Article
Medicine, General & Internal
Ameeta Lubina Nayak, Arthur Travis Pickett, Megan Delisle, Brittany Dingley, Ranjeeta Mallick, Trevor Hamilton, Heather Stuart, Martha Talbot, Gregory Mckinnon, Evan Jost, Eva Thiboutot, Valerie Francescutti, Sal Samman, Alexandra Easson, Angela Schellenberg, Shaila Merchant, Julie La, Kaitlin Vanderbeck, Frances Wright, David Berger-Richardson, Pamela Hebbard, Olivia Hershorn, Rami Younan, Erica Patocskai, Samuel Rodriguez-Qizilbash, Ari Meguerditichian, Vanina Tchuente, Suzanne Kazandjian, Alex Mathieson, Farisa Hossain, Jessika Hetu, Martin Corsten, Angelina Tohme, Carolyn Nessim, Stephanie Johnson-Obaseki
Summary: This study, the largest Canadian evaluation of survival outcomes for head and neck MCC, found that disease staging and treatment modalities are associated with survival. Multimodal treatment is associated with higher survival rates across all stages of the disease.
Review
Dentistry, Oral Surgery & Medicine
Y. Ye, D. D. Jensen, C. T. Viet, H. L. Pan, W. M. Campana, M. Amit, M. D. Boada
Summary: Head and neck cancer not only has a high mortality rate, but also causes severe pain that affects patients' quality of life. The pathophysiology of HNC pain involves anatomical, histopathological, and molecular differences between cancers. The tumor microenvironment and peripheral nerves play a crucial role in HNC pain, and there is evidence of a functional loop of cross-activation between them. Understanding the mechanisms underlying pain and cancer progression in HNC can help develop targeted treatments for both conditions.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Article
Otorhinolaryngology
Fabio Muradas Girardi, Vivian P. Wagner, Manoela Domingues Martins, Aliende Lengler Abentroth, Luiz Alberto Hauth
Summary: In a cohort of HNCSCC patients from South Brazil, ear/nose/zygomatic or periorbital site, compromised or exiguous margins, and advanced pT stage were associated with worse disease-free survival (DFS), while age, pN stage, and loco-regional recurrence were associated with worse disease-specific survival (DSS). AJCC 8 was able to stratify tumors with a significant risk of poor outcomes only in the lower categories (T1 and T2).
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Liyuan Chen, Michael Dohopolski, Zhiguo Zhou, Kai Wang, Rongfang Wang, David Sher, Jing Wang
Summary: The study introduced an attention-guided classification scheme for accurate prediction of lymph node malignancy in patients with head and neck cancer, demonstrating superior performance in machine learning compared to traditional methods.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Pathology
Keisuke Goto, Yoji Kukita, Keiichiro Honma, Nobuyuki Ohike, Takaya Komori, Yoshihiro Ishida, Misawo Ishikawa, Takashi Nakatsuka, Soichi Fumita, Koichi Nakagawa, Aya Okabayashi, Yoshifumi Iwahashi, Tomoyuki Tanino, Keisuke Kikuchi, Yoshie Kawahara, Tsunekazu Hishima, Jiro Uehara, Takuma Oishi, Taiki Isei
Summary: LGNECS, proposed in 2017, is a rare skin tumor with neuroendocrine differentiation, renamed as SCAND. Most cases show intraepidermal pagetoid spreading and stromal mucin deposits. Tumor size may be a better prognostic factor than nuclear atypia, mitotic count, and Ki67 index.
Article
Pathology
Akihiro Ohmoto, Yukiko Sato, Reimi Asaka, Naoki Fukuda, Xiaofei Wang, Tetsuya Urasaki, Naomi Hayashi, Yasuyoshi Sato, Kenji Nakano, Mayu Yunokawa, Makiko Ono, Junichi Tomomatsu, Takashi Toshiyasu, Hiroki Mitani, Kengo Takeuchi, Seiichi Mori, Shunji Takahashi
Summary: Neuroendocrine carcinoma (NEC) of the head and neck is a rare malignancy with favorable clinical characteristics but aggressive pathological features. Patients who received multimodal curative treatments had relatively higher survival rates. Genomic analysis revealed potential therapeutic targets such as the FGFR3-TACC3 fusion gene and mutations in genes encoding components of the NOTCH and PI3K/AKT/mTOR pathways.
Article
Oncology
Alvin K. Liu, Jonn Wu, Eric Berthelet, Nafisha Lalani, Nicole Chau, Eric Tran, Sarah Nicole Hamilton
Summary: Brain metastases from head and neck cancer are rare and carry a poor prognosis, with treatment involving intracranial radiotherapy associated with improved survival.
Review
Chemistry, Multidisciplinary
Enrico Antonio Lo Faso, Orazio Gambino, Roberto Pirrone
Summary: The review focuses on delineation methods for head-neck cancer tumors, emphasizing the importance of multimodal images in radiotherapy. A comparison among different approaches highlights the gap in performance between computerized and manual methods.
APPLIED SCIENCES-BASEL
(2021)
Article
Medicine, General & Internal
Giuseppe Riva, Laura Salonia, Elisabetta Fassone, Silvia Sapino, Fabrizio Piano, Giancarlo Pecorari
Summary: This observational study found that electrochemotherapy is a safe and effective treatment for skin and mucosal head and neck tumors in patients without other curative options, leading to improvements in quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Emad Rakha, Puay Hoon Tan
Summary: Breast cancer is a heterogeneous disease with various morphological features. The existence and clinical significance of neuroendocrine tumors in the breast are still controversial. When encountering NETs, metastatic origin needs to be excluded.
Article
Biochemistry & Molecular Biology
Daniela Duarte-Bateman, Alan Shen, Taylor Bullock, Payam Sadeghi, Joseph M. Escandon, Eliska Dedkova, Brian R. Gastman
Summary: Merkel cell carcinoma is a rare and highly aggressive skin cancer with controversial optimal management. This article provides an algorithm for decision-making in MCC management based on the latest guidelines and summarizes relevant evidence. The initial management of MCC depends on the pathology of the primary tumor and presence of metastatic disease.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Walid A. Al-Soneidar, Sam Harper, Babatunde Y. Alli, Belinda Nicolau
Summary: This study investigates the interaction between HPV16 and cutaneous HPV in the development of HNC. It found that co-infection with beta HPV may weaken the carcinogenic effect of HPV16, while co-infection with gamma HPV may strengthen the carcinogenic effect. However, further research is needed to confirm these findings.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Dermatology
Thibault Kervarrec, Silke Appenzeller, Mahtab Samimi, Bhavishya Sarma, Eva-Maria Sarosi, Patricia Berthon, Yannick Le Corre, Ewa Hainaut-Wierzbicka, Astrid Blom, Nathalie Benethon, Guido Bens, Charline Nardin, Francois Aubin, Monica Dinulescu, Marie-Laure Jullie, Agnes Pekar-Lukacs, Eduardo Calonje, Soumanth Thanguturi, Anne Tallet, Marion Wobser, Antoine Touze, Serge Guyetant, Roland Houben, David Schrama
Summary: The study reveals the association between virus-negative Merkel cell carcinoma (MCC) and squamous cell carcinoma (SCC), suggesting a common origin. RB1 inactivation in SCC facilitates MCC development and epigenetic changes contribute to the transition from SCC to MCC.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Otorhinolaryngology
Laishyang Melody Ouyoung, Mark S. Swanson, Brenda Capobres Villegas, Dhanur Damodar, Niels Kokot, Uttam K. Sinha
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2016)
Review
Oncology
Mark S. Swanson, Uttam K. Sinha
Article
Otorhinolaryngology
Mark S. Swanson, Rachael L. Hudson, Nipun Bhandari, Uttam K. Sinha, Dennis R. Maceri, Niels Kokot
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2015)
Review
Oncology
Mark S. Swanson, Niels Kokot, Uttam K. Sinha
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey W. Prescott, Thomas M. Best, Mark S. Swanson, Furqan Haq, Rebecca D. Jackson, Metin N. Gurcan
JOURNAL OF DIGITAL IMAGING
(2011)
Article
Orthopedics
M. S. Swanson, J. W. Prescott, T. M. Best, K. Powell, R. D. Jackson, F. Haq, M. N. Gurcan
OSTEOARTHRITIS AND CARTILAGE
(2010)
Article
Medicine, Research & Experimental
Caitlin Bertelsen, Kevin G. King, Mark Swanson, Vinay Duddalwar, Jon-Paul Pepper
Article
Audiology & Speech-Language Pathology
Uttam K. Sinha, Mark S. Swanson, Brenda Capobres Villegas, Laishyang Melody Ouyoung, Niels Kokot
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2019)
Article
Medicine, Research & Experimental
Kyohei Itamura, Niels Kokot, Uttam Sinha, Mark Swanson
Editorial Material
Otorhinolaryngology
Kyohei Itamura, Mark Swanson
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Janet S. Choi, Liyang Tang, Alison J. Yu, Mark S. Swanson, Niels C. Kokot, Uttam K. Sinha
Review
Otorhinolaryngology
Mark S. Swanson, Garren Low, Uttam K. Sinha, Niels Kokot
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2017)
