Article
Oncology
Yang-kun Wang, Xue-xia Lv, Zhi-qiang Wang, Yong-mei Zhou, Bo Jiang, Su-nan Wang, Xiao-dong Chen
Summary: This study aimed to investigate the relationship between microlymphangiogenesis, microangiogenesis, and combined detection of PD-1/ki67 in gastric cancer patients and their disease prognosis. Immunohistochemistry was used to detect microlymphatic density (MLD) and microvessel density (MVD) in different zones of gastric cancer tissue, as well as the expression of PD-1 and ki67. The results showed that the central zone had fewer atretic cord-like lymphatic vessels but the peripheral zone had more lymphatic vessels, and the MLD was significantly decreased in the central zone compared to the peripheral zone. The expression of PD-1 and ki67 also differed between the zones. The differences in microlymphangiogenesis, microangiogenesis, and PD-1/ki67 expression were not statistically significant among different histological types, but were significantly decreased in early-stage gastric cancer compared to advanced-stage cancer. These findings suggest that MLD, MVD, PD-1, and ki67 are important indicators for predicting the prognosis of gastric cancer.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Yunlong Yang, Yihai Cao
Summary: Metastasis, the leading cause of cancer-associated mortality, is still poorly understood. Both blood and lymphatic vasculatures play crucial roles in distal metastasis, with VEGF being a key angiogenic factor. Anti-VEGF drugs have been widely used in clinical treatment of various cancers, but their impact on cancer metastasis and systemic disease is largely unknown.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Kruszyna, Dawid Murawa, Pawel Piotr Jagodzinski, Grzegorz Oszkinis, Zbigniew Krasinski
Summary: The expression of VEGF and CXCR4 in gastric cancer and their prognostic significance were investigated. The study found that high expression of VEGF and CXCR4 correlated with tumor progression and poor prognosis.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Laura Dupont, Loic Joannes, Florent Morfoisse, Silvia Blacher, Christine Monseur, Christophe F. Deroanne, Agnes Noel, Alain C. M. A. Colige
Summary: The study demonstrates that ADAMTS2 and ADAMTS14 are as efficient as ADAMTS3 in activating pro-VEGFC and play a crucial role in maintaining the homeostasis of the lymphatic vasculature in adulthood.
Article
Chemistry, Multidisciplinary
Zhonghua Wu, Bicheng Qu, Minxian Yuan, Jingjing Liu, Cen Zhou, Mingwei Sun, Zhexu Guo, Yaqing Zhang, Yongxi Song, Zhenning Wang
Summary: The overexpression of cysteine-rich intestinal protein-1 (CRIP1) in gastric cancer promotes lymphangiogenesis and lymphatic vessel permeability, leading to lymphatic metastasis. This study uncovers the role and mechanism of CRIP1 in mediating gastric cancer lymphatic metastasis, providing potential targets for future therapeutics.
Review
Immunology
Xiaoxin Liu, Xinyu Li, Haotian Wei, Yanyan Liu, Ningxu Li
Summary: The characteristics of tumour cells and their interactions with the tumour microenvironment influence cancer prognosis. Mast cells (MCs), known for their role in allergic responses, have been found to be associated with tumour development. In colorectal cancer (CRC), MC proliferation is linked to angiogenesis, lymph node involvement, and patient prognosis. MCs play a significant role in CRC development by releasing angiogenic and lymphangiogenic factors. Additionally, MCs can actively promote tumour growth through signaling pathways and histamine production. This article discusses the impact of MC-derived mediators on tumour growth, the prognostic importance of MCs in CRC patients, and the crosstalk between MCs and CRC cells in the tumour microenvironment, highlighting the need for a deeper understanding of MC function in CRC and the potential of targeting MCs as a therapeutic approach in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Jia Wang, Xue Dong, Dandan Li, Zhiyao Fang, Xianyao Wan, Jing Liu
Summary: This study found that fucoxanthin can inhibit lymphangiogenesis and lymph node metastasis in gastric cancer by regulating Ran expression and the importin beta/NF-kappa B/VEGF-C nuclear transport signaling pathway. These novel findings provide the basis for the research and development of novel treatments using traditional Chinese medicine in the treatment of lymph node metastasis, which has important theoretical significance and clinical value.
Article
Medicine, General & Internal
Anni Kujala, Elina Valkonen, Hanna Sallinen, Laura Tuppurainen, Hanne Laakso, Elias Yla-Herttuala, Timo Liimatainen, Jouni Kujala, Otto Jokelainen, Reijo Sironen, Maarit Anttila, Seppo Yla-Herttuala
Summary: The study shows that the combined use of AAV8-sVEGFR2 and AAV8-sVEGFR3 with chemotherapy can reduce intratumoral angiogenesis and tumor growth in an ovarian cancer mouse model, improving overall survival. The antitumoral effect was mainly attributed to AAV8-sVEGFR2.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Karina Hadrian, Sebastian Willenborg, Felix Bock, Claus Cursiefen, Sabine A. Eming, Deniz Hos
Summary: Macrophages play a critical role in tissue vascularization in both health and disease contexts. Understanding the mechanisms of macrophage-mediated blood and lymphatic vessel growth in different tissues can provide insights into potential therapeutic interventions for various diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giovanna Azzarito, Michele Visentin, Brigitte Leeners, Raghvendra K. Dubey
Summary: Vascular and lymphatic vessels play a crucial role in breast cancer growth and metastasis. The study found that the secretome of estrogen receptor-positive breast cancer cells can stimulate vascular angiogenesis and inhibit lymphatic growth, which has significant pathological and physiological implications for breast cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marissa J. Harmsen, Arda Arduc, Maaike C. G. Bleeker, Lynda J. M. Juffermans, Arjan W. Griffioen, Ekaterina S. Jordanova, Judith A. F. Huirne
Summary: Evidence suggests that adenomyosis patients have increased angiogenesis and lymphangiogenesis in both ectopic and eutopic endometrium. This finding indicates a potential link between adenomyosis and blood vessel and lymph vessel formation in the endometrium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Tingting Zhu, Zhangding Wang, Tianhui Zou, Lei Xu, Shu Zhang, Yali Chen, Chen Chen, Weijie Zhang, Shouyu Wang, Qingqing Ding, Guifang Xu
Summary: Metabolic reprogramming is a hallmark of malignancies such as gastric cancer, with the rate-limiting enzyme SOAT1 identified as highly expressed in cancerous tissues and associated with advanced tumor stage and lymph node metastasis. Inhibition of SOAT1 suppresses GC cell proliferation, cholesterol ester synthesis, and lymphangiogenesis, while overexpression promotes these processes by regulating cholesterol metabolism genes. Therefore, SOAT1 may serve as a promising prognostic biomarker for guiding clinical management and treatment decisions in gastric cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhui Bai, Xiaohang Jiao, Jinge Hu, Wenxin Xue, Ziyu Zhou, Weiqun Wang
Summary: This study found that Wilms' tumor 1-associated protein (WTAP) regulates macrophage recruitment to endothelial cells through N6-methyladenosine (m6A) modification of H3K9me3-mediated CCL2 gene transcription. Additionally, WTAP affects macrophage secretion of VEGFA/C/D through m6A-mediated translation regulation of HIF-1α, thereby influencing angiogenesis and lymphangiogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Zhe Ge, Shan Wu, Zhengtang Qi, Shuzhe Ding
Summary: This study found that moderate intensity constant load exercise has a better therapeutic effect on lung cancer compared to high-intensity interval exercise. It can reduce tumor growth and metastasis, as well as control tumor invasiveness. On the other hand, high-intensity interval exercise, although it can reduce the expression of a gene, may increase the metastatic ability of tumor tissues.
Article
Immunology
Xin Qing, Wenjing Xu, Shengli Liu, Zhencheng Chen, Chunping Ye, Yewei Zhang
Summary: This study systematically assessed the association between angiogenesis and gastric cancer (GC). The authors identified two molecular subtypes and determined the correlation between angiogenesis-associated genes mutations, clinicopathological characteristics, prognosis, immune cell infiltration, and tumor microenvironment. They established an AAG_score for predicting overall survival (OS) and created a reliable nomogram for clinical viability. The study provides insights into the characteristics of TME and potential immunotherapy strategies in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daiki Hirano, Yuji Urabe, Shinji Tanaka, Koki Nakamura, Yuki Ninomiya, Ryo Yuge, Ryohei Hayashi, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
Article
Gastroenterology & Hepatology
Naoki Yorita, Masanori Ito, Tomoyuki Boda, Takahiro Kotachi, Naoko Nagasaki, Madina Abuduwaili, Kosaku Hata, Yuichi Hiyama, Shiro Oka, Masaharu Yoshihara, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Medicine, General & Internal
Ryo Yuge, Toshiko Fujii, Kei Shinagawa, Yoji Sanomura, Shiro Oka, Shintaro Nagashima, Masayuki Ohisa, Yasuhiko Kitadai, Shinji Tanaka, Nobuoki Kohno, Junko Tanaka
Article
Oncology
Hidehiko Takigawa, Satoshi Masaki, Toshikatsu Naito, Ryo Yuge, Yuji Urabe, Shinji Tanaka, Kazuhiro Sentani, Taiji Matsuo, Keisuke Matsuo, Kazuaki Chayama, Yasuhiko Kitadai
Article
Pathology
Satoshi Masaki, Yoshimi Hashimoto, Shoma Kunisho, Akiko Kimoto, Yasuhiko Kitadai
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2020)
Article
Gastroenterology & Hepatology
Kenta Matsumoto, Shiro Oka, Shinji Tanaka, Katsuaki Inagaki, Yuki Okamoto, Hidenori Tanaka, Toshikatsu Naito, Masaki Wakai, Ken Yamashita, Yuki Ninomiya, Ryohei Hayashi, Yasuhiko Kitadai, Fumio Shimamoto, Kazuaki Chayama
Summary: The study found that linked color imaging (LCI) is a useful method for accurately assessing endoscopic activity and predicting relapse in patients with ulcerative colitis. LCI can detect mild inflammation unrecognized by white light imaging, making it a valuable tool in clinical practice for UC management.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Naoki Yorita, Ryo Yuge, Hidehiko Takigawa, Atsushi Ono, Toshio Kuwai, Kazuya Kuraoka, Yasuhiko Kitadai, Shinji Tanaka, Kazuaki Chayama
Summary: This study found that the combination of anti-PD-1 antibody and imatinib has an anti-tumor effect on excluded-type tumors in colorectal cancer. The combination therapy suppressed stromal reaction and increased the number of CD8-positive T cells in the tumor nest, suggesting potential efficacy for CRC cases resistant to anti-PD-1 monotherapy.
Article
Oncology
Katsuaki Inagaki, Shoma Kunisho, Hidehiko Takigawa, Ryo Yuge, Shiro Oka, Shinji Tanaka, Fumio Shimamoto, Kazuaki Chayama, Yasuhiko Kitadai
Summary: Macrophages, especially M2 subtype, play a crucial role in colorectal cancer progression, with high M2 macrophage count at the invasive front correlated with poor clinicopathological features like lymphovascular invasion and metastasis. The M2/M1 ratio could be a better predictor of lymph node metastasis risk than individual macrophage counts.
Article
Cell Biology
Akiko Kimoto, Shoma Kunisho, Ryohei Morita, Minako Onishi, Qian Zhou, Atsushi Ono, Daiki Miki, Fumio Shimamoto, Yasuhiko Kitadai
Summary: This study investigated the effects of low-dose alcohol consumption on colorectal cancer development using a transplant colon cancer model. The results showed that low-dose alcohol intake significantly inhibited tumor growth and caused changes in T-cell immunity and gut microbiome composition.
Article
Gastroenterology & Hepatology
Toshikatsu Naito, Ryo Yuge, Shinji Tanaka, Rina Otani, Hiroki Kadota, Hidehiko Takigawa, Tadamasa Tamura, Kazuhiro Sentani, Wataru Yasui, Yasuhiko Kitadai, Kazuaki Chayama
Summary: A 53-year-old woman presented with chest discomfort after meals and was found to have multiple granular elevations in the gastric body. Treatment to eradicate Helicobacter pylori and H. suis was successful in eliminating the bacteria, although the granular elevations persisted without lymphoma cells present.
CLINICAL JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Tomoyuki Nishimura, Shiro Oka, Shinji Tanaka, Naoki Asayama, Shinji Nagata, Yuzuru Tamaru, Toshio Kuwai, Ken Yamashita, Yuki Ninomiya, Yasuhiko Kitadai, Koji Arihiro, Kazuya Kuraoka, Mayumi Kaneko, Fumio Shimamoto, Kazuaki Chayama
Summary: This study showed that immunohistochemical lymphovascular evaluation is important for indicating additional surgery for T1 CRC patients after ESD, and can predict lymph node metastasis. Preoperative immunohistochemical testing has clinical significance in determining the presence of lymphovascular invasion.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Meeting Abstract
Oncology
Ryo Yuge, Yasuhiko Kitadai, Hidehiko Takigawa, Toshikatsu Naito, Shinji Tanaka, Kazuaki Chayama
Meeting Abstract
Oncology
Yuji Urabe, Shinji Tanaka, Daiki Hirano, Koki Nakamura, Yuki Ninomiya, Ryo Yuge, Shiro Oka, Yasuhiko Kitadai, Fumio Shimamoto, Koji Arihiro, Kazuaki Chayama
Meeting Abstract
Oncology
Fumio Shimamoto, Yasuhiko Kitadai, G. Qi, Tunemi Okamoto, Rina Haruki, Hnae Izu
Meeting Abstract
Oncology
Toshikatsu Naito, Yasuhiko Kitadai, Hidehiko Takigawa, Ryo Yuge, Toshio Kuwai, Wataru Yasui, Shinji Tanaka, Kazuaki Chayama
