Pancreatic Cancer Gene Therapy: From Molecular Targets to Delivery Systems

Urokinase-Type Plasminogen Activator Receptor Transcriptionally Controlled Adenoviruses Eradicate Pancreatic Tumors and Liver Metastasis in Mouse Models

(2015) Meritxell Huch et al.   NEOPLASIA

Sodium Iodide Symporter (NIS)-Mediated Radiovirotherapy for Pancreatic Cancer

(2010) Alan R. Penheiter et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Cell cycle control pathways act as conditioning factors for TK/GCV sensitivity in pancreatic cancer cells

(2010) Daniel Abate-Daga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Blood outgrowth endothelial cell-based systemic delivery of antiangiogenic gene therapy for solid tumors

(2010) V Bodempudi et al.   CANCER GENE THERAPY

Adipose-Derived Mesenchymal Stem Cells as Stable Source of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Delivery for Cancer Therapy

(2010) Giulia Grisendi et al.   CANCER RESEARCH

MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity

(2010) Elisa Giovannetti et al.   CANCER RESEARCH

Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF

(2010) Shadan Ali et al.   CANCER RESEARCH

Improved Potency and Selectivity of an Oncolytic E1ACR2 and E1B19K Deleted Adenoviral Mutant in Prostate and Pancreatic Cancers

(2010) D. Oberg et al.   CLINICAL CANCER RESEARCH

MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions

(2010) M. C. du Rieu et al.   CLINICAL CHEMISTRY

Mesenchymal stromal cells alone or expressing interferon-β suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment

(2010) Shannon Kidd et al.   CYTOTHERAPY

E-cadherin contributes to the bystander effect of TK/GCV suicide therapy and enhances its antitumoral activity in pancreatic cancer models

(2010) L Garcia-Rodríguez et al.   GENE THERAPY

A combinatorial approach for targeted delivery using small molecules and reversible masking to bypass nonspecific uptake in vivo

(2010) Q Shi et al.   GENE THERAPY

Delivering the goods: viral and non-viral gene therapy systems and the inherent limits on cargo DNA and internal sequences

(2010) Helen Atkinson et al.   GENETICA

Enhancement of NK cell antitumor responses using an oncolytic parvovirus

(2010) Rauf Bhat et al.   INTERNATIONAL JOURNAL OF CANCER

Suppression of growth of pancreatic cancer cell and expression of vascular endothelial growth factor by gene silencing with RNA interference

(2010) Jian WANG et al.   Journal of Digestive Diseases

Ultrastructural Analysis of ICP34.5- Herpes Simplex Virus 1 Replication in Mouse Brain Cells In Vivo

(2010) H. Mehta et al.   JOURNAL OF VIROLOGY

Sindbis viral vector induced apoptosis requires translational inhibition and signaling through Mcl-1 and Bak

(2010) Lisa Venticinque et al.   Molecular Cancer

Ad.Egr-TNF and Local Ionizing Radiation Suppress Metastases by Interferon-β-Dependent Activation of Antigen-specific CD8+ T Cells

(2010) Yuru Meng et al.   MOLECULAR THERAPY

Targeting of XIAP Combined with Systemic Mesenchymal Stem Cell-Mediated Delivery of sTRAIL Ligand Inhibits Metastatic Growth of Pancreatic Carcinoma Cells

(2010) Andrea Mohr et al.   STEM CELLS

Targeting Tumor Stroma Using Engineered Mesenchymal Stem Cells Reduces the Growth of Pancreatic Carcinoma

(2009) Christoph Zischek et al.   ANNALS OF SURGERY

Adenovirus-Mediated ING4 Expression Suppresses Pancreatic Carcinoma Cell Growth via Induction of Cell-Cycle Alteration, Apoptosis, and Inhibition of Tumor Angiogenesis

(2009) Yu Feng Xie et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma

(2009) K F D Kuhlmann et al.   CANCER GENE THERAPY

Intratumoral delivery of shRNA targeting cyclin D1 attenuates pancreatic cancer growth

(2009) S J Deharvengt et al.   CANCER GENE THERAPY

Using lentiviral vectors for efficient pancreatic cancer gene therapy

(2009) E Ravet et al.   CANCER GENE THERAPY

Combination of conditionally replicative adenovirus and standard chemotherapies shows synergistic antitumor effect in pancreatic cancer

(2009) Amy R. Nelson et al.   CANCER SCIENCE

hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells

(2009) Manabu Onimaru et al.   CANCER SCIENCE

Origins and Mechanisms of miRNAs and siRNAs

(2009) Richard W. Carthew et al.   CELL

Oncolytic Adenoviral Mutants with E1B19K Gene Deletions Enhance Gemcitabine-induced Apoptosis in Pancreatic Carcinoma Cells and Anti-Tumor Efficacy In vivo

(2009) S. Leitner et al.   CLINICAL CANCER RESEARCH

The Antitumor and Immunoadjuvant Effects of IFN-  in Combination with Recombinant Poxvirus Vaccines

(2009) K. W. Hance et al.   CLINICAL CANCER RESEARCH

Mathematical Modeling of Herpes Simplex Virus Distribution in Solid Tumors: Implications for Cancer Gene Therapy

(2009) W. Mok et al.   CLINICAL CANCER RESEARCH

Reovirus-based therapy for cancer

(2009) Kevin Kelly et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer

(2009) Maria–Theresa Mueller et al.   GASTROENTEROLOGY

Retinoic Acid Receptor Antagonists Inhibit miR-10a Expression and Block Metastatic Behavior of Pancreatic Cancer

(2009) Frank Ulrich Weiss et al.   GASTROENTEROLOGY

Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer

(2009) J R Tysome et al.   GENE THERAPY

Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob

(2009) T Nishimoto et al.   GENE THERAPY

Adenovirus-Derived Vectors for Prostate Cancer Gene Therapy

(2009) Jeroen de Vrij et al.   HUMAN GENE THERAPY

Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival

(2009) Thomas Greither et al.   INTERNATIONAL JOURNAL OF CANCER

PERIOD1 is an Anti-apoptotic Factor in Human Pancreatic and Hepatic Cancer Cells

(2009) F. Sato et al.   JOURNAL OF BIOCHEMISTRY

MicroRNAs in Cancer: Small Molecules With a Huge Impact

(2009) Marilena V. Iorio et al.   JOURNAL OF CLINICAL ONCOLOGY

Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68

(2009) Y. A. Yu et al.   MOLECULAR CANCER THERAPEUTICS

Redundant and Synergistic Mechanisms Control the Sequestration of Blood-born Adenovirus in the Liver

(2009) Nelson C Di Paolo et al.   MOLECULAR THERAPY

Integration-deficient Lentiviral Vectors: A Slow Coming of Age

(2009) Klaus Wanisch et al.   MOLECULAR THERAPY

Treatment of Pancreatic Cancer With an Oncolytic Adenovirus Expressing Interleukin-12 in Syrian Hamsters

(2009) Sergia Bortolanza et al.   MOLECULAR THERAPY

Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer

(2009) Sant P Chawla et al.   MOLECULAR THERAPY

Optimization of conditionally replicative adenovirus for pancreatic cancer and its evaluation in an orthotopic murine xenograft model

(2008) Pedro J. Ramírez et al.   AMERICAN JOURNAL OF SURGERY

Myxoma Virus Is Oncolytic for Human Pancreatic Adenocarcinoma Cells

(2008) Yanghee Woo et al.   ANNALS OF SURGICAL ONCOLOGY

Progress in developing cationic vectors for non-viral systemic gene therapy against cancer

(2008) Marie Morille et al.   BIOMATERIALS

VEGF expression by mesenchymal stem cells contributes to angiogenesis in pancreatic carcinoma

(2008) B M Beckermann et al.   BRITISH JOURNAL OF CANCER

Improved lentiviral transduction of human mesenchymal stem cells for therapeutic intervention in pancreatic cancer

(2008) G Kallifatidis et al.   CANCER GENE THERAPY

Adenovirus Serotype 5 Hexon Mediates Liver Gene Transfer

(2008) Simon N. Waddington et al.   CELL

Adenoviral Gene Therapy for Pancreatic Cancer: Where Do We Stand?

(2008) Koert F.D. Kuhlmann et al.   DIGESTIVE SURGERY

Generation of optimized and urokinase-targeted oncolytic Sendai virus vectors applicable for various human malignancies

(2008) H Kinoh et al.   GENE THERAPY

Midkine promoter-based conditionally replicative adenovirus therapy for midkine-expressing human pancreatic cancer

(2008) Eiji Toyoda et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Substitution of Hexon Hypervariable Region 5 of Adenovirus Serotype 5 Abrogates Blood Factor Binding and Limits Gene Transfer to Liver

(2008) Frédéric Vigant et al.   MOLECULAR THERAPY

Polyplex Micelles from Triblock Copolymers Composed of Tandemly Aligned Segments with Biocompatible, Endosomal Escaping, and DNA-Condensing Functions for Systemic Gene Delivery to Pancreatic Tumor Tissue

(2008) Kanjiro Miyata et al.   PHARMACEUTICAL RESEARCH

Adenovirus serotype 5 hexon is critical for virus infection of hepatocytes in vivo

(2008) O. Kalyuzhniy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progression elevated gene-3 promoter (PEG-Prom) confers cancer cell selectivity to human polynucleotide phosphorylase (hPNPaseold-35)-mediated growth suppression

(2007) Isaac Chan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Telomerase Transcriptional Targeting of Inducible Bax/TRAIL Gene Therapy Improves Gemcitabine Treatment of Pancreatic Cancer

(2007) Séverine Wack et al.   MOLECULAR THERAPY