The Future of Glioblastoma Therapy: Synergism of Standard of Care and Immunotherapy

RTOG 0525: A randomized phase III trial comparing standard adjuvant temozolomide (TMZ) with a dose-dense (dd) schedule in newly diagnosed glioblastoma (GBM).

(2017) M. R. Gilbert et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemo-Immunotherapy with Oxaliplatin and Interleukin-7 Inhibits Colon Cancer Metastasis in Mice

(2014) Hong-Feng Gou et al.   PLoS One

Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer

(2013) Khursheed Anwer et al.   GYNECOLOGIC ONCOLOGY

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

(2013) Jing Zeng et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Immunotherapy of Radioresistant Mammary Tumors with Early Metastasis Using Molecular Chaperone Vaccines Combined with Ionizing Radiation

(2013) D. Weng et al.   JOURNAL OF IMMUNOLOGY

Establishing percent resection and residual volume thresholds affecting survival and recurrence for patients with newly diagnosed intracranial glioblastoma

(2013) Kaisorn L. Chaichana et al.   NEURO-ONCOLOGY

Peptide Vaccine Therapy for Childhood Gliomas

(2013) Ian F. Pollack et al.   NEUROSURGERY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioma IL13Rα2 Is Associated with Mesenchymal Signature Gene Expression and Poor Patient Prognosis

(2013) Christine E. Brown et al.   PLoS One

Ipilimumab and radiation therapy for melanoma brain metastases

(2013) Ann W. Silk et al.   Cancer Medicine

Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma

(2012) Surasak Phuphanich et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Interleukin-21 Has Activity in Patients With Metastatic Melanoma: A Phase II Study

(2012) Teresa M. Petrella et al.   JOURNAL OF CLINICAL ONCOLOGY

Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial

(2012) Annika Malmström et al.   LANCET ONCOLOGY

In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer

(2012) C. Guo et al.   MOLECULAR CANCER THERAPEUTICS

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Potential Role for STAT3 Inhibitors in Glioblastoma

(2012) Christopher Jackson et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Temozolomide and Other Potential Agents for the Treatment of Glioblastoma Multiforme

(2012) Daniel T. Nagasawa et al.   NEUROSURGERY CLINICS OF NORTH AMERICA

Adult glioblastoma multiforme survival in the temozolomide era: A population-based analysis of Surveillance, Epidemiology, and End Results registries

(2011) Amy S. Darefsky et al.   CANCER

Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair

(2011) E. M. Goellner et al.   CANCER RESEARCH

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

(2011) Stuart A. Grossman et al.   CLINICAL CANCER RESEARCH

Concurrent Temozolomide and Dose-Escalated Intensity-Modulated Radiation Therapy in Newly Diagnosed Glioblastoma

(2011) C. I. Tsien et al.   CLINICAL CANCER RESEARCH

Cancer Immunotherapy Comes of Age

(2011) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma

(2011) A. L. Rivera et al.   NEURO-ONCOLOGY

Antibodies in oncology

(2011) Vinochani Pillay et al.   New Biotechnology

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells

(2010) E M Reddy et al.   CANCER GENE THERAPY

Novel Gamma-Chain Cytokines as Candidate Immune Modulators in Immune Therapies for Cancer

(2010) Natasha M. Fewkes et al.   CANCER JOURNAL

Modulation of T-Cell Activation by Malignant Melanoma Initiating Cells

(2010) T. Schatton et al.   CANCER RESEARCH

Phase I Study of Recombinant Human Interleukin-7 Administration in Subjects with Refractory Malignancy

(2010) C. Sportes et al.   CLINICAL CANCER RESEARCH

Glioma-Associated Cancer-Initiating Cells Induce Immunosuppression

(2010) J. Wei et al.   CLINICAL CANCER RESEARCH

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

Clinical Responses in a Phase II Study Using Adoptive Transfer of Short-term Cultured Tumor Infiltration Lymphocytes in Metastatic Melanoma Patients

(2010) M. J. Besser et al.   CLINICAL CANCER RESEARCH

Dendritic cell vaccines to combat glioblastoma

(2010) Christopher J Wheeler   Expert Review of Neurotherapeutics

Allogeneic gene-modified tumor cells (RCC-26/IL-7/CD80) as a vaccine in patients with metastatic renal cell cancer: a clinical phase-I study

(2010) J Westermann et al.   GENE THERAPY

Implications for immunotherapy of tumor-mediated T-cell apoptosis associated with loss of the tumor suppressor PTEN in glioblastoma

(2010) James S. Waldron et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Immunologic Escape After Prolonged Progression-Free Survival With Epidermal Growth Factor Receptor Variant III Peptide Vaccination in Patients With Newly Diagnosed Glioblastoma

(2010) John H. Sampson et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Trial of a Personalized Peptide Vaccine for Patients Positive for Human Leukocyte Antigen–A24 With Recurrent or Progressive Glioblastoma Multiforme

(2010) Mizuhiko Terasaki et al.   JOURNAL OF CLINICAL ONCOLOGY

Glioblastoma Cancer-Initiating Cells Inhibit T-Cell Proliferation and Effector Responses by the Signal Transducers and Activators of Transcription 3 Pathway

(2010) J. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

(2010) J. H. Sampson et al.   NEURO-ONCOLOGY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Enhancing therapy of B16F10 melanoma efficacy through tumor vaccine expressing GPI-anchored IL-21 and secreting GM-CSF in mouse model

(2010) Fengshu Zhao et al.   VACCINE

IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

(2009) C. Bucher et al.   BLOOD

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

EGFRvIII-Targeted Vaccination Therapy of Malignant Glioma

(2009) Bryan D. Choi et al.   BRAIN PATHOLOGY

Treg depletion with a low-dose metronomic temozolomide regimen in a rat glioma model

(2009) Claire Banissi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma

(2009) B. Mukherjee et al.   CANCER RESEARCH

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

MSH6 Mutations Arise in Glioblastomas during Temozolomide Therapy and Mediate Temozolomide Resistance

(2009) S. Yip et al.   CLINICAL CANCER RESEARCH

Heat-shock protein vaccines as active immunotherapy against human gliomas

(2009) Isaac Yang et al.   Expert Review of Anticancer Therapy

Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer

(2009) K Anwer et al.   GENE THERAPY

Combination approaches to immunotherapy: the radiotherapy example

(2009) Michael J Gough et al.   Immunotherapy

Phase II Trial of Temozolomide Plus O6-Benzylguanine in Adults With Recurrent, Temozolomide-Resistant Malignant Glioma

(2009) Jennifer A. Quinn et al.   JOURNAL OF CLINICAL ONCOLOGY

Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNγ-transduced tumor cell immunotherapy of experimental glioma

(2009) Salina Gunnarsson et al.   JOURNAL OF NEUROIMMUNOLOGY

An epidermal growth factor receptor variant III-targeted vaccine is safe and immunogenic in patients with glioblastoma multiforme

(2009) J. H. Sampson et al.   MOLECULAR CANCER THERAPEUTICS

Immunotherapy of neuroblastoma by an Interleukin-21-secreting cell vaccine involves survivin as antigen

(2008) Michela Croce et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Vaccination Elicits Correlated Immune and Clinical Responses in Glioblastoma Multiforme Patients

(2008) C. J. Wheeler et al.   CANCER RESEARCH

A New Model for Prediction of Drug Distribution in Tumor and Normal Tissues: Pharmacokinetics of Temozolomide in Glioma Patients

(2008) L. Rosso et al.   CANCER RESEARCH

Concomitant (without Adjuvant) Temozolomide and Radiation to Treat Glioblastoma: a Retrospective Study

(2008) T. Sridhar et al.   CLINICAL ONCOLOGY

Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines

(2008) Robert J. Schmittling et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Mechanisms Involved in Radiation Enhancement of Intratumoral Dendritic Cell Therapy

(2008) Seagal Teitz-Tennenbaum et al.   JOURNAL OF IMMUNOTHERAPY

Expression of MAGE and GAGE genes in medulloblastoma and modulation of resistance to chemotherapy

(2008) Chinatsu Kasuga et al.   Journal of Neurosurgery-Pediatrics

Local IL-21 Promotes the Therapeutic Activity of Effector T cells by Decreasing Regulatory T Cells Within the Tumor Microenvironment

(2008) Seunghee Kim-Schulze et al.   MOLECULAR THERAPY

GLIOMA EXTENT OF RESECTION AND ITS IMPACT ON PATIENT OUTCOME

(2008) Nader Sanai et al.   NEUROSURGERY

Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: Case study

(2007) Amy B. Heimberger et al.   NEURO-ONCOLOGY