Article
Oncology
Heloise Smet, David Martin, Emilie Uldry, Rafael Duran, Raphael Girardet, Niklaus Schaefer, John O. Prior, Alban Denys, Nermin Halkic, Nicolas Demartines, Emmanuel Melloul
Summary: This study aimed to compare future liver remnant function (FLR-F) assessed by hepatobiliary scintigraphy (HBS) with FLR volume (FLR-V) in predicting posthepatectomy liver failure (PHLF). The study found that FLR function gain after portal vein embolization or liver venous deprivation could predict PHLF effectively.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fabiana Grisanti, Elena Prieto, Juan Fernando Bastidas, Lidia Sancho, Pablo Rodrigo, Carmen Beorlegui, Mercedes Inarrairaegui, Jose Ignacio Bilbao, Bruno Sangro, Macarena Rodriguez-Fraile
Summary: This study identified that the mean absorbed dose in non-tumoral treated volumes (NTL-Dmean) and the fraction of NTL exposed to >= 30 Gy (NTL-V30) were significantly associated with an increase in future liver remnant (FLR) after lobar/extended lobar SIRT with Y-90-resin microspheres, particularly among patients with T0-FLR < 30%. When >= 49% of NTL received >= 30 Gy, FLR increased to >= 40% with higher accuracy among patients with T0-FLR < 30%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Carole Allimant, Emmanuel Deshayes, Marilyne Kafrouni, Lore Santoro, Delphine de Verbizier, Marjolaine Fourcade, Christophe Cassinotto, Margaux Hermida, Chloe Guillot, Denis Mariano-Goulart, Boris Guiu
Summary: Y-90-radioembolization with personalized dosimetry induces significant regional changes in liver function over time. Treated liver function decreases significantly after the procedure, while nontreated liver function recovers after 3 months and greatly increases afterwards.
Article
Chemistry, Multidisciplinary
Alessia Milano, Alex Vergara Gil, Enrico Fabrizi, Marta Cremonesi, Ivan Veronese, Salvatore Gallo, Nico Lanconelli, Riccardo Faccini, Massimiliano Pacilio
Summary: The study validates a novel treatment planning system based on Monte Carlo for personalized radioembolization of liver malignancies. It emphasizes the importance of personalized dosimetry in accurately estimating absorbed dose, especially in the presence of tissue heterogeneities.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Matteo Serenari, Diletta Calabro, Rachele Bonfiglioli, Stefano Fanti, Matteo Ravaioli
Summary: Recent studies suggest that incorporating a noninvasive and low-cost functional test is more reliable than considering liver volume alone in predicting liver failure posthepatectomy, especially with advancements in liver regeneration techniques. This case report details a unique case of a 40-year-old male who underwent heterotopic liver transplantation, with hepatobiliary scintigraphy performed to monitor graft function and regeneration prior to native liver removal.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Philippe d'Abadie, Michel Hesse, Amandine Louppe, Renaud Lhommel, Stephan Walrand, Francois Jamar
Summary: The article discusses the development of inert microspheres labeled with radionuclides for intra-arterial treatment of liver tumors over the past two decades. These microspheres are designed to deliver high levels of local radiation to liver tumors by embolizing them into hepatic capillaries accessible through the hepatic artery. The study focuses on the relationship between microsphere properties and internal dosimetry parameters.
Review
Oncology
Laura Crocetti, Elena Bozzi, Paola Scalise, Irene Bargellini, Giulia Lorenzoni, Davide Ghinolfi, Daniela Campani, Emanuele Balzano, Paolo De Simone, Roberto Cioni
Summary: Liver transplantation is the primary treatment for patients with unresectable early-stage hepatocellular carcinoma and cirrhosis. While traditional Milan criteria are restrictive, there is a trend towards expanding inclusion criteria due to a limited organ supply. Locoregional therapies play a crucial role in selecting patients who will benefit the most from transplantation and meet the criteria for transplantation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kailash Chaurasiya, Elena Kireeva, Mikhail Yadgarov, Dmitry Akhaladze, Yury Likar
Summary: This study evaluated the use of future remnant liver volume and the ratio of remnant liver volume to body weight in assessing liver function before hepatectomy in pediatric patients with liver tumors. The findings suggest that hepatobiliary scintigraphy can be used for future remnant liver function assessment in children with a remnant liver volume of less than 25% to prevent posthepatectomy liver failure.
CLINICAL NUCLEAR MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Leana Frankul, Catherine Frenette
Summary: Downstaging treatment is crucial for patients with unresectable hepatocellular carcinoma who are not eligible for liver transplantation, but severe organ shortage limits its broader application. Debate over the optimal treatment protocol and assessment method for downstaging treatment is pushing the boundaries of liver transplantation candidate selection.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fourat Ridouani, Mohamed M. Soliman, Ryan W. England, Meier Hsu, Chaya S. Moskowitz, Raphael Doustaly, Constantinos T. Sofocleous, F. Edward Boas, Hooman Yarmohammadi, Amy R. Deipolyi
Summary: This study aimed to investigate the relationship between tumoral and nontumoral radiation doses and response/toxicity in breast cancer patients with liver metastasis undergoing TARE. The results indicated that higher tumoral radiation doses were associated with objective response and longer survival, while pre-existing liver dysfunction was linked to increased hepatotoxicity and reduced survival.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amirtaha Taebi, Nursultan Janibek, Roger Goldman, Rex Pillai, Catherine T. Vu, Emilie Roncali
Summary: This study used computational simulation to investigate the effect of injection location on the distribution of Y-90 microspheres in the liver during radioembolization. The results showed that varying the injection location resulted in different microsphere distributions in the downstream vascular bed, and the radial movement of the catheter tip had a weaker effect on microsphere distribution when the injection plane was farther from the bifurcation.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Oncology
Qimeng Gao, Imran J. Anwar, Nader Abraham, Andrew S. Barbas
Summary: Immune checkpoint inhibitors have transformed the treatment of hepatocellular carcinoma, with increasing interest in using them in the neoadjuvant setting prior to liver transplantation. While liver transplant offers excellent outcomes for HCC patients, further research is needed to assess the safety and efficacy of using ICIs as bridging or downstaging therapies. Minimal washout periods between ICI use and liver transplantation are crucial factors to consider for successful transplant outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Stella, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Arthur J. A. T. Braat
Summary: This study compares the performance of an automatic method using the Ho-166-Tc-99m dual-isotope protocol with manual segmentation for healthy liver dosimetry and corresponding hepatotoxicity. The results show that the automatic segmentation method can accurately and quickly segment the liver without affecting the dosimetry assessment of Ho-166.
Article
Radiology, Nuclear Medicine & Medical Imaging
Heying Duan, Mohamed H. Khalaf, Valentina Ferri, Lucia Baratto, Shyam M. Srinivas, Daniel Y. Sze, Andrei Iagaru
Summary: Tc-99m-MAA SPECT/CT showed great accuracy for treatment planning dosimetry. The SiPM-based PET/CT scanner demonstrated good image quality at a 10-min scan time in one bed position. A 5-min PET/CT scan time revealed acceptable image quality, which is sufficient for dosimetry and treatment verification.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin P. Lopez, Armeen Mahvash, James P. Long, Marnix G. E. H. Lam, S. Cheenu Kappadath
Summary: This study investigates the accuracy and biases of predicted lung shunt fraction (LSF) and lung dose (LD) calculations using Tc-99m-macro-aggregated albumin (Tc-99m-MAA) planar imaging for treatment planning of Y-90-microsphere radioembolization. The results suggest that calculating planar LSF from lung and liver contours of a single view and using that same LSF and 1000 g lung mass can improve accuracy and minimize bias in planar lung dosimetry.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caren van Roekel, Remco Bastiaannet, Maarten L. J. Smits, Rutger C. Bruijnen, Arthur J. A. T. Braat, Hugo W. A. M. de Jong, Sjoerd G. Elias, Marnix G. E. H. Lam
Summary: The study investigated the relationship between dose and effect in CRC patients treated with Ho-166 radioembolization, finding a significant dose-response relationship and a positive association between toxicity and parenchymal dose. Patients with a mean tumor-absorbed dose of more than 90 Gy had significantly better survival compared to those with less than 90 Gy.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Rob van Rooij
Summary: The study assessed gamma camera performance and SPECT image quality at high Ho-166 activities. Despite high count rates, images showed no artifacts, but accurate tumor dosimetry was impacted by dead time.
Article
Radiology, Nuclear Medicine & Medical Imaging
Evert-Jan P. A. Vonken, Rutger C. G. Bruijnen, Tom J. Snijders, Tatjana Seute, Marnix G. E. H. Lam, Bart de Keizer, Arthur J. A. T. Braat
Summary: Intraarterial administration of Lu-177-high-affinity (HA)-DOTATATE shows promising results for the treatment of meningiomas. It significantly increases tracer accumulation and is a safe improvement for salvage meningioma patients.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Stella, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Arthur J. A. T. Braat
Summary: This study investigated the relationship between lung dose and the occurrence of radiation pneumonitis after Y-90 radioembolization. The results showed that no radiation pneumonitis developed in patients with a measured lung mean dose (LMDY-90) lower than 12 Gy.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sander C. Ebbers, Tessa Brabander, Margot E. T. Tesselaar, Johannes Hofland, Manon N. G. J. A. Braat, Frank J. Wessels, Maarten W. Barentsz, Marnix G. E. H. Lam, Arthur J. A. T. Braat
Summary: Sequential treatment with PRRT and [Ho-166]-radioembolization can achieve additional tumor reduction in patients with neuroendocrine tumor liver metastases. The hematotoxicity profiles are temporary, and the changes in NLR and TLR can serve as early predictors of treatment response.
Article
Radiology, Nuclear Medicine & Medical Imaging
Margot T. M. Reinders, Karel J. van Erpecum, Maarten L. J. Smits, Arthur J. A. T. Braat, Joep de Bruijne, Rutger Bruijnen, Dave Sprengers, Robert A. de Man, Erik Vegt, Jan N. M. IJzermans, Adriaan Moelker, Marnix G. E. H. Lam
Summary: This study aimed to determine the toxicity profile of 166Ho radioembolization in HCC patients who met certain criteria. The results showed low major toxicity and efficacy, supporting further evaluation.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Stella, Arthur J. A. T. Braat, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Rob van Rooij
Summary: This study assessed the accuracy of automatic healthy-liver segmentation using Tc-99m images and investigated the impact of different Tc-99m activities on Ho-166-scout images. The results showed that Tc-99m image reconstructions and automatic healthy-liver segmentation were independent of Tc-99m activity, while the reconstructed Ho-166 count density was influenced by downscatter correction. Tc-99m could be injected up to at least 126 MBq without compromising Ho-166 image quality.
Review
Oncology
Khalil Ramdhani, Arthur J. A. T. Braat
Summary: This review provides basic insights into radioembolization as a treatment for neuroendocrine liver metastases, discussing its promising results in terms of efficacy and toxicity, as well as the need for clarification of data and challenges in this field.
Article
Biochemistry & Molecular Biology
Esmee C. A. van der Sar, Adinda J. S. Kuhr, Sander C. Ebbers, Andrew M. Henderson, Bart de Keizer, Marnix G. E. H. Lam, Arthur J. A. T. Braat
Summary: This study investigated the predictive ability of PET/CT imaging factors before and after [Lu-177]Lu-PSMA-617 treatment in metastatic castration resistant prostate cancer patients. The study found that SUVpeak of the most avid lesion was the key factor in predicting the imaging-based response at the patient-level.
Article
Medicine, General & Internal
Manon N. Braat, Caren van Roekel, Marnix G. Lam, Arthur J. Braat
Summary: The aim of this study was to assess changes in [F-18]FDG liver metabolism after hepatic Y-90 resin radioembolization. The study found that the [F-18]FDG metabolism in the normal liver parenchyma is significantly but mildly increased after radioembolization, which can interfere with its use as a threshold for therapy response.
Article
Radiology, Nuclear Medicine & Medical Imaging
Esmee C. A. van der Sar, Sebastiaan L. Meyer Viol, Arthur J. A. T. Braat, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Bart de Keizer
Summary: This study evaluates the possibility of a shorter time interval between [Ga-68]Ga-PSMA administration and PET/CT acquisition. The results show that a shorter time interval of 45 min instead of 60 min has a significant but small impact on image quality and lesion detection.
Article
Gastroenterology & Hepatology
Daan Andel, Jeroen Hagendoorn, Ahmed Aziz Alsultan, Miangela Marie Lacle, Maarten Leonard Johannes Smits, Arthur Johannes Anthonius Theodorus Braat, Onno Kranenburg, Marnix Gerard Ernest Hendrik Lam, Inne Hilbrand Max Borel Rinkes
Summary: This study found that the treatment response in patients with colorectal liver metastases who received radiation lobectomy was correlated with tumor proliferation, hypoxia, and cancer stem cell expression. Non-responsive lesions had a high presence of cancer stem cells, while responding lesions were more hypoxic. These findings emphasize the importance of prompt resection after radiation lobectomy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Martina Stella, Rob van Rooij, Marnix G. E. H. Lam, Hugo W. A. M. de Jong, Arthur J. A. T. Braat
Summary: This study compares the performance of an automatic method using the Ho-166-Tc-99m dual-isotope protocol with manual segmentation for healthy liver dosimetry and corresponding hepatotoxicity. The results show that the automatic segmentation method can accurately and quickly segment the liver without affecting the dosimetry assessment of Ho-166.
Article
Pediatrics
Isabelle S. A. de Vries, Roelof van Ewijk, Laura M. E. Adriaansen, Anneloes E. Bohte, Arthur J. A. T. Braat, Raquel Davila Fajardo, Laura S. Hiemcke-Jiwa, Marinka L. F. Hol, Simone A. J. ter Horst, Bart de Keizer, Rutger R. G. Knops, Michael T. Meister, Reineke A. Schoot, Ludi E. Smeele, Sheila Terwisscha van Scheltinga, Bas Vaarwerk, Johannes H. M. Merks, Rick R. van Rijn
Summary: Rhabdomyosarcoma is the most common soft tissue sarcoma in children and adolescents, although it is rare. It can occur in various parts of the body, with the head and neck, genitourinary tract, and extremities being the most common sites. The optimal approach to diagnosing and treating rhabdomyosarcoma involves a multidisciplinary team and multimodal treatment. Despite improvements in survival, further advancements in management are necessary as the 5-year overall survival rate varies from 35% to 100% depending on the disease and patient characteristics. In the journey of two patients with rhabdomyosarcoma, the role and impact of the pediatric radiologist and nuclear physician in the clinical setting are discussed, emphasizing the implementation of guidelines and providing up-to-date insights on all aspects of the disease, from diagnosis to follow-up.
PEDIATRIC RADIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Martina Stella, Arthur J. A. T. Braat, Rob van Rooij, Hugo W. A. M. de Jong, Marnix G. E. H. Lam
Summary: Since its suggestion as a possible option for liver radioembolization treatment, holmium-166 (Ho-166) has attracted attention due to its imaging possibilities and potential for individualized treatment. Ho-166 can be imaged using single-photon emission computed tomography and magnetic resonance imaging, and also allows for both scout and treatment procedures with the same particle.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)