Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Hypoxia-inducible proto-oncogene Pim-1 is a prognostic marker in pancreatic ductal adenocarcinoma

(2010) Carolin Reiser-Erkan et al.   CANCER BIOLOGY & THERAPY

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

(2010) Julian Carretero et al.   CANCER CELL

Fructose Induces Transketolase Flux to Promote Pancreatic Cancer Growth

(2010) H. Liu et al.   CANCER RESEARCH

PTEN Loss Accelerates KrasG12D-Induced Pancreatic Cancer Development

(2010) R. Hill et al.   CANCER RESEARCH

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

LKB1 Haploinsufficiency Cooperates With Kras to Promote Pancreatic Cancer Through Suppression of p21-Dependent Growth Arrest

(2010) Jennifer P. Morton et al.   GASTROENTEROLOGY

Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in Pancreatic Cancer

(2010) D. L. Schwartz et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth

(2009) K. Kisfalvi et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Selective Killing of Hypoxia-Inducible Factor-1-Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer

(2009) S. Kizaka-Kondoh et al.   CLINICAL CANCER RESEARCH

Inflammation and EMT: an alliance towards organ fibrosis and cancer progression

(2009) Jose Miguel López-Novoa et al.   EMBO Molecular Medicine

Antidiabetic Therapies Affect Risk of Pancreatic Cancer

(2009) Donghui Li et al.   GASTROENTEROLOGY

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect

(2009) Yijun Chen et al.   PLoS One

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Redox mechanisms switch on hypoxia-dependent epithelial–mesenchymal transition in cancer cells

(2008) Stefania Cannito et al.   CARCINOGENESIS

Pancreatic Lkb1 Deletion Leads to Acinar Polarity Defects and Cystic Neoplasms

(2008) A. F. Hezel et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA