Article
Biochemistry & Molecular Biology
Helena Deris, Petra Tominac, Frano Vuckovic, Arne Astrup, Ellen E. Blaak, Gordan Lauc, Ivan Gudelj
Summary: The aberrant plasma protein glycosylation associated with various diseases was studied by analyzing glycomes from participants of the Diogenes study. Significant alterations in glycan structures were observed 8 weeks after the low-calorie diet, but these effects were nullified during the weight-maintenance diets period.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Ana Karina Zambrano, Santiago Cadena-Ullauri, Patricia Guevara-Ramirez, Evelyn Frias-Toral, Viviana A. Ruiz-Pozo, Elius Paz-Cruz, Rafael Tamayo-Trujillo, Sebastian Chapela, Martha Montalvan, Gerardo Sarno, Claudia V. Guerra, Daniel Simancas-Racines
Summary: The very-low-calorie KD (VLCKD) is a diet with a caloric intake of under 800 kcal/day, less than 50 g/day of carbohydrate, and a balance of protein and fat. VLCKD has been proven to have beneficial effects on diseases like heart failure, schizophrenia, multiple sclerosis, Parkinson's, and obesity. The gut microbiota plays a role in metabolism, appetite, and energy regulation, and there is evidence of an association between gut microbiota dysbiosis and obesity. More research is needed to understand the mechanisms and potential benefits of VLCKD on gut microbiota composition in individuals with obesity.
Article
Nutrition & Dietetics
Inez Trouwborst, Gijs H. Goossens, Arne Astrup, Wim H. M. Saris, Ellen E. Blaak
Summary: Low-calorie diet is effective in weight loss and improving cardiometabolic risk factors, with differences in outcomes between men and women. Men tend to lose more weight during the diet period but regain more weight afterwards, while women show more stable improvements in lipid levels during follow-up. This study highlights the importance of considering sexual dimorphism in the effectiveness of low-calorie diets on weight loss and cardiometabolic health.
Article
Immunology
Helena Deris, Petra Tominac, Frano Vuckovic, Nina Briski, Arne Astrup, Ellen E. Blaak, Gordan Lauc, Ivan Gudelj
Summary: Obesity-induced inflammation activates the adaptive immune system through changes in IgG glycosylation. Different dietary regimes for weight control after weight loss do not significantly affect IgG glycosylation, but individuals may still experience significant changes in their IgG glycome composition regardless of the diet type.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Mariangela Rondanelli, Clara Gasparri, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso, Simone Perna, Philip Bazire, Ignacio Sajuox, Roberto Maugeri, Chiara Rigon
Summary: Studies have shown that very low calorie diets and very low carbohydrate diets can affect the gut microbiota composition of obese patients, while very low calorie ketogenic diets alter the composition of fecal microbial populations and impact the plasma metabolome and fecal bile acid composition.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Surgery
Tyler McKechnie, Christopher A. Povolo, Jay Lee, Yung Lee, Lily Park, Aristithes G. Doumouras, Dennis Hong, Mohit Bhandari, Cagla Eskicioglu
Summary: Although the evidence currently available is heterogeneous, preoperative very low energy diets are safe, well tolerated, and effectively induce preoperative weight loss in patients undergoing nonbariatric surgery for both benign and malignant disease. Further prospective studies are warranted.
Review
Endocrinology & Metabolism
Nami Mohammadian Khonsari, Patricia Khashayar, Ehsan Shahrestanaki, Roya Kelishadi, Sahar Mohammadpoor Nami, Motahar Heidari-Beni, Zahra Esmaeili Abdar, Ozra Tabatabaei-Malazy, Mostafa Qorbani
Summary: This systematic review and meta-analysis showed that normal weight obesity (NWO) increased the odds of cardiometabolic risk factors (CMRFs). These findings indicate the inadequacy of BMI measurement and emphasize the need for body fat assessment for a better obesity risk assessment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Gaber Bergant, Dzhamilyat Abdulkhalikova, Ana Sustarsic, Borut Peterlin, Eda Vrtacnik Bokal, Ales Maver, Mateja Videmsek, Tanja Burnik Papler
Summary: Obesity is a common problem in women with polycystic ovaries syndrome (PCOS) and can affect fertility. This study aimed to investigate the effect of a lifestyle intervention weight loss program on endometrial gene expression during the window of implantation (WOI) in infertile women with PCOS. RNASeq analysis of endometrial samples before and after the program showed no significant differential gene expression. However, comparison with previous studies suggested that weight loss may improve endometrial receptivity, as biomarker genes associated with receptivity were further down-regulated after the program. Furthermore, 25% of women who achieved the desired weight reduction conceived spontaneously.
Article
Nutrition & Dietetics
Govindarajan Raghavan, Arohi Bapna, Arti Mehta, Akash Shah, Tejas Vyas
Summary: Added sugars contribute to caloric intake and may lead to obesity. Replacing added sugar with a natural substitute like stevia can help reduce sugar and calorie intake.
Article
Medicine, General & Internal
Anastassia Amaro, Neil S. Skolnik, Danny Sugimoto
Summary: People with overweight or obesity often suffer from cardiometabolic diseases. Current therapies include lifestyle intervention, surgery, and medication. The study found that once-weekly subcutaneous semaglutide 2.4 mg had significant effects on weight loss and improvement in cardiometabolic parameters compared to placebo.
POSTGRADUATE MEDICINE
(2022)
Review
Nutrition & Dietetics
Anjali Kashyap, Alexander Mackay, Ben Carter, Claire L. Fyfe, Alexandra M. Johnstone, Phyo K. Myint
Summary: Vegan diets do not have a significant impact on weight and glycemic control, but they can significantly lower LDL cholesterol. Low-calorie diets have a significant improvement in glycemic control and are beneficial for weight loss and improvement in anthropometric markers.
Article
Nutrition & Dietetics
Laurie Lynn Carelli, Patrizia D'Aquila, Francesco de Rango, Armida Incorvaia, Giada Sena, Giuseppe Passarino, Dina Bellizzi
Summary: Different nutritional regimens can have beneficial effects on obesity by regulating gut microbiota composition and function. In this study, obese subjects underwent two dietary interventions for 8 weeks: a low-calorie diet and a two-phase (ketogenic plus low-calorie) diet. Anthropometric and clinical parameters were evaluated, and gut microbiota composition was assessed. Significant reductions in abdominal circumference and insulin levels were observed in subjects following the two-phase diet. Changes in gut microbial composition were also observed, including a decrease in Proteobacteria and an increase in Verrucomicrobiaceae in both diets. Only the two-phase diet resulted in an increase in Bacteroidetes. These findings suggest that targeted nutritional regimens and probiotic use can modulate gut microbiota to achieve a favorable composition and restore the balance disrupted by obesity and other conditions.
Article
Biochemistry & Molecular Biology
Ludovica Verde, Maria Dalamaga, Xavier Capo, Giuseppe Annunziata, Maria Hassapidou, Annamaria Docimo, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri, Luigi Barrea
Summary: High adherence to the Mediterranean diet (MD) leads to better results in the very low-calorie ketogenic diet (VLCKD), possibly due to the antioxidant and anti-inflammatory properties of the MD, which create a metabolic state favorable for more effective ketosis.
Article
Medicine, General & Internal
Sevil Karahan Yilmaz, Gunay Eskici, Cuma Mertoglu, Aylin Ayaz
Summary: This study investigated the effects of diets with different protein contents on obese women and found that a high-protein diet was effective in improving insulin resistance, blood pressure, LDL-C, hs-CRP, TNF-alpha, IL-6, and resulted in weight loss.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Junren Kang, Xiaodong Shi, Ji Fu, Hailong Li, Enling Ma, Wei Chen
Summary: This retrospective cohort study evaluated the efficacy of intermittent fasting 5:2 plus program in Chinese patients with overweight or obesity. The results showed that the intermittent fasting 5:2 plus group achieved the highest weight loss compared to the daily calorie restriction group and the meal replacement group.
Article
Obstetrics & Gynecology
Inger Sundstrom Poromaa, Jan Roar Mellembakken, Laure Morin Papunen, Terhi Piltonen, Johanna Puurunen, Juha S. Tapanainen, Elisabet Stener-Victorin, Angelica Linden Hirschberg, Eszter Vanky, Pernille Ravn, Dorte Glintborg, Marianne Andersen
HUMAN REPRODUCTION
(2016)
Article
Obstetrics & Gynecology
Pekka Pinola, Katri Puukka, Terhi T. Piltonen, Johanna Puurunen, Eszter Vanky, Inger Sundstrom-Poromaa, Elisabet Stener-Victorin, Angelica Linden Hirschberg, Pernille Ravn, Marianne Skovsager Andersen, Dorte Glintborg, Jan Roar Mellembakken, Aimo Ruokonen, Juha S. Tapanainen, Laure C. Morin-Papunen
FERTILITY AND STERILITY
(2017)
Correction
Obstetrics & Gynecology
Inger Sundstrom Poromaa, Jan Roar Mellembakken, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurenen, Juha Tapanainen, Elisabet Stener-Victorin, Angelica Lindn Hirschberg, Eszter Vanky, Pernille Ravn, Dorte Glintborg, Marianne Andersen
HUMAN REPRODUCTION
(2017)
Article
Obstetrics & Gynecology
Rasa Pelanis, Jan Roar Mellembakken, Inger Sundstr MPoromaa, Pernille Ravn, Laure Morin-Papunen, Juha S. Tapanainen, Terhi Piltonen, Johanna Puurunen, Angelica Linden Hirschberg, Peter Fedorcsak, Marianne Andersen, Dorte Glintborg
HUMAN REPRODUCTION
(2017)
Review
Obstetrics & Gynecology
Tom Tanbo, Jan Mellembakken, Sverre Bjercke, Eva Ring, Thomas Abyholm, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2018)
Letter
Obstetrics & Gynecology
Tom Tanbo, Jan Mellembakken, Sverre Bjercke, Eva Ring, Thomas Abyholm, Peter Fedorcsak
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2019)
Article
Genetics & Heredity
D. Misceo, O. K. Rodningen, T. Baroy, H. Sorte, J. R. Mellembakken, P. Stromme, M. Fannemel, E. Frengen
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2011)
Article
Obstetrics & Gynecology
Hans Kristian Opoien, Peter Fedorcsak, Anne Katerine Omland, Thomas Abyholm, Sverre Bjercke, Gudvor Ertzeid, Nan Oldereid, Jan Roar Mellembakken, Tom Tanbo
FERTILITY AND STERILITY
(2012)
Article
Obstetrics & Gynecology
S. B. Kjotrod, S. M. Carlsen, P. E. Rasmussen, T. Holst-Larsen, J. Mellembakken, A. Thurin-Kjellberg, K. HaapaniemiKouru, L. Morin-Papunen, P. Humaidan, A. Sunde, V. von During
HUMAN REPRODUCTION
(2011)
Article
Obstetrics & Gynecology
Jan R. Mellembakken, Sarah L. Berga, Mirjam Kilen, Tom G. Tanbo, Thomas Abyholm, Peter Fedorcsak
HUMAN REPRODUCTION
(2011)
Article
Pathology
Jan Roar Mellembakken, Vibeke Engh, Tom Tanbo, Bernard Czernobilsky, Evgeny Edelstein, Ottar Lunde, Lawrence M. Roth
PATHOLOGY RESEARCH AND PRACTICE
(2010)
Article
Obstetrics & Gynecology
Jessica L. Chan, Sujata Kar, Eszter Vanky, Laure Morin-Papunen, Terhi Piltonen, Johanna Puurunen, Juha S. Tapanainen, Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, Jose Maria Soares, Edmund Chada Baracat, Jan Roar Mellembakken, Anuja Dokras
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
A Hognestad, K Endresen, R Wergeland, JR Mellembakken, TE Mollnes, T Omland, JK Kjekshus, P Aukrust, AK Andreassen
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2005)
Article
Immunology
L Boursier, IN Farstad, JR Mellembakken, P Brandtzaeg, J Spencer
EUROPEAN JOURNAL OF IMMUNOLOGY
(2002)