Journal
FRONTIERS IN ONCOLOGY
Volume 3, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2013.00302
Keywords
W-CIN; chromosomal instability; intra-tumor heterogeneity; aneuploidy; cancer
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Funding
- Intramural Research Program of the National Institute of Health, National Cancer Institute, Center for Cancer Research
- NATIONAL CANCER INSTITUTE [ZICBC010930] Funding Source: NIH RePORTER
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Whole-chromosomal instability (W-CIN) unequal chromosome distribution during cell division is a characteristic feature of a majority of cancer cells distinguishing them from their normal counterparts. The precise molecular mechanisms that may cause mis-segregation of chromosomes in tumor cells just recently became more evident. The consequences of W-CIN are numerous and play a critical role in carcinogenesis. W-CIN mediates evolution of cancer cell population under selective pressure and can facilitate the accumulation of genetic changes that promote malignancy. It has both tumor-promoting and tumor suppressive effects, and their balance could be beneficial or detrimental for carcinogenesis. The characterization of W-CIN as a complex multi-layered adaptive phenotype highlights the intra- and extracellular adaptations to the consequences of genome reshuffling. It also provides a framework for targeting aggressive chromosomally unstable cancers.
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