Article
Medicine, General & Internal
Konstantinos Markakis, Nikolaos Pagonas, Eleni Georgianou, Panagiota Zgoura, Benjamin J. Rohn, Sebastian Bertram, Maximilian Seidel, Sebastian Bettag, Hans-Joachim Trappe, Nina Babel, Timm H. Westhoff, Felix S. Seibert
Summary: The study found that in patients with shock, both oscillometric blood pressure monitoring devices were successful in completing hemodynamic assessments, but there were significant differences between invasive and non-invasive techniques. There were discrepancies in pulse wave velocity measurements between the two devices. Non-invasive peripheral blood pressure measurement may not always be successful in certain circumstances.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Sport Sciences
Yu Lun Tai, Erica M. Marshall, Jason C. Parks, J. Derek Kingsley
Summary: This study compared the effects of upper- and lower-body resistance exercise with and without blood flow restriction on hemodynamics and pulse wave reflection. The results showed that regardless of upper- or lower-body exercise, the cardiovascular responses were similar between BFR and without BFR conditions. Upper-body resistance exercise placed greater stress on pulse wave reflection, while lower-body exercise resulted in greater responses in blood pressure.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2022)
Article
Engineering, Biomedical
Rashid Afkhami, Sarah Johnson
Summary: In this study, a mathematical model for the reflection time and augmentation index was derived using transmission-line theory, and it was tested against reported values in the literature. Insights from the model were discussed, such as the age-related shift in the reflection site, variation of AI with heart rate, and flattening of Trefl in older participants.
MEDICAL ENGINEERING & PHYSICS
(2021)
Article
Physiology
Yi-Bang Cheng, Jia-Hui Xia, Yan Li, Ji-Guang Wang
Summary: Newer antihypertensive agents, such as RAS inhibitors and CCBs, were found to be significantly more efficacious than older agents in their effects on central hemodynamics.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Paolo Salvi, Filippo Valbusa, Anna Kearney-Schwartz, Carlos Labat, Andrea Grillo, Gianfranco Parati, Athanase Benetos
Summary: This study found a significant inverse correlation between carotid-femoral pulse wave velocity and carotid distensibility, indicating a close relationship between aortic stiffness evaluated by the propagative method and local carotid cross-sectional distensibility.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Peripheral Vascular Disease
Daime Campos-Arias, Marc L. De Buyzere, Julio A. Chirinos, Ernst R. Rietzschel, Patrick Segers
Summary: Studies have shown that changes in the arterial system due to aging are complex and not fully understood, with differences in parameters such as pulse wave velocity, input impedance, and wave reflection between genders and age groups. The findings suggest that aortic dilation and elongation may play a crucial role in determining longitudinal age-related changes in impedance parameters in middle-aged individuals. Future research should focus on the interaction between geometric remodeling and wall stiffening as determinants of pulsatile hemodynamics.
Article
Biophysics
Rahul Manoj, Kiran Raj, P. M. Nabeel, Mohanasankar Sivaprakasam, Jayaraj Joseph
Summary: In this study, a multi-Gaussian decomposition (MGD) modelled wave separation analysis (MGD(WSA)) was developed for non-aortic sites, such as the carotid artery. The proposed method successfully separated and quantitatively analyzed carotid pressure waveforms without relying on measured or modelled flow velocity information. The results showed a strong correlation between the MGD modelled pressures and the reference counterparts, indicating its potential in vascular health assessment.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Peripheral Vascular Disease
Takamichi Takahashi, Hiroki Nakano, Kazuki Shiina, Masatsune Fujii, Chisa Matsumoto, Kazuhiro Satomi, Akira Yamashina, Hirofumi Tomiyama, Taishiro Chikamori
Summary: Elevated central systolic blood pressure may be an independent risk factor for accelerated progression of arterial stiffness in middle-aged Japanese men.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Physiology
M. A. McNarry, L. Lester, E. A. Ellins, J. P. Halcox, G. Davies, C. O. N. Winn, K. A. Mackintosh
Summary: The study found that high-intensity interval training did not influence arterial stiffness or clustered cardiometabolic risk in adolescents with or without asthma, despite significant changes in blood lipid and pressure profiles. Blood pressure, augmentation, and pulse wave velocity were suggested as distinct constructs and potential markers of cardiovascular health.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Avinash Kondiboyina, Joseph J. Smolich, Michael M. H. Cheung, Jonathan P. Mynard
Summary: The authors propose a novel method for measuring the time shift in waveform between diastole and systole in the heart. They demonstrate the accuracy and robustness of this method by comparing it to a ground truth measurement. This is significant for studying the changes in backward waveform timing with aging.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Cardiac & Cardiovascular Systems
Cindy Z. Kalenga, Jacqueline L. Hay, Kevin F. Boreskie, Todd A. Duhamel, Jennifer M. MacRae, Amy Metcalfe, Kara A. Nerenberg, Magali Robert, Sofia B. Ahmed
Summary: Oral estrogen therapy is associated with increased blood pressure while non-oral estrogen therapy is not. The use of oral estrogen is also associated with higher aortic pulse wave velocity and augmentation index, although these associations are no longer significant after adjusting for covariates.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Peripheral Vascular Disease
Lazaros K. Yofoglu, Fotios Karachalias, Marios K. Georgakis, Christos Tountas, Antonios A. Argyris, Yi Zhang, Theodoros G. Papaioannou, Jacques Blacher, Thomas Weber, Charalampos Vlachopoulos, Michel Safar, Athanase D. Protogerou
Summary: This study aimed to examine the relationship between pressure wave reflections (PWRs) and left ventricular mass. Through a meta-analysis of 19 studies, it was found that there is a significant association between PWRs and left ventricular mass, except for the aortic augmentation index as estimated by generalized transfer functions. The association between carotid augmentation index and left ventricular mass was higher among populations with higher heart rate.
Article
Pharmacology & Pharmacy
Ivan Cavero-Redondo, Alicia Saz-Lara, Cristina Lugones-Sanchez, Diana P. Pozuelo-Carrascosa, Leticia Gomez-Sanchez, Jose Francisco Lopez-Gil, Luis Garcia-Ortiz, Rosa Maria Bruno, Manuel Angel Gomez-Marcos
Summary: This study synthesized and evaluated scientific evidence on the efficacy of antihypertensive drugs on arterial stiffness in patients with hypertension. The findings suggest that thiazide diuretics, ACE inhibitors, ARBs, and their combinations can effectively reduce pulse wave velocity, while ACE inhibitors and ARBs can reduce augmentation index.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Acoustics
Rashid Afkhami, Rachel Wong, Saadallah Ramadan, Frederick Rohan Walker, Sarah Johnson
Summary: This study introduced a new TCD-based timing index, TITCD, as an indicator of vascular stiffening and health, showing stronger correlations with CRF and PIMRI compared to existing indices. The clearer relationship of the proposed timing index with vascular aging factors underlines its utility as an early indicator of vascular stiffening.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Physiology
Christian P. Cheung, Alexandra M. Coates, Katharine D. Currie, Trevor J. King, Margo L. Mountjoy, Jamie F. Burr
Summary: This study found that the central artery stiffness and wave reflection properties of aquatic athletes are influenced by the training load of different disciplines, with some gender differences between disciplines.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Engineering, Biomedical
Annette Caenen, Mathieu Pernot, Kathryn R. Nightingale, Jens-Uwe Voigt, Hendrik J. Vos, Patrick Segers, Jan D'hooge
Summary: Shear wave elastography offers a new method for measuring myocardial stiffness in echocardiography. It has the potential to improve diagnosis and treatment of cardiac diseases by providing additional diagnostic value. However, the proper interpretation and processing methods for shear wave data are still challenging, and further research is needed to optimize this technique.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Engineering, Biomedical
Matthias Van Impe, Lisa Caboor, Violette Deleeuw, Margie Olbinado, Julie De Backer, Patrick Sips, Patrick Segers
Summary: This study successfully provides a biomechanical reference for the circulation in adult zebrafish by establishing 3D models of the cardiovascular system. By providing reference values for biomechanical stimuli in wild-type animals and a pipeline for image-based animal-specific computational biomechanical models, this study contributes to a more comprehensive understanding of the role of altered biomechanics and hemodynamics in heritable cardiovascular pathologies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Annette Caenen, Stephanie Bezy, Aniela Petrescu, Annegret Werner, Jens-Uwe Voigt, Jan D'hooge, Patrick Segers
Summary: Shear wave elastography (SWE) is a promising technique for assessing myocardial stiffness non-invasively. The study found that the transmural wave speed gradient can distinguish between intrinsic myocardial stiffening and stiffening caused by increased pressure. This gradient may have potential as a new diagnostic parameter for future clinical studies.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study investigates whether pulse wave velocity (PWV) can guide in determining appropriate parameter values for the Gasser-Ogden-Holzapfel (GOH) constitutive model. The results show that PWV80 and PWV110 are complementary measures that can reduce the parameter space in arterial models, particularly for media- and collagen-related parameters.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Kristian Sorensen, Solveig Fadnes, Luc Mertens, Matthew Henry, Patrick Segers, Lasse Lovstakken, Siri Ann Nyrnes
Summary: This study developed and validated the calculation of intraventricular pressure difference (IVPD) using blood speckle-tracking (BST) in children and investigated its potential role in assessing diastolic function. The results showed that BST is highly feasible and provides information on diastolic suction and early filling in children with heart disease. The IVPD was significantly reduced in children with dilated cardiomyopathies (DCMs) and hypertrophic cardiomyopathies (HCMs) compared to controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Physiology
Sandra Sjostrand, Alice Widerstrom, Ingrid Svensson, Patrick Segers, Tobias Erlov, Asa Ryden Ahlgren, Magnus Cinthio
Summary: Longitudinal motion of the carotid arterial wall, as measured with ultrasound, is a promising indicator of vascular health, but its underlying mechanisms are not fully understood. Blood pressure has a strong relation to the antegrade longitudinal displacement in early systole. Tapered geometry and intramural friction between two parts of a vessel wall also influence the longitudinal displacement.
PHYSIOLOGICAL REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Jordi Alastruey, Peter H. Charlton, Vasiliki Bikia, Birute Paliakaite, Bernhard Hametner, Rosa Maria Bruno, Marijn P. Mulder, Samuel Vennin, Senol Piskin, Ashraf W. Khir, Andrea Guala, Christopher C. Mayer, Jonathan Mynard, Alun D. Hughes, Patrick Segers, Berend E. Westerhof
Summary: Arterial pulse waves (PWs), such as blood pressure and photoplethysmogram (PPG) signals, are rich sources of information for assessing vascular age and identifying individuals at elevated cardiovascular risk. This review explores the possibilities and limitations of reduced-order biophysical models and theoretical and empirical methods for analyzing PW signals and extracting clinically relevant information. Detailed mathematical derivations are provided, demonstrating the relationships between these models and methods. Suggestions for future research are also outlined to fully utilize the potential of modeling and analyzing PW signals for accurate vascular age assessment.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Edward Horton, Bryce Johnson, Mahesh Vidula, Soumya Kondaveety, Srinivas Denduluri, Patrick Segers, Howard C. Herrmann, Julio A. Chirinos
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biophysics
Lise Gheysen, Lauranne Maes, Nele Famaey, Patrick Segers
Summary: This study developed a computational model to simulate the thickening process of dissected aorta wall, considering the effects of stress and inflammation on elastin and collagen. The results showed that the model with transient inflammation pattern was able to reproduce the clinically observed membrane thickening rates, diameter expansion rates, and adaptations in microstructure.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marija Smoljkic, Jos Vander Sloten, Patrick Segers, Nele Famaey
Summary: This study provides an estimation method for material parameters in the study of continuous diseases using non-invasively measured human carotid artery data. Both different material models are able to simulate the behavior of the arteries, but the structural model provides more realistic results. Gender has a greater impact on mechanical properties, and there is a stiffening trend in arteries with age, body mass index, and blood pressure, although not strong. Meanwhile, there is a high intersubject variability.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Peripheral Vascular Disease
Hasan Obeid, Vasiliki Bikia, Catherine Fortier, Mathilde Pare, Patrick Segers, Nikos Stergiopulos, Mohsen Agharazii
JOURNAL OF HYPERTENSION
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Julie de Backer, Violette de Leeuw, Mathias Van Impe, Marine Vanhomwegen, Gerlinde Logghe, Margie Oblinado, Marco Stampanoni, Patrick Segers, Laura Muino Mosquera, Lynn Sakai, Patrick Sips
CARDIOVASCULAR RESEARCH
(2022)