Article
Biochemistry & Molecular Biology
Maria Yoshida, Ayumu Nakashima, Naoki Ishiuchi, Kisho Miyasako, Keisuke Morimoto, Yoshiki Tanaka, Kensuke Sasaki, Satoshi Maeda, Takao Masaki
Summary: Both adipose-derived and bone marrow-derived mesenchymal stem cells (ADSCs and BMSCs) can suppress renal fibrosis, with ADSCs showing a stronger effect under serum-containing culture conditions. However, ADSC infusion in mice may lead to a higher death rate from pulmonary embolism. Therefore, the selection of ADSCs or BMSCs for clinical applications should consider the target disease and culture method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
Andrea Pintore, Donato Notarfrancesco, Arnaldo Zara, Antonio Oliviero, Filippo Migliorini, Francesco Oliva, Nicola Maffulli
Summary: The study found that autologous mesenchymal stem cell (MSC) injections can improve clinical and functional outcomes in knee osteoarthritis (KOA) patients, with similar results between autologous bone marrow cells (BMAC) and adipose-derived stromal cells (ADSCs). Measurements of Knee Injury and Osteoarthritis Outcome Score (KOOS), Oxford Knee Score (OKS), and visual analog scale (VAS) were collected from 102 patients with KOA before the procedures, at one month, and at six months post-injection.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Cell Biology
Domenico Aprile, Nicola Alessio, Ibrahim H. Demirsoy, Tiziana Squillaro, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi
Summary: The study demonstrated that multi-lineage stem cells can be isolated from a mouse model, offering a valid alternative for disease research and cell therapy, and showing potential applications for these cells.
Article
Biochemistry & Molecular Biology
Zahra Eydian, Alaleh Mohammad Ghasemi, Samira Ansari, Ali Naghi Kamali, Maryam Khosravi, Sima Momtaz, Sanaz Riki, Laleh Rafighdoost, Reza Entezari Heravi
Summary: This study demonstrates the differentiation of mesenchymal stem cells (MSCs) from human adipose tissue and bone marrow into functional beta-islet cells. It suggests that adipose stem cells may be a better choice for the treatment of diabetes mellitus due to their higher potency.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Engineering, Biomedical
Jiang-Shan Gong, Guo-Qiang Zhu, Yu Zhang, Bei Chen, Yi-Wei Liu, Hong-Ming Li, Ze-Hui He, Jing-Tao Zou, Yu-Xuan Qian, Sheng Zhu, Xin-Yue Hu, Shan-Shan Rao, Jia Cao, Hui Xie, Zhen-Xing Wang, Wei Du
Summary: This study developed a novel BMSC-aptamer functionalized hydrogel and demonstrated its effectiveness in recruiting BMSCs and promoting bone regeneration.
MATERIALS TODAY BIO
(2023)
Article
Cell Biology
Wu Duan, Huajie Zou, Nan Zang, Dongxia Ma, Bo Yang, Lin Zhu
Summary: Bone marrow adipose tissue (MAT) can have both local and systemic effects on metabolic homeostasis. The effects of metformin, a first-line drug for type 2 diabetes, on MAT and bone marrow mesenchymal stem cell (BM-MSC) differentiation are conflicting. In vivo and in vitro experiments showed that metformin increased MAT in mice tibia and promoted both osteogenic and lipogenic gene expression in mouse bone marrow. However, metformin inhibited lipogenesis and promoted osteogenesis of MSC in vitro. The increased MAT may be attributed to the filling of adipose tissue after metformin-induced apoptosis of bone marrow stromal cells.
Article
Agriculture, Dairy & Animal Science
Ejaz R. Dar, Mudasir B. Gugjoo, Moien Javaid, Shahid Hussain, Mujeeb R. Fazili, Kuldeep Dhama, Taha Alqahtani, Ali M. Alqahtani, Riaz A. Shah, Talha Bin Emran
Summary: The study evaluates the influence of ambient temperature, donor physiological status, and tissue source on sheep mesenchymal stem cells. Results show that adipose tissue-derived MSCs from full term pregnant female sheep exhibit higher potential for proliferation and differentiation compared to male sheep-derived MSCs. Cryopreserved MSCs have similar characteristics to fresh cells. Therefore, it is important to consider tissue type and donor physiological status when applying MSCs in clinical settings.
Article
Biochemistry & Molecular Biology
Cui Zhang, Shali Wu, Erman Chen, Luyang Yu, Jinfu Wang, Mengrui Wu
Summary: This study reveals that the lncRNA AC132217.4 plays a critical role in BMSC osteogenesis, promoting the development and function of osteoblasts. AC132217.4 interacts with IGF2 mRNA to regulate its expression and activate the AKT pathway, thereby controlling osteoblast maturation and function. Additionally, the splicing factors SC35 and HNRNPA1 are involved in the biogenesis of AC132217.4, while the transcription factor ALX1 regulates the expression of AC132217.7 to promote osteogenesis. In vivo over-expression of AC132217.4 significantly promotes bone healing in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Veterinary Sciences
Rudy Oyarzo, Ximena Valderrama, Francisca Valenzuela, Javiera Bahamonde
Summary: The viability of bovine fetal MSCs extracted from bone marrow (BM), adipose tissue (AT), and placenta (PT) was compared after exposure to different cryoprotectant solutions. BM-MSC exhibited significantly lower viability compared to AT-MSC and PT-MSC, with BM-MSC showing higher sensitivity to experimental conditions. BCL-2 expression was higher in BM-MSC, but the BAX/BCL-2 ratio did not differ among the cell types.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Saleheh Jahani, Nabi Zare, Yousef Mirzaei, Reza Arefnezhad, Hooman Zarei, Pouya Goleij, Nader Bagheri
Summary: Ovarian cancer is a heterogeneous complex condition with high mortality, weak prognosis, and late-stage presentation. Current treatments have diverse side effects and limited effectiveness. The use of mesenchymal stem cells (MSCs) from various sources has gained attention for treating ovarian cancer. This review aims to discuss the effects of MSCs from different sources on ovarian cancer and their underlying mechanisms.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Cell & Tissue Engineering
Mahshid Saleh, Amir Ali Sohrabpour, Mohammad Reza Mehrabi, Iman Seyhoun, Amir Abbas Vaezi
Summary: Peptic ulcer is a common gastrointestinal disorder that can be challenging to treat, often requiring long-term use of medication. Stem cell therapy, particularly using adipose-derived mesenchymal stem cells, is a promising new approach for patients who do not respond to conventional treatments or experience recurring ulcers.
STEM CELL RESEARCH & THERAPY
(2021)
Retraction
Biochemistry & Molecular Biology
Sabine Wislet-Gendebien, Emerence Laudet, Virginie Neirinckx, Philippe Alix, Pierre Leprince, Aneta Glejzer, Christophe Poulet, Benoit Hennuy, Lukas Sommer, Olga Shakhova, Bernard Rogister
Summary: A correction to this paper has been published.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Cell Biology
Yuan Liu, Christina Holmes
Summary: This review explores the tissue regeneration potential of EVs isolated from bone marrow and adipose tissue, the two most common clinical sources of adult MSCs, focusing on their angiogenic, osteogenic, and immunomodulatory potentials. Other important issues in the development of MSC-derived EV based therapies are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Yan Shi, Shang Wang, Weiwei Zhang, Yihan Zhu, Zhiqiang Fan, Yuesheng Huang, Furong Li, Ronghua Yang
Summary: This study reveals that hypoxic BMSCs can regulate the autophagy of epidermal cells through the HIF-1 alpha/TGF-beta 1/SMAD pathway, promoting the repair and healing of diabetic wounds.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Hsien Wu, Yu-Ting Liao, Chi-Han Huang, Yi-Chou Chen, En-Rung Chiang, Jung-Pan Wang
Summary: ADSCs tend to spontaneously differentiate into neuron-like cells during high confluence culture, with enhanced expression of neuronal markers and neurotrophins, while BMSCs do not show this tendency. Additionally, ADSCs do not exhibit spontaneous adipogenic and osteogenic differentiation during this process.
