Review
Food Science & Technology
Monica R. Meza-Meza, Adolfo I. Ruiz-Ballesteros, Ulises de la Cruz-mosso
Summary: Vitamin D can be obtained from various sources and plays a critical role in immune regulation through both genomic and non-genomic mechanisms.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Neurosciences
Tanya M. Galyuk, Anton J. M. Loonen
Summary: Vitamin D deficiency may affect patients with addictions, but research on its mechanistic role in addiction is still insufficient. Studies suggest a possible influence of vitamin D on dopaminergic transmission, with vitamin D status depending on genetic variants and other involved genes.
ACTA NEUROPSYCHIATRICA
(2021)
Article
Genetics & Heredity
Monica R. Meza-Meza, Barbara Vizmanos, Melissa Rivera-Escoto, Adolfo Ruiz-Ballesteros, Karen Pesqueda-Cendejas, Isela Parra-Rojas, Margarita Montoya-Buelna, Sonia Luquin, Bertha Campos-Lopez, Paulina E. Mora-Garcia, Sergio Cerpa-Cruz, Ulises De la Cruz-Mosso
Summary: The study found that the TT FokI VDR genotype is associated with high VDR expression and clinical disease activity in systemic lupus erythematosus patients.
Review
Nutrition & Dietetics
Jordi Bover, Elisabet Masso, Laia Gifre, Carlo Alfieri, Jordi Soler-Majoral, Maria Fusaro, Jordi Calabia, Rosely Rodriguez-Pena, Nestor Rodriguez-Chitiva, Victor Lopez-Baez, Maya Sanchez-Baya, Iara da Silva, Armando Aguilar, Misael C. Bustos, Natacha Rodrigues, Jonathan S. Chavez-Iniguez, Gregorio Romero-Gonzalez, Jose Manuel Valdivielso, Pablo Molina, Jose L. Gorriz
Summary: Chronic kidney disease (CKD) is a common condition that impairs kidney function and can lead to vitamin D (VD) deficiency. While studies have shown a link between low VD levels and negative outcomes, recent research has lowered expectations for the benefits of VD supplementation. However, guidelines still recommend VD supplementation for CKD patients. It is important to carefully balance the adverse effects of VD derivatives with the prevention of severe secondary hyperparathyroidism.
Article
Nutrition & Dietetics
Andrius Bleizgys
Summary: In modern societies, many people may be at risk of low vitamin D levels, so testing serum 25-hydroxy-vitamin D (25OH-D) levels before prescribing supplementation is crucial. In emergency situations, patients should be advised to take moderate vitamin D doses and have their 25-OH-D levels checked later.
Review
Neurosciences
Kiana Saadatmand, Saba Khan, Quaratulain Hassan, Raymond Hautamaki, Rani Ashouri, Josh Lua, Sylvain Dore
Summary: Vitamin D supplementation has been shown to improve patient outcomes in various illnesses, while deficiencies may worsen symptoms. Research on the effects of vitamin D in traumatic brain injury is still in its early stages, with much to be learned about its potential benefits.
TRANSLATIONAL NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Michal Chojnacki, Jakub Anisiewicz, Ilona Lesniowska, Marta Kinga Lemieszek
Summary: Vitamin D3 deficiency is a pandemic with serious health consequences, including chronic respiratory diseases. Vitamin D supplementation has proven ineffective in improving this situation. This study demonstrates the usefulness and safety of delivering 1,25(OH)2-vitamin D3 and its precursor directly into the respiratory tract through nebulization. This method restores physiological calcitriol levels in animals with vitamin D deficiencies.
APPLIED SCIENCES-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Alfonso Rodriguez-Gil, Estrella Carrillo-Cruz, Cristina Marrero-Cepeda, Guillermo Rodriguez, Jose A. Perez-Simon
Summary: Vitamin D plays a dual role in the immune system and tumor cells, potentially decreasing graft-versus-host disease and relapse rates.
Article
Immunology
L. J. Berghaus, J. Cathcart, R. D. Berghaus, K. A. Hart
Summary: This study assessed the impact of age on equine vitamin D metabolism and VDR expression in alveolar macrophages (AM phi), and found that both vitamin D metabolism and VDR expression in horses are influenced by age, which may have implications for pulmonary immunity in foals.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2023)
Editorial Material
Cell Biology
Reinhold Vieth
Summary: There has been a trend in recent years to trivialize the terminology surrounding molecules based on a secosteroid structure. The generic use of the term "vitamin D" has led to confusion between a drug commonly used for patients with kidney failure and the nutritional use of vitamin D. This commentary criticizes this trivialization and highlights the misleading nature of sloppy terminology without providing any clinical evidence for the increased risk of Alzheimer's disease or dementia due to vitamin D supplementation.
Article
Agriculture, Dairy & Animal Science
A. Vieira-Neto, M. B. Poindexter, M. Nehme Marinho, R. Zimpel, A. Husnain, A. C. M. Silva, J. G. Prim, C. D. Nelson, J. E. P. Santos
Summary: The study found that supplementing vitamin D prepartum can alter the composition of blood leukocytes and attenuate granulocyte phagocytosis during the transition period, while prepartum supplementation of calcidiol (CA) increased mRNA expression of genes involved in immune cell function, including those related to pathogen recognition and antimicrobial effects of leukocytes.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
M. B. Poindexter, R. Zimpel, A. Vieira-Neto, A. Husnain, A. C. M. Silva, A. Faccenda, A. Sanches de Avila, P. Celi, C. Cortinhas, J. E. P. Santos, C. D. Nelson
Summary: The objectives of this experiment were to investigate the effects of different levels of 25-hydroxyvitamin D3 on the concentrations, absorptions, and retentions of Ca, Mg, and P in periparturient dairy cows. The results suggest that calcidiol can increase the concentration of 25-hydroxyvitamin D3 in serum and have a positive effect on the concentrations of Ca and P.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Antonela Gverovic Antunica, Ljubo Znaor, Mira Ivankovic, Velibor Puzovic, Irena Markovic, Snjezana Kastelan
Summary: Diabetic retinopathy, the most common eye disease complication of diabetes, is associated with hypovitaminosis D. Vitamin D2 and D3 are the main forms of vitamin D, with sunlight being a major source. Vitamin D plays a crucial role not only in maintaining healthy bones and immune system but also in the development of various diseases, including diabetic retinopathy. Diagnosis of vitamin D deficiency, which is prevalent worldwide, is done through measuring serum concentration of 25-hydroxyvitamin D. Supplementation of vitamin D has been proven effective in treating diabetic retinopathy, but under the recommendation and supervision of a doctor to prevent potential negative side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Milosz Caban, Urszula Lewandowska
Summary: This article reviews the current knowledge on the link between vitamin D and its receptor and the occurrence of eye disease, as well as the influence of analogues of calcitriol, an active metabolite of vitamin D. It is found that patients with various ocular disorders generally have vitamin D deficiency, and vitamin D may modulate the course of eye diseases and serve as a marker. Supplementation of vitamin D could potentially alleviate some eye disorders, but further randomized trials are recommended to clarify the link and activity between vitamin D and eye disease.
Article
Nutrition & Dietetics
Antonio Gazquez, Maria Sanchez-Campillo, Alejandro Barranco, Ricardo Rueda, Jia P. Chan, Matthew J. Kuchan, Elvira Larque
Summary: Oral 25-OH-D3 provides better vitamin D availability for both mother and fetus during pregnancy compared to vitamin D3. No adverse effects on pregnancy outcomes were observed. The effects of 25-OH-D3 on the expression of VDR and GAD67 in fetal brain require further investigation.
FRONTIERS IN NUTRITION
(2022)