Article
Biochemistry & Molecular Biology
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Gianluca Colussi, Alessandro Cavarape, Leonardo A. Sechi, Cristiana Catena
Summary: The study found a significant association between plasma lipoprotein(a) (Lp(a)) levels and markers of vascular stiffening in hypertensive patients. This association may help predict cardiovascular risk and suggests that reducing Lp(a) levels could be beneficial for cardiovascular protection in hypertensive patients.
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Fabio Anastasio, Marzia Testa, Cinzia Ferreri, Arianna Rossi, Gaetano Ruocco, Mauro Feola
Summary: This study aimed to evaluate the prognostic role of arterial stiffness in heart failure patients. The results showed that arterial stiffness was inversely correlated with patient survival and could serve as a prognostic predictor. This study is important for understanding the pathogenesis and clinical outcome of heart failure patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Terentes-Printzios, Vasiliki Gardikioti, Konstantinos Aznaouridis, George Latsios, Maria Drakopoulou, Gerasimos Siasos, Evangelos Oikonomou, Vasiliki Tsigkou, Maria Xanthopoulou, Manolis Vavuranakis, Konstantinos Toutouzas, Dimitrios Tousoulis, Charalambos Vlachopoulos
Summary: The study found that arterial stiffness significantly increases in patients with aortic valve stenosis who undergo TAVI, especially in the long term. Additionally, there are improvements in arterial pressure indices and subendocardial viability ratio after the surgery.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Urology & Nephrology
Mohamed Mamdouh Elsayed, Elhassan Mohamed Ayman
Summary: Atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients, as it can help maintain stable arterial stiffness parameters while the placebo treatment group showed a significant increase. This suggests that atorvastatin may have a potential role in delaying arterial stiffness progression in hemodialysis patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Laurence Guy Howes, Tanya Unni, Ameer Hamza, Jan B. Howes, Rohan Jayasinghe, Anna Kablak-Ziembicka, Mark Butlin
Summary: Antioxidants can reduce arterial stiffness, but the previous effects were weak. This study found that the combination therapy of sulfur-containing antioxidants with ascorbic acid had a significant effect on the stiffness index, which was stronger than previous studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
A. Colak, M. E. Ozpelit, M. Birlik, E. Ozpelit
Summary: The prognostic value of arterial stiffness (AS) parameters in predicting all-cause mortality in systemic sclerosis (SSc) patients was investigated. The results showed that AS parameters were not associated with all-cause mortality. Large-scale studies are needed to determine the exact mechanisms of cardiovascular mortality in SSc patients.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Vasiliki Gardikioti, Dimitrios Terentes-Printzios, Dimitrios Iliopoulos, Konstantinos Aznaouridis, Evangelia Sigala, Konstantinos Tsioufis, Charalambos Vlachopoulos
Summary: Degenerative aortic valve stenosis is a common primary valve disease, and the role of the arterial system in its pathogenesis needs further study. Arteriosclerosis may increase cardiac workload and affect cardiovascular function, with arterial stiffness potentially impacting prognosis and quality of life. Studies suggest arterial biomarkers could play a role in optimizing treatment timing and method for aortic stenosis.
Article
Peripheral Vascular Disease
Keeron Stone, Simon Fryer, James Faulkner, Michelle L. Meyer, Kevin Heffernan, Anna Kucharska-Newton, Gabriel Zieff, Craig Paterson, Kunihiro Matsushita, Timothy M. Hughes, Hirofumi Tanaka, Lee Stoner
Summary: The study found no significant relationship between aortic-femoral arterial stiffness gradient (af-SG) and mean arterial pressure (MAP) in healthy older adults, as well as adults with hypertension and diabetes, indicating that af-SG may be considered as a MAP independent index of arterial health and cardiovascular disease (CVD) risk in older adults.
JOURNAL OF HYPERTENSION
(2021)
Review
Cardiac & Cardiovascular Systems
Zhenyu Chu, Yao Wei, Yan Hao, Jun Wang, Fang Huang, Miao Hou
Summary: This meta-analysis showed that fish oil supplementation has a beneficial effect on pulse wave velocity, especially in low dosage, short time, low DHA to EPA ratio, and among young participants.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Nutrition & Dietetics
Rosaria Del Giorno, Ania Maddalena, Stefano Bassetti, Luca Gabutti
Summary: This systematic literature review examines the association between alcohol use and arterial stiffness. The results suggest a J-shaped relationship, where light-to-moderate alcohol consumption is associated with lower arterial stiffness values, while high doses of alcohol accelerate arterial aging. Gender and age may also influence this association.
Article
Endocrinology & Metabolism
Zheng-Wei Chen, Chien-Ting Pan, Che-Wei Liao, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Shuo-Meng Wang, Ching-Chu Lu, Jeff S. Chueh, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin
Summary: This study compared the reversal of arterial stiffness in surgically and medically treated PA patients and identified predictors of effective medical treatment. The findings showed that adrenalectomy and medically treated PA patients with unsuppressed plasma renin activity (PRA) had an improvement in arterial stiffness.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Mohammad Yavarimanesh, Hao-Min Cheng, Chen-Huan Chen, Shih-Hsien Sung, Aman Mahajan, Rabih A. Chaer, Sanjeev G. Shroff, Jin-Oh Hahn, Ramakrishna Mukkamala
Summary: Abdominal aortic aneurysms (AAAs) can be lethal but treatable, and current methods of diagnosis and monitoring are inadequate. In this study, researchers aimed to test the hypothesis that analysis of arterial waveforms can provide information about AAA size, and developed linear regression models to predict maximal aortic diameter. The results showed promising potential for developing convenient monitoring devices and serving as an adjunct to imaging.
NPJ DIGITAL MEDICINE
(2022)
Article
Cell Biology
Klaas F. Franzen, Moritz Meusel, Julia Engel, Tamara Roecker, Daniel Droemann, Friedhelm Sayk
Summary: PE-induced hypertension results in a strong reflex-mediated decrease in cardiac output, and has stronger effects on PWV, AIx, total peripheral resistance, and pulse pressure compared to Ang II at equal mean aortic BP. Furthermore, there are minimal changes in circulating markers of endothelial function in response to both vasoactive infusions.
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Rheumatology
John Bowes, Sabine Loehr, Ashley Budu-Aggrey, Steffen Uebe, Ian N. Bruce, Marie Feletar, Helena Marzo-Ortega, Philip Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Matthew A. Brown, Frank Behrens, Harald Burkhardt, Neil McHugh, Ulrike Huffmeier, Pauline Ho, Andre Reis, Anne Barton
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Biochemistry & Molecular Biology
Ciara Coleman, Emma M. Quinn, Anthony W. Ryan, Judith Conroy, Valerie Trimble, Nasir Mahmud, Nicholas Kennedy, Aiden P. Corvin, Derek W. Morris, Gary Donohoe, Colm O'Morain, Padraic MacMathuna, Valerie Byrnes, Clifford Kiat, Gosia Trynka, Cisca Wijmenga, Dermot Kelleher, Sean Ennis, Richard J. L. Anney, Ross McManus
EUROPEAN JOURNAL OF HUMAN GENETICS
(2016)
Correction
Multidisciplinary Sciences
John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe, Kathryn Steel, Harry L. Hebert, Chris Wallace, Jonathon Massey, Ian N. Bruce, James Bluett, Marie Feletar, Ann W. Morgan, Helena Marzo-Ortega, Gary Donohoe, Derek W. Morris, Philip Helliwell, Anthony W. Ryan, David Kane, Richard B. Warren, Eleanor Korendowych, Gerd-Marie Alenius, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Neil McHugh, Matthew A. Brown, Pauline Ho, Frank Behrens, Harald Burkhardt, Andre Reis, Anne Barton
NATURE COMMUNICATIONS
(2015)
Letter
Rheumatology
Ashley Budu-Aggrey, John Bowes, Sabine Loehr, Steffen Uebe, Maria I. Zervou, Philip Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Emiliano Giardina, Jonathan Packham, Ross McManus, Oliver FitzGerald, Neil McHugh, Frank Behrens, Harald Burkhardt, Ulrike Huffmeier, Pauline Ho, Javier Martin, Santos Castaneda, George Goulielmos, Andre Reis, Anne Barton
ANNALS OF THE RHEUMATIC DISEASES
(2016)
Article
Genetics & Heredity
Serban Radian, Yoan Diekmann, Plamena Gabrovska, Brendan Holland, Lisa Bradley, Helen Wallace, Karen Stals, Anna-Marie Bussell, Karen McGurren, Martin Cuesta, Anthony W. Ryan, Maria Herincs, Laura C. Hernandez-Ramirez, Aidan Holland, Jade Samuels, Elena Daniela Aflorei, Sayka Barry, Judit Denes, Ida Pernicova, Craig E. Stiles, Giampaolo Trivellin, Ronan McCloskey, Michal Ajzensztejn, Noina Abid, Scott A. Akker, Moises Mercado, Mark Cohen, Rajesh V. Thakker, Stephanie Baldeweg, Ariel Barkan, Madalina Musat, Miles Levy, Stephen M. Orme, Martina Unterlaender, Joachim Burger, Ajith V. Kumar, Sian Ellard, Joseph McPartlin, Ross McManus, Gerard J. Linden, Brew Atkinson, David J. Balding, Amar Agha, Chris J. Thompson, Steven J. Hunter, Mark G. Thomas, Patrick J. Morrison, Marta Korbonits
Article
Rheumatology
Maria Apel, Steffen Uebe, John Bowes, Emiliano Giardina, Eleanor Korendowych, Kristina Juneblad, Francesca Pasutto, Arif B. Ekici, Ross McManus, Pauline Ho, Ian N. Bruce, Anthony W. Ryan, Frank Behrens, Beate Boehm, Heiko Traupe, Joerg Lohmann, Christian Gieger, Heinz-Erich Wichmann, Leonid Padyukov, Oliver FitzGerald, Gerd-Marie Alenius, Neil J. McHugh, Giuseppe Novelli, Harald Burkhardt, Anne Barton, Andre Reis, Ulrike Hueffmeier
ARTHRITIS AND RHEUMATISM
(2013)
Letter
Hematology
Prerna Tewari, Anthony W. Ryan, Patrick J. Hayden, Mark Catherwood, Stephen Drain, Anthony Staines, Tim Grant, Alexandra Nieters, Nikolaus Becker, Silvia de Sanjose, Lenka Foretova, Mark Maynardie, Pierluigi Cocco, Paolo Boffetta, Paul Brennan, Stephen Chanock, Mark Lawler, Paul V. Browne
BRITISH JOURNAL OF HAEMATOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Jo Knight, Sarah L. Spain, Francesca Capon, Adrian Hayday, Frank O. Nestle, Alex Clop, Jonathan N. Barker, Michael E. Weale, Richard C. Trembath
HUMAN MOLECULAR GENETICS
(2012)
Article
Genetics & Heredity
Lam C. Tsoi, Sarah L. Spain, Jo Knight, Eva Ellinghaus, Philip E. Stuart, Francesca Capon, Jun Ding, Yanming Li, Trilokraj Tejasvi, Johann E. Gudjonsson, Hyun M. Kang, Michael H. Allen, Ross McManus, Giuseppe Novelli, Lena Samuelsson, Joost Schalkwijk, Mona Stahle, A. David Burden, Catherine H. Smith, Michael J. Cork, Xavier Estivill, Anne M. Bowcock, Gerald G. Krueger, Wolfgang Weger, Jane Worthington, Rachid Tazi-Ahnini, Frank O. Nestle, Adrian Hayday, Per Hoffmann, Juliane Winkelmann, Cisca Wijmenga, Cordelia Langford, Sarah Edkins, Robert Andrews, Hannah Blackburn, Amy Strange, Gavin Band, Richard D. Pearson, Damjan Vukcevic, Chris C. A. Spencer, Panos Deloukas, Ulrich Mrowietz, Stefan Schreiber, Stephan Weidinger, Sulev Koks, Kuelli Kingo, Tonu Esko, Andres Metspalu, Henry W. Lim, John J. Voorhees, Michael Weichenthal, H. Erich Wichmann, Vinod Chandran, Cheryl F. Rosen, Proton Rahman, Dafna D. Gladman, Christopher E. M. Griffiths, Andre Reis, Juha Kere, Rajan P. Nair, Andre Franke, Jonathan N. W. N. Barker, Goncalo R. Abecasis, James T. Elder, Richard C. Trembath, Kristina Callis Duffin, Cindy Helms, David Goldgar, Yun Li, Justin Paschall, Mary J. Malloy, Clive R. Pullinger, John P. Kane, Jennifer Gardner, Amy Perlmutter, Andrew Miner, Bing Jian Feng, Ravi Hiremagalore, Robert W. Ike, Enno Christophers, Tilo Henseler, Andreas Ruether, Steven J. Schrodi, Sampath Prahalad, Stephen L. Guthery, Judith Fischer, Wilson Liao, Pui Kwok, Alan Menter, G. Mark Lathrop, C. Wise, Ann B. Begovich, Alexandros Onoufriadis, Michael E. Weale, Angelika Hofer, Wolfgang Salmhofer, Peter Wolf, Kati Kainu, Ulpu Saarialho-Kere, Sari Suomela, Petra Badorf, Ulrike Hueffmeier, Werner Kurrat, Wolfgang Kuester, Jesus Lascorz, Rotraut Moessner, Funda Schuermeier-Horst, Markward Staender, Heiko Traupe, Judith G. M. Bergboer, Martin den Heijer, Peter C. van de Kerkhof, Patrick L. J. M. Zeeuwen, Louise Barnes, Linda E. Campbell, Caitriona Cusack, Ciara Coleman, Judith Conroy, Sean Ennis, Oliver Fitzgerald, Phil Gallagher, Alan D. Irvine, Brian Kirby, Trevor Markham, W. H. Irwin McLean, Joe McPartlin, Sarah F. Rogers, Anthony W. Ryan, Agnieszka Zawirska, Emiliano Giardina, Tiziana Lepre, Carlo Perricone, Gemma Martin-Ezquerra, Ramon M. Pujol, Eva Riveira-Munoz, Annica Inerot, Asa T. Naluai, Lotus Mallbris, Katarina Wolk, Joyce Leman, Anne Barton, Richard B. Warren, Helen S. Young, Isis Ricano-Ponce, Gosia Trynka, Fawnda J. Pellett, Andrew Henschel, Marin Aurand, Bruce Bebo, Christian Gieger, Thomas Illig, Susanne Moebus, Karl-Heinz Joeckel, Raimund Erbe, Peter Donnelly, Leena Peltonen, Jenefer M. Blackwell, Elvira Bramon, Matthew A. Brown, Juan P. Casas, Aiden Corvin, Nicholas Craddock, Audrey Duncanson, Janusz Jankowski, Hugh S. Markus, Christopher G. Mathew, Mark I. McCarthy, Colin N. A. Palmer, Robert Plomin, Anna Rautanen, Stephen J. Sawcer, Nilesh Samani, Ananth C. Viswanathan, Nicholas W. Wood, Celine Bellenguez, Colin Freeman, Garrett Hellenthal, Eleni Giannoulatou, Matti Pirinen, Zhan Su, Sarah E. Hunt, Rhian Gwilliam, Suzannah J. Bumpstead, Serge Dronov, Matthew Gillman, Emma Gray, Naomi Hammond, Alagurevathi Jayakumar, Owen T. McCann, Jennifer Liddle, Marc L. Perez, Simon C. Potter, Radhi Ravindrarajah, Michelle Ricketts, Matthew Waller, Paul Weston, Sara Widaa, Pamela Whittaker
Review
Genetics & Heredity
[Anonymous]
FRONTIERS IN GENETICS
(2014)
Review
Cell Biology
Jedd Pratt, Colin Boreham, Sean Ennis, Anthony W. Ryan, Giuseppe De Vito
Article
Rheumatology
Mehreen Soomro, Michael Stadler, Nick Dand, James Bluett, Deepak Jadon, Farideh Jalali-najafabadi, Michael Duckworth, Pauline Ho, Helena Marzo-Ortega, Philip S. Helliwell, Anthony W. Ryan, David Kane, Eleanor Korendowych, Michael A. Simpson, Jonathan Packham, Ross McManus, Cem Gabay, Celine Lamacchia, Michael J. Nissen, Matthew A. Brown, Suzanne M. M. Verstappen, Tjeerd Van Staa, Jonathan N. Barker, Catherine H. Smith, Oliver FitzGerald, Neil McHugh, Richard B. Warren, John Bowes, Anne Barton
Summary: A novel susceptibility locus for PsA and key biological pathways differentiating PsA from PsC were identified in this study. The heritability of PsA was found to be moderate and similar to PsC. Published classification pipelines showed modest performance, indicating the need for future predictive models to be tested in PsC patients recruited from primary care.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Geriatrics & Gerontology
Jedd Pratt, Laura Whitton, Anthony Ryan, Thorhildur Juliusdottir, Jackie Dolan, Judith Conroy, Marco Narici, Giuseppe De Vito, Colin Boreham
Summary: The genes AGRN and PRSS12 are associated with muscle mass and strength, indicating their importance in maintaining muscle health during aging. This study provides novel evidence supporting the role of the neuromuscular junction (NMJ) in sarcopenia phenotypes.
Article
Rheumatology
John Bowes, James Ashcroft, Nick Dand, Farideh Jalali-Najafabadi, Eftychia Bellou, Pauline Ho, Helena Marzo-Ortega, Philip S. Helliwell, Marie Feletar, Anthony W. Ryan, David J. Kane, Eleanor Korendowych, Michael A. Simpson, Jonathan Packham, Ross McManus, Matthew A. Brown, Catherine H. Smith, Jonathan N. Barker, Neil McHugh, Oliver FitzGerald, Richard B. Warren, Anne Barton
ANNALS OF THE RHEUMATIC DISEASES
(2017)
Meeting Abstract
Endocrinology & Metabolism
Serban Radian, Plamena Gabrovska, Brendan Holland, Helen Wallace, Anthony W. Ryan, Karen McGurren, Karen Stals, Anna-Marie Bussell, Mark G. Thomas, Aidan Holland, Elena Daniela Aflorei, Sayka Barry, Craig E. Stiles, Ida Pernicova, Giampaolo Trivellin, Judit Denes, Maria Herincs, Laura C. Hernandez-Ramirez, Jade Samuels, Ronan McCloskey, Michal Azjensztejn, Noina Abid, Ajith V. Kumar, Brew A. Atkinson, Sian Ellard, Ross McManus, Chris John Thompson, Gerard J. Linden, Lisa Bradley, Amar Agha, Steven J. Hunter, Patrick J. Morrison, Marta Korbonits