Article
Medicine, General & Internal
Jianmin Zeng, Man Li, Huasheng Shi, Jianhui Guo
Summary: This study revealed that FGD6 was significantly overexpressed in GC tissues and associated with higher histological grade, stage, and poor prognosis. Multivariate Cox regression analysis indicated that FGD6 was an independent prognostic factor for survival in GC patients.
FRONTIERS IN MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Shanglin Wang, Rong Fan, Huayu Gao, Xiaoli Ma, Yufei Wu, Yuanxin Xing, Yunshan Wang, Yanfei Jia
Summary: The overphosphorylation of signal transduction and transcriptional activator 5A (STAT5A) is associated with tumor invasion and poor prognosis in gastric cancer (GC). STAT5A promotes GC cell proliferation by upregulating CD44 expression and directly binds to the CD44 promoter to promote its transcription. The STAT5A/CD44 pathway plays a critical role in GC progression, showing potential clinical applications for improving GC treatment.
Article
Pharmacology & Pharmacy
Xu-Bin Ma, Yang Wang, Ying-Jie Jia, Ya-Jie Liu, Ying-Qi Tian, Ying Liu, Gui-Qin Hou, Yi-Chao Xu, Hong-Min Liu
Summary: This study found that the PI3K alpha inhibitor BYL719 effectively inhibited the proliferation of certain gastric cancer cells and identified PIK3IP1 as a potential biomarker for monitoring treatment response.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Malvina Hoxha, Calogero C. Tedesco, Silvana Quaglin, Visar Malaj, Linda Pustina, Valerie Capra, Jilly F. Evans, Angelo Sala, G. Enrico Rovati
Summary: The observational retrospective study suggests that the use of montelukast may be protective against incident cardiac ischemic events in older asthmatic patients. Analyses indicate that exposure to montelukast remains a significant protective factor for incident ischemic events, leading to a considerable risk reduction. The event-free Kaplan-Meier survival curves confirm the lower cardiovascular event incidence in patients exposed to montelukast.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yanhui Zhang, Jingru Bai, Runfen Cheng, Danfang Zhang, Zhiqiang Qiu, Tieju Liu, Na Che, Xueyi Dong, Nan Zhao, Xian Lin, Xiaohui Liang, Fan Li, Yue Li, Baocun Sun, Xiulan Zhao
Summary: This study found that TAZ is highly expressed in gastric cancer and is associated with poor prognosis. TAZ promotes the migration and invasion capacity of gastric cancer cells through epithelial-mesenchymal transition (EMT) and upregulation of VM-associated proteins. TAZ directly interacts with TEAD4, regulating EMT and VM formation in gastric cancer.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Yingming Jiang, Jintuan Huang, Zhenze Huang, Weiyao Li, Rongchang Tan, Tuoyang Li, Zijian Chen, Xiaocheng Tang, Yandong Zhao, Jun Qiu, Chujun Li, Hao Chen, Zuli Yang
Summary: This study found that ADAMTS12 plays a role in promoting tumor development and angiogenic activity in gastric cancer. High expression of ADAMTS12 is associated with chemoresistance and worse overall survival outcomes.
CELLULAR SIGNALLING
(2023)
Article
Oncology
Elzbieta Pawluczuk, Marta Lukaszewicz-Zajac, Mariusz Gryko, Agnieszka Kulczynska-Przybik, Barbara Mroczko
Summary: The study suggests that serum CXCL8 and CXCR2 concentrations are significantly higher in gastric cancer patients compared to healthy controls, with CXCL8 showing the highest diagnostic sensitivity among all tested proteins. Serum CXCL8 levels are indicated as a significant risk factor for gastric cancer occurrence and are a promising candidate for a biomarker in gastric cancer diagnosis.
Article
Biochemistry & Molecular Biology
Hana Lee, Won-Jin Kim, Hyeon-Gu Kang, Jun-Ho Jang, Il Ju Choi, Kyung-Hee Chun, Seok-Jun Kim
Summary: The study found that LAMB1 is upregulated in gastric cancer and contributes to cell growth and motility. The expression level of LAMB1 is closely associated with the prognosis of patients with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xiaowen Zhu, Yumin Zou, Tong Wu, Jian Ni, Qingyun Tan, Qingdong Wang, Meijia Zhang
Summary: This study investigates the potential role of ANP32E in the development of gastric cancer. The results demonstrate that ANP32E is overexpressed in gastric cancer tissues and its overexpression promotes malignancy while its knockdown inhibits proliferation and induces apoptosis of gastric cancer cells. ANP32E is also found to be positively associated with NUF2 expression and shown to induce NUF2 expression, promoting tumor cell proliferation and inhibiting apoptosis in gastric cancer cell lines.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Anna Di Matteo, Elisa Belloni, Davide Pradella, Anna Maria Chiaravalli, Giacomo Maria Pini, Mattia Bugatti, Roberta Alfieri, Chiara Barzan, Elena Franganillo Tena, Silvia Bione, Elisa Terenzani, Fausto Sessa, Christopher D. R. Wyatt, William Vermi, Claudia Ghigna
Summary: Angiogenesis is crucial for cancer progression, but current anti-angiogenic drugs have limited clinical benefits. This study provides a deeper understanding of the mechanisms regulating tumor vessel growth and identifies NOVA2 as a critical regulator of angiogenesis and vascular development. Moreover, the upregulation of NOVA2 in gastric cancer endothelial cells is associated with poor patient outcome, suggesting its potential as a biomarker and therapeutic target for anti-angiogenic treatment of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alyssa Schledwitz, Margaret H. Sundel, Madeline Alizadeh, Shien Hu, Guofeng Xie, Jean-Pierre Raufman
Summary: Studies have found that acetylcholine is not only produced and released by neurons, but also present in immune, cancer, and other cells. In addition, selected bile acids can modulate the function of muscarinic receptors. Muscarinic receptor subtypes may have unexpectedly diverse actions based on similar G protein coupling and downstream signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Xinyu Li, Wen Chen, Chunkang Yang, Yisen Huang, Jing Jia, Rongyu Xu, Shen Guan, Ruijun Ma, Haitao Yang, Lifeng Xie
Summary: IGHG1 acts as an oncogene in gastric cancer by promoting cellular proliferation, migration, and chemo-resistance, and it activates the AKT/GSK-3/beta-Catenin axis to regulate these behaviors in gastric cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Review
Medicine, Research & Experimental
Bingyu Wang, Zaibo Zhang, Wenbo Liu, Bibo Tan
Summary: Gastric cancer is a common malignancy worldwide, and regulatory T cells (Tregs) play a crucial role in its pathogenesis and prognosis. This review discusses the role of Tregs in gastric cancer, and strategies for targeting Tregs through various mechanisms. It also highlights the importance of Tregs metabolism and the emerging role of microbiome and combined therapy in modulating Tregs in gastric cancer treatment. Additionally, a novel regulator, magnesium, is mentioned as being involved in mediating Tregs in gastric cancer. These research advances provide new insights and challenges for gastric cancer progression, treatment, and prognosis, and stimulate further discovery and implication of mediators and pathways targeting Tregs.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Robert Jenke, Miriam Holzhauser-Rein, Stefanie Mueller-Wilke, Florian Lordick, Achim Aigner, Thomas Buch
Summary: MET-amplified gastric cancer cells are highly sensitive to MET inhibition in vitro, but the clinical efficacy of MET inhibitors is disappointing. It is suggested that compensatory activation of other oncogenic growth factor receptors may lead to resistance. In this study, a strategy of combined HER3/MET inhibition is proposed to overcome resistance towards MET inhibitors, as the upregulation of HER3 by HRG was found to contribute to partial resistance to MET inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiaolong Tang, Yahang Liang, Guorui Sun, Qingsi He, Zhenyu Hou, Xingzhi Jiang, Peng Gao, Hui Qu
Summary: In this study, the researchers identified the protein CRABP2 as a potential target for reversing oxaliplatin resistance in gastric cancer patients. They found that CRABP2 was significantly upregulated in chemoresistant tumor tissues and played a role in promoting oxaliplatin resistance through inhibiting BAX-dependent cell apoptosis. The study suggests that targeting CRABP2 could be a new strategy to overcome chemotherapy resistance in gastric cancer.
CELL DEATH & DISEASE
(2022)
