Review
Immunology
Meihong Da, Luxia Chen, Alexander Enk, Sabine Ring, Karsten Mahnke
Summary: Adenosine (Ado) has immunosuppressive effects, and the ectoenzyme CD73 is crucial for the production of extracellular Ado. CD73 is highly expressed in regulatory T cells (Tregs) and upregulated after activation. Ado generated by CD73(+) Tregs plays a role in immune suppression of dendritic cells, monocytes, and T cells, making CD73 a novel checkpoint inhibitor in immunosuppressive environments such as tumors. Therapeutic intervention targeting CD73 is currently under investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hospitality, Leisure, Sport & Tourism
Ahmet Bulent Ozturk, Wei Wei, Nan Hua, Ruoxi Qi
Summary: The study found that users' continued usage behavior of mobile event application technology is influenced by factors such as effort expectancy, performance expectancy, habit, facilitating condition, and perceived security. Personal innovativeness also has a positive impact on effort expectancy and performance expectancy.
JOURNAL OF HOSPITALITY AND TOURISM TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tunde Fekete, Dora Bencze, Eduard Biro, Szilvia Benko, Kitti Pazmandi
Summary: NLRX1 is a regulatory NOD-like receptor that fine-tunes inflammatory signaling cascades, regulates metabolism, autophagy, and cell death. Its effects may be highly cell type-specific, and further research is needed to clarify its impact on different cellular functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Philip L. Mar, Piotr Horbal, Mina K. Chung, Jonathan W. Dukes, Michael Ezekowitz, Dhanunjaya Lakkireddy, Gregory Y. H. Lip, Mike Miletello, Peter A. Noseworthy, James A. Reiffel, James E. Tisdale, Brian Olshansky, Rakesh Gopinathannair
Summary: Antiarrhythmic drugs (AAD) play a crucial role in managing arrhythmias. Drug interactions involving AAD are common and can lead to serious adverse reactions. These interactions can be either pharmacokinetic, resulting in drug accumulation, or pharmacodynamic, causing QT prolongation. It is important to avoid serious drug interactions involving AAD whenever possible.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Critical Care Medicine
Baharan Zarrabian, Hannah Wunsch, Henry T. Stelfox, Theodore J. Iwashyna, Hayley B. Gershengorn
Summary: This study examined the association between extubation while receiving vasopressors and outcomes. The results showed that extubation while on high-dose vasopressors was associated with an increased risk of reintubation. Meanwhile, extubation on low-dose vasopressors was associated with a lower mortality rate and a shorter ICU stay.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Jie-quan Wang, Ya-ru Liu, Qing-rong Xia, Jun Liang, Jin-liang Wang, Jun Li
Summary: Alcohol use disorder (AUD) is a prevalent neuropsychological disorder with a complex and poorly understood pathogenesis. Recent research has shown the important role of noncoding RNAs (ncRNAs) in mental diseases, including AUD. However, the exact molecular mechanisms are still unclear.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Substance Abuse
Brian J. Miller, Andrew B. Meshnick, Boris D. Lushniak
Summary: This article reviews the regulatory approaches of the US FDA to tobacco products and discusses the potential of a harm reduction framework for the regulation of electronic nicotine delivery systems (ENDS).
Review
Environmental Sciences
Thiruchelvi Pulingam, Kwai Lin Thong, Jimmy Nelson Appaturi, Chin Wei Lai, Bey Fen Leo
Summary: The recent advances in nanotechnology have led to increased use of nanomaterials in various fields. Graphene oxide (GO) shows promise as an antibacterial material, but further research is needed to fully understand its mechanism of action.
Article
Oncology
Borja Puertas, Veronica Gonzalez-Calle, Eduardo Sobejano-Fuertes, Fernando Escalante, Jose A. Queizan, Abelardo Barez, Jorge Labrador, Jose Maria Alonso-Alonso, Alfonso Garcia de Coca, Alberto Cantalapiedra, Teresa Villaescusa, Carlos Aguilar-Franco, Elena Alejo-Alonso, Beatriz Rey-Bua, Lucia Lopez-Corral, Ramon Garcia-Sanz, Noemi Puig, Norma C. Gutierrez, Maria-Victoria Mateos
Summary: Survival of multiple myeloma patients has improved over time with the development of new treatments, especially with the combination of novel agents. Using at least two novel agents in induction therapy significantly prolongs overall survival, even in older patients. This suggests that multiple myeloma has become a chronic and potentially curable disease in a subset of patients with the current therapeutic approaches.
Article
Information Science & Library Science
Alex Koohang, Carol Springer Sargent, Jeretta Horn Nord, Joanna Paliszkiewicz
Summary: The research model includes constructs like IoT awareness, users' knowledge of IoT privacy and security, users' IoT trust, and intention to continue using IoT. Results indicate that IoT awareness influences users' privacy and security knowledge, which in turn impacts user trust and intention to use IoT.
INTERNATIONAL JOURNAL OF INFORMATION MANAGEMENT
(2022)
Review
Physiology
Kazutaka Ueda, Nobuaki Fukuma, Yusuke Adachi, Genri Numata, Hiroyuki Tokiwa, Masayuki Toyoda, Akira Otani, Masaki Hashimoto, Pang-Yen Liu, Eiki Takimoto
Summary: Recent clinical studies have identified sex differences in the efficacy of drug treatment for heart failure, potentially offering new mechanistic insights into sex differences in cardiovascular diseases. By outlining clinical trial results and discussing the role of sex differences in cardiovascular tissue homeostasis, the significance of sex differences in CVD pathogenesis has been underscored.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rosalba Florio, Barbara De Filippis, Serena Veschi, Viviana di Giacomo, Paola Lanuti, Giulia Catitti, Davide Brocco, Annalisa di Rienzo, Amelia Cataldi, Ivana Cacciatore, Rosa Amoroso, Alessandro Cama, Laura De Lellis
Summary: Pancreatic cancer has limited response to current therapeutic options, so there is a need for more effective and low-toxic agents. In this study, the antiproliferative activities of newly synthetized resveratrol analogues in pancreatic cancer cell lines were explored. The most active compound exhibited marked antiproliferative effects through mechanisms involving DNA damage, apoptosis induction, and interference in cell cycle progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yong-xiang Li, Jiawen Lu, Cheng He, Xun Wu, Yu Cui, Lin Chen, Jie Zhang, Yuxin Xie, Yixin An, Xuyang Liu, Sihan Zhen, Yunjun Liu, Chunhui Li, Dengfeng Zhang, Yun-Su Shi, Yanchun Song, Jianhua Wang, Yu Li, Guoying Wang, Junjie Fu, Tianyu Wang
Summary: cis-regulatory variations play an important role in the regulation of maize kernel size. This study dissected the genetic architecture of maize kernel size using two independent association populations and transcriptomic and genotypic data. The results showed that cis-regulatory variations control kernel size by fine-tuning the expression of proximal genes, and the accumulation of favorable cis-regulatory variations contributes to the improvement of maize kernel size.
Article
Cell Biology
Asrafun Nahar, Vladyslava Sokolova, Suganya Sekaran, James D. Orth, Soyeon Park
Summary: The assembly checkpoint of the proteasome holoenzyme relies on the characteristics of chaperones, which can sense ATP binding and hydrolysis to ensure the proper functioning of the proteasome.
Review
Energy & Fuels
Jeovan Assis Silva, Tomas Aquino Guimaraes
Summary: This study examined 1353 judicial reviews of appealed decisions by nine Brazilian regulatory agencies and found that factors such as length of proceedings, decision subject, and involvement in norm and price-setting regulatory tasks influenced court rulings. The electricity authority was the only regulatory body with statistically significant results showing that appeal rulings were more likely to be against them.
