Article
Food Science & Technology
Manman Zhao, Wei Zhao, Li Li
Summary: This study investigates the mechanisms of PEF-induced microbial inactivation and sublethal damage. Combining PEF with mild heat treatment can enhance the bactericidal effect of PEF. Heat shock proteins play an important role in this process, and knocking out specific heat shock proteins can reduce sublethal cells and increase inactivation rate.
Review
Cell Biology
Shadi Shams, Chirag B. Patel
Summary: Therapeutic alternating electric fields (TTFields) is a new form of anti-cancer therapy that has shown improved survival outcomes in patients, either alone or in combination with chemotherapy. However, the mechanisms of TTFields are not fully understood, and ongoing investigations are aimed at better understanding how it selectively kills cancer cells and impedes their proliferation.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Alireza Sarkaki, Mojtaba Rashidi, Mina Ranjbaran, Aram Asareh Zadegan Dezfuli, Zahra Shabaninejad, Ebrahim Behzad, Maryam Adelipour
Summary: Resveratrol, a phenol compound produced by plants in response to pathogens, has antioxidant and protective roles in preventing cancer and other serious disorders. It is considered a candidate agent for the prevention and treatment of human diseases due to its bioactive impacts. Additionally, resveratrol has cardioprotective, anti-tumorigenic, anti-inflammatory, phytoestrogenic, and neuroprotective effects, making it a potential treatment for various disorders.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Karolina Lawkowska, Marta Pokrywczynska, Krzysztof Koper, Luis Alex Kluth, Tomasz Drewa, Jan Adamowicz
Summary: Graphene is a strong and flexible biomaterial with unique properties that make it suitable for tissue engineering of the nervous system. It can be modified for a wide range of applications in cell cultures and has the potential for producing tissues and organs for transplantation without rejection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Jia-Qi Xu, Qian-Qi Liu, Sheng-Yuan Huang, Chun-Yue Duan, Hong-Bin Lu, Yong Cao, Jian-Zhong Hu
Summary: The lymphatic vasculature in the central nervous system plays important roles in fluid homeostasis, metabolite clearance, and immune surveillance. It has been found that lymphatic vessels are present in the meninges and serve as major pathways for fluid exchange. Additionally, the abundance of immune cells suggests the involvement of lymphatic vessels in neuroimmunity. The lymphatic system also participates in the pathogenesis of neurological disorders through its functions in protein clearance, autoimmune cell infiltration, and pro-inflammatory signaling.
NEURAL REGENERATION RESEARCH
(2023)
Review
Cell & Tissue Engineering
Yu-Ting Zhang, Kai-Jie He, Jin-Bao Zhang, Quan-Hong Ma, Fen Wang, Chun-Feng Liu
Summary: This review discusses the possible brain-entry routes of stem cells administered intranasally to bypass the blood-brain barrier, as well as the advantages and disadvantages of this treatment method in central nervous system diseases, providing a reference for the application of intranasal stem cell therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Agricultural Engineering
Benai Cheng, JianGuo Bao, Jiangkun Du, Haseeb Tufail, Tiantian Xu, Yi Zhang, Qidi Mao
Summary: The study found that applying electric fields can enhance the tolerance of tetracycline, improve nitrogen removal performance, and help mitigate irreversible inhibition, thus enhancing the stability of community structure.
BIORESOURCE TECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Charlotte A. Rene, Robin J. Parks
Summary: This review discusses the dual role of the blood-brain barrier (BBB) in protecting the central nervous system and impeding the delivery of therapeutic drugs into the CNS. It emphasizes the use of extracellular vesicles as delivery vehicles to bypass the BBB and target cells within the CNS.
Article
Biochemistry & Molecular Biology
Helene Gateau, Vincent Blanckaert, Brigitte Veidl, Odile Burlet-Schiltz, Carole Pichereaux, Audrey Gargaros, Justine Marchand, Benoit Schoefs
Summary: This study successfully extracted proteins from living cells of the green microalga using a pulsed electric field treatment, and found that the conditions at 1 kV cm(-1) represented a good compromise between protein extraction efficiency and culture survival.
BIOELECTROCHEMISTRY
(2021)
Article
Neurosciences
Li Zhang, Lei Mao, Handong Wang
Summary: The article presents a review on the applications of exosomes in CNS injuries, highlighting their potential in improving cognition function, inhibiting apoptosis, suppressing inflammation, and protecting blood brain barrier. Exosomes may be developed as therapeutic agents for CNS injury patients.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Neurosciences
Daniela Nogueira Rocha, Eva Daniela Carvalho, Joao Bettencourt Relvas, Maria Jose Oliveira, Ana Paula Pego
Summary: This article explores the importance of mechanotransduction in the central nervous system (CNS) and its role in CNS pathology. It highlights the influence of the extracellular matrix's biochemical and biophysical components on cell behavior. Integrating mechanical properties into our understanding of CNS disease at a molecular level is crucial, as alterations in tissue mechanical properties are common in neurological diseases. Therefore, understanding CNS mechanotransduction pathways could lead to improvements in medical devices, diagnostic methods, and therapeutic strategies for CNS repair.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Logan W. Gaudette, Molly M. Bradach, Jose Roberto de Souza Junior, Bryan Heiderscheit, Caleb D. Johnson, Joshua Posilkin, Mitchell J. Rauh, Lauren K. Sara, Lindsay Wasserman, Karsten Hollander, Adam S. Tenforde
Summary: This article discusses the relationship between running and injury, as well as the potential role of gait retraining in treating injured runners. Studies have shown that gait retraining in patients with specific pain syndromes can reduce pain and improve functionality.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Karla V. Torres-Juarez, Felisbina Luisa Queiroga, Laura P. Romero-Romero
Summary: The nervous system can participate in cancer development by inducing biochemical, physiological, and cellular modifications associated with the hallmarks of cancer, although its role is still controversial. Despite the need for further research, there is now enough evidence to support these theories and provide hope for finding additional potential treatments.
Review
Neurosciences
Caidi Ying, Jiahao Zhang, Haocheng Zhang, Shiqi Gao, Xiaoming Guo, Jun Lin, Haijian Wu, Yuan Hong
Summary: Central nervous system (CNS) diseases are a major cause of death and disability. Stem cell therapy has emerged as a potential treatment strategy for these diseases, with mechanisms such as cell replacement, immunoregulation, and neurotrophic effects underlying its use. However, there are still issues that need to be addressed to support its clinical application.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Physical
Ervin Lumnitzer, Elena Lukac Jurgovska, Miriam Andrejiova, Ruzena Kralikova
Summary: In recent decades, the background level of electromagnetic fields (EMFs) has dramatically increased due to the improvement in quality, volume, and speed of mobile operators' voice and data services. This paper focuses on protecting the internal environment from the negative effects of EMFs through the use of metal materials that absorb this radiation. Measurements were conducted on different days and hours, and the results were evaluated using the ANOVA method. The goal was to understand the effects of electromagnetic fields and propose measures to eliminate their impact indoors. Additionally, measurements were taken using shielding elements made of various metal materials to compare their efficiency. It is recommended to use shading blinds with the highest efficiency to enhance safety, protect people's health, and mitigate electromagnetic fields.
Article
Cell Biology
Gaofeng Zhang, Mathew Edmundson, Vsevolod Telezhkin, Yu Gu, Xiaoqing Wei, Paul J. Kemp, Bing Song
JOURNAL OF CELLULAR PHYSIOLOGY
(2016)
Review
Neurosciences
Bangfu Zhu, Maeve Caldwell, Bing Song
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2016)
Article
Cell Biology
Qian Liu, Yun Li, Wenkai Jiang, Yunzi Li, Lin Zhou, Bing Song, Xinfeng Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2016)
Article
Psychiatry
Anna L. Moon, Niels Haan, Lawrence S. Wilkinson, Kerrie L. Thomas, Jeremy Hall
SCHIZOPHRENIA BULLETIN
(2018)
Article
Multidisciplinary Sciences
Alex J. L. Morgan, Lorena Hidalgo San Jose, William D. Jamieson, Jennifer M. Wymant, Bing Song, Phil Stephens, David A. Barrow, Oliver K. Castell
Article
Biotechnology & Applied Microbiology
Ying Li, Yu Gu, He Wang, Zhipeng Liu, Bing Song, Tao Yin
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Cell & Tissue Engineering
Wenkai Jiang, Diya Wang, Amr Alraies, Qian Liu, Bangfu Zhu, Alastair J. Sloan, Longxing Ni, Bing Song
STEM CELLS INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Ana Silva, Josephine E. Haddon, Yasir Ahmed Syed, Simon Trent, Tzu-Ching E. Lin, Yateen Patel, Jenny Carter, Niels Haan, Robert C. Honey, Trevor Humby, Yaniv Assaf, Michael J. Owen, David E. J. Linden, Jeremy Hall, Lawrence S. Wilkinson
NATURE COMMUNICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Yali Gao, Yaling Li, Xueli Niu, Yutong Wu, Xiuhao Guan, Yuxiao Hong, Hongduo Chen, Bing Song
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Immunology
Laura J. Westacott, Trevor Humby, Niels Haan, Sophie A. Brain, Emma-Louise Bush, Margarita Toneva, Andreea-Ingrid Baloc, Anna L. Moon, Jack Reddaway, Michael J. Owen, Jeremy Hall, Timothy R. Hughes, B. Paul Morgan, William P. Gray, Lawrence S. Wilkinson
Summary: Complement plays a key role in emotional reactivity, with different components impacting innate anxiety and learned fear selectively. The effects on anxiety and fear are mediated by different signaling mechanisms within the complement system.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Correction
Biochemistry & Molecular Biology
Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes, Min Zhao
CELL AND BIOSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bing Song, Yu Gu, Wenkai Jiang, Ying Li, Wayne Nishio Ayre, Zhipeng Liu, Tao Yin, Christopher Janetopoulos, Miho Iijima, Peter Devreotes, Min Zhao
Summary: The study demonstrated that PTEN coordinates the asymmetric redistribution of myosin to the posterior and PIP3/F-actin to the anterior of directed migration cells, controlling electrotaxis.
CELL AND BIOSCIENCE
(2021)
Article
Psychiatry
Niels Haan, Laura J. Westacott, Jenny Carter, Michael J. Owen, William P. Gray, Jeremy Hall, Lawrence S. Wilkinson
Summary: The haploinsufficiency of Cyfip1 may impact on psychopathology by affecting the survival and migration of newborn neurons in the hippocampus, resulting in increased numbers of adult-born hippocampal neurons without altering proliferation. This is believed to be due to a failure of microglia to induce apoptosis and abnormal migration of adult-born neurons due to altered actin dynamics.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biotechnology & Applied Microbiology
Jingyi Li, Yaling Li, Yali Gao, Xueli Niu, Mingsui Tang, Chang Fu, Zihan Wang, Jiayi Liu, Bing Song, Hongduo Chen, Xinghua Gao, Xiuhao Guan
Summary: This study accurately predicts the prognosis of cancer and invasive candidiasis patients using machine learning models, which can help clinicians intervene early in high-risk patients.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Qi Zeng, Shoujun Yu, Zihui Fan, Yubin Huang, Bing Song, Tian Zhou
Summary: In this study, a nanocone-shaped Pt-IrOx neural microelectrode is proposed, with a uniform nanocone-shaped Pt created through controlling the ratio of ions in the electrolyte. The coated microelectrode exhibits low impedance, high charge storage capacity, and excellent stability and biocompatibility.