Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Article
Biotechnology & Applied Microbiology
Yao Xiao, Guohu Guo, Huaiming Wang, Bin Peng, Yinglin Lin, Gaowen Qu, Ben Li, Zhaojun Jiang, Fan Zhang, Jiaming Wu, Min Liang
Summary: The constructed Cur/L-OHP@HAP NPs nanoparticles hold promise for improving cancer immunotherapy by activating the cGAS-STING pathway to enhance natural immunity and increase immune cell infiltration into the tumor microenvironment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Jia-Rui Zheng, Zi-Long Wang, Bo Feng
Summary: Hepatitis B virus infection causes indirect damage to hepatocytes through the immune system. The exhaustion of virus-specific immune cells and immune suppression by virus antigens contribute to the chronicity of the infection. Functional cure can be achieved by restoring the specific immune function, providing a theoretical basis for complete cure of hepatitis B.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Andrew T. Abad, Pranav Danthi
Summary: Viruses infect host cells to replicate, but hosts can activate defenses to limit replication. This study provides new insights into how host cells detect the genomes of invading reovirus particles and the factors that determine the magnitude of the immune response triggered during infection.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
David P. Maison, Youping Deng, Mariana Gerschenson
Summary: The SARS-CoV-2 pandemic and COVID-19 disease have had a global impact, sparking a significant surge in research. To evaluate future approaches, understanding the host immune response and viral antagonism is crucial. This review summarizes current knowledge on SARS-CoV-2, focusing on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. Efforts should be directed towards current research to develop treatments and prepare for future outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fan Mao, Xiaoying Zheng, Nai-Kei Wong, Wenjie Yi, Jingchen Song, Shiwei Fu, Zhiming Xiang, Shu Xiao, Yongbo Bao, Ziniu Yu, Yang Zhang
Summary: This study reveals the regulatory mechanisms of the Hippo pathway in immune responses of Crassostrea hongkongensis hemocytes, highlighting its importance in maintaining immune homeostasis and orchestrating hemocytic functions. It also demonstrates the divergence of the Hippo pathway's roles in marine invertebrate immunity from mammalian observations, indicating the need for further comparative studies across species.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Ngoc Tuan Tran, Huifen Liang, Ming Zhang, Md. Akibul Hasan Bakky, Yueling Zhang, Shengkang Li
Summary: This review summarizes the functions of cellular receptors in the innate immune defense of crustaceans, particularly shrimp and crabs, against white spot syndrome virus (WSSV) infection. The study provides important information on the interaction between viruses and hosts during infections, which is crucial for the development of preventative strategies and antiviral targets in cultured aquatic animals.
Review
Multidisciplinary Sciences
Hongliang Zhang, Jie Gao, Yujie Tang, Tengchuan Jin, Jinhui Tao
Summary: Inflammasomes play a crucial role in both the innate and adaptive immune systems, acting as a bridge between these two components to maintain a fine balance in immune responses. Understanding the function of inflammasomes in lymphocytes can provide new insights into the mechanisms and treatment of various diseases, including autoimmune diseases and tumors.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Oncology
Ronan Talty, Kelly Olino
Summary: Both cancer cells and immune cells rely on specific metabolic programs for survival and function, with immune cells having the capability to either enhance or suppress the antitumor immune response based on metabolic changes. The shared microenvironment within tumors affects the metabolism of immune cells and can impact the efficacy of immunotherapies, highlighting the importance of understanding the interplay between metabolism, immune response, and cancer progression.
Article
Multidisciplinary Sciences
Bruna Stuqui, Paola Jocelan Scarin Provazzi, Maria Leticia Duarte Lima, Agata Silva Cabral, Ellen Cristina Rivas Leonel, Natalia Maria Candido, Sebastiao Roberto Taboga, Marcia Guimaraes da Silva, Flavio de Oliveira Lima, Patricia Pereira dos Santos Melli, Silvana Maria Quintana, Marilia de Freitas Calmon, Paula Rahal
Summary: This study identified candidate genes and pathways associated with immune alterations in individuals with persistent human papillomavirus (HPV) infection and genital warts. Gene expression analysis revealed differentially expressed genes in genital warts, and immunohistochemical analysis showed changes in immune markers. These findings contribute to our understanding and management of genital warts.
Article
Biology
Klara Kubelkova, Vanda Bostik, Lokesh Joshi, Ales Macela
Summary: The cellular and humoral mechanisms of natural immunity play a crucial role in the defense processes of an organism by recognizing pathogen-associated molecular patterns and damage-associated molecular patterns. Recognition of these patterns activates the innate immune defense mechanisms, but if not regulated properly, can lead to damaging inflammation. This review highlights the integration of innate immune recognition, cell-autonomous stress response, infection, and tumorigenesis.
Article
Biochemistry & Molecular Biology
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Reiko Nakagawa, Hiroyuki Oshiumi
Summary: Post-translational modification of LGP2 fine-tunes antiviral innate immune responses by promoting late-phase expression of type I interferons, while attenuating other antiviral proteins.
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
W. M. Gayashani Sandamalika, Hyukjae Kwon, Chaehyeon Lim, Hyerim Yang, Jehee Lee
Summary: Catalase is a key enzyme in the antioxidant defense system of organisms, playing a crucial role in maintaining cellular oxidative balance and host immune protection. The study identified and characterized a catalase homolog from Amphiprion clarkii, highlighting its essential function in cell survival and immune defense through scavenging of reactive oxygen species. The research findings suggest that this catalase homolog may be a potential target for enhancing oxidative stress tolerance and immune response in organisms.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Oncology
T. Karantanos, S. Karanika, B. Seth, G. Gignac
CLINICAL & TRANSLATIONAL ONCOLOGY
(2019)
Letter
Biophysics
Theodoros Karantanos, Haesook T. Kim, Natalia M. Tijaro-Ovalle, Lequn Li, Corey Cutler, Joseph H. Antin, Karen K. Ballen, Jerome Ritz, Ioannis Politikos, Vassiliki A. Boussiotis
BONE MARROW TRANSPLANTATION
(2020)
Article
Immunology
Theodoros Karantanos, Haesook T. Kim, Natalia M. Tijaro-Ovalle, Lequn Li, Corey Cutler, Joseph H. Antin, Karen Ballen, Francisco M. Marty, Chen Sabrina Tan, Jerome Ritz, Ioannis Politikos, Vassiliki Boussiotis
CLINICAL IMMUNOLOGY
(2019)
Article
Hematology
Theodoros Karantanos, Shruti Chaturvedi, Evan M. Braunstein, Jerry Spivak, Linda Resar, Styliani Karanika, Donna M. Williams, Ophelia Rogers, Christopher D. Gocke, Alison R. Moliterno
Article
Oncology
Breann Yanagisawa, Brandy Perkins, Theodoros Karantanos, Mark Levis, Gabriel Ghiaur, B. Douglas Smith, Richard J. Jones
Review
Biochemistry & Molecular Biology
Theodoros Karantanos, Tania Jain, Alison R. Moliterno, Richard J. Jones, Amy E. DeZern
Summary: Men with chronic myeloid neoplasms have overall worse survival and higher incidence of transformation to acute leukemia, with a male predominance for mutations in high-risk genes. Current research on the genomic profile and sex-related differences in patients with chronic myeloid neoplasms is ongoing, with further investigation needed into the hypothesized biological mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Theodoros Karantanos, Lukasz P. Gondek, Ravi Varadhan, Alison R. Moliterno, Amy E. DeZern, Richard J. Jones, Tania Jain
Summary: Male patients with MDS/MPN have worse outcomes, potentially due to a higher number of somatic mutations, especially in high-risk genes. Further validation in larger cohorts and investigation of underlying mechanisms are warranted.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Immunology
James T. T. Gordy, Avinaash K. K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. R. Kapoor, Samuel K. K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. C. Sunshine, Petros C. C. Karakousis, Richard B. B. Markham
Summary: The fusion of chemokine MIP-3 alpha gene with melanoma-associated antigen genes in DNA vaccines has shown enhanced anti-tumor immunity. Combination therapy with DNA vaccine, type-I interferon, and 5Aza significantly upregulated intratumoral mRNA expression of immune infiltration chemokines and increased infiltration of CD8+ DCs, CCR7+ DCs, NK cells, and memory T-cells while reducing myeloid-derived suppressor cells. This approach holds promise for melanoma treatment and further studies are needed to understand its mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Styliani Karanika, Theodoros Karantanos, Herman Carneiro, Sabrina A. Assoumou
Summary: The study aimed to develop a model to accurately predict the 10-year cardiovascular disease risk of HIV-infected patients. A retrospective cohort study was conducted, dividing patients into model development and validation cohorts. Logistic regression analysis was used to create a prediction risk model with 11 variables, and the model's discrimination was evaluated using the area under the receiver operating characteristics curve. The model showed good accuracy in predicting cardiovascular disease risk when applied to the validation cohort. Rating: 8/10.
Review
Biochemistry & Molecular Biology
Phaedon D. D. Zavras, Ilias Sinanidis, Panagiotis Tsakiroglou, Theodoros Karantanos
Summary: Myelodysplastic syndrome (MDS) is a blood cancer characterized by bone marrow dysplasia and failure of hematopoiesis. Recent studies have shown that specific molecular abnormalities at earlier stages of MDS can predict progression to acute myeloid leukemia (AML). Different chromosomal abnormalities and somatic mutations present in MDS and AML-MRC have important prognostic implications. Changes in the classification of these neoplasms reflect the advances in understanding their biology. Novel therapeutic approaches, including adding venetoclax to hypomethylating agents and targeting specific mutations, have emerged for high-risk MDS and AML-MRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Stamatia C. Vorri, Ilias Christodoulou, Styliani Karanika, Theodoros Karantanos
Summary: The advancement of antiretroviral therapies has improved the lifespan of people with HIV, but they now face various comorbidities such as cardiovascular disease and malignancies. Recent studies have shown that HIV-infected individuals have a higher prevalence of clonal hematopoiesis (CH), which is associated with increased cardiovascular disease risk. CH in HIV-infected individuals is also linked to poorer control of the virus and an increased risk of myeloid neoplasms. Further understanding through molecular-level research and clinical studies is needed.
Review
Immunology
Natalia M. Tijaro-Ovalle, Theodoros Karantanos, Hong-Tao Wang, Vassiliki A. Boussiotis
FRONTIERS IN IMMUNOLOGY
(2019)