Article
Chemistry, Medicinal
Hung-Ju Lin, Chun-Chi Wang, Hwang-Shang Kou, Cheng-Wei Cheng, Shou-Mei Wu
Summary: A highly stable and facile method for selectively detecting deferasirox (DFX) in beta-thalassemia plasma using copper nanoclusters coated with poly(allylamine hydrochloride) (PAH) was successfully synthesized in this study. The PAH-Cu NCs showed stable fluorescence and could selectively quantify DFX through fluorescence quenching effect. The method demonstrated excellent reproducibility and was comparable to results obtained from capillary electrophoresis method when applied to clinical samples.
Article
Biochemistry & Molecular Biology
Akmal Zahra, Abdullah Ragab, Hanan Al-Abboh, Ali Ismaiel, Adekunle D. Adekile
Summary: Deferasirox (DFX), an oral iron chelator, is commonly associated with mild gastrointestinal symptoms, but can also lead to gastrointestinal bleeding and ulcers. This case report highlights the importance of being vigilant for perforated duodenal ulcer in patients on DFX therapy.
Article
Clinical Neurology
Aron T. Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B. Fitzgerald, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: This study utilized TMS-EEG to investigate the differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC), revealing increased oscillatory power in the DLPFC area in MDD subjects before treatment, and decreased power after convulsive therapy. These findings suggest that convulsive therapy may modulate neural oscillatory activity in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Tubagus Djumhana Atmakusuma, Intan Russiana Nasution, Noorwati Sutandyo
Summary: Iron overload is a major problem in thalassemia patients, but there was no significant change in MDA levels before and after transfusion. The study did not find a correlation between markers of iron overload and MDA levels in thalassemia patients both before and after transfusion.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Isita Tripathy, Amrita Panja, Tuphan Kanti Dolai, Asim Kumar Mallick
Summary: Deferasirox is more effective in reducing chelating drug-related complications and iron overload compared to Deferiprone. The study results indicate that in beta-thalassemia patients, Deferasirox can significantly decrease serum ferritin levels.
Article
Pediatrics
Nandini Dixit, Chandan Kumar Shaw, Garima Agrawal Varshney, Ravindra Kumar, Purti Agrawal Saini, Pramila Verma
Summary: The study revealed that short stature, delayed puberty, hypothyroidism, and diabetes mellitus are common endocrinopathies in multiply transfused patients with beta thalassemia major. Serum ferritin levels showed a significant positive correlation with these abnormalities. Regular evaluation of endocrinopathies is essential in these patients, emphasizing the importance of chelation therapy to both parents and patients.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Shengfang Song, Zhehui Luo, Chenxi Li, Xuemei Huang, Eric J. Shiroma, Eleanor M. Simonsick, Honglei Chen
Summary: This study longitudinally assessed depressive symptoms in older adults with Parkinson's disease (PD) and found that depressive symptoms start to increase a few years prior to PD diagnosis and become significantly different from expected levels one year before diagnosis.
Article
Urology & Nephrology
Osama Tanous, Yossi Azulay, Raphael Halevy, Tal Dujovny, Neta Swartz, Raul Colodner, Ariel Koren, Carina Levin
Summary: A high prevalence of renal tubular damage was observed in TDT patients, particularly those treated with DFX; uNAG was negatively associated with mean 10-year serum ferritin, suggesting ICT's involvement in tubular injury. A significant decline in eGFR compared to a decade earlier was observed only in patients currently treated with DFX. Strict follow-up of renal function in TDT patients is warranted.
Article
Oncology
Jiawen Yu, Lu Che, Afang Zhu, Li Xu, Yuguang Huang
Summary: Goal-directed intraoperative fluid therapy is associated with fewer postoperative complications in patients undergoing major gynecologic oncology surgery.
FRONTIERS IN ONCOLOGY
(2022)
Article
Integrative & Complementary Medicine
Sayeh Mottaghi, Hassan Abbaszadeh
Summary: This study aimed to investigate the iron-chelating, antioxidant, anti-inflammatory, and hepatoprotective activities of grape seed extract (GSE) supplement in beta-thalassemia major (beta-TM) pediatric patients, as well as its safety.
COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
(2023)
Article
Hematology
Tobias Geisler, Sven Poli, Kurt Huber, Dominik Rath, Parwez Aidery, Steen D. Kristensen, Robert F. Storey, Alex Ball, Jean-Philippe Collet, Jurrien ten Berg
Summary: This article discusses major bleeding as a common complication in patients undergoing antiplatelet therapy and the challenges in resuming the therapy. Understanding the patient's bleeding risk and weighing it against the thrombotic risk is crucial in preventing adverse events. The article focuses on the most life-threatening bleeding events, such as intracranial hemorrhage and gastrointestinal bleeding, and discusses the evidence for resumption of antiplatelet therapy based on individual risk assessment in high-risk cardiovascular disease patients.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
Sunil K. Nadar, Shahina Daar, Wael A. Abdelmottaleb, Muhammad M. Shaikh, Hafsa Al Mahrouqi, Majida Al-Raiisi, Moez Hassan, Badar Al Rawahi, Sarah Al Rahbi
Summary: The study aimed to assess the correlation between echocardiographic parameters and myocardial iron concentration in patients with Thalassemia major. The findings suggest that diastolic dysfunction may persist even with normal MRI T2* levels, emphasizing the importance of continuous follow-up for monitoring cardiac function in these patients.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Peter Schullian, Edward Johnston, Gregor Laimer, Daniel Putzer, Gernot Eberle, Arno Amann, Maria Effenberger, Manuel Maglione, Martin C. Freund, Alexander Loizides, Reto Bale
Summary: The study assessed the frequency of major complications after multi-probe stereotactic radiofrequency ablation (SRFA) in a large cohort of patients over 15 years and identified risk factors for adverse events. The 30-day mortality after SRFA was 0.5% with an overall major complication rate of 7.4%. History of bile duct surgery/intervention, number of coaxial needles, and tumor location in certain segments were independent prognostic factors for major complications. Experience and adaptations over time contributed to a significant decrease in complications.
EUROPEAN RADIOLOGY
(2021)
Article
Surgery
Anne-Marleen Van Keulen, Stefan Buettner, Marc G. Besselink, Olivier R. Busch, Thomas M. van Gulik, Jan N. M. IJzermans, Jeroen de Jonge, Wojciech G. Polak, Rutger-Jan Swijnenburg, Joris Erdmann, Bas Groot Koerkamp, Pim B. Olthof
Summary: This study investigated the incidence and risk factors of primary and secondary liver failure after major liver resection for perihilar cholangiocarcinoma. The results showed that liver failure occurred in 20.9% of patients, with primary liver failure at 9.1% and secondary liver failure at 11.9%. Risk factors included abdominal sepsis, portal vein thrombosis, preoperative cholangitis, etc. By subdividing into primary and secondary liver failure, differences in outcomes between centers can be better understood and liver failure can potentially be reduced.
Article
Oncology
Heloise Smet, David Martin, Emilie Uldry, Rafael Duran, Raphael Girardet, Niklaus Schaefer, John O. Prior, Alban Denys, Nermin Halkic, Nicolas Demartines, Emmanuel Melloul
Summary: This study aimed to compare future liver remnant function (FLR-F) assessed by hepatobiliary scintigraphy (HBS) with FLR volume (FLR-V) in predicting posthepatectomy liver failure (PHLF). The study found that FLR function gain after portal vein embolization or liver venous deprivation could predict PHLF effectively.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Mohamed A. Yassin, Ashraf T. Soliman, Abdulqadir J. Nashwan, Ans A. Alamami, Mohammad A. J. Abdulla, Saloua M. Hmissi, Mahmood B. Aldapt, Prem Chandra, Aasir M. Suliman, Ezzeddin A. Ibrahim, Khadra S. Yassin, Niloofar Allahverdi, Shehab F. Mohamed
Summary: Hematologic reference intervals vary with gender, age, ethnicity, and geographic area. This study aims at establishing a hematology reference guide for Arabs in Qatar. The findings show significant differences in hematological parameters between Arab males and females, as well as between different Arab populations in Qatar.
Letter
Hematology
Waail Rozi, Alaa Rahhal, Elrazi A. Ali, Abdulrahman Al-Mashdali, Yousef Hilan, Ibrahim Khamees, Liam J. Fernyhough, Mohamed A. Yassin
Article
Medicine, General & Internal
Elrazi Ali, Ahmed Hatim, Mohamed Yassin
Summary: COVID-19 is a respiratory viral illness caused by SARS-Cov-2, with non-specific symptoms and respiratory involvement. Sickle cell disease patients infected with SARS-CoV-2 have a higher risk of hospitalization and complications. Limited data suggest severe acute painful crisis in sickle cell disease patients after infection with the Omicron variant.
CLINICAL CASE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Giulia Lombardi, Roberta Valeria Latorre, Alessandro Mosca, Diego Calvanese, Luisa Tomasello, Christian Boni, Manuela Ferracin, Massimo Negrini, Nader Al Dewik, Mohamed Yassin, Mohamed A. Ismail, Bruno Carpentieri, Claudio Sorio, Paola Lecca
Summary: This study analyzed the modulation of the K562 transcriptome in the context of Chronic Myeloid Leukemia (CML) using the tumor suppressor gene PTPRG and the tyrosine kinase inhibitor Imatinib. The analysis identified genes whose expression levels were altered by PTPRG and Imatinib, providing insights into the transcriptomic landscape of CML. Two different methods were used in the analysis, with one focusing on gene set enrichment analysis and the identification of transcription factors, and the other focusing on selecting transcription factors from differentially expressed genes. The study revealed the potential upregulation of RARG and CD36 genes by PTPRG, suggesting a role in cell differentiation. The findings provide new insights into the molecular mechanisms of tumor suppression in the context of CML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Hematology
Narcisse Elenga, Gylna Loko, Maryse Etienne-Julan, Randa Al-Okka, Ahmad M. M. Adel, Mohamed A. A. Yassin
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Review
Urology & Nephrology
Abdulqadir J. Nashwan, Mohamed A. Yassin, Alaa Abd-Alrazaq, Farag Shuweihdi, Muftah Othman, Hanan F. Abdul Rahim, Mujahed Shraim
Summary: This review examines the prevalence of hepatic and cardiac iron overload in patients with end-stage renal disease (ESRD). The findings suggest a high prevalence of severe hepatic iron overload in ESRD patients undergoing hemodialysis. Further research is needed to determine the impact of iron overload on vital organs and guide future studies in this field.
HEMODIALYSIS INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Abdulrahman F. Al-Mashdali, Mahmood B. Aldapt, Alaa Rahhal, Yousef M. Hailan, Israa Elhakeem, Elrazi A. Ali, Waail Rozi, Mohamed A. Yassin
Summary: Philadelphia-negative myeloproliferative neoplasms (MPNs) are rarely diagnosed in pediatrics, leading to limited knowledge about their clinical presentation, mutational status, and complications. This study reviewed the literature and found that pediatric MPNs have different clinical characteristics, vascular and long-term complications, types of driver mutations, and treatment approaches compared to adults.
Article
Medicine, General & Internal
Nusiba H. H. Elamin, Farah Rashid, Muhammad S. S. Afana, Honar Cherif, Mohamed A. A. Yassin
Summary: A 48-year-old male with acute promyelocytic leukemia (APL) responded well to all-trans-retinoic acid and arsenic trioxide therapy but developed differentiation syndrome, which improved with steroids. Therefore, close monitoring for differentiation syndrome and prompt steroid therapy is essential for APL patients receiving chemotherapy.
CLINICAL CASE REPORTS
(2023)
Review
Medicine, General & Internal
Amal Al-Haidose, Mohamed A. Yassin, Muna N. Ahmed, Hasna H. Kunhipurayil, Asrar A. Al-Harbi, Musheer A. Aljaberi, Saddam A. Abbasi, Shahram Kordasti, Atiyeh M. Abdallah
Summary: The aim of this study was to assess the clinical, laboratory, and pathologic characteristics of myelodysplastic syndrome (MDS) and identify distinct clinical features in the Middle East and North Africa (MENA) region. The findings revealed that MDS is more prevalent and more severe in the MENA region compared to Western populations. Patients from the Asian MENA population had a worse prognosis compared to the North African MENA population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Basel Elsayed, Amgad M. Elshoeibi, Mohamed Elhadary, Khaled Ferih, Ahmed Adel Elsabagh, Alaa Rahhal, Mohammad Abu-Tineh, Mohammad S. Afana, Mohammed Abdulgayoom, Mohamed Yassin
Summary: Philadelphia-negative myeloproliferative neoplasms (MPNs) are difficult to diagnose due to their similar clinical and laboratory features. Accurate classification and prognostication are crucial for optimal management. Artificial intelligence and machine learning offer potential tools for improving diagnosis, prognosis, and therapy planning in patients with Philadelphia-negative MPNs.
Review
Medicine, General & Internal
Amgad M. Elshoeibi, Khaled Ferih, Ahmed Adel Elsabagh, Basel Elsayed, Mohamed Elhadary, Mahmoud Marashi, Yasser Wali, Mona Al-Rasheed, Murtadha Al-Khabori, Hani Osman, Mohamed Yassin
Summary: Thrombocytopenia is a medical condition characterized by a very low blood platelet count, which can be caused by various factors including medication, sepsis, viral infections, and autoimmunity. Early detection and evaluation of thrombocytopenia are crucial for prompt and appropriate intervention. Artificial intelligence has shown great potential in the early diagnosis, prognosis assessment, and prediction of thrombocytopenia distribution by simultaneously considering multiple variables.
Review
Medicine, General & Internal
Mohamed Elhadary, Ahmed Adel Elsabagh, Khaled Ferih, Basel Elsayed, Amgad M. Elshoeibi, Rasha Kaddoura, Susanna Akiki, Khalid Ahmed, Mohamed Yassin
Summary: Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm caused by the BCR-ABL1 fusion gene, characterized by dysregulated growth and proliferation of myeloid cells in the bone marrow. Diagnosis of CML requires confirmation of the BCR-ABL1 gene in addition to traditional examination methods. Treatment for CML involves the use of tyrosine kinase inhibitors (TKIs) tailored to individual patients, considering disease stage and comorbidities. Recent studies utilizing machine learning (ML) algorithms have shown potential in diagnosing, assessing risk, and treating CML patients.
Review
Biochemistry & Molecular Biology
Luai Abu-Ismail, Mohammad J. J. Taha, Mohammad T. Abuawwad, Yaqeen Al-Bustanji, Khayry Al-Shami, Abdulqadir Nashwan, Mohamed Yassin
Summary: On 11 March 2020, the World Health Organization declared COVID-19 as a global pandemic caused by the novel SARS-CoV-2 virus. There is a suspected link between anemia and severe COVID-19 cases, and researchers are investigating the long-term complications of COVID-19 in anemic patients. Anemia increases the risk of severe COVID-19 infections due to various pathophysiological mechanisms, including decreased hemoglobin levels and exacerbation of hypoxia caused by COVID-19-induced acute respiratory distress syndrome (ARDS).
Article
Endocrinology & Metabolism
Yasamin Abdu, Sarah Naja, Mohamed Izham Mohamed Ibrahim, Mariam Abdou, Romaisa Ahmed, Salma Elhag, Ahmed Saleh, Mohamed Yassin, Iheb Bougmiza
Summary: This study aimed to investigate the sleep quality and its determinants among patients with type 2 diabetes during the COVID-19 pandemic. The results showed that approximately one-third of the patients had poor sleep quality, and high depressive symptoms and history of sleep disorders were significant predictors of poor sleep quality.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Hematology
Mouhammad J. Alawad, Mohammad Abu-Tineh, Awni Alshurafa, Alaa Al-Taie, Anil Yousaf, Mohamed A. Yassin
Summary: Glanzmann thrombasthenia is a rare bleeding disorder characterized by superficial bleeding and infrequent deep organ involvement. This article presents a case of a 17-year-old boy with Glanzmann thrombasthenia who developed ankle pain after a minor trauma. After multiple assessments and treatments, chronic arthropathy was diagnosed.
JOURNAL OF BLOOD MEDICINE
(2023)