual films considerably improved drug dissolution and bioavailability.