Article
Oncology
Joseph A. Sparano, Anne O'Neill, Noah Graham, Donald W. Northfelt, Chau T. Dang, Antonio C. Wolff, George W. Sledge, Kathy D. Miller
Summary: Systemic inflammation is associated with an increased risk of distant recurrence in breast cancer patients. Higher levels of the proinflammatory cytokine IL-6 at diagnosis are significantly associated with a higher risk of distant recurrence.
Article
Oncology
Raquel Nunes, Tal Sella, Kai Treuner, Jennifer M. Atkinson, Jenna Wong, Yi Zhang, Pedro Exman, David Dabbs, Andrea L. Richardson, Catherine A. Schnabel, Dennis C. Sgroi, Steffi Oesterreich, Ashley Cimino-Mathews, Otto Metzger
Summary: The study evaluated the prognostic utility of the Breast Cancer Index (BCI) for assessing the risk of distant recurrence (DR) in hormone receptor-positive invasive lobular carcinoma (ILC) patients. BCI was found to be a significant independent prognostic factor for overall 10-year, early, and late DR, adding value beyond clinicopathologic characteristics.
CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Saroj Kumar Shrestha, Kyung Hyun Min, Se Woong Kim, Hyoungsu Kim, William H. Gerwick, Yunjo Soh
Summary: In this study, it was found that kalkitoxin, a toxin derived from marine cyanobacterium, inhibits cancer cell migration and invasion. It also suppresses the secondary growth of breast cancer cells in the bone, brain, and lungs by inhibiting the expression of CXCL5 and CXCR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Maria Escala-Garcia, Sander Canisius, Renske Keeman, Jonathan Beesley, Hoda Anton-Culver, Volker Arndt, Annelie Augustinsson, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Fergus J. Couch, Kamila Czene, Mary B. Daly, Joe Dennis, Peter Devilee, Thilo Dork, Alison M. Dunning, Douglas F. Easton, Arif B. Ekici, A. Heather Eliassen, Peter A. Fasching, Henrik Flyger, Manuela Gago-Dominguez, Montserrat Garcia-Closas, Jose A. Garcia-Saenz, Juergen Geisler, Graham G. Giles, Mervi Grip, Melanie Guendert, Eric Hahnen, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Jaana M. Hartikainen, Bernadette A. M. Heemskerk-Gerritsen, Antoinette Hollestelle, Reiner Hoppe, John L. Hopper, David J. Hunter, William Jacot, Anna Jakubowska, Esther M. John, Audrey Y. Jung, Rudolf Kaaks, Elza Khusnutdinova, Linetta B. Koppert, Peter Kraft, Vessela N. Kristensen, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Annika Lindblom, Robert N. Luben, Jan Lubinski, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Dimitrios Mavroudis, Taru A. Muranen, Heli Nevanlinna, Andrew F. Olshan, Hakan Olsson, Tjoung-Won Park-Simon, Alpa V. Patel, Paolo Peterlongo, Paul D. P. Pharoah, Kevin Punie, Paolo Radice, Gad Rennert, Hedy S. Rennert, Atocha Romero, Rebecca Roylance, Thomas Ruediger, Matthias Ruebner, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Christopher Scott, Melissa C. Southey, Harald Surowy, Anthony J. Swerdlow, Rulla M. Tamimi, Lauren R. Teras, Emilie Thomas, Ian Tomlinson, Melissa A. Troester, Celine M. Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Argyrios Ziogas, Kyriaki Michailidou, Georgia Chenevix-Trench, Thomas Bachelot, Marjanka K. Schmidt
Summary: Two germline variants on chromosome 1 were significantly associated with breast cancer-specific survival, however, validation in a smaller replication dataset was not successful. Larger replication studies are needed to confirm the identified associations.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Xinbo Qiao, Yixiao Zhang, Lisha Sun, Qingtian Ma, Jie Yang, Liping Ai, Jinqi Xue, Guanglei Chen, Hao Zhang, Ce Ji, Xi Gu, Haixin Lei, Yongliang Yang, Caigang Liu
Summary: The study found that a higher frequency of CD44(-)/CD24(-) breast cancer cells was associated with delayed breast cancer metastasis, and that RHBDL2 may play a role in breast cancer metastasis and CSC formation.
Review
Oncology
Maria Gion, Cristina Saavedra, Jose Perez-Garcia, Javier Cortes
Summary: Breast cancer diagnosed at an advanced stage is often incurable, but in selected cases with few metastatic lesions and organs involved, radical treatment with surgery or radiotherapy can improve prognosis. However, the definition of oligometastatic disease remains unclear and there are current challenges in treating patients with this condition, such as the lack of remarkable biomarkers and appropriate clinical trial designs.
Article
Biochemistry & Molecular Biology
Jaclyn M. Einstein, Mark Perelis, Isaac A. Chaim, Jitendra K. Meena, Julia K. Nussbacher, Alexandra T. Tankka, Brian A. Yee, Heyuan Li, Assael A. Madrigal, Nicholas J. Neill, Archana Shankar, Siddhartha Tyagi, Thomas F. Westbrook, Gene W. Yeo
Summary: RNA-binding proteins (RBPs) play crucial roles in post-transcriptional gene expression regulation, and disrupting YTHDF2-dependent mRNA degradation can induce apoptosis in triple-negative breast cancer (TNBC) cells and tumors. Our study identified 57 RBP candidates with distinct functions in supporting MYC-driven oncogenic pathways, highlighting the therapeutic potential of RBPs, especially YTHDF2, in counteracting global mRNA synthesis in MYC-driven breast cancers.
Article
Oncology
Duc-Vinh Pham, Pil-Hoon Park
Summary: This study elucidates the multifaceted role of adiponectin in tumor fatty acid metabolic reprogramming and provides evidence for the connection between its metabolic actions and suppression of breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Xueyan Wei, Yingze Li, Haotian Chen, Rui Gao, Peng Ning, Yingying Wang, Wanxin Huang, Erzhen Chen, Lan Fang, Xingrong Guo, Cheng Lv, Yu Cheng
Summary: In this study, a lysosome-targeted magnetic nanotorquer (T7-MNT) was proposed as a mechanical tool to induce ferroptosis in breast cancer cells. Under the stimulation of a programmed magnetic field, T7-MNT generated torques to disrupt the lysosomal membrane and trigger the release of endogenous Fe2+. This magneto-mechanical manipulation induced oxidative damage and imbalance in antioxidant defense, leading to ferroptosis. In vivo studies showed that T7-MNTs effectively triggered ferroptosis and enhanced the efficacy of ferrotherapy in combination with RSL3. This dynamic targeted strategy has the potential to improve cancer treatment.
Article
Cell Biology
Haizhou Liu, Zihan Zhang, Yi Huang, Wene Wei, Shufang Ning, Jilin Li, Xinqiang Liang, Kaisheng Liu, Litu Zhang
Summary: The study demonstrated the association of pre-treatment plasma HSP90AA1 with the risk of breast cancer onset and metastasis, showing that combining with other markers could conveniently predict patients' risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Josh Sanyal, Amara Tariq, Allison W. Kurian, Daniel Rubin, Imon Banerjee
Summary: This study developed a weak-supervision framework for breast cancer recurrence prediction by training a deep learning model on a large sample of free-text clinic notes using a combination of manually curated labels and NLP-generated non-perfect recurrence labels. The model achieved high accuracy when validated on manually annotated data, demonstrating the effectiveness of learning from a larger dataset with imperfect labels.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Xiaojiao Ge, Yi Cao, Xueli Zhu, Bo Yuan, Lulu He, Aiguo Wu, Juan Li
Summary: In this study, an enzyme-responsive precursor based on the neuropeptide Y Y-1 receptor ligand is developed. It can self-assemble into nanoscale aggregates in lysosomes and cause significant destruction to mitochondria and cytoskeleton, leading to apoptosis of breast cancer cells. In vivo studies demonstrate that Y1L-KGRR-FF-IR has excellent therapeutic effects, reducing breast cancer tumor volume and exhibiting efficient tracing in lung metastasis models. This research provides a novel strategy for targeted therapy and precise regulation of tumor growth through functional neuropeptide Y-based artificial aggregates for intracellular spatiotemporal regulation.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
J. M. van Rees, S. Nordkamp, P. W. Harmsen, H. Rutten, J. W. A. Burger, C. Verhoef
Summary: This study aimed to investigate the impact of distant metastases on oncological outcomes in patients with locally recurrent rectal cancer (LRRC) undergoing curative treatment. The study found that LRRC patients with synchronous distant metastases undergoing curative surgery have relatively poor prognosis, but LRRC patients with a history of distant metastases diagnosed nearby the primary tumor have comparable oncological survival as LRRC patients without distant metastases.
Article
Biochemistry & Molecular Biology
Qiuyu Liu, Wanda van der Stel, Vera E. van der Noord, Hanneke Leegwater, Bircan Coban, Kim Elbertse, Joannes T. M. Pruijs, Olivier J. M. Bequignon, Gerard van Westen, Sylvia E. Le Devedec, Erik H. J. Danen
Summary: Hypoxia triggers HIF1 stabilization in luminal and basal A triple negative breast cancer cells. High throughput targeted RNA sequencing reveals overlapping and distinct target genes being modulated in these subtypes. Hypoxia induces phosphorylation of TAZ at Ser89 in basal A cells, leading to cytoplasmic sequestration of TAZ(Ser89). Hypoxia attenuates growth of basal A cells and diminishes the effect of verteporfin, a disruptor of YAP/TAZ-TEAD-mediated transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chao Zhang, Lisha Qi, Jun Cai, Haixiao Wu, Yao Xu, Yile Lin, Zhijun Li, Vladimir P. Chekhonin, Karl Peltzer, Manqing Cao, Zhuming Yin, Xin Wang, Wenjuan Ma
Summary: Clinomics-guided prediction models using artificial intelligence can accurately predict distant metastasis in breast cancer patients. This strategy has the potential to provide individualized prophylactic therapy for breast cancer patients.