Review
Oncology
Kevinn Eddy, Raj Shah, Suzie Chen
Summary: Melanoma, a skin cancer originating from transformed melanocytes, has high mutational burden attributed to UV-induced DNA damage. Targeted therapies and immunotherapies have shown clinical responses, but most patients develop resistance and disease relapse over time. Further understanding of the complex processes of cancer cell dissemination is crucial for improving treatment outcomes for all cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Josefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Guliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Moebs, Peter Vajkoczy, Anna Vidal, Sandra Hoegler, Petra Kodajova, Dana Westphal, Friedegund Meier, Frank Heppner, Susanne Kreuzer-Redmer, Florian Grebien, Karsten Juerchott, Torben Redmer
Summary: This study uses a multi-OMICS approach and targeted sequencing to uncover the potential programs that control the development of melanoma brain metastases (MBM). The expression of E-cadherin and NGFR is found to classify MBM into different subtypes, and these subtypes control cell migration and proliferation through downstream transcription factors. Additionally, differential methylation analysis can distinguish between different types of MBM.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Jessie Zhao, Angela Huang, Johannes Zeller, Karlheinz Peter, James D. Mcfadyen
Summary: Platelets not only play a crucial role in mediating thrombosis and haemostasis in cardiovascular disease, but also have key contributions to cancer growth, metastasis, and modulation of the tumor microenvironment. Therefore, targeting platelets therapeutically presents valuable opportunities for the development of novel cancer diagnosis tools and therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Scott Gross, Robert Hooper, Dhanendra Tomar, Alexander P. Armstead, No'ad Shanas, Pranava Mallu, Hinal Joshi, Suravi Ray, Parkson Lee-Gau Chong, Igor Astsaturov, Jeffrey M. Farma, Kathy Q. Cai, Kumaraswamy Naidu Chitrala, John W. Elrod, M. Raza Zaidi, Jonathan Soboloff
Summary: The study reveals the critical role of store-operated Ca2+ entry (SOCE) suppression in melanoma metastasis. UV-induced cholesterol biosynthesis is crucial for the suppression of SOCE and subsequent metastasis. Functional analyses show that increased glucose uptake leads to metabolic shifts critical for melanoma metastasis.
Article
Immunology
Seyedeh Alia Moosavian, Maryam Hashemi, Leila Etemad, Sara Daneshmand, Zahra Salmasi
Summary: Exosomes play a crucial role in early diagnosis and various functions related to angiogenesis, immune modulation, migration, metastasis, chemotherapy resistance, and tumor progression in melanoma. Natural exosomes have the potential to be utilized as nanocarriers and cancer vaccines for more efficient cancer treatment in the era of novel bioengineering and immunotherapy approaches.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Ting Huang, Yong-Jie Wang, Mi-Tao Huang, Yu Guo, Li-Chang Yang, Xiao-Jin Liu, Wu-Yuan Tan, Jian-Hong Long
Summary: Studies have shown that LINC00470 enhances the expression of APEX1 in melanoma by activating the transcription factor ZNF131, thereby promoting the proliferation and migration of melanoma cells. This suggests that LINC00470 may be a potential therapeutic target for the treatment of melanoma.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Won-Min Song, Praveen Agrawal, Richard Von Itter, Barbara Fontanals-Cirera, Minghui Wang, Xianxiao Zhou, Lara K. Mahal, Eva Hernando, Bin Zhang
Summary: This study establishes predictive gene network models of molecular alterations in primary melanoma by integrating various types of data, revealing key factors influencing melanoma development. Tumors with high immune infiltrates are associated with good prognosis, potentially due to induced CD8+ T-cell cytotoxicity. Experimental validation shows that 17 key regulators associated with poor prognosis have pro-tumorigenic effects in melanoma.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Qi Zhang, Linbo Jin, Quanxin Jin, Qiang Wei, Mingyuan Sun, Qi Yue, Huan Liu, Fangfang Li, Honghua Li, Xiangshan Ren, Guihua Jin
Summary: The study found that DHA has inhibitory effects on the proliferation, migration, and metastasis of melanoma, and can also impact immune cells in the tumor microenvironment. This suggests that DHA may serve as a potential treatment for melanoma.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Guenzle, Harue Akasaka, Katharina Joechle, Wilfried Reichardt, Aina Venkatasamy, Jens Hoeppner, Claus Hellerbrand, Stefan Fichtner-Feigl, Sven A. Lang
Summary: This study demonstrates the significant reduction in migration, invasion, and proliferation of melanoma cells upon specific inhibition of mTORC2 using the novel inhibitor JR-AB2-011, leading to cell death through non-apoptotic pathways. In a syngeneic murine metastasis model, therapy with JR-AB2-011 showed a remarkable decrease in liver metastasis, highlighting the potential of pharmacological blockade of mTORC2 as a novel anti-cancer approach for melanoma liver metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Georgina Long, Susan M. Swetter, Alexander M. Menzies, Jeffrey E. Gershenwald, Richard A. Scolyer
Summary: Cutaneous melanoma is a malignancy derived from skin melanocytes, primarily caused by ultraviolet radiation. Diagnosis is based on clinical and histopathological findings, and treatment options vary depending on disease stage and characteristics. Multidisciplinary care, including systemic drug therapies, has significantly improved melanoma survival rates.
Article
Multidisciplinary Sciences
Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, Vito W. Rebecca, Gloria E. Marino, Filipe Almeida, Brett L. Ecker, Daniel J. Zabransky, Laura Huser, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, Meenhard Herlyn, David W. Speicher, Wei Xu, Xiaowei Xu, Elizabeth M. Jaffee, Julio A. Aguirre-Ghiso, Ashani T. Weeraratna
Summary: The aged lung microenvironment provides a permissive niche for the growth and dissemination of melanoma cells, while age-related changes in the skin suppress melanoma growth but drive dissemination. Reprogramming of lung fibroblasts and activation of WNT5A promote the metastasis and dissemination of melanoma cells by inhibiting WNT5A in melanoma cells.
Article
Biochemistry & Molecular Biology
Nahoko Tomonobu, Rie Kinoshita, Hidenori Wake, Yusuke Inoue, I. Made Winarsa Ruma, Ken Suzawa, Yuma Gohara, Ni Luh Gede Yoni Komalasari, Fan Jiang, Hitoshi Murata, Ken-ichi Yamamoto, I. Wayan Sumardika, Youyi Chen, Junichiro Futami, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Shinichi Toyooka, Masahiro Nishibori, Masakiyo Sakaguchi
Summary: The secretion of S100A8/A9 proteins plays a crucial role in promoting the cancer environment and cultivating premetastatic cancer sites, while the presence of HRG protein in the brain prevents the metastasis of melanoma cells. Clinical findings suggest that HRG protects the brain and lungs from melanoma metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Hannah M. Neuendorf, Jacinta L. Simmons, Glen M. Boyle
Summary: The acquisition of resistance to anoikis is crucial for the survival and metastasis of disseminating and circulating tumor cells (CTCs) in melanoma. However, the full understanding of the mechanisms involved is still lacking. This review discusses the potential of small molecule, peptide, and antibody inhibitors in targeting molecules associated with anoikis resistance in melanoma, which could potentially improve the prognosis for patients by preventing metastatic melanoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Immunology
Guohang Xiong, Yu Feng, Xiaojia Yi, Xuedan Zhang, Xiaoyu Li, Lijuan Yang, Zihan Yi, Buqing Sai, Zhe Yang, Qiao Zhang, Yingmin Kuang, Yuechun Zhu
Summary: The study found that PRPS1 is upregulated in melanoma and promotes proliferation, migration, invasion, and inhibits apoptosis of melanoma cells. Additionally, NRF2 acts as an upstream transcription factor of PRPS1 which drives the malignant progression of melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vipin Rawat, Parmanand Malvi, Deborah Della Manna, Eddy S. Yang, Suresh Bugide, Xuchen Zhang, Romi Gupta, Narendra Wajapeyee
Summary: Metabolic deregulation in cancer cells promotes tumor growth and metastasis. In this study, PSPH, a key enzyme in serine metabolism pathway, was found to be upregulated in melanoma samples. Knocking down PSPH resulted in inhibition of melanoma growth and metastasis through suppression of 2-HG levels and subsequent activation of pro-oncogenic gene expression pathways.
