Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study proposed a novel way to classify and report surgical outcomes, integrating efficacy and safety at the patient level. By presenting results in four outcome groups ranging from good to poor, the study highlights the importance of balancing efficacy and complications in surgical interventions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Friso de Vries, Daniel J. Lobatto, Marco J. T. Verstegen, Pieter J. Schutte, Irene C. Notting, Mark C. Kruit, S. Faisal Ahmed, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: Transsphenoidal surgery is the standard treatment for hormone-secreting pituitary adenomas. This study proposes a novel way to classify and report surgical outcomes by integrating efficacy and safety at the patient level. The results show that surgical interventions can be presented in four categories, incorporating both efficacy and safety.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Yoon-Hee Choo, Youngbeom Seo, Oh-Lyong Kim
Summary: This study retrospectively analyzed the outcomes of the transsphenoidal approach for nonfunctioning pituitary adenomas treated at a single institute. The study found that the transsphenoidal approach is an effective and safe treatment, improving visual impairment and restoring endocrine function. Diabetes insipidus was the most common complication, and complete resection during surgery helped to lower the risk of recurrence.
ANNALS OF MEDICINE
(2022)
Article
Clinical Neurology
Lea M. Alhilali, Andrew S. Little, Kevin C. J. Yuen, Jae Lee, Timothy K. Ho, Saeed Fakhran, William L. White
Summary: In this study of 102 patients undergoing microscopic transsphenoidal resection of a pituitary adenoma, early postoperative MRI showed high sensitivity and specificity for detecting residual tumors, with better reliability than late postoperative MRI. Early MRI identified 4 residual tumors that were missed by intraoperative assessment and late MRI, providing important guidance for reoperation in select patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Alies J. Dekkers, Friso de Vries, Amir H. Zamanipoor Najafabadi, Emmy M. van der Hoeven, Marco J. T. Verstegen, Alberto M. Pereira, Wouter R. van Furth, Nienke R. Biermasz
Summary: This study retrospectively assessed the healthcare costs and cost drivers in perioperative care for pituitary tumour patients. The results showed that length of hospital stay and complications were the main drivers of costs, and certain baseline features were also associated with higher costs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Chao Tao, Gang Cheng, Yunxiang Chen, Peiyuan Gu, Weixing Hu
Summary: This study retrospectively reviewed the tumor characteristics and surgical outcomes of a consecutive series of endoscopic endonasal approach pituitary adenomas resection mainly performed by a single author between March 2018 and June 2019. The results demonstrated that EEA is an effective and safe approach for resecting pituitary adenomas with satisfactory gross total resection rate, near-total resection rate, and endocrinological remission rate, while maintaining minimal nasal injury.
Article
Clinical Neurology
Christina E. Sarris, Scott T. Brigeman, Estelle Doris, Maggie Bobrowitz, Thomas Rowe, Eva M. Duran, Griffin D. Santarelli, Ryan M. Rehl, Garineh Ovanessoff, Monica C. Rodriguez, Kajalben Buddhdev, Kevin C. J. Yuen, Andrew S. Little
Summary: After implementing a comprehensive quality improvement program for pituitary surgery patients, there were significant improvements in patient outcomes, decreased outcome variability, and enhanced hospital financial performance. Future studies may provide further insight into disease remission, patient satisfaction, and how the surgeon learning curve impacts quality efforts.
JOURNAL OF NEUROSURGERY
(2021)
Article
Endocrinology & Metabolism
Nasrin Al-Shamkhi, Katarina Berinder, Henrik Borg, Pia Burman, Per Dahlqvist, Charlotte Hoybye, Daniel S. Olsson, Oskar Ragnarsson, Bertil Ekman, Britt Eden Engstrom
Summary: Objective data on pituitary function before and after transsphenoidal surgery in nonfunctioning pituitary adenomas were inconsistent. This study found that adrenocorticotrophic hormone deficiency increased significantly at 1 year postoperatively, while other axis function changes were not significant. Therefore, continuous individual evaluations are needed during longer follow-up of patients operated for NFPA.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Juan Chen, Xiang Guo, Zhuangzhuang Miao, Zhuo Zhang, Shengwen Liu, Xueyan Wan, Kai Shu, Yan Yang, Ting Lei
Summary: This study retrospectively analyzed the effectiveness and risks of extra-pseudocapsular transsphenoidal surgery (EPTSS) for young women with microprolactinoma. The results showed that EPTSS increased the surgical remission rate without increasing the risk of complications. For patients with microprolactinoma located in the hypo-pituitary region and with Knosp grade 0-II, first-line EPTSS may offer a greater chance of long-term cure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Vicki M. Butenschoen, Alexander von Werder, Stefanie Bette, Veronika Schmette, Nina Schwendinger, Bernhard Meyer, Jens Gempt
Summary: Transsphenoidal surgery is a minimally invasive treatment for pituitary adenoma, and a study found that cortisol measurements taken 6 weeks after surgery are more reliable in predicting corticotroph function compared to measurements taken 5 days postoperatively.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Ryan Delport, James King, Mendel Castle-Kirszbaum, Tony Goldschlager, Carmela Caputo, Yi Yuen Wang
Summary: This study aimed to determine if resection of pituitary adenomas via the endoscopic endo-nasal approach (EEA) improves headaches and investigate factors that may be associated with headaches in patients with pituitary adenoma. The results showed that surgery using this method can significantly improve headaches and patients with cavernous sinus invasion are more likely to experience improvement in headaches.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Hyung-Chul Lee, Hyun-Kyu Yoon, Jung Hee Kim, Yong Hwy Kim, Hee-Pyoung Park
Summary: The study suggests that preoperative steroid administration may not be necessary for patients without adrenal insufficiency undergoing endoscopic transsphenoidal surgery for nonfunctioning pituitary adenomas, as it does not affect the pituitary hormone levels postoperatively. However, further large-scale studies are needed to determine the impact of preoperative steroid administration on clinically meaningful events such as perioperative AI and postoperative 3-month ACTH deficiency in these patients.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Taemin Oh, Rushikesh S. Joshi, Alexander F. Haddad, Kaitlyn M. Pereira, Kevin C. Donohue, Zain Peeran, William Carson, Aarav Badani, Elaina J. Wang, Sweta Sudhir, Ankush Chandra, Saket Jain, Angad Beniwal, Jose Gurrola II, Ivan H. El-Sayed, Lewis S. Blevins Jr, Philip V. Theodosopoulos, Sandeep Kunwar, Manish K. Aghi
Summary: This study assessed the correlation between tumor volume and prolactin level in prolactinoma and its impact on surgical outcomes. The results showed a strong association between tumor volume and prolactin levels, with an increase in tumor volume leading to a significant increase in prolactin levels in patients without biochemical remission after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Iyan Younus, Mina Gerges, Theodore H. Schwartz, Rohan Ramakrishna
Summary: Patients with Medicaid insurance undergoing endonasal endoscopic transsphenoidal surgery for pituitary adenoma tend to have larger tumor diameter, longer postoperative length of stay, higher rate of complications, and increased likelihood of long-term cranial neuropathy. However, there were no statistically significant differences in baseline comorbidities, apoplexy, endocrine outcome, vision outcome, or 30-day readmission.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Rupa G. Juthani, Anne S. Reiner, Ankur R. Patel, Aimee Cowan, Marie Roguski, Katherine S. Panageas, Eliza B. Geer, Sasan Karimi, Marc A. Cohen, Viviane Tabar
Summary: The study evaluated the safety and efficacy of iMRI for pituitary adenoma resection, comparing endoscopic transsphenoidal and microscopic transsphenoidal approaches. Results showed that iMRI can improve the extent of resection for pituitary adenomas while preserving hormone function, with low rates of postoperative complications.
JOURNAL OF NEUROSURGERY
(2021)
Article
Oncology
Moonsik Kim, Jihwan Yoo, Jong Hee Chang, Se Hoon Kim
Summary: This study suggests a possible association between MGMT methylation status and ATRX mutations in GBM with wild-type IDH, and indicates a correlation between MGMT methylation and patients' survival.
ANTICANCER RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Jihwan Eom, Dain Kim, Sung Soo Ahn, Eui Hyun Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study developed a fully automatic radiomics model to differentiate adult pilocytic astrocytomas from high-grade gliomas. The model showed superior performance compared to both clinical and radiomics models, and outperformed human judgement. The model explanation suggested that intratumoural heterogeneity from T2-weighted images was highly associated with the diagnosis of pilocytic astrocytomas.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yae Won Park, Ki Sung Park, Ji Eun Park, Sung Soo Ahn, Inho Park, Ho Sung Kim, Jong Hee Chang, Seung-Koo Lee, Se Hoon Kim
Summary: Qualitative and quantitative MRI parameters, including infiltrative pattern, maximal diameter, and the 95th percentile of normalized cerebral blood volume (nCBV), were found to be independent predictors of CDKN2A/B homozygous deletion in IDH-mutant astrocytomas. The presence of an infiltrative pattern, larger maximal diameter, and higher 95th percentile of the nCBV may serve as useful MRI biomarkers for identifying CDKN2A/B homozygous deletion in these tumors.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
In Ki Baek, Hyun Sub Cheong, Seok Namgoong, Jeong-Hyun Kim, Seok-Gu Kang, Seon-Jin Yoon, Se Hoon Kim, Jong Hee Chang, Lyoung Hyo Kim, Hyoung Doo Shin
Summary: This study provides evidence that functional variants of EGFR are associated with an increased risk of glioma in the Korean population, highlighting the importance of further investigating the functional association between EGFR variants and glioma.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Eun-Jun Kim, Jung Yun Kim, Sung-Ok Kim, Nayoung Hong, Sang-Hun Choi, Min Gi Park, Junseok Jang, Seok Won Ham, Sunyoung Seo, Seon Yong Lee, Kanghun Lee, Hyeon Ju Jeong, Sung Jin Kim, Sohee Jeong, Kyungim Min, Sung-Chan Kim, Xiong Jin, Se Hoon Kim, Sung-Hak Kim, Hyunggee Kim
Summary: JAG1 intracellular domain (JICD1) induces cancer stem cell properties and tumorigenicity by forming a transcriptional complex with DDX17, SMAD3, and TGIF2 to increase SOX2 expression.
Article
Oncology
Yae Won Park, Kyunghwa Han, Sooyon Kim, Hyuk Kwon, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Jinna Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study investigated prognostic factors in adult glioma patients with leptomeningeal metastases. It found that chemotherapy and antiangiogenic therapy were associated with longer overall survival, while male sex and initial leptomeningeal metastases were associated with shorter survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Daham Kim, Soohyun Lee, Yoon Hee Cho, Min Jeong Kang, Cheol Ryong Ku, Hyunjin Chi, Jungsuk Ahn, Kyungsun Lee, Jaekyu Han, Susan Chi, Moo Young Song, Sang-Hoon Cha, Eun Jig Lee
Summary: A new technology was developed to create a long-acting form of follicle-stimulating hormone (FSH) for the treatment of hypogonadotropic hypogonadism. The study showed that this technology increased the biological activity of FSH and improved sperm production. These findings represent a significant advancement in the treatment of patients with hypogonadotropic hypogonadism.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: A radiomics model based on dynamic contrast-enhanced (DCE) MRI was developed and validated to predict epidermal growth factor receptor (EGFR) amplification in patients with glioblastoma, isocitrate dehydrogenase (IDH) wildtype.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Kyungwon Kim, Dong Kyu Kim, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Cheol Ryong Ku, Eun Jig Lee
Summary: This study evaluated whether dexamethasone (DEX) suppression can improve the localization of adrenocorticotropic hormone-secreting adenomas in the pituitary gland in Cushing's disease (CD) using fluorine-fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET). The results showed that DEX suppression did not improve PET localization in patients with CD.
Article
Oncology
Gi Jeong Kim, Tonghyun Lee, Sangjeong Ahn, Youngjung Uh, Se Hoon Kim
Summary: This study introduces the development of 1p/19qNET, a deep-learning network that accurately identifies molecular alterations in gliomas and classifies IDH-mutant gliomas. The results demonstrate that 1p/19qNET outperforms traditional FISH in predicting 1p and 19q fold change values and classifying IDH-mutant gliomas.
NPJ PRECISION ONCOLOGY
(2023)
Article
Oncology
Kyeongmin Kim, Se Hoon Kim, Jung-Yun Lee, Yoo-Na Kim, Seung-Tae Lee, Eunhyang Park
Summary: The expression of RAD51 is closely associated with prognosis in patients with ovarian high-grade serous carcinoma (HGSC), and the changes in RAD51 expression status before and after chemotherapy have a greater impact on prognosis. Therefore, RAD51 expression status can serve as a predictive marker for the treatment of ovarian HGSC, and sequential monitoring of RAD51 status before and after treatment can reflect the biological behavior of the tumor.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Chae Hun Lee, Byeong Joo Choi, Jung Hun Kim, Tae Woong Yang, Gi Jeong Kim, Ha Young Shin, Se Hoon Kim, Seung Woo Kim
Summary: Intravesical bacillus Calmette-Guerin (BCG) instillation is an adjuvant treatment for non-muscle-invasive urinary bladder cancer. While most complications are mild and self-limiting, rare but serious complications have been reported. This study presents a case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation, with a diagnosis of drug-induced myopathy confirmed through muscle biopsy.
JOURNAL OF YEUNGNAM MEDICAL SCIENCE
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: The study developed and validated a radiomics model based on dynamic contrast-enhanced (DCE) MRI to predict EGFR amplification in glioblastoma patients. The radiomics model using the K-trans map showed higher accuracy than conventional MRI in predicting EGFR amplification.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Eui Hyun Kim, Soo Jeong Park, Minkyun Na, Ju Hyung Moon, Sun Ho Kim
Summary: The study introduced an arachnoid remodeling by clipping technique to enhance visualization and surgical accessibility in pituitary adenoma surgery. Evaluation of anterior pituitary function showed no deterioration, suggesting the technique is safe.
JOURNAL OF KOREAN NEUROSURGICAL SOCIETY
(2022)