Review
Chemistry, Medicinal
Feihong Ji, Xinguang Qiu
Summary: This paper summarizes recent research on the mechanisms of thyroid diseases and the role of NAPCD in treatment, helping to better understand the pathophysiology of thyroid diseases and providing guidance for the development of new therapeutic strategies in the future.
Review
Biochemistry & Molecular Biology
Luke Loftus, Sarah R. Amend, Kenneth J. Pienta
Summary: Cell division and cell death are essential processes in growth and development. Cancer is caused by abnormal regulation of these processes, and traditional anti-cancer treatments trigger apoptosis, to which cancer cells are resistant. Understanding how drugs kill cancer cells is crucial for developing more effective treatments. Cell cycle-independent forms of cell death, such as necroptosis or ferroptosis, have potential immunogenic effects, providing alternative strategies against tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Jeferson da Costa Lopes, Luiz Fabio Magno Falcao, Arnaldo Jorge Martins Filho, Marcos Luiz Gaia Carvalho, Caio Cesar Henriques Mendes, Fabio Alves Olimpio, Vanessa do Socorro Cabral Miranda, Lais Carneiro Dos Santos, Jannifer Oliveira Chiang, Ana Cecilia Ribeiro Cruz, Vanessa Costa Alves Galucio, Raimunda do Socorro da Silva Azevedo, Livia Caricio Martins, Maria Irma Seixas Duarte, Jorge Rodrigues de Sousa, Pedro Fernando da Costa Vasconcelos, Juarez Antonio Simoes Quaresma
Summary: This study identified and quantified proteases and protein targets involved in apoptosis cascades triggered by YFV infection in human hepatocytes using immunohistochemistry. The complexity of YFV infection-induced apoptosis and its potential contribution to the pathogenesis of fatal YF in humans were confirmed.
Review
Oncology
William A. Weston, Alexis R. Barr
Summary: Tumour dormancy and recurrent metastatic cancer pose significant challenges in cancer treatment. Cellular quiescence plays a central role in promoting and maintaining tumour dormancy by reducing proliferation and enhancing cyto-protective mechanisms. Understanding the regulation of cyclin-dependent kinases (CDKs) and the signals that activate them can shed light on the mechanisms of cancer cell quiescence, thus providing opportunities for therapeutic intervention. This review discusses the regulation of CDK activity in cellular quiescence during tumour dormancy and highlights the therapeutic challenges and opportunities associated with it.
BRITISH JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Article
Microbiology
Erxiong Liu, Yutong Chen, Jinmei Xu, Shunli Gu, Ning An, Jiajia Xin, Wenting Wang, Zhixin Liu, Qunxing An, Jing Yi, Wen Yin
Summary: Platelets can inhibit the growth of MRSA by promoting the overproduction of hydroxyl radicals and inducing apoptosis-like death.
MICROBIOLOGY SPECTRUM
(2022)
Article
Biochemistry & Molecular Biology
Jinning Li, Xiaoming Zhao, Bing Wu, Zhongpeng Ji, Han Liu, Xuehan Wang, Haibing Zhang, Zhiping He
Summary: Cell death detection is traditionally invasive, but this study demonstrates the non-invasive use of near-infrared spectroscopy to distinguish between different types of cell death. By measuring the scattering of NIR light in the wavelength range of 1100-1700 nm, the study successfully differentiated between normal, apoptotic, and necroptotic mouse dermal fibroblast cells. The attenuation coefficient (8μ) was used to quantify the ease of light passing through the cells and confirmed the distinction between cell death types.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Min-Hee Jo, Yong-Tae Kim, Sun Joo Park
Summary: Dieckol, a natural polyphenol, inhibits the growth of melanoma cells by inducing apoptotic cell death through affecting lysosomal function and mitochondrial membrane. This suggests its potential value as a chemotherapeutic drug candidate for melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Raffaella Pacchiana, Nidula Mullappilly, Andrea Pinto, Stefania Bova, Stefania Forciniti, Gregorio Cullia, Elisa Dalla Pozza, Emanuela Bottani, Ilaria Decimo, Ilaria Dando, Stefano Bruno, Paola Conti, Massimo Donadelli
Summary: This study tested the effects of 3-bromo-isoxazoline derivatives on pancreatic ductal-adenocarcinoma cells and found that these compounds inhibited cell proliferation. Two promising compounds were selected for in vivo testing and one of them, AXP-3019, effectively blocked PDAC-cell growth without apparent toxicity. These findings support the idea that targeting the glycolytic pathway, specifically GAPDH, is an effective therapy for pancreatic cancer, and 3-bromo-isoxazoline derivatives represent a new class of anti-cancer compounds.
Article
Pharmacology & Pharmacy
R. Raina, N. Afroze, M. Kedhari Sundaram, S. Haque, K. Bajbouj, M. Hamad, A. Hussain
Summary: The study demonstrated that Chrysin significantly inhibited proliferation and induced apoptosis by modulating various apoptotic genes and AKT/MAPK pathway genes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Jaemyun Kim, Seungwon Ji, Jin-Young Lee, Jean Lorquin, Barbora Orlikova-Boyer, Claudia Cerella, Aloran Mazumder, Florian Muller, Mario Dicato, Olivier Detournay, Marc Diederich
Summary: Palytoxin can induce cancer cell death at low picomolar concentrations without toxicity to normal cells. The mechanism involves downregulation of antiapoptotic proteins and upregulation of proteasomal enzymatic activity. Protein phosphatase 2A plays a critical role in the induction of apoptosis by palytoxin. Palytoxin also shows strong inhibitory effects on leukemia and tumor formation in vivo.
Review
Biochemistry & Molecular Biology
Plinio A. Trinidad-Calderon, Carlos Daniel Varela-Chinchilla, Silverio Garcia-Lara
Summary: With cancer becoming the second deadliest disease, there is a need for specific candidates with confirmed anticancer effects to develop new drugs. Proteins, particularly bioactive peptides, are considered a relevant source among the novel therapeutic options. While databases report peptide effects, uncertainties in their molecular mechanisms call for further analyses to elucidate their effects on cancer cells entirely.
Article
Chemistry, Analytical
Emma B. Hartnett, Mengli Zhou, Yi-Nan Gong, Yu-Chih Chen
Summary: The study developed a label-free method to classify cell death status using machine learning and image processing. It enables the precise categorization of live, apoptotic, and necrotic cells and allows for tracking the time dynamics of cell death process, enhancing the understanding of cell death regulation at the molecular level.
ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Mimoune Berehab, Redouane Rouas, Haidar Akl, Hugues Duvillier, Fabrice Journe, Hussein Fayyad-Kazan, Ghanem Ghanem, Dominique Bron, Philippe Lewalle, Makram Merimi
Summary: Thymoquinone (TQ) selectively kills DLBCL cells through non-apoptotic cell death mechanisms, with cytosolic calcium and necroptosis playing critical and selective roles. TQ shows improved selectivity over standard chemotherapy, suggesting therapeutic relevance of its pro-necroptotic effect as a fail-safe mechanism for DLBCL therapies targeting apoptosis.
Review
Biochemistry & Molecular Biology
Cuie Chen, Yukiko M. Yamashita
Summary: The asymmetry of centrosomes plays a crucial role in cell division, with mother and daughter centrosomes potentially carrying different information to contribute to asymmetric cell fate during stem cell divisions.
