Review
Chemistry, Medicinal
Junyu Wu, Yau-Tuen Chan, Yuanjun Lu, Ning Wang, Yibin Feng
Summary: Surgery is the main treatment for hepatocellular carcinoma (HCC), but postoperative recurrence, caused by intrahepatic metastasis or de novo tumorigenesis, significantly impairs its efficacy. Recent research shows that the postoperative tumor microenvironment (TME) plays a crucial role in tumor recurrence. This review discusses the impact of surgical stress and perturbation on the TME and highlights the potential of targeting the postoperative TME for adjuvant therapeutics.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Takeshi Matsui, Susumu Hamada-Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Ken Shirabe, Koichi Kimura, Yoichi Hiasa, Natthaya Chuaypen, Pisit Tangkijvanich, Aya Naiki-Ito, Satoru Takahashi, Takahiro Ochiya, Yasuhito Tanaka
Summary: The miRNA clusters miR-183/96/182 and miR-217/216a/216b are significantly upregulated in nonviral hepatocellular carcinoma (NBNC-HCC). High levels of miR-182-5p and miR-217-5p, but low levels of miR-96-5p, in tumor tissues are associated with poor recurrence-free survival of NBNC-HCC patients. Further upregulation of miR-96-5p in tumors may have an inhibitory effect on recurrence, suggesting its potential as a tumor suppressor in NBNC-HCC patients at high risk of recurrence. Transfection of miR-96-5p mimic induced apoptosis of HepG2 cells and suppressed proliferation and invasion, indicating its potential antitumor effects.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Nada El-Domiaty, Faouzi Saliba, Vincent Karam, Rodolphe Sobesky, Wafaa Ibrahim, Eric Vibert, Gabriella Pittau, Khaled Amer, Maysaa A. Saeed, Jihan A. Shawky, Daniel Cherqui, Rene Adam, Didier Samuel
Summary: The study found that the BMI of HCC patients undergoing liver transplantation did not significantly impact the recurrence of HCC. Obesity should not be considered as a predictive factor for HCC recurrence in patient selection for liver transplantation.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Wen-Tao Yan, Chao Li, Lan-Qing Yao, Hai-Bo Qiu, Ming-Da Wang, Xin-Fei Xu, Ya-Hao Zhou, Hong Wang, Ting-Hao Chen, Wei-Min Gu, Jian-Hong Zhong, Han Wu, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study identified predictors and long-term prognosis of early and late recurrence after hepatic resection for hepatocellular carcinoma (HCC). Results showed that there were different independent predictors associated with early and late recurrence, with patients experiencing early recurrence having poorer long-term survival compared to those with late recurrence.
HEPATOBILIARY SURGERY AND NUTRITION
(2021)
Article
Medicine, General & Internal
Lea Penzkofer, Jens Mittler, Stefan Heinrich, Nicolas Wachter, Beate K. Straub, Roman Kloeckner, Fabian Stoehr, Simon Johannes Gairing, Fabian Bartsch, Hauke Lang
Summary: Liver cirrhosis is a common risk factor for hepatocellular carcinoma (HCC), but a small percentage of HCC cases occur in non-cirrhotic livers. This study found that liver resection for non-cirrhotic HCC is an acceptable treatment approach with relatively good outcomes, even for extensive tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Gastroenterology & Hepatology
Lorenza Rimassa, Richard S. Finn, Bruno Sangro
Summary: Single-agent immune checkpoint inhibitors (ICIs) have limited efficacy in advanced hepatocellular carcinoma (HCC) patients, and approximately 30% of patients show intrinsic resistance to ICIs. Therefore, researchers are exploring combination therapies, such as anti-angiogenic agents and other ICIs. Some trials have shown promising results and potential for clinical application. However, there are still many unanswered questions that require further research.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, Research & Experimental
Mingzhen Zhou, Baorui Liu, Jie Shen
Summary: Hepatocellular carcinoma (HCC) is a common malignancy with late-appearing symptoms, making diagnosis and treatment challenging. Immunotherapy, including immune checkpoint inhibitors, liver cancer vaccines, and cellular therapies, has emerged as a new hope for HCC treatment by regulating the immune system to target liver cancer cells.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Chen-Ta Chi, Chi-Yi Chen, Chien-Wei Su, Po-Yueh Chen, Chi-Jen Chu, Keng-Hsin Lan, I-Cheng Lee, Ming-Chih Hou, Yi-Hsiang Huang
Summary: The study examines the impact of DAAs treatment on HCC patients with CHC in Taiwan, showing high SVR rates within BCLC B HCV-HCC patients and no increased risk of HCC recurrence or progression. For intermediate stage HCC patients, DAAs treatment results in a high percentage maintaining in BCLC B status.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Gastroenterology & Hepatology
Xin-Fei Xu, Han Wu, Ju-Dong Li, Lan-Qing Yao, Bin Huang, Yong-Kang Diao, Ting-Hao Chen, Wei-Min Gu, Zhong Chen, Jie Li, Yao-Ming Zhang, Hong Wang, Ying-Jian Liang, Ya-Hao Zhou, Chao Li, Ming-Da Wang, Cheng-Wu Zhang, Timothy M. Pawlik, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study found that the prognosis of solitary huge hepatocellular carcinoma (HCC) is associated with tumor morphology, with patients having balloon-shaped HCC (BS-HCC) showing better long-term survival after liver resection. This finding helps guide the treatment strategy for patients with solitary huge HCC.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Review
Oncology
Jianpeng Liu, Xinhua Chen, Shusen Zheng
Summary: Nanosecond pulsed electric field (nsPEF) is a novel and minimally invasive modality that can ablate solid tumors by inducing apoptosis. Recent studies show that nsPEF can induce immunogenic cell death of hepatocellular carcinoma (HCC) and stimulate the host immune response, potentially preventing HCC recurrence and metastasis. The potential mechanisms of how nsPEF enhances systemic anticancer immune responses were explored, demonstrating its promising role in HCC treatment.
FRONTIERS OF MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Jin Hean Koh, Darren Jun Hao Tan, Yuki Ong, Wen Hui Lim, Cheng Han Ng, Phoebe Wen Lin Tay, Jie Ning Yong, Mark D. Muthiah, Eunice X. Tan, Ning Qi Pang, Beom Kyung Kim, Nicholas Syn, Alfred Kow, Brian K. P. Goh, Daniel Q. Huang
Summary: Mortality after LR for HCC is nearly 50% higher compared to LT. Survival between LR and LT were similar in uninodular disease. The risk of recurrence after LR is threefold that of LT.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Medicine, General & Internal
Mauro Giuffre, Enrico Zuliani, Alessia Visintin, Paola Tarchi, Paola Martingano, Riccardo Pizzolato, Deborah Bonazza, Flora Masutti, Rita Moretti, Lory Saveria Croce
Summary: This study aims to determine factors associated with early recurrence of hepatocellular carcinoma (HCC). The results indicate that male gender and larger tumor nodules are the main risk factors for early HCC recurrence.
Article
Surgery
Fredrik Aberg, Jenny Abrahamsson, Andreas Schult, William Bennet, Magnus Rizell, Malin Sternby-Eilard
Summary: The RETREAT score was found to be a valid predictor of post-LT HCC recurrence in a European setting, capable of discriminating between high, intermediate, and low risk for HCC recurrence in a clinically significant manner. Prognosis after recurrence did not vary based on the RETREAT score in this study.
TRANSPLANT INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Review
Oncology
Maria Tampaki, George V. Papatheodoridis, Evangelos Cholongitas
Summary: Patients with decompensated hepatocellular carcinoma (HCC) have limited therapeutic options and are often excluded from clinical trials. Liver transplantation is the best treatment option, but strict criteria and donor shortages limit its availability. Locoregional treatments may provide a survival benefit if well tolerated. Systemic treatments, particularly immunotherapy, may be the safest choice based on real-life data. Close monitoring is necessary due to the high risk of liver disease deterioration.
Article
Surgery
Ruby Siu-Ting Lau, Philip Ip, Grace Lai-Hung Wong, Vincent Wai-Sun Wong, Eugene Jun-Yee Lo, Kandy Kam-Cheung Wong, Andrew Kai-Yip Fung, John Wong, Kit-Fai Lee, Kelvin Kwok-Chai Ng, Paul Bo-San Lai, Henry Lik-Yuen Chan, Charing Ching-Ning Chong
Summary: Preoperative liver stiffness measurement can predict late recurrence of hepatocellular carcinoma after curative resection.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Article
Surgery
Kit Fai Lee, Charing Ching Ning Chong, John Wong, Sunny Yue Sun Cheung, Andrew Kai Yip Fung, Hon Ting Lok, Eugene Yee Juen Lo, Paul Bo San Lai
Summary: Robotic spleen preserving distal pancreatectomy has advantages of shorter operative time and hospital stay compared to robotic distal pancreatectomy with Splenectomy, and it also avoids the risk of overwhelming postsplenectomy sepsis.
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND
(2022)
Editorial Material
Surgery
Paul B. S. Lai
Article
Surgery
Janet W. C. Kung, Charing C. N. Chong, Kit-Fai Lee, John Wong, Paul B. S. Lai, Kelvin K. C. Ng
Summary: This novel technique of using the falciform ligament to fashion an interposition tube graft for reconstruction of IVC and HV has shown promising short-term outcomes, offering the benefits of autologous tissue graft with customizable dimensions.
JOURNAL OF VASCULAR SURGERY CASES INNOVATIONS AND TECHNIQUES
(2021)
Article
Computer Science, Interdisciplinary Applications
Xin Lai, Xiao Li, Liu Liu, Fugee Tsung, Paul B. S. Lai, Jiayin Wang, Xuanping Zhang, Xiaoyan Zhu, Jiaqi Liu
Summary: This study extends the risk-adjusted monitoring approach to include both average surgical risk changes and the existence of variance, leading to improved monitoring efficiency. Simulation results show that the proposed method is more efficient in detecting changes in surgical performance variance and small shifts in risk.
COMPUTERS & INDUSTRIAL ENGINEERING
(2021)
Editorial Material
Surgery
Paul B. S. Lai
Article
Gastroenterology & Hepatology
Alissa Michelle Wong, Xiaofan Ding, Aikha Melissa Wong, Mingjing Xu, Luyao Zhang, Howard Ho-Wai Leung, Anthony Wing-Hung Chan, Qi Xiu Song, Joseph Kwong, Loucia Kit-Ying Chan, Matthew Man, Mian He, Jinna Chen, Zhe Zhang, Wenxing You, Coleen Lau, Allen Yu, Yingying Wei, Yunfei Yuan, Paul Bo-San Lai, Jingmin Zhao, Kwan Man, Jun Yu, Michael Kahn, Nathalie Wong
Summary: The study revealed unique mutational processes in the livers of NAFLD-HCC patients, suggesting susceptibility to tumor formation through defective DNA repair pathways. CTNNB1 mutation plays a significant role in immune exclusion, providing important insights for the development of potential therapies.
JOURNAL OF HEPATOLOGY
(2022)
Editorial Material
Surgery
Paul B. S. Lai
Article
Surgery
Angela Y. W. Yuen, Justin C. Y. Chan, Man-Ping Luk, Kit-fai Lee, Tak-wing Lai, Paul B. S. Lai, Kelvin K. C. Ng, Charing C. N. Chong
Summary: This study evaluated the performance of a biodegradable pancreatic stent in pancreatoduodenectomy, with a high technical success rate and no hospital mortality, but some patients experienced complications such as post-operative pancreatic fistula.
Editorial Material
Surgery
Paul B. S. Lai
Editorial Material
Surgery
Paul B. S. Lai
Article
Immunology
Wenshu Tang, Jingying Zhou, Weiqin Yang, Yu Feng, Haoran Wu, Myth T. S. Mok, Lingyun Zhang, Zhixian Liang, Xiaoyu Liu, Zhewen Xiong, Xuezhen Zeng, Jing Wang, Jiahuan Lu, Jingqing Li, Hanyong Sun, Xiaoyu Tian, Philip Chun Yeung, Yong Hou, Heung Man Lee, Candice C. H. Lam, Howard H. W. Leung, Anthony W. H. Chan, Ka Fai To, John Wong, Paul B. S. Lai, Kelvin K. C. Ng, Simon K. H. Wong, Vincent W. S. Wong, Alice P. S. Kong, Joseph J. Y. Sung, Alfred S. L. Cheng
Summary: Obesity and hypercholesterolemia are major risk factors for hepatocellular carcinoma. This study found that obesity leads to hepatic cholesterol accumulation, which suppresses natural killer T (NKT) cell-mediated antitumor immunosurveillance. By lowering cholesterol and inhibiting cholesterol biosynthesis, the function of NKT cells can be restored to prevent HCC development promoted by obesity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jianqing Yu, Xianfeng Xia, Yujuan Dong, Zhongqin Gong, Gang Li, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 is significantly down-regulated in HCC tumor tissues and its high expression is associated with better prognosis. CYP1A2 functions as a tumor suppressor in HCC by inhibiting HGF/MET signaling and MMPs expression, thus reducing cell growth and invasion capabilities.
Article
Biochemistry & Molecular Biology
Jianqing Yu, Nuozhou Wang, Zhongqin Gong, Liping Liu, Shengli Yang, George Gong Chen, Paul Bo San Lai
Summary: The study revealed that CYP1A2 can sensitize sorafenib-resistant cells to the drug by inhibiting the NF-kappa B p65 axis, thereby increasing drug sensitivity and enhancing the inhibitory effect of the drug.
Article
Surgery
Kit-fai Lee, Charing Chong, Sunny Cheung, John Wong, Andrew Fung, Hon-ting Lok, Eugene Lo, Paul Lai
Summary: Compared with open hepatectomy, robotic hemihepatectomy has longer operation time but shorter hospital stay. The use of robot is feasible and effective in hemihepatectomy, with the benefit of shorter hospital stay.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)