Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

Results from ARQ 197-209: A global randomized placebo-controlled phase II clinical trial of erlotinib plus ARQ 197 versus erlotinib plus placebo in previously treated EGFR inhibitor-naive patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).

(2017) J. H. Schiller et al.   JOURNAL OF CLINICAL ONCOLOGY

Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors

(2010) Myung Hee Chang et al.   CANCER

MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor-Dependent Fashion to Suppress Carcinoma Growth

(2010) Y.-W. Zhang et al.   CANCER RESEARCH

Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non-Small Cell Lung Adenocarcinoma

(2010) K. Kasahara et al.   CLINICAL CANCER RESEARCH

Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks

(2010) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

The MET Receptor Tyrosine Kinase Is a Potential Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma

(2009) T. Y. Seiwert et al.   CANCER RESEARCH

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells

(2009) Koji Kawaguchi et al.   CARCINOGENESIS

EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts

(2009) B. Lal et al.   MOLECULAR CANCER THERAPEUTICS

Amphiregulin Promotes BAX Inhibition and Resistance to Gefitinib in Non-small-cell Lung Cancers

(2009) Benoît Busser et al.   MOLECULAR THERAPY

The Pittsburgh Lung Screening Study (PLuSS)

(2008) David O. Wilson et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MET as a target for treatment of chest tumors

(2008) Nicole A. Cipriani et al.   LUNG CANCER

Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis

(2008) L. P. Stabile et al.   MOLECULAR CANCER THERAPEUTICS

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA