Article
Pharmacology & Pharmacy
Andressa Daniele Artico Silva, Michelle Alvares Sarcinelli, Beatriz Ferreira de Carvalho Patricio, Marcelo Henrique da Cunha Chaves, Leandro Martins Lima, Patricia Martins Parreiras, Priscila de Faria Pinto, Livia Deris Prado, Helvecio Vinciius Antunes Rocha
Summary: Wet milling methods were used to prepare microcrystals and nanocrystals, which showed improved dissolution of racemate praziquantel, leading to enhanced bioavailability. The developed formulations exhibited significant anti-parasitic activity against both adult worms and infected mice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Eung-Dab Kim, Young-Sik Cho, Young-Duk Huh
Summary: In this study, Cu2O microcrystals with various shapes were successfully prepared by adjusting the reaction conditions. The morphology of Cu2O crystals changed with increasing reaction temperature, NaOH concentration, and glucose amount.
Article
Veterinary Sciences
Maria Elisa Melian, Manuel Ibarra, Laura Ceballos, Alejandro J. Paredes, Beatriz Munguia, Ricardo Faccio, Santiago Palma, Luis Ignacio Alvarez, Laura Dominguez
Summary: The pharmacokinetic behavior of self-dispersible nanocrystals (SDNCs) of the anthelmintic fenbendazole (FBZ) was compared to a physical mixture (PM) of its components in sheep. Results showed that the SDNCs treatment resulted in significantly higher plasma concentrations and exposure of FBZ and its metabolites compared to the PM treatment.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Mengyan Cao, Xiujian Zhao, Xiao Gong
Summary: In this work, stable Sb3+ and Bi3+ codoped Cs2ZrCl6 microcrystals were prepared on a large scale for highly efficient white light emission using ionic liquids. The dual emissions originate from the associated self-trapped excitons of the [SbCl6](3-) and [BiCl6](3-) octahedra. The method allows for facile synthesis of large batches of microcrystalline powders and shows potential for future applications in the lighting field.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Daofu Wu, Jiaer Zhou, Wei Kang, Kang An, Jiayu Yang, Miao Zhou, Peng He, Qiang Huang, Xiaosheng Tang
Summary: Lead halide perovskite has gained significant attention for its remarkable performance in optoelectronic applications, but its toxicity and instability have been major obstacles. This study introduces a facile synthesis process for novel lead-free CsAgCl2 perovskite microcrystals without organic ligands, showcasing excellent stability and potential applications in photocatalysis and photoelectrochemistry. The fundamental properties of CsAgCl2 microcrystals were characterized through temperature-dependent X-ray diffraction and photoluminescence measurements, revealing promising prospects for practical use.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Omary Mashiku Minzi, Rajabu Hussein Mnkugwe, Eliford Ngaimisi, Safari Kinung'hi, Anna Hansson, Anton Pohanka, Appolinary Kamuhabwa, Eleni Aklillu
Summary: The study found that co-administration of dihydroartemisinin-piperaquine significantly increases systemic exposure of praziquantel, which may contribute to the increased effectiveness of praziquantel + dihydroartemisinin-piperaquine combination therapy compared to praziquantel alone in treating schistosomiasis.
Article
Pharmacology & Pharmacy
Thomas Eason, Gisela Ramirez, Andrew J. Clulow, Malinda Salim, Ben J. Boyd
Summary: Praziquantel, a poorly water-soluble drug used to treat parasitic infections, shows slow dissolution in milk and biorelevant media compared to pharmacopoeial-recommended medium, despite reported positive food effect. This study reexamines praziquantel dissolution in biorelevant media and milk, incorporating digestion to mimic gastrointestinal conditions. The presence of sodium lauryl sulfate (SLS) in dissolution media promotes drug dissolution, and significant dissolution in milk is observed during digestion. This suggests potential use of milk to enhance oral bioavailability of praziquantel, and inclusion of digestion step in in vitro dissolution testing to reflect positive food effect in the presence of lipids.
Article
Chemistry, Physical
Xiaojing Xia, Anupum Pant, Xuezhe Zhou, Elena A. Dobretsova, Alexander B. Bard, Matthew B. Lim, Joo Yeon D. Roh, Daniel R. Gamelin, Peter J. Pauzauskie
Summary: Hydrothermal methods were used to synthesize four distinct crystal phases doped with Yb(III) ions within the potassium-lutetium-fluoride phase diagram, with the KLuF4 phase showing the most significant cooling effect and the K2LuF s phase demonstrating cooling for the first time in vacuum.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Physical
Weiqing Yang, Meilian Li, Mingyi Xie, Yuxi Tian
Summary: The photoluminescence (PL) and photothermal (PT) properties of CH3NH3PbBr3 (MAPbBr3) microcrystals (MCs) were simultaneously investigated using a home-built PL and PT microscope. The heterogeneity of PL and PT images and kinetics of different MCs were observed, and the variation in the absorption and dissipation of energy from the nonradiative channel was demonstrated. This study provides insights into the charge carrier behaviors of optoelectronic materials at the single particle level.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Biochemical Research Methods
Robert L. Shoeman, Elisabeth Hartmann, Ilme Schlichting
Summary: Recent technological advances have allowed for the use of much smaller crystals to obtain structural information. Microcrystals are particularly useful for structure determination using serial data collection approaches and time-resolved crystallography. This article describes milling and seeding techniques, as well as filtration approaches, for the reproducible and size-adjustable preparation of homogeneous nano- and microcrystals.
Article
Chemistry, Physical
Yangxiang Hu, Xinxin Yan, Liya Zhou, Peican Chen, Qi Pang, Yibo Chen
Summary: This study synthesized Mn2+-doped Cs3Cu2I5 microcrystals and significantly improved the luminescence performance by further introducing alkali metal ions (Rb+, K+, Na+), resulting in enhanced photoluminescence quantum yield (PLQY).
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Medicine, Research & Experimental
Reynaldo Salas-Zuniga, Karina Mondragon-Vasquez, Sergio Alcala-Alcala, Enrique Lima, Herbert Hopfl, Dea Herrera-Ruiz, Hugo Morales-Rojas
Summary: Nanoconfinement is a recent strategy to improve solubility and dissolution rate of active pharmaceutical ingredients (APIs) with poor biopharmaceutical properties. Combining cocrystals of racemic praziquantel (PZQ) with glutaric acid (PZQ-GLU) and confining them in mesoporous silica material leads to increased solubility and dissolution rate. The confined PZQ-GLU phase shows transient supersaturation behavior in simulated gastric fluid, providing a dissolution advantage over pristine PZQ.
MOLECULAR PHARMACEUTICS
(2022)
Article
Fisheries
Dimitra Kogiannou, Chrysanthi Nikoloudaki, Vasilia Valsamidi, Mado Kotsiri, Eleni Golomazou, George Rigos
Summary: The pharmacokinetics of orally administered praziquantel (PZQ) were studied in gilthead seabream, with rapid absorption and higher drug levels observed in both plasma and gills with the high dose regimen. However, the elimination rate of PZQ from fish tissues was fast.
Article
Chemistry, Physical
Liang Jing, Qingmei Cen, Qi Pang, Jin Zhong Zhang
Summary: Lead-free zero-dimensional all-inorganic perovskite microcrystals with Mn2+ and Bi3+ ions were synthesized and show enhanced red emission. The electronic bandgap and absorption were tuned by incorporating Bi3+ ions. A yellow-light LED device based on these microcrystals demonstrated high color saturation and stability.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Agriculture, Multidisciplinary
Meiyu Zhang, Fangyu Zhang, Jingli Qiu, Xiaogui Shu, Tong Zhou, Sijia Liu, Yaxin Wang, Rong Liu, Xiantong Zheng, Limin He
Summary: This study systematically investigated the pharmacokinetics, tissue distribution, and residue depletion of praziquantel in swine. The findings have important implications for rational dosing strategies, reducing drug usage and side effects, accurately assessing the risks associated with praziquantel administration, and future use of the active enantiomer R-PZQ.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)