Review
Biochemistry & Molecular Biology
Suyog Basnet, Evan Michael Vallenari, Urusha Maharjan, Sunita Sharma, Olaf Schreurs, Dipak Sapkota
Summary: S100A16 is a member of the S100 protein family and is expressed in various human tissues, particularly those rich in epithelial cells. It is differentially expressed in the majority of human cancers and has been implicated in tumorigenesis, including cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition. Additionally, S100A16 expression has prognostic potential in various cancer types.
Article
Cell Biology
Huanhuan Deng, Leihong Deng, Haichao Chao, Zhaojun Yu, Jianbiao Huang, Zhen Song, Lifen Peng, Tao Zeng
Summary: Bladder cancer (BLCA) is a common cancer with high mortality ranking 9th. The relationship between autophagy and epithelial to mesenchymal transition (EMT) in BLCA is poorly understood. This study identified the autophagy-related gene RAB14 and demonstrated its promotion of EMT, migration, and invasion in bladder cancer cells through the Akt-associated autophagic pathway. Knocking down RAB14 inhibited EMT and autophagy in T24 cells, and RAB14 levels were positively correlated with key autophagy genes LC3B and Beclin1. These findings suggest the potential role of RAB14 in BLCA progression.
CELL DEATH DISCOVERY
(2023)
Article
Biotechnology & Applied Microbiology
Yuanzhe Zhu, Huala Wu, Xi Yang, Zhijuan Xiong, Tiantian Zhao, Xin Gan
Summary: This study revealed that LINC00514 is upregulated in NSCLC and plays a role in the proliferation, migration, and invasion of NSCLC cells through activation of the Wnt/β-catenin pathway and EMT. Silencing LINC00514 restored the biological phenotypes of NSCLC cells by inhibiting the Wnt/β-catenin pathway. Additionally, silencing LINC00514 attenuated the growth of xenograft tumors in vivo.
Article
Biochemistry & Molecular Biology
Abdullah Al Subayyil, Yasser S. Basmaeil, Hayaa Bin Kulayb, Maha Alrodayyan, Lama Abdulaziz A. Alhaber, Taghreed N. Almanaa, Tanvir Khatlani
Summary: Stem cell therapy is becoming important in cancer treatment due to its anti-tumor properties. This study found that the cellular component of preconditioned CVMSCs significantly inhibited the proliferation, migration, and invasion of MDA231 breast cancer cells, while the conditioned media only affected the proliferation of these cells. These findings suggest that preconditioned CVMSCs have potential in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yichi Xu, Shuya Pan, Hong Chen, Hongfei Qian, Zhiwei Wang, Xueqiong Zhu
Summary: The study revealed that MEX3A plays an anti-tumor role in cervical cancer by inhibiting the Akt signaling pathway and EMT. Targeting MEX3A may have therapeutic potential in treating cervical cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Maria do Carmo Greier, Annette Runge, Jozsef Dudas, Viktoria Pider, Ira-Ida Skvortsova, Dragana Savic, Herbert Riechelmann
Summary: Mitochondrial dysfunction can induce epithelial mesenchymal transition in head and neck cancer cell lines, thereby promoting cancer aggressiveness and metastasis. However, this phenomenon is observed only in one of the cell lines.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Xiaoting Huang, Leyang Xiang, Baiyao Wang, Jijie Hu, Chunshan Liu, Anbang Ren, Kunpeng Du, Gengtai Ye, Yingying Liang, Yunqiang Tang, Dinghua Yang, Yawei Yuan
Summary: This study demonstrates that CMTM6 plays a critical role in promoting proliferation, migration, and invasion in HCC through interacting with and stabilizing vimentin. The overexpression of CMTM6 is significantly associated with poor prognosis in HCC, suggesting its potential as a biomarker and therapeutic target for treating HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Zhuo Chen, Jing Wu, Liang Wang, Hua Zhao, Jie He
Summary: The study reveals that M2-tumor associated macrophages (TAMs) are more abundant in TNBC and associated with poor prognosis. M2-TAMs promote invasion, migration, and proliferation of breast cancer cells, possibly through the mechanism of epithelial-mesenchymal transition.
Article
Oncology
Hangyu Zhang, Changgang Liu, Xinbo Wang, Yongfang Wang, Jie Zheng
Summary: SCARA5 expression is downregulated in gastric cancer, associated with promoter methylation, aggressive clinicopathological characteristics, and poor prognosis. Overexpression of SCARA5 inhibits the growth and migration of GC cells, potentially serving as a biomarker for diagnosis and therapeutic target.
Article
Oncology
Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi, Wei Pei
Summary: In this study, the role of CDC42EP3 in colorectal cancer (CRC) was investigated. The results showed that CDC42EP3 was significantly upregulated in CRC and its knockdown inhibited proliferation, colony formation, and migration, while promoting apoptosis of CRC cells. Furthermore, in vivo results confirmed that knockdown of CDC42EP3 attenuated tumor growth in CRC, indicating its potential as a target for innovative therapeutic approaches.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Qingzhi Lan, Xiaoping Tan, Pengzhan He, Wei Li, Shan Tian, Weiguo Dong
Summary: TRIM11 is upregulated in gastric cancer tissues and cell lines, promoting proliferation, migration, invasion, and EMT in gastric cancer cells through activation of the beta-catenin signaling pathway.
ONCOTARGETS AND THERAPY
(2021)
Article
Oncology
Yuhai Zhang, Yuling Hong, Dan Wang, Linshan Duan, Yanling Liu, Long Li, Di Liu, Kunbin Zhuang, Chaoxin Wei, Guogeng Zheng, Chunyong Huo, Guoyan Liu
Summary: Recent studies have shown that the circular RNA hsa_circ_0076305 plays a crucial role in gastric cancer development by regulating cell proliferation and migration, indicating a potential target for cancer therapy.
Article
Agriculture, Dairy & Animal Science
Gabriele Scattini, Martina Pellegrini, Giulio Severi, Monica Cagiola, Luisa Pascucci
Summary: Adipose-derived MSCs are commonly isolated by collagenase digestion, but waste tissue fragments contain cells that adhere belatedly to the plastic. In this study, three sets of cells that adhered at different time points were analyzed for their properties, and no significant differences were found between the three subpopulations. This procedure improves MSCs yield and shortens the time required for clinical applications.
Article
Oncology
Wei Li, Sihui Hu, Zhiqiang Han, Xuejun Jiang
Summary: HER2 positivity in breast cancer is associated with higher levels of phosphorylated retinoblastoma protein (pRb). pRb levels are positively correlated with HER2 gene copy number in amplification. This suggests potential responsiveness of HER2-positive breast cancer to CDK4/6 inhibitors, with pRb serving as a predictive biomarker. Additionally, FAM111B is highly expressed in breast cancer and its overexpression is associated with poor prognosis. Silencing FAM111B inhibits proliferation, migration, and invasion of breast cancer cells. YY1-induced transcriptional activation of FAM111B promotes breast cancer progression.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Mary-Keara Boss, Lauren G. Harrison, Alexandra Gold, Sana D. Karam, Daniel P. Regan
Summary: This study aimed to investigate the immune landscape of canine oral squamous cell carcinoma (OSCC) and its potential as a surrogate model for human OSCC. The results showed that canine OSCC has a heterogenous tumor immune microenvironment, with CD3+ T cells being the predominant tumor infiltrating immune cell population. Gene expression analysis revealed an inflamed microenvironment with an anti-tumor immune response dominated by cytotoxic T cells and NK cells, but also showed overexpression of genes associated with immunosuppression. The study identified potential immunotherapy targets for future comparative oncology trials.
FRONTIERS IN ONCOLOGY
(2023)
Article
Integrative & Complementary Medicine
Yingying Yang, Tianfang Wang, Jian Dong, Ling Tang, Yanping Wang, Ning Li, Lihong Zhao
Summary: By observing the changes in pulse graph, this study explored the effectiveness of electroacupuncture in relieving primary dysmenorrhea. The pulse graph showed opposite patterns between different stages of pain and differences between different patterns of dysmenorrhea.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Mathematics, Applied
Tian-Fang Wang, Jianhua Chen
Summary: This paper investigates the existence of solutions to a specific quasilinear Schrodinger equation, obtaining certain solutions and infinitely many pairs of geometrically distinct solutions by using a change of variable and a version of Trudinger-Moser inequality. The results extend the known results in the literature.
APPLIED MATHEMATICS LETTERS
(2022)
Article
Mathematics, Applied
Xiaoliang Xie, Tianfang Wang, Wen Zhang
Summary: (Summary in English:)
In this paper, we study the (p, q)-Laplacian equation with nonlocal Choquard reaction and obtain new existence results of nontrivial solutions under suitable conditions on the absorption potential and nonlinear term using variational methods.
APPLIED MATHEMATICS LETTERS
(2023)
Article
Oncology
Xiaosong Liu, Guoying Ni, Pingping Zhang, Hejie Li, Junjie Li, Bernardo Cavallazzi Sebold, Xiaolian Wu, Guoqiang Chen, Songhua Yuan, Tianfang Wang
Summary: This study investigated the tumor microenvironment of cervical cancer patients at different stages using single-nucleus transcriptomic and proteomic analysis. The results revealed the suppression of immune response pathways and the enrichment of cell and tissue development pathways in advanced stage cervical cancer patients. Additionally, certain collagens were found to be significantly upregulated and may serve as diagnostic markers for cervical cancer progression. A novel transcript, AC244205.1, was also identified as upregulated in advanced stage cervical cancer patients, suggesting its potential mechanistic role in cervical cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Correction
Parasitology
Conor E. Fogarty, Min Zhao, Donald P. McManus, Mary G. Duke, Scott F. Cummins, Tianfang Wang
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Hongpeng Lv, Tianfang Wang, Jing Zhang, Zhaolan Liu, Jian Dong, Haotian Xie, Yingying Yang, Peiwen Xue, Yuwen Che, Pengpeng Han
Summary: Facial appearance provides insights into personality traits, particularly in relation to facial width-to-height ratio (fWHR) and mandibular morphology. This study found that males had larger bilateral mandibular line angles, while females had a greater fWHR. Canonical correlation analysis demonstrated that facial features were correlated with personality traits, with the loadings of bilateral mandibular line angles being more significant than fWHR. Moreover, the correlations between these facial features and certain personality factors varied between males and females.
Review
Oncology
Bernardo Cavallazzi Sebold, Guoying Ni, Junjie Li, Hejie Li, Xiaosong Liu, Tianfang Wang
Summary: The purpose of this review is to discuss the current understanding and role of pegilodecakin in inhibiting tumor growth and metastasis. Despite promising results in preclinical models and early clinical trials, the efficacy of pegilodecakin in phase II and III trials did not justify its application as potential immunotherapy in selected cancers. Further investigation of pegilodecakin's efficacy in other cancers, either as monotherapy or in combination with current treatments, is warranted.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Endocrinology & Metabolism
Tomer Abramov, Saowaros Suwansa-ard, Patricia Mirella da Silva, Tianfang Wang, Michael Dove, Wayne O'Connor, Laura Parker, Fraser D. D. Russell, David A. A. Lovejoy, Scott F. F. Cummins, Abigail Elizur
Summary: TCAP plays a role in regulating cardiac activity through modulation of physiological and molecular components associated with energy conservation, stress, and adaptation. This finding provides important insights into the novel function of TCAP and its potential implications for higher-order metazoans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biology
Zubaida P. Patwary, Min Zhao, Tianfang Wang, Nicholas A. Paul, Scott F. Cummins
Summary: This study investigated the proteins in Asparagopsis taxiformis using different extraction methods and provided a comprehensive overview of expressed proteins in the seaweed. The findings offer insights into the potential functions of these proteins and lay a foundation for future targeted protein extraction and biodiscovery.
Review
Oncology
Bernardo Cavallazzi Sebold, Junjie Li, Guoying Ni, Quanlan Fu, Hejie Li, Xiaosong Liu, Tianfang Wang
Summary: Multidrug-resistant (MDR) bacteria pose a global health threat, and the ESKAPE group of pathogens is a major concern due to high death rates and nosocomial infections. Host defence peptides (HDPs) show promise in combating MDR, including ESKAPE pathogens, but their pharmacokinetics hinder their clinical use. Chemical engineering of HDPs offers a solution by improving their pharmacokinetics and efficacy against pathogens. This review explores various chemical modifications of HDPs, particularly against ESKAPE pathogens, and provides an overview of current research findings.
Correction
Multidisciplinary Sciences
Meaghan K. K. Smith, Bronwyn A. A. Rotgans, Tomas Lang, Ryan Johnston, Tianfang Wang, Saowaros Suwansa-ard, Utpal Bose, Nori Satoh, Michaela Egertova, Michael R. R. Hall, Maria Byrne, Maurice R. R. Elphick, Cherie A. A. Motti, Scott F. F. Cummins
SCIENTIFIC REPORTS
(2023)
Review
Food Science & Technology
Blake Lausen, Anahita Ahang, Scott Cummins, Tianfang Wang
Summary: This systematic literature review examines the important factors to consider when extracting and purifying jellyfish venom toxins. The results indicate that the toxins of box jellyfish are the most easily purified, followed by cubozoans and hydrozoans. The best practices for maintaining venom bioactivity include strict thermal management, autolysis extraction, and two-step liquid chromatography purification. This review provides a valuable resource for efficient extraction, purification, and identification of jellyfish venom toxins.
Article
Chemistry, Multidisciplinary
Yihang Chen, Chengao Yang, Tianfang Wang, Hongguang Yu, Jianmei Shi, Xiangbin Su, Yu Zhang, Youwen Zhao, Cunzhu Tong, Donghai Wu, Yingqiang Xu, Haiqiao Ni, Zhichuan Niu
Summary: A novel graded AlGaAsSb layer growth method was proposed to achieve a super-linear interface. Atomically smooth surface and lattice-matched epitaxy was confirmed. High-power, high-efficiency GaSb-based laser emitters and laser bars were obtained with the inserted graded layer. The smooth graded interface layer resulted in low turn-on voltage, ultra-low series resistance, and high power conversion efficiency.
APPLIED SCIENCES-BASEL
(2023)
Article
Medicine, Research & Experimental
Tiantian He, Juan Du, Keke Zhu, Yixuan Zhou, Zewei Xiao, Wenjie Liu, Weiwei Ren, Xiongying Liu, Tongsheng Chen, Wenjuan Liu, Zhuanming Chen, Guoying Ni, Xiaosong Liu, Tianfang Wang, Jiangtao Quan, Peipei Zhang, Jianwei Yuan
Summary: This study analyzed and compared the therapeutic effects of 131I-caerin 1.1 and 131I-c(RGD)2 on TE-1 esophageal cancer cell xenografts. The results showed that 131I-caerin 1.1 had tumor-targeting properties, could bind to TE-1 esophageal cancer cells and had a cytotoxic effect, while 131I-c(RGD)2 had no cytotoxic effect. 131I-caerin 1.1 better suppressed tumor cell proliferation and tumor growth compared to pure caerin 1.1, 131I-c(RGD)2, and pure c(RGD)2.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Pingping Zhang, Shuxian Tang, Quanlan Fu, Yuandong Luo, Junjie Li, Zhu Chen, Hejie Li, Guoying Ni, Tianfang Wang, Guoqiang Chen, Xiaosong Liu
Summary: Caerin 1.1 and Caerin 1.9, natural antimicrobial peptides derived from tree frogs, have demonstrated the ability to inhibit the growth of antibiotic-resistant bacteria, comparable to certain widely used antibiotics. Additionally, these peptides exhibit the capacity to prevent or treat biofilms formed by bacteria in conjunction with bodily components. The mechanisms underlying their antibacterial effects were investigated through a mouse model of bacterial skin infection, utilizing proteomic analysis as a technological approach.
MICROBIOLOGY SPECTRUM
(2023)