Drosophila HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development

Structural mechanisms of HECT-type ubiquitin ligases

(2018) Sonja Lorenz   BIOLOGICAL CHEMISTRY

Polyploidy in tissue homeostasis and regeneration

(2018) Jan Inge Øvrebø et al.   DEVELOPMENT

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

(2018) Jan B Heidelberger et al.   EMBO REPORTS

Endoreplication: The Good, the Bad, and the Ugly

(2018) Zhiqiang Shu et al.   TRENDS IN CELL BIOLOGY

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

(2017) Martin A. Michel et al.   MOLECULAR CELL

E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling

(2017) Carmen Dominguez-Brauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway

(2017) I. K. Mandemaker et al.   Scientific Reports

The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development

(2017) Karla J. Opperman et al.   Cell Reports

dMyc is required in retinal progenitors to prevent JNK-mediated retinal glial activation

(2017) Lígia Tavares et al.   PLoS Genetics

A conformational switch regulates the ubiquitin ligase HUWE1

(2017) Bodo Sander et al.   eLife

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

(2016) Kevin B Myant et al.   EMBO Molecular Medicine

The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

(2016) Fumiaki Ohtake et al.   MOLECULAR CELL

HUWE1 mutations in Juberg-Marsidi and Brooks syndromes: the results of an X-chromosome exome sequencing study

(2016) Michael J Friez et al.   BMJ Open

RNF4-Dependent Oncogene Activation by Protein Stabilization

(2016) Jane J. Thomas et al.   Cell Reports

Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death

(2015) C K Lee et al.   ONCOGENE

The canonical Wg signaling modulates Bsk-mediated cell death in Drosophila

(2015) S Zhang et al.   Cell Death & Disease

A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation

(2015) Li Li et al.   eLife

FUCCI sensors: powerful new tools for analysis of cell proliferation

(2015) N. Zielke et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy

(2015) S. Chittaranjan et al.   Biology Open

Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

(2014) Antoine Forget et al.   DEVELOPMENTAL CELL

Tipping the MYC-MIZ1 balance: targeting the HUWE1 ubiquitin ligase selectively blocks MYC-activated genes

(2014) F. X. Schaub et al.   EMBO Molecular Medicine

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

(2014) S. Peter et al.   EMBO Molecular Medicine

Endocycles: a recurrent evolutionary innovation for post-mitotic cell growth

(2014) Bruce A. Edgar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Towards Long Term Cultivation of Drosophila Wing Imaginal Discs In Vitro

(2014) Björn Handke et al.   PLoS One

Homeostatic defects in B cells deficient in the E3 ubiquitin ligase ARF-BP1 are restored by enhanced expression of MYC

(2013) Chen-Feng Qi et al.   LEUKEMIA RESEARCH

A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

(2013) M. Kurokawa et al.   Science Signaling

Endoreplication

(2013) N. Zielke et al.   Cold Spring Harbor Perspectives in Biology

HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation

(2012) Tahel Noy et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p53 Binding Prevents Phosphatase-mediated Inactivation of Diphosphorylated c-Jun N-terminal Kinase

(2012) Pramod S. Gowda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

NOPO modulates Egr-induced JNK-independent cell death in Drosophila

(2011) Xianjue Ma et al.   CELL RESEARCH

Control of Drosophila endocycles by E2F and CRL4CDT2

(2011) Norman Zielke et al.   NATURE

Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum

(2010) D. D'Arca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-Myc-DLL3 Cascade Is Suppressed by the Ubiquitin Ligase Huwe1 to Inhibit Proliferation and Promote Neurogenesis in the Developing Brain

(2009) Xudong Zhao et al.   DEVELOPMENTAL CELL

Differential roles of the fan-shaped body and the ellipsoid body in Drosophila visual pattern memory

(2009) Y. Pan et al.   LEARNING & MEMORY

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF- -induced JNK1 activation

(2009) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression

(2008) Asako Sakaue-Sawano et al.   CELL

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

(2008) Steffi Herold et al.   EMBO JOURNAL

The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles

(2008) N. Zielke et al.   GENES & DEVELOPMENT

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage

(2008) Jonathan R. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Multiple Pathways Differentially Regulate Global Oxidative Stress Responses in Fission Yeast

(2007) Dongrong Chen et al.   MOLECULAR BIOLOGY OF THE CELL