The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment

Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: Implications for intervention

(2017) Hildegard M. Schuller   Cancer Biomarkers

Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy

(2013) H. M. Wang et al.   ANNALS OF ONCOLOGY

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease

(2013) Louisa CY Lee et al.   Future Medicinal Chemistry

cGMP-Dependent Protein Kinase Iβ Interacts with p44/WDR77 to Regulate Androgen Receptor-Driven Gene Expression

(2013) Liran Zhou et al.   PLoS One

Identification of Biologically Active PDE11-Selective Inhibitors Using a Yeast-Based High-Throughput Screen

(2012) Ozge Ceyhan et al.   CHEMISTRY & BIOLOGY

Cyclic GMP/protein kinase G type-Iα (PKG-Iα) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Iα kinase activity synergizes with cisplatin in non-small cell lung c

(2012) Janica C. Wong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

Beta-adrenergic blocking drugs in breast cancer: a perspective review

(2012) Thomas I. Barron et al.   Therapeutic Advances in Medical Oncology

Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint

(2012) P J Fitzgerald   Clinical Epidemiology

Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

(2011) P. A. Insel et al.   Acta Physiologica

Cyclic Nucleotide Compartmentalization: Contributions of Phosphodiesterases and ATP-Binding Cassette Transporters

(2011) Satish Cheepala et al.   Annual Review of Pharmacology and Toxicology

Inhibition of PDE5 by Sulindac Sulfide Selectively Induces Apoptosis and Attenuates Oncogenic Wnt/ -Catenin-Mediated Transcription in Human Breast Tumor Cells

(2011) H. N. Tinsley et al.   Cancer Prevention Research

Cyclic GMP induced apoptosis via protein kinase G in oestrogen receptor-positive and -negative breast cancer cell lines

(2011) Faranak Fallahian et al.   FEBS Journal

Expanding Our Therapeutic Options: Beta Blockers for Breast Cancer?

(2011) Patricia A. Ganz et al.   JOURNAL OF CLINICAL ONCOLOGY

Multidrug resistance associated proteins in multidrug resistance

(2011) Kamlesh Sodani et al.   Chinese Journal of Cancer

Protein Kinase A in Cancer

(2011) Antonio Caretta et al.   Cancers

Adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs, aspirin and coxibs) on upper gastrointestinal tract

(2010) Carlos Sostres et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Colon Tumor Cell Growth-Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition

(2010) H. N. Tinsley et al.   Cancer Prevention Research

8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells

(2010) Zhor Bouizar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

(2010) I-K Kwon et al.   ONCOGENE

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

EPAC proteins transduce diverse cellular actions of cAMP

(2009) Gillian Borland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates

(2009) Brenda K. Edwards et al.   CANCER

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

(2009) K. M. Sakamoto et al.   CLINICAL CANCER RESEARCH

The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue

(2009) Roberta L. Gonçalves et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting cancer with phosphodiesterase inhibitors

(2009) Rajkumar Savai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Signalling Pathway Alterations in Pituitary Adenomas: Involvement of Gsα, cAMP and Mitogen-Activated Protein Kinases

(2009) M. Pertuit et al.   JOURNAL OF NEUROENDOCRINOLOGY

Protein kinase A activators and the pan-PPAR agonist tetradecylthioacetic acid elicit synergistic anti-leukaemic effects in AML through CREB

(2009) Bjarte Skoe Erikstein et al.   LEUKEMIA RESEARCH

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

(2009) H. N. Tinsley et al.   MOLECULAR CANCER THERAPEUTICS

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

(2008) In-Kiu Kwon et al.   CANCER

Activation of Protein Kinase G Increases the Expression of p21CIP1, p27KIP1, and Histidine Triad Protein 1 through Sp1

(2008) B. Cen et al.   CANCER RESEARCH

EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase

(2008) Martine Müller Kloster et al.   CELLULAR SIGNALLING

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

(2008) Nancy Gerits et al.   CELLULAR SIGNALLING

Protein Kinase A Type I and Type II Define Distinct Intracellular Signaling Compartments

(2008) Giulietta Di Benedetto et al.   CIRCULATION RESEARCH

Protein kinase G as a therapeutic target for the treatment of metastatic colorectal cancer

(2008) Darren D Browning   EXPERT OPINION ON THERAPEUTIC TARGETS

Protein Kinase G-dependent Cardioprotective Mechanism of Phosphodiesterase-5 Inhibition Involves Phosphorylation of ERK and GSK3β

(2008) Anindita Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Inflammatory, Antiproliferative, and Cytoprotective Activity of NO Chimera Nitrates of Use in Cancer Chemoprevention

(2008) G. K. Hagos et al.   MOLECULAR PHARMACOLOGY

NO-donating NSAIDs and cancer: An overview with a note on whether NO is required for their action

(2008) Basil Rigas et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Nucleotide-Regulated Proliferation and Differentiation Vary in Human Hematopoietic Progenitor Cells Derived from Healthy Persons, Tumor Patients, and Chronic Myelocytic Leukemia Patients

(2008) Anna Kobsar et al.   STEM CELLS AND DEVELOPMENT

Guanylin peptides and colorectal cancer (CRC)

(2007) Marcello Camici   BIOMEDICINE & PHARMACOTHERAPY

Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G

(2007) Jae-Won Soh et al.   MOLECULAR CARCINOGENESIS