Article
Chemistry, Multidisciplinary
Pradeep Chopra, Tejabhiram Yadavalli, Francesco Palmieri, Seino A. K. Jongkees, Luca Unione, Deepak Shukla, Geert-Jan Boons
Summary: Inhibition of human heparanase (Hpse) has been found to be a promising therapeutic strategy for preventing the spread of herpes simplex virus (HSV-1). The synthesis of hexa- and octasaccharide inhibitors of Hpse showed potent enzyme inhibition and the presence of 2-O-sulfation on iduronic acid was tolerated. These inhibitors not only blocked viral-induced shedding of cell-surface heparan sulfate (HS) but also inhibited cell migration and proliferation in corneal epithelial cells infected with HSV-1.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Plant Sciences
Xing-Long Chen, Yi-Juan Geng, Fei Li, Wei-Yan Hu, Rong-Ping Zhang
Summary: This study found that terpenoids from Tripterygium hypoglaucum can inhibit pancreatic cancer cells and increase Bax protein expression. These findings provide candidate molecules for the development of anti-pancreatic cancer drugs.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Oncology
Hayle Scanlan, Zachary Coffman, Jeffrey Bettencourt, Timothy Shipley, Debra E. Bramblett
Summary: This review provides an overview of HSV-1 as an oncolytic virus candidate and the genomic organization of T-VEC. The advantages and limitations of T-VEC compared to other HSV-1 oncolytic virus variants currently in clinical trials are discussed. Additionally, future directions for the use of HSV-1 oncolytic viruses as cancer therapy are explored.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bishajit Sarkar, Md. Asad Ullah, Yusha Araf, Sowmen Das, Md. Hasanur Rahman, Abu Tayab Moin
Summary: HSV is a highly infectious virus with two types, HSV-1 and HSV-2, infecting millions worldwide. This study designed three polyvalent subunit vaccines targeting multiple strains of HSV, which showed stability and potential effectiveness through molecular docking and simulation studies. Validation of these vaccines in wet lab-based studies is still needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Anita Toscani, Rossana Denaro, Sergio Fernando Castillo Pacheco, Matteo Biolatti, Silvia Anselmi, Valentina Dell'Oste, Daniele Castagnolo
Summary: A series of amidinourea compounds have been synthesized as potential non-nucleoside anti-HSV agents, showing micromolar activity against HSV-1 with low cytotoxicity. These compounds act in an early stage of the HSV replication cycle, just after viral attachment and entry.
Article
Chemistry, Medicinal
Maryam Zangi, Katherine A. Donald, Andreu Gazquez Casals, Abaigeal D. Franson, Alice J. Yu, Elise M. Marker, Molly E. Woodson, Scott D. Campbell, M. Abdul Mottaleb, Tanguturi Venkata Narayana Hajay Kumar, Makala Shakar Reddy, Lingala Vijaya Raghava Reddy, Subir Kumar Sadhukhan, David W. Griggs, Lynda A. Morrison, Marvin J. Meyers
Summary: The derivative compounds of ciclopirox olamine effectively inhibit replication of HSV-2 with low cytotoxicity, indicating their strong therapeutic potential. Structural comparison confirms the importance of hydrophobic groups in the efficacy of ciclopirox and its derivatives.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Virology
Brent A. Stanfield, Konstantin G. Kousoulas, Agustin Fernandez, Edward Gershburg
Summary: Diseases caused by human herpes simplex virus types 1 and 2 affect millions worldwide, but there are currently no FDA-approved vaccines. The development of novel live-attenuated vaccines aims to prevent or reduce the impact of herpes simplex infections, building on the success of past live-attenuated vaccines in combating viral diseases. These vaccines are designed to generate robust and protective immune responses based on our understanding of the immunopathogenesis of herpesviral infections.
Article
Biochemistry & Molecular Biology
Ji Xiao, Miaomiao Cai, Yifei Wang, Ping Ding
Summary: The iridoid compounds in traditional Chinese medicine have significant antiviral effects. This study identified seven new iridoid compounds from the aerial parts of Morinda officinalis, with officinaloside C showing significant anti-HSV-1 activity.
Review
Virology
Isadora Zhang, Zoe Hsiao, Fenyong Liu
Summary: Herpes simplex virus 1 (HSV-1) can cause cold sores or keratitis in healthy individuals, but severe complications in immune-compromised or neonatal patients. Current therapies can block viral replication but have limited effect on viral latency, necessitating the development of new strategies. Genome editing methods like homing endonucleases and CRISPR/Cas systems show promise in inhibiting HSV-1 infection.
Article
Biochemistry & Molecular Biology
Jose Louzinho Lopes, Vinicius Seiki Takemura Quinteiro, Jessica Wouk, Maria Laura Darido, Robert F. H. Dekker, Aneli M. Barbosa-Dekker, Vaclav Vetvicka, Mario A. A. Cunha, Ligia Carla Faccin-Galhardi, Alexandre Orsato
Summary: By introducing carboxyl and sulfonate groups into β-D-glucan, researchers attempted to improve its antiviral activity against enveloped viruses. The results showed that sulfonated-carboxymethylated derivatives could inhibit herpes virus, while their inhibition of dengue virus was weaker, indicating varying resistance of different viruses to anionic β-D-glucans. Comparing with a previous study, the presence of carboxymethyl groups might have a negative impact on antiviral activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Mehdi Gholami Barzoki, Somayeh Shatizadeh Malekshahi, Mohammad Shayestehpour
Summary: This study investigated the potential antiviral activity of Shouchella clausii probiotic strain and bacterial supernatant against HSV-1 for the first time. The results showed that S. clausii and its supernatant had the greatest inhibitory activity toward HSV-1 in the pre-treatment assay, indicating their potential as a novel inhibitor for HSV-1 infection.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Infectious Diseases
Zhaoqi Wang, Han Yan, Fujie He, Jie Wang, Yang Zhang, Lishan Sun, Cui Hao, Wei Wang
Summary: The natural compound wedelolactone (WDL) exhibits strong inhibitory effects against both HSV-1 and HSV-2 in vitro and in vivo, with mechanisms distinct from acyclovir and involving interference with host genes and signaling pathways. WDL treatment improves survival, attenuates inflammatory symptoms, and reduces viral titres in infected mice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Review
Immunology
Divya Sharma, Supriya Sharma, Natasha Akojwar, Ayusha Dondulkar, Nikhil Yenorkar, Deepti Pandita, Satyendra K. K. Prasad, Mahaveer Dhobi
Summary: This review summarizes the history, life cycle, current treatment methods, and limitations of two herpes viruses. It also discusses vaccine strategies and nanotechnological approaches for oral and genital herpes infections. The article provides insight for researchers and the healthcare sector on challenges and upcoming solutions in the treatment and vaccine development against HSV infections.
