Tau pathology: predictive diagnostics, targeted preventive and personalized medicine and application of advanced research in medical practice

GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?

(2017) Ana Martinez et al.   JOURNAL OF ALZHEIMERS DISEASE

Stratification of Patients is the Way to Go to Develop Neuroprotective/Disease-Modifying Drugs for Alzheimer's Disease

(2017) Khalid Iqbal et al.   JOURNAL OF ALZHEIMERS DISEASE

Tau Phosphorylated at Tyrosine 394 is Found in Alzheimer's Disease Tangles and can be a Product of the Abl-Related Kinase, Arg

(2017) Matthew A. Tremblay et al.   JOURNAL OF ALZHEIMERS DISEASE

The H1 Haplotype of the Tau Gene (MAPT) is Associated with Mild Cognitive Impairment

(2017) Emilio Di Maria et al.   JOURNAL OF ALZHEIMERS DISEASE

Interneuronal Transfer of Human Tau Between Lamprey Central Neurons in situ

(2017) WonHee Kim et al.   JOURNAL OF ALZHEIMERS DISEASE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

The Distribution and Most Recent Common Ancestor of the 17q21 Inversion in Humans

(2010) Michael P. Donnelly et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Combining MR Imaging, Positron-Emission Tomography, and CSF Biomarkers in the Diagnosis and Prognosis of Alzheimer Disease

(2010) K.B. Walhovd et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Correlation of Longitudinal Cerebrospinal Fluid Biomarkers With Cognitive Decline in Healthy Older Adults

(2010) Erik Stomrud et al.   ARCHIVES OF NEUROLOGY

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance

(2010) Max A. Tischfield et al.   CELL

Tau Pathology and Future Therapeutics

(2010) I. Gozes   Current Alzheimer Research

CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's Disease

(2010) A. M. Fjell et al.   JOURNAL OF NEUROSCIENCE

Analysis of Human Tau in Cerebrospinal Fluid

(2010) Katja Hanisch et al.   JOURNAL OF PROTEOME RESEARCH

‘Prion-Like’ Propagation of Mouse and Human Tau Aggregates in an Inducible Mouse Model of Tauopathy

(2010) Astrid Sydow et al.   Neurodegenerative Diseases

Metastatic breast tumors express increased tau, which promotes microtentacle formation and the reattachment of detached breast tumor cells

(2010) M A Matrone et al.   ONCOGENE

NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse—A microtubule-deficient model of schizophrenia

(2010) Avia Merenlender-Wagner et al.   PEPTIDES

Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis

(2009) Jane Marian Anderson et al.   ACTA NEUROPATHOLOGICA

Development of Tau Aggregation Inhibitors for Alzheimer's Disease

(2009) Bruno Bulic et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Identification of Aminothienopyridazine Inhibitors of Tau Assembly by Quantitative High-Throughput Screening

(2009) Alex Crowe et al.   BIOCHEMISTRY

Tau-Focused Immunotherapy for Alzheimers Disease and Related Tauopathies

(2009) Einar Sigurdsson   Current Alzheimer Research

Addressing Alzheimers Disease Tangles: From NAP to AL-108

(2009) Illana Gozes et al.   Current Alzheimer Research

Peptide Inhibitors Targeting Protein Kinases

(2009) Hagit Eldar-Finkelman et al.   CURRENT PHARMACEUTICAL DESIGN

NAP protects against cytochrome c release: Inhibition of the initiation of apoptosis

(2009) Ilona Zemlyak et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Validation of Alzheimer’s disease CSF and plasma biological markers: The multicentre reliability study of the pilot European Alzheimer’s Disease Neuroimaging Initiative (E-ADNI)

(2009) Katharina Buerger et al.   EXPERIMENTAL GERONTOLOGY

Heterogeneous nuclear ribonucleoprotein E3 modestly activates splicing of tau exon 10 via its proximal downstream intron, a hotspot for frontotemporal dementia mutations

(2009) Yan Wang et al.   GENE

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation

(2009) Dominik Paquet et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport

(2009) Will Stoothoff et al.   JOURNAL OF NEUROCHEMISTRY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies

(2009) Kurt R. Brunden et al.   NATURE REVIEWS DRUG DISCOVERY

NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

(2009) Natalia Shiryaev et al.   NEUROBIOLOGY OF DISEASE

Alzheimer's Disease Neuroimaging Initiative: A one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition

(2009) Alex D. Leow et al.   NEUROIMAGE

Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis

(2009) Manjit Braitch et al.   NEUROIMMUNOMODULATION

Tau phosphorylation: the therapeutic challenge for neurodegenerative disease

(2009) Diane P. Hanger et al.   TRENDS IN MOLECULAR MEDICINE

Kinetic Studies of Cdk5/p25 Kinase: Phosphorylation of Tau and Complex Inhibition by Two Prototype Inhibitors

(2008) Min Liu et al.   BIOCHEMISTRY

NAP and D-SAL: neuroprotection against the β amyloid peptide (1–42)

(2008) Illana Gozes et al.   BMC NEUROSCIENCE

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics

(2008) Hanna Rosenmann et al.   EXPERIMENTAL NEUROLOGY

The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush

(2008) T. Jehle et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Dissociation of tau toxicity and phosphorylation: role of GSK-3β, MARK and Cdk5 in a Drosophila model

(2008) Shreyasi Chatterjee et al.   HUMAN MOLECULAR GENETICS

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Animal models of Alzheimer's disease and frontotemporal dementia

(2008) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Establishing short-term prognosis in Frontotemporal Lobar Degeneration spectrum: Role of genetic background and clinical phenotype

(2008) Barbara Borroni et al.   NEUROBIOLOGY OF AGING

Lithium, a Potential Protective Drug in Alzheimer’s Disease

(2008) T. Engel et al.   Neurodegenerative Diseases

Levels of brain related proteins in cerebrospinal fluid: An aid in the differential diagnosis of parkinsonian disorders

(2008) Radu Constantinescu et al.   PARKINSONISM & RELATED DISORDERS

Akt and CHIP coregulate tau degradation through coordinated interactions

(2008) C. A. Dickey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling

(2008) S. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau-Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching

(2008) Or A. Shemesh et al.   TRAFFIC

New directions for frontotemporal dementia drug discovery

(2007) John Q. Trojanowski et al.   Alzheimers & Dementia

Pattern of Tau forms in CSF is altered in progressive supranuclear palsy

(2007) B. Borroni et al.   NEUROBIOLOGY OF AGING

Complete Sequence of a Novel Protein Containing a Femtomolar-Activity-Dependent Neuroprotective Peptide

(2003) Merav Bassan et al.   JOURNAL OF NEUROCHEMISTRY