Article
Multidisciplinary Sciences
Ji-Hye Choi, Bok-Soon Lee, Jeon Yeob Jang, Yun Sang Lee, Hyo Jeong Kim, Jin Roh, Yoo Seob Shin, Hyun Goo Woo, Chul-Ho Kim
Summary: This study profiles the molecular mechanisms behind the stepwise progression of HNSCC through single-cell RNA-seq analysis. It reveals the role of interactions with the tumor microenvironment in the progression of HNSCC.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Molly E. Heft Neal, J. Chad Brenner, Mark E. P. Prince, Steven B. Chinn
Summary: Cancer stem cells play a crucial role in head and neck cancer, affecting tumor heterogeneity, treatment resistance, metastasis, and recurrence. Recent evidence shows that the tumor microenvironment plays a key role in maintaining the cancer stem cell niche and promoting their plasticity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanli Jin, Seung-Nam Jung, Mi Ae Lim, Chan Oh, Yudan Piao, Hae Jong Kim, QuocKhanh Nguyena, Yea Eun Kang, Jae Won Chang, Ho-Ryun Won, Bon Seok Koo
Summary: The high expression of SHMT2 in head and neck cancer is associated with tumor invasion and metastasis. Silencing SHMT2 inhibits cell proliferation and invasion in HNC, while also affecting the expression of stemness markers and tumor spheroid formation. The study suggests that targeting SHMT2 may play an important role in inhibiting HNC progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Review
Cell Biology
Martina Raudenska, Jan Balvan, Michal Masarik
Summary: Many cancer therapies target apoptosis in cancer cells, but the presence of oncogenic alterations and tumor microenvironment composition limit their efficacy. There are about 10 different cell death subroutines that cancer cells cannot avoid, highlighting the need for individualized therapy. Understanding the molecular heterogeneity of tumors and their cell death pathways is crucial for improving treatment response.
CELL DEATH & DISEASE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shijin Yu, Zongjun Ma, Tao Chen, Hong Wang, Qin Yao, Jin Li, Jie Cheng
Summary: The overexpression of ETV5 in head and neck squamous cell carcinoma is associated with aggressive features and reduced survival. Silencing ETV5 inhibits cell proliferation, migration, invasion, and induces apoptosis in vitro, and impairs tumor growth in vivo. ETV5 activates Slug transcription by binding its promoter region in HNSCC cells. Patients with ETV5highSlughigh have the worst survival outcomes.
Article
Biochemistry & Molecular Biology
Fei Liu, Lindong Tang, Qing Li, Leihui Chen, Yuyue Pan, Zhao Yin, Jingjun He, Junzhang Tian
Summary: This study identified a close correlation between ferroptosis and the prognosis and development of HNSCC, suggesting that the ferroptosis pathway could be a potential therapeutic target for HNSCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Genetics & Heredity
Zeng-Hong Wu, Cheng Li, You-Jing Zhang, Wen Zhou
Summary: This study identifies key genes related to stemness in HNSCC by analyzing HNSCC mRNAsi data and gene interaction networks. The study reveals the critical role of these genes in HNSCC.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Annette Affolter, Anne Lammert, Johann Kern, Claudia Scherl, Nicole Rotter
Summary: Despite advances in precision medicine concepts such as targeted therapies and immune checkpoint inhibition for HNSCC, overall survival rates have not improved due to intratumoral and intertumoral heterogeneity hindering biomarker identification and lack of reliable preclinical models. There is an urgent need for tools to stratify patients and pave the way for personalized therapeutic options.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Mintao Xiao, Xinyi Zhang, Duoli Zhang, Shuai Deng, Anfu Zheng, Fukuan Du, Jing Shen, Lin Yue, Tao Yi, Zhangang Xiao, Yueshui Zhao
Summary: This study reveals the heterogeneity of cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC) and their underlying mechanisms in the formation of the tumor microenvironment (TME). The functional diversity and signal transduction of CSCs are found to play a crucial role in the progression of HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marilina Mascaro, Exequiel G. Alonso, Karen Schweitzer, Martin E. Rabassa, Jessica A. Carballido, Agustina Ibarra, Eliana N. Alonso, Vicente Bermudez, Lucia Fernandez Chavez, Georgina P. Colo, Maria Julia Ferronato, Pamela Pichel, Sergio Recio, Valentina Clemente, Maria Eugenia Fermento, Maria Marta Facchinetti, Alejandro C. Curino
Summary: This study elucidates the mechanisms of HO-1 in HNSCC, showing that high expression of HO-1 is associated with decreased patient survival. HO-1 promotes cell cycle progression and cell viability. HO-1's protumor activities depend, at least in part, on its nuclear localization.
Article
Oncology
Su Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Moonkyoo Kong, Seong-Gyu Ko, Young-Gyu Eun
Summary: This study examined the clinical significance of cancer stem cell (CSC) biomarker genes in head and neck squamous cell carcinoma (HNSCC) and found that the CSC gene expression signature is associated with the prognosis of HNSCC. It may help in personalized treatments, especially in cases with HPV (-) status.
Article
Oncology
Nils Ludwig, Saigopalakrishna S. Yerneni, Malgorzata Harasymczuk, Miroslaw J. Szczepanski, Alicja Gluszko, Wojciech Kukwa, Theresa Jordan, Gerrit Spanier, Juergen Taxis, Steffen Spoerl, Johannes K. Meier, Cynthia S. Hinck, Phil G. Campbell, Torsten E. Reichert, Andrew P. Hinck, Theresa L. Whiteside
Summary: This study investigates the contributions of TGF beta-carrying exosomes to the progression of head and neck squamous cell carcinoma (HNSCC). Circulating TGF beta(+) exosomes emerge as potential non-invasive biomarkers for disease progression in HNSCC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Benjamin Ross Belvin, Janina P. P. Lewis
Summary: This study demonstrates the importance of iron-related pathways in Head and Neck Squamous Cell Carcinoma (HNSCC) cell proliferation and growth. Overexpression of Ferroportin (FPN) inhibits HNSCC cell proliferation and colony formation by disrupting iron homeostasis and protecting cells from ferroptotic cell death. Iron-based interventions such as ferroptosis or iron chelation may have therapeutic potential in advanced HNSCC. Rating: 8/10.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cell Biology
Marisol Miranda-Galvis, Reid Loveless, Luiz Paulo Kowalski, Yong Teng
Summary: Environmental factors and genetic elements interact to influence one's susceptibility to cancer, particularly in the pathogenesis and progression of head and neck cancer. Latest research and treatment strategies emphasize the importance of gene-environment interactions, aiming to inhibit environmental drivers of tumor progression and improve survival outcomes for patients.
