Review
Chemistry, Multidisciplinary
Qi Zeng, Zhaoling Huang
Summary: Implantable neural interfaces with high spatial/time resolution are desired to accurately record bioelectrical signals from neurons and regulate neural activities. However, miniaturization and integration of neural electrodes limit their electrochemical performance and uneven electric field distribution causes crosstalk, reducing stimulation/recording efficiency. Mismatch between stiff electrodes and soft tissues exacerbates inflammatory responses, weakening signal transmission. Further development is needed for chronic stability and long-term activity of neural electrodes.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Fajuan Tian, Jiawen Yu, Wen Wang, Dianbo Zhao, Jie Cao, Qi Zhao, Fucheng Wang, Hanjun Yang, Zhixin Wu, Jingkun Xu, Baoyang Lu
Summary: By using a simple two-step electropolymerization method, we have developed an adhesive and long-term stable conducting polymer neural interface that shows excellent adhesion to metallic electrodes. This interface can potentially serve as a powerful tool for advanced neuroscience research and cutting-edge clinical applications like brain-controlled intelligence.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Multidisciplinary Sciences
Damiano G. Barone, Alejandro Carnicer-Lombarte, Panagiotis Tourlomousis, Russell S. Hamilton, Malwina Prater, Alexandra L. Rutz, Ivan B. Dimov, George G. Malliaras, Stephanie P. Lacour, Avril A. B. Robertson, Kristian Franze, James W. Fawcett, Clare E. Bryant
Summary: Fibrotic scarring caused by foreign body reaction (FBR) obstructs the functional interaction of implantable medical devices with host tissue. In a peripheral nerve injury-implant model, FBR shows dysregulated innate immune features and increased myofibroblast activity and inflammasome constituents. The use of NLRP3 inflammasome inhibitor MCC950 can reduce fibrosis and inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Sebastian Roubert Martinez, Paul Le Floch, Jia Liu, Robert D. D. Howe
Summary: Cutaneous electrodes are commonly used for noninvasive sensing of bioelectronic signals from the brain, heart, and neuromuscular system. However, the high impedance at the tissue-to-electrode contact interface leads to a low signal-to-noise ratio. This paper introduces soft conductive polymer hydrogels made of poly(3,4-ethylenedioxy-thiophene) doped with poly(styrene sulfonate) that significantly decrease the skin-electrode contact impedance compared to clinical electrodes. Integrating these hydrogels into adhesive wearable sensors improves the fidelity of bioelectronic signals and enables applications in neural interfaces.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Multidisciplinary
Yiqun Liu, Qi Yu, Li Yang, Yue Cui
Summary: This article discusses the challenges in selecting suitable materials for implantable electronic devices and provides answers to related questions. By exploring various materials and their applications, new opportunities are provided for the construction of future implantable electronic devices and disease diagnosis and therapy.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Rowoon Park, Dong Hyeon Lee, Chin Su Koh, Young Woo Kwon, Seon Yeong Chae, Chang-Seok Kim, Hyun Ho Jung, Joonsoo Jeong, Suck Won Hong
Summary: This work introduces a facile strategy for the development of flexible and stretchable electrodes using laser processing techniques on liquid crystal polymer films. It demonstrates control over laser irradiation parameters to achieve efficient pattern generation and transfer printing of highly conductive laser-induced graphene bioelectrodes. Kirigami-inspired on-skin bioelectrodes and brain-interfaced LIG microelectrode arrays are proposed, combining mechanically compliant architectures with LCP encapsulation for stimulation and recording purposes. This approach offers a cost-effective and scalable route for producing patterned arrays of laser-converted graphene as bioelectrodes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Chan Wang, Qiongfeng Shi, Chengkuo Lee
Summary: This review provides an overview of the development of IMDs based on triboelectric nanogenerators, including self-powered biosensors, in vivo energy harvesting devices, and direct electrical stimulation therapy devices. Future challenges and opportunities are discussed to enhance output performance, develop advanced triboelectric nanogenerators with multifunctional materials, and self-driven close-looped diagnosis and treatment systems.
Review
Engineering, Biomedical
Pei Liu, Guomin Wang, Qingdong Ruan, Kaiwei Tang, Paul K. Chu
Summary: Cell signaling is important in disease monitoring and usually occurs at interfaces between organisms/cells or between organisms/cells and abiotic materials. Plasma containing energetic species has been used to construct interfaces for various biomedical demands. This review summarizes state-of-art plasma-activated interfaces and aims to guide researchers in selecting the proper plasma and conditions for designing optimal biological interfaces.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Analytical
Pawel Jurgielewicz, Tomasz Fiutowski, Ewa Kublik, Andrzej Skoczen, Malgorzata Szypulska, Piotr Wiacek, Pawel Hottowy, Bartosz Mindur
Summary: This paper introduces a modular Data Acquisition (DAQ) system for simultaneous electrical stimulation and recording of brain activity, with a focus on efficient software design and hardware performance. Results show that the Neurostim-3 system exhibits linear signal gain and is suitable for recording both Local Field Potential (LFP) and spiking brain activity signals. The hardware and software were proven to work efficiently and effectively in tandem, providing valuable insights into how the brain processes information.
Article
Engineering, Electrical & Electronic
Riccardo Raho, Elisa Scarpa, Antonio Nunzio D'Angelo, Denis Desmaele, Federica Raheli, Antonio Qualtieri, Francesco Rizzi, Massimo De Vittorio
Summary: This paper reports on the fabrication and characterization of a novel reusable Flexible Dry Electrode (FDE) for medical applications. The FDEs were made using two flexible substrates and conductive layers, and their performance was tested and compared to commercial gel electrodes. The results showed that the FDEs had comparable performance in bioelectrical impedance analysis (BIA) measurements and demonstrated promising long-term reliability for wearable and portable devices.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Multidisciplinary Sciences
Mengmeng Yao, Zhijian Wei, Junjin Li, Zhicheng Guo, Zhuojun Yan, Xia Sun, Qingyu Yu, Xiaojun Wu, Chaojie Yu, Fanglian Yao, Shiqing Feng, Hong Zhang, Junjie Li
Summary: The authors report a microgel reinforced zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties. The hydrogel coating shows favorable stability and prevents thrombus formation, making it a potential coating material for biomedical devices.
NATURE COMMUNICATIONS
(2022)
Review
Materials Science, Multidisciplinary
Yuhao Zhou, Bowen Ji, Minghao Wang, Kai Zhang, Shuaiqi Huangfu, Huicheng Feng, Honglong Chang, Xichen Yuan
Summary: Significant progress has been made in high resolution, biocompatibility, durability, and stretchability of implantable brain-computer interface (BCI) devices in recent decades. Thin film devices are rapidly developing and attracting considerable attention due to the inevitable damage of brain tissue caused by traditional rigid devices. This review categorizes flexible thin film devices, discusses fabrication approaches, highlights key issues such as high resolution and special substrates, and provides a discussion on remaining obstacles and future research directions.
Article
Materials Science, Biomaterials
Arturo Vera, Isidoro Martinez, Luiz Guilherme Enger, Bruno Guillet, Ruben Guerrero, Jose Manuel Diez, Olivier Rousseau, Marc Lam Chok Sing, Victor Pierron, Paolo Perna, Jaime J. Hernandez, Isabel Rodriguez, Ivo Calaresu, Anja Meier, Carmen Huck, Ana Dominguez-Bajo, Ankor Gonzalez-Mayorga, Elisa Lopez-Dolado, Maria C. Serrano, Laura Ballerini, Lucas Perez, Rodolfo Miranda, Stephane Flament, Maria Teresa Gonzalez, Laurence Mechin, Julio Camarero
Summary: We have developed an implantable neural interface based on anisotropic magnetoresistive (AMR) magnetic-field sensors, which have reduced size and high performance at body temperature. The sensors use La0.67Sr0.33MnO3 (LSMO) as a ferromagnetic material, engineered to have uniaxial anisotropy and large AMR output with low noise even at low frequencies. The LSMO sensors have been optimized to detect low magnetic signals from neural activity with a sensitivity of approximately 400%/T, making them suitable for implantable detectors.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
Ieva Vebraite, Moshe David-Pur, David Rand, Eric Daniel Glowacki, Yael Hanein
Summary: This study introduced a novel fabrication process for soft electrode arrays to record and stimulate neural activity in intact retinas. The development of high capacitance electrodes on a soft substrate was demonstrated, along with ex vivo electrical recording of retina activity using carbon electrodes. Additionally, simultaneous photo-electrical stimulation and electrical recording was achieved with the addition of organic photo-capacitors. Results showed successful electrical activity recordings from intact chick retinas, enabling analysis of photosensitive retinal ganglion cell responses and spontaneous retina waves.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Engineering, Electrical & Electronic
Muath Al-Hasan, Penchala Reddy Sura, Amjad Iqbal, Jun Jiat Tiang, Ismail Ben Mabrouk, Mourad Nedil
Summary: This paper proposes a miniaturized dual-band implantable antenna operating at 0.91 GHz and 2.45 GHz, with performances analyzed in different parts of the human body and low SAR. The compact antenna achieves maximum input power of 3.32 mW at 0.91 GHz and 4.37 mW at 2.45 GHz, making it the most compact dual-band implantable antenna reported in the literature for these frequency bands.
AEU-INTERNATIONAL JOURNAL OF ELECTRONICS AND COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Lina Gallentoft, Lina M. E. Pettersson, Nils Danielsen, Jens Schouenborg, Christelle N. Prinz, Cecilia Eriksson Linsmeier
Article
Multidisciplinary Sciences
Per Kohler, Anette Wolff, Fredrik Ejserholm, Lars Wallman, Jens Schouenborg, Cecilia E. Linsmeier
Article
Anesthesiology
B. Ljungquist, T. Jensen, L. Etemadi, J. Thelin, G. Lind, M. Garwicz, P. Petersson, F. Tsanakalis, J. Schouenborg
EUROPEAN JOURNAL OF PAIN
(2016)
Article
Pharmacology & Pharmacy
Alexander Dontsios Holmkvist, Annika Friberg, Ulf J. Nilsson, Jens Schouenborg
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2016)
Article
Multidisciplinary Sciences
Leila Etemadi, Mohsin Mohammed, Palmi Thor Thorbergsson, Joakim Ekstrand, Annika Friberg, Marcus Granmo, Lina M. E. Pettersson, Jens Schouenborg
Article
Biotechnology & Applied Microbiology
Lina Gallentoft, Lina M. E. Pettersson, Nils Danielsen, Jens Schouenborg, Christelle N. Prinz, Cecilia Eriksson Linsmeier
JOURNAL OF NANOBIOTECHNOLOGY
(2016)
Article
Engineering, Biomedical
Heui Chang Lee, Fredrik Ejserholm, Janak Gaire, Seth Currlin, Jens Schouenborg, Lars Wallman, Martin Bengtsson, Kinam Park, Kevin J. Otto
JOURNAL OF NEURAL ENGINEERING
(2017)
Article
Engineering, Biomedical
Lucas S. Kumosa, Valdemar Zetterberg, Jens Schouenborg
ACTA BIOMATERIALIA
(2018)
Article
Computer Science, Interdisciplinary Applications
Bengt Ljungquist, Per Petersson, Anders J. Johansson, Jens Schouenborg, Martin Garwicz
Article
Biotechnology & Applied Microbiology
Alexander Dontsios Holmkvist, Johan Agorelius, Matilde Forni, Ulf J. Nilsson, Cecilia Eriksson Linsmeier, Jens Schouenborg
JOURNAL OF NANOBIOTECHNOLOGY
(2020)
Article
Biochemical Research Methods
Mohsin Mohammed, Jonas Thelin, Lina Gallentoft, Palmi Thor Thorbergsson, Lucas S. Kumosa, Jens Schouenborg, Lina M. E. Pettersson
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Neurosciences
Georgy Bakalkin, Olga Nosova, Daniil Sarkisyan, Mathias Hallberg, Mengliang Zhang, Jens Schouenborg, Niklas Marklund, Hiroyuki Watanabe
Summary: Traumatic brain injury and controlled cortical impact (CCI) caused asymmetry in posture in rats, with left side injuries unexpectedly resulting in flexion on the left hindlimb. The effects on hindlimb postural asymmetry were not mirror-symmetrical between the left and right CCI, suggesting differences in neural pathways between the two types of injuries.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Matilde Forni, Palmi Thor Thorbergsson, Jonas Thelin, Jens Schouenborg
Summary: Developed a biocompatible microelectrode cluster to provide powerful and selective analgesia in awake rats without noticeable side effects. This method had minimal impact on gait, spontaneous cortical activity, and tactile responses, indicating a highly selective action.
Article
Clinical Neurology
Daniel Tornero, Oleg Tsupykov, Marcus Granmo, Cristina Rodriguez, Marita Gronning-Hansen, Jonas Thelin, Ekaterina Smozhanik, Cecilia Laterza, Somsak Wattananit, Ruimin Ge, Jemal Tatarishvili, Shane Grealish, Oliver Bruestle, Galina Skibo, Malin Parmar, Jens Schouenborg, Olle Lindvall, Zaal Kokaia
Article
Neurosciences
Johan Agorelius, Fotios Tsanakalis, Annika Friberg, Palmi T. Thorbergsson, Lina M. E. Pettersson, Jens Schouenborg
FRONTIERS IN NEUROSCIENCE
(2015)