Review
Nutrition & Dietetics
Anna Rudzinska, Pola Juchaniuk, Jakub Oberda, Jolanta Wisniewska, Witold Wojdan, Katarzyna Szklener, Slawomir Mandziuk
Summary: Phytochemicals are non-nutritive substances found in plants that contribute to flavor and color. They have potential health benefits in preventing diseases, including cancer. This review explores the therapeutic benefits of dietary phytochemicals in cancer treatment and prevention using epidemiological studies and clinical trials. However, while epidemiological studies show positive effects, clinical trials often fail to replicate these effects due to a lack of evidence and potential risks.
Article
Biology
Tomonari Kinoshita, Hideki Terai, Tomonori Yaguchi
Summary: This article summarizes the current use of immunotherapies in lung cancer treatment, including immune checkpoint inhibitors, and discusses the future prospects of personalized immunotherapy.
Review
Biochemistry & Molecular Biology
Adithya J. Kammath, Bhagyalakshmi Nair, P. Sreelekshmi, Lekshmi R. Nath
Summary: This review highlights the potential of spices as cancer chemo-preventive agents, discussing their antioxidant, anti-inflammatory, and anticancer properties. It also explores the role of specific dietary spices in cancer prevention and treatment, drawing from in vitro, in vivo, and clinical studies.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
Richard T. Bryan, Sarah J. Pirrie, Ben Abbotts, Shanna Maycock, Vinnie During, Carolyn Lewis, Margaret Grant, Deborah Bird, Adam J. Devall, D. Michael A. Wallace, Nicholas D. James, Lucinda J. Billingham, Maurice P. Zeegers, K. K. Cheng, SELENIB Investigators
Summary: In this multicenter clinical trial, selenium and vitamin E were found to have no significant effect on the risk of recurrence in patients with newly diagnosed non-muscle-invasive bladder cancer (NMIBC). However, vitamin E supplementation was associated with an increased risk of recurrence.
Review
Biochemistry & Molecular Biology
Francesca Celiberto, Adriana Aloisio, Bruna Girardi, Maria Pricci, Andrea Iannone, Francesco Russo, Giuseppe Riezzo, Benedetta D'Attoma, Enzo Ierardi, Giuseppe Losurdo, Alfredo Di Leo
Summary: Colorectal cancer is a major cause of cancer-related deaths in developed countries and is strongly influenced by dietary habits. Inadequate fiber intake in Western countries may contribute to the increased incidence of colorectal cancer. Daily fiber intake has been inversely associated with the risk of colorectal cancer, and dietary interventions based on high-fiber diets have shown promising results in preventing the development of this type of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Ressin Varghese, Thomas Efferth, Siva Ramamoorthy
Summary: Lung cancer, a leading malignancy worldwide, has been mitigated through the use of phytopigments such as carotenoids. While in vitro and animal studies have shown promising results, clinical trials have yielded contradictory outcomes, highlighting the need for further verification.
Review
Cell Biology
Cecilia Bergonzini, Kim Kroese, Annelien J. M. Zweemer, Erik H. J. Danen
Summary: Integrins play a crucial role in mediating adhesive interactions between cells and their environment, and their dysregulation is closely associated with cancer progression. Despite promising preclinical results, targeting integrin adhesion complexes in clinical trials for cancer therapy has not met expectations so far, possibly due to variable integrin expression, redundancy in integrin function, distinct roles at different disease stages, and sequestering by tumor-derived extracellular vesicles. However, improving therapeutic delivery at the tumor site through integrin binding ligands is emerging as a successful approach in enhancing the efficacy and safety of conventional therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Plant Sciences
Srimanta Patra, Biswajita Pradhan, Rabindra Nayak, Chhandashree Behera, Surajit Das, Samir Kumar Patra, Thomas Efferth, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Dietary polyphenols demonstrate chemopreventive activity by modulating key molecular targets and pathways to limit cancer initiation and progression. Combining polyphenols with existing anticancer drugs enhances anticancer activity and offers promising perspectives for clinical applications.
Review
Oncology
Izabela Chmielewska, Katarzyna Stencel, Ewa Kalinka, Rodryg Ramlau, Pawel Krawczyk
Summary: Surgical resection is the standard treatment for early-stage NSCLC, but the majority of patients experience recurrence within 5 years. Immunotherapy has shown promising results in the treatment of metastatic lung cancer, leading to ongoing clinical trials in early NSCLC. However, challenges remain in determining the efficacy, timing, and treatment regimens of immunotherapy in neoadjuvant and adjuvant settings for NSCLC patients.
Review
Immunology
Chenglong Liu, Mengxuan Yang, Daizhou Zhang, Ming Chen, Di Zhu
Summary: Immune checkpoint therapy utilizing PD-1 antibodies has demonstrated significant clinical value and therapeutic potential, although it is not without limitations such as immune-related adverse events, cytokine storm, and low response rates. This review discusses the basic classification, research progress, and limitations of cancer immunotherapy, as well as providing insights into the development of new anticancer immunotherapy strategies through the analysis of resistance mechanisms and combination therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Asma Ismail Mahmod, Shatha Khaled Haif, Ayah Kamal, Israa A. Al-ataby, Wamidh H. Talib
Summary: This review aims to explore the anti-inflammatory and anti-colorectal cancer potential of natural bioactive compounds derived from the main foods in the Mediterranean diet.
FRONTIERS IN NUTRITION
(2022)
Review
Microbiology
Qiong Ma, Xueke Li, Hua Jiang, Xi Fu, Liting You, Fengming You, Yifeng Ren
Summary: The oral microbiota plays an important role in regulating physiological processes and changes in it can increase the risk of lung cancer. Disruption of the oral microecology and specific oral bacteria can contribute to the development of lung cancer through various mechanisms. The oral microbiota shows potential for clinical treatment of lung cancer, including prevention and improving the side effects of anticancer therapy.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hugo Loureiro, Andreas Roller, Meike Schneider, Carlos Talavera-Lopez, Tim Becker, Anna Bauer-Mehren
Summary: This study evaluates the construction of eControls using different methods to estimate overall survival in advanced non-small cell lung cancer. The findings suggest that eControls based on prognostic scores, specifically ROPRO, have lower errors and include more matched patients compared to other methods. Prognostic scores provide a reliable basis for constructing eControls.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Oncology
Haroon Khan, Hammad Ullah, Miquel Martorell, Susana Esteban Valdes, Tarun Belwal, Silvia Tejada, Antoni Sureda, Mohammad Amjad Kamal
Summary: Traditional cancer therapies face challenges such as poor accessibility to tumor tissues and adverse drug reactions. Flavonoids have shown effectiveness against cancer, but their safety profile and tumor site-specific action need further evaluation. Nanocarriers can improve drug delivery, bioavailability, and therapeutic efficacy, offering new possibilities in cancer therapeutics.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eun-Ryeong Hahm, Su-Hyeong Kim, Krishna B. Singh, Shivendra Singh
Summary: The study revealed that Withaferin A (WA) may prevent breast cancer by downregulating genes associated with cellular senescence, upregulating p21, affecting cellular response to stress, and decreasing glycolysis-related proteins. Additionally, NRF2 knockout cells were found to be more resistant to WA-induced apoptosis, suggesting a potential mechanism for WA's chemopreventive efficacy in breast cancer.
MOLECULAR CARCINOGENESIS
(2021)