Article
Biochemistry & Molecular Biology
Yushi Abe, Daigo Ochiai, Masako Taguchi, Seiji Kanzaki, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: Human amniotic fluid stem cells (hAFSCs) can form aggregates with host immune cells and alleviate inflammation. Additionally, hAFSCs can increase regulatory T cells in the acquired immune system. Therefore, hAFSCs play an important role in the treatment of inflammation-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jiali Wang, Yongda Lin, Xiutian Chen, Yiping Liu, Tianbiao Zhou
Summary: Chronic kidney disease has significant impact on public health and requires more effective treatment tools. Mesenchymal stem cells show potential as a new tool for CKD treatment, with the ability to improve renal function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Marcella Liciani Franco, Stephany Beyerstedt, erika Bevilaqua Rangel
Summary: Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems associated with comorbidities such as diabetes mellitus and hypertension. Klotho has shown promising potential as a therapeutic approach for these kidney conditions. It exerts renoprotective effects by reducing inflammation, oxidative stress, and fibrosis. Mesenchymal stem cells (MSCs) are an important strategy for delivering Klotho.
Article
Cell Biology
Hyoungnae Kim, Mi Ra Yu, Haekyung Lee, Soon Hyo Kwon, Jin Seok Jeon, Dong Cheol Han, Hyunjin Noh
Summary: Research has shown that MSCs from patients with CKD exhibit reduced proliferation, accelerated senescence, and increased DNA damage compared to healthy MSCs, but these changes were significantly reduced after metformin treatment. Metformin enhances the paracrine action of CKD MSCs, leading to lower expression of inflammatory and fibrotic markers in kidney cells co-cultured with metformin-treated MSCs. Furthermore, metformin-treated CKD MSCs effectively reduce inflammation and fibrosis in diseased kidneys, suggesting a therapeutic benefit in targeting accelerated senescence of CKD MSCs.
Article
Biochemistry & Molecular Biology
Dayane Mayumi Miyasaki, Alexandra Cristina Senegaglia, Sergio Adriane Bezerra de Moura, Amanda Leitolis, Luiz Guilherme Achcar Capriglione, Leticia Fracaro, Lidiane Maria Boldrini Leite, Paulo Henrique Utumi, Felipe Yukio Ishikawa Fragoso, Fernando Meyer, Alejandro Correa, Paulo Roberto Slud Brofman
Summary: This study evaluated the effects of extracellular vesicles (EVs) from human umbilical cord tissue and human umbilical cord blood on rats with chronic kidney disease. The results demonstrated that EVs have the potential to improve renal function, suggesting their use as a cell-free treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Milad Hasanpour, Reza Rahbarghazi, Alireza Nourazarian, Fatemeh Khaki-Khatibi, Cigir Biray Avci, Mehdi Hassanpour, Mehdi Talebi, Hossein Taghavi, Leila Salimi
Summary: This study investigated the paracrine effect of amniotic fluid-derived mesenchymal stem cells on Alzheimer's disease changes. The results showed that the secretion of amniotic fluid stem cells can reduce AD-like pathologies and improve cell viability.
Article
Biochemistry & Molecular Biology
Naiyou Liu, Charles M. Bowen, Mohammadali M. Shoja, Karen Larissa Castro de Pereira, Laxmi Priya Dongur, Antonio Saad, William K. Russell, Thomas Christopher Broderick, Jeffrey H. Fair, William Samuel Fagg
Summary: Myofibroblast activation is a cellular response to physiological or pathological insults. In this study, co-cultured amniotic cell conditioned media (coACCM) was found to activate myofibroblast, while amniotic fluid (AF) represses it. These findings suggest that different biologics can elicit different cellular responses and may have broad utility in the clinic and the lab.
Article
Cell & Tissue Engineering
Ji-Hye Yea, Yeo Min Yoon, Jun Hee Lee, Chul Won Yun, Sang Hun Lee
Summary: This study found that Exocue can treat CKD by regulating inflammation and fibrosis, reducing the expression of related genes, and significantly improving kidney function.
JOURNAL OF TISSUE ENGINEERING
(2021)
Article
Cell Biology
Yushi Abe, Daigo Ochiai, Seiji Kanzaki, Yu Sato, Toshimitsu Otani, Satoru Ikenoue, Yoshifumi Kasuga, Mamoru Tanaka
Summary: This study demonstrates that hAFSCs are effective in the treatment and prevention of inflammation-induced preterm birth. hAFSCs suppress inflammation and reduce preterm birth by switching macrophage polarity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Ying-Cheng Chen, Ying-Wei Lan, Shiaw-Min Huang, Chih-Ching Yen, Wei Chen, Wan-Ju Wu, Theresa Staniczek, Kowit-Yu Chong, Chuan-Mu Chen
Summary: The study demonstrates that hAFMSCs can inhibit the proliferation, tumor growth, and invasion of PDAC cells by altering cell cycle and signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Medicine, General & Internal
Han Luo, Zhen Wang, Fang Qi, Dali Wang
Summary: Complete wound regeneration is crucial for maintaining skin structure and physiological functions, and amniotic fluid stem cells (AFSCs) have the potential to play a significant role in wound generation and treatment. AFSCs are easily accessible and have advantages such as anti-inflammatory and immunomodulatory properties, which can promote full wound regeneration.
CHINESE MEDICAL JOURNAL
(2022)
Review
Cell & Tissue Engineering
Rodrigo N. Riedel, Antonio Perez-Perez, Victor Sanchez-Margalet, Cecilia L. Varone, Julieta L. Maymo
Summary: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to significant social, economic, and health challenges globally. Stem cells, particularly human amniotic membrane cells, have shown promising potential as a therapeutic approach for COVID-19 due to their immunoregulatory and anti-inflammatory properties.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Massimo Conese, Ottavio Napolitano, Onofrio Laselva, Sante Di Gioia, Luigi Nappi, Luigia Trabace, Maria Matteo
Summary: This study found that the levels of PLAC1 in AMSCs were lower in patients with preeclampsia, and abnormal shedding of PLAC1 from AMSC plasma membranes may contribute to trophoblast proliferation and support its role in the development of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Amany Solaiman, Radwa A. Mehanna, Ghada A. Meheissen, Soha Elatrebi, Rasha Said, Nahed H. Elsokkary
Summary: Amniotic fluid-mesenchymal stem cells have shown promising protective and therapeutic effects against hyperoxia-induced lung fibrosis, as evaluated in terms of physiology, histology, and biochemistry.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Nengqing Liu, Yi Cheng, Ding Wang, Hongmei Guan, Diyu Chen, Juan Zeng, Dian Lu, Yuanshuai Li, Yinghong Yang, Qian Luo, Lifen Zhu, Bin Jiang, Xiaofang Sun, Bing Song
Summary: Amniotic fluid derived mesenchymal stem cells (AFMSCs) exhibit superior multipotency and immunomodulatory properties compared to MSCs derived from other somatic tissues. This study categorized AFMSCs into three distinct groups and found that a minority population (AFMSCs-X) displayed the highest multipotency and immunomodulatory abilities. Experimental results in a septic mice model showed that AFMSCs-X significantly improved survival rates and reduced bacterial colonization.
Article
Cell Biology
Jessica Liliane Paz, Debora Levy, Beatriz Araujo Oliveira, Thatiana Correia de Melo, Fabio Alessandro de Freitas, Cadiele Oliana Reichert, Alessandro Rodrigues, Juliana Pereira, Sergio Paulo Bydlowski
Article
Parasitology
Larissa Rodrigues Bosqui, Marcelo Andreetta Corral, Debora Levy, Sergio Paulo Bydlowski, Ronaldo Cesar Borges Gryschek, Luiz Antonio Custodio, Wander Rogerio Pavanelli, Ivete Conchon-Costa, Julia Maria Costa-Cruz, Fabiana Martins de Paula, Idessania Nazareth Costa
Review
Cell Biology
Antonio Carlos Ribeiro-Filho, Debora Levy, Jorge Luis Maria Ruiz, Marluce da Cunha Mantovani, Sergio Paulo Bydlowski
Letter
Hematology
Daniela F. Valadares, Rosangela R. P. Soares, Giovanna Di Giacomo, Tania Rocha, Cadiele O. Reichert, Sergio P. Bydlowski
THROMBOSIS RESEARCH
(2020)
Article
Orthopedics
Pedro Nogueira Giglio, Nelson Foresto Lizier, Debora Levy, Marcel Faraco Sobrado, Riccardo Gomes Gobbi, Jose Ricardo Pecora, Sergio Paulo Bydlowski, Marco Kawamura Demange
ACTA ORTOPEDICA BRASILEIRA
(2020)
Article
Multidisciplinary Sciences
Camila Zogbi, Nathalia C. Oliveira, Debora Levy, Sergio P. Bydlowski, Vinicius Bassaneze, Elida A. Neri, Jose E. Krieger
SCIENTIFIC REPORTS
(2020)
Article
Microbiology
Debora Levy, Mari Cleia M. R. Ferreira, Cadiele O. Reichert, Lis Vilela de Almeida, Graciela Brocardo, Luis Alberto P. C. Lage, Hebert F. Culler, Youko Nukui, Sergio P. Bydlowski, Juliana Pereira
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Cadiele Oliana Reichert, Fabio Alessandro de Freitas, Juliana Sampaio-Silva, Leonardo Rokita-Rosa, Priscila de Lima Barros, Debora Levy, Sergio Paulo Bydlowski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Karina de Oliveira Goncalves, Daniel Perez Vieira, Debora Levy, Sergio Paulo Bydlowski, Lilia Coronato Courrol
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2020)
Article
Cell Biology
Rodrigo Pinheiro Araldi, Thatiana Correa de Melo, Debora Levy, Dener Madeiro de Souza, Beatriz Mauricio, Gabriel Avelar Colozza-Gama, Sergio Paulo Bydlowski, Hongzhuang Peng, Frank J. Rauscher, Janete Maria Cerutti
Review
Biochemistry & Molecular Biology
Cadiele Oliana Reichert, Debora Levy, Sergio P. Bydlowski
Summary: The human body has biological redox systems that can prevent or reduce damage caused by increased oxidative stress throughout life. The PON enzymes, particularly PON1, are associated with neurodegenerative diseases and play a crucial role in their development.
Article
Behavioral Sciences
Diego Gomes Candido Reis, Debora Levy, Luis Alberto de Padua Covas Lage, Hebert Fabricio Culler, Vanderson Rocha, Sergio Paulo Bydlowski, Maria Claudia Nogueira Zerbini, Juliana Pereira
Summary: Overexpression of MYC and MGMT were found to be prognostic markers associated with unfavorable clinical outcomes in PCNSL-DLBCL patients. Age > 60 years and moderate/high IELSG score were also linked to worse prognosis.
BRAIN AND BEHAVIOR
(2021)
Review
Cell Biology
Fabio Alessandro de Freitas, Debora Levy, Amira Zarrouk, Gerard Lizard, Sergio Paulo Bydlowski
Summary: Oxysterols, oxidized derivatives of cholesterol, have various physiological and pharmacological activities that could be beneficial in cancer treatment and regenerative medicine.
Review
Cell Biology
Fabio Alessandro de Freitas, Debora Levy, Cadiele Oliana Reichert, Edecio Cunha-Neto, Jorge Kalil, Sergio Paulo Bydlowski
Summary: Oxysterols have diverse effects on the immune system and play a significant role in immune-related diseases. They can influence the function and migration of immune cells as well as immune responses. The main oxysterol receptors LXR and EBI2 also have important roles in the immune system.
Article
Biochemistry & Molecular Biology
Cadiele Oliana Reichert, Carolina Garcia de Macedo, Debora Levy, Bruno Carnevale Sini, Andreia Moreira Monteiro, Magnus Gidlund, Luciana Morganti Ferreira Maselli, Sandra Fatima Menosi Gualandro, Sergio Paulo Bydlowski