Article
Microbiology
Sara P. H. A. van den Berg, Lyanne J. Derksen, Julia Drylewicz, Nening Nanlohy, Lisa Beckers, Josien Lanfermeijer, Stephanie Gessel, Martijn Vos, Sigrid Otto, Rob de Boer, Kiki Tesselaar, Jose A. M. Borghans, Debbie van Baarle
Summary: Cytomegalovirus (CMV) infection has a significant impact on the T-cell pool and is associated with immune system aging. However, the phenotypical differences between CMV-positive and CMV-negative individuals cannot be solely explained by the presence of large CMV-specific CD8(+) T-cell populations. CMV infection seems to have minimal effect on the dynamics of the T-cell pool, and the abundance of CMV-specific CD8(+) T-cells is not attributed to their longer lifespans.
Article
Medical Laboratory Technology
Canyang Zhan, Weiyan Wang, Lihua Chen
Summary: The combination of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) shows potential as a predictor of CMV infection in infants less than 3 months, with higher predictive value compared to NLR or PLR alone.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Editorial Material
Immunology
Stanley A. Plotkin
Summary: Cytomegalovirus is the leading cause of congenital infections, resulting in numerous abnormalities. Despite 50 years of unsuccessful attempts, modern vaccine construction platforms offer hope for an effective prophylactic.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Wenjian Mo, Xiangting Chen, Xu Zhang, Shunqing Wang, Ling Li, Yuehong Zhang
Summary: This study aimed to observe the recovery trend of peripheral lymphocyte subsets and immunoglobulins in HSCT recipients who developed CMVR. The results showed that CMVR cases had significantly lower T lymphocyte subsets, including CD3, CD4, and CD8, within six months post-HSCT, as well as slower recovery of immunoglobulins. Therefore, dynamic monitoring of T lymphocyte subsets and immunoglobulin levels can provide assistance in screening for CMVR in HSCT recipients with severe aplastic anemia, in addition to relying on CMV serostatus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tatiana Galperine, Ilka Engelmann, Sebastien Hantz, Deiborah Postil, Anny Dewilde, Dominique Deplanque, Renaud Martin, Julien Labreuche, Mouna Lazrek, Stephanie Somers, Elodie Ribot, Sophie Alain
Summary: Fecal Microbiota Transplantation (FMT) is the preferred treatment for recurrent Clostridioides difficile Infections (CDI). However, the donor screening process varies between countries and guidelines differ on the need for CMV testing. This study found that healthy donors with positive CMV serology do not shed CMV DNA in their stool, suggesting that CMV screening may not be necessary.
Review
Immunology
Susanna Esposito, Giulia Chiopris, Giulia Messina, Tiziana D'Alvano, Serafina Perrone, Nicola Principi
Summary: CMV is a common cause of congenital infection and non-genetic sensorineural hearing loss in children, with up to 2% of neonates affected, particularly in developing countries. Research on a vaccine to prevent CMV infection faces challenges due to the complex relationship between the host's immune system and the virus, highlighting the need for further studies.
Article
Cell Biology
Thomas F. Marandu, Michael Dombek, Michael Gutknecht, Marion Griessl, Ingred Goretti Rica, Barbora Vlkova, Kristina Macakova, Eleni Panagioti, Alec Griffith, James Lederer, Michael Yaffe, Sidharth Shankar, Leo Otterbein, Kiyoshi Itagaki, Carl J. Hauser, Charles H. Cook
Summary: Chronic CMV infection enhances the function of neutrophils in immunocompetent hosts, which is long-lasting and dependent on viral load.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Samantha M. Lee, Ruth Mitchell, Julia A. Knight, Tony Mazzulli, Caroline Relton, Elham Khodayari Moez, Rayjean J. Hung
Summary: This study found that early childhood CMV infection was associated with suboptimal total IQ at 8 years, but not at 15 years. Additionally, suboptimal attentional control at 8 years and reading comprehension at 9 years were also linked to CMV infection. Other cognitive measures assessed did not show association with CMV infection.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Virology
Angelica Rico, Sheila C. Dollard, Diana Valencia, Sheryll Corchuelo, Van T. Tong, Katherine Laiton-Donato, Minal M. Amin, Monica Benavides, Phili Wong, Suzanne Newton, Marcela Daza, Jordan Cates, Maritza Gonzalez, Laura D. Zambrano, Marcela M. Mercado, Elizabeth C. Ailes, Helena M. Rodriguez, Suzanne M. Gilboa, Jacqueline Acosta, Jessica Ricaldi, Dioselina Pelaez, Margaret A. Honein, Martha L. Ospina, Tatiana M. Lanzieri
Summary: In Colombia, maternal CMV seroprevalence is high at 98.1%, with a congenital CMV prevalence of 8.4 per 1000 live births. Among infants without confirmed congenital CMV infection, over half were diagnosed with postnatal infection at age 6 months.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Multidisciplinary Sciences
Isreal Moreno, Irene Rodriguez-Sanchez, Xenia Schafer, Joshua Munger
Summary: HCMV infection induces the expression of a tissue atypical neuronal glycolytic enzyme, activating glycolysis and UDP-sugar metabolism, increasing the accumulation of glycosyl building blocks, and enabling the expression of an essential viral glycoprotein and the production of infectious virions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Suresh B. Boppana, Michiel van Boven, William J. Britt, Soren Gantt, Paul D. Griffiths, Scott D. Grosse, Terri B. Hyde, Tatiana M. Lanzieri, Marisa M. Mussi-Pinhata, Sarah E. Pallas, Swetha G. Pinninti, William D. Rawlinson, Shannon A. Ross, Ann C. T. M. Vossenm, Karen B. Fowler
Summary: Cytomegalovirus is the most common infectious cause of congenital malformation and is a leading cause of sensory neural hearing loss and motor cognitive deficits. The global burden of congenital CMV infection may be underestimated, but there are candidate vaccines in development and licensure is possible within the next five years.
Article
Infectious Diseases
Rituparna Das, Daniel Blazquez-Gamero, David Bernstein, Soren Gantt, Oliver Bautista, Karen Beck, Anthony Conlon, Daniel I. S. Rosenbloom, Dai Wang, Michael Ritter, Beth Arnold, Paula Annunziato, Kevin L. Russell
Summary: This study evaluated the safety and efficacy of the V160 vaccine in CMV-seronegative women. The results showed that the three-dose V160 vaccine did not reduce the incidence of CMV infection, but it was generally well-tolerated and immunogenic. This study provides insights for the design of future CMV vaccine trials.
LANCET INFECTIOUS DISEASES
(2023)
Article
Immunology
Yuki Shiina, Mayuko Kawabe, Yohei Suehiro, Haruki Katsumata, Yasuyuki Nakada, Akimitsu Kobayashi, Izumi Yamamoto, Fumihiko Urabe, Jun Miki, Hiroki Yamada, Takahiro Kimura, Yudo Tanno, Ichiro Ohkido, Hiroyasu Yamamoto, Takashi Yokoo
Summary: The aim of this study was to investigate whether absolute lymphocyte count could predict cytomegalovirus infection in kidney transplant recipients. The results showed that the incidence of cytomegalovirus infection was significantly higher when the absolute lymphocyte count was <1100 cells/mu L on day 28 post-transplantation.
TRANSPLANTATION PROCEEDINGS
(2023)
Article
Pediatrics
Megan H. Pesch, Mark R. Schleiss
Summary: This article reviews recent developments in the understanding of congenital cytomegalovirus (cCMV), including epidemiology and transmission, diagnostic strategies, newborn screening programs, therapeutics, and vaccine trials. It discusses how this knowledge informs the pathophysiology of cCMV and directs strategies for improving outcomes and quality of life for infected children. The article also provides an update on the epidemiology of cCMV in the United States, evolving understanding of maternal-fetal transmission, enhanced screening approaches, and recognition of neonatal and long-term sequelae. Finally, it reviews the current landscape of pediatric cCMV research and gives recommendations for future investigation.
Article
Otorhinolaryngology
Daniel Suarez, Christopher Nielson, Stephanie B. McVicar, Max Sidesinger, Betsy Ostrander, Elizabeth O'Brien, Krow Ampofo, Con Y. Ling, Lonnie J. Miner, Albert H. Park
Summary: This study aimed to evaluate the detection rate of an expanded targeted early CMV testing program. A retrospective analysis of data from a large healthcare system showed that the annual CMV testing has increased almost 10-fold since the implementation of the program in 2019. This program identified 14 symptomatic cCMV cases.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Pharmacology & Pharmacy
Atibordee Meesing, Raymund R. Razonable
Review
Pharmacology & Pharmacy
Atibordee Meesing, Raymund R. Razonable
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2018)
Letter
Public, Environmental & Occupational Health
Anucha Apisarnthanarak, Pansachee Damronglerd, Atibordee Meesing, Sasinuj Rutjanawech, Thana Khawcharoenporn
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2014)
Article
Immunology
Atibordee Meesing, Roshini S. Abraham, Raymund R. Razonable
Article
Immunology
Atibordee Meesing, Jeffrey J. Germer, Joseph D. Yao, Michelle L. Gartner, Benjamin J. Digmann, Raymund R. Razonable
JOURNAL OF INFECTIOUS DISEASES
(2020)
Meeting Abstract
Surgery
A. Meesing, R. Abraham, R. Razonable
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Meeting Abstract
Surgery
A. Meesing, R. Abraham, R. Razonable
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Review
Public, Environmental & Occupational Health
Atibordee Meesing, Apichat Jittjareon, Arpa Pornpetchpracha, Boonrat Tassaneetrithep, Angsana Phuphuakrat, Sasisopin Kiertiburanakul
SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH
(2014)
